Bp38 QTL Report (Rattus norvegicus) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
QTL Registration

QTL: Bp38 (Blood pressure QTL 38) Rattus norvegicus

Symbol: Bp38
Name: Blood pressure QTL 38
RGD ID: 61357
Previously known as: C7QTL
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: 1.6
P Value: 0.052
Variance: 4.8
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8740,540,077 - 123,682,549RGD_MAPPER_PIPELINE
mRatBN7.2741,333,674 - 119,109,060RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0748,118,835 - 128,611,831RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0748,134,589 - 128,652,785RGDRnor5.0
RGSC_v3.4744,698,822 - 125,481,104RGDRGSC3.4
RGSC_v3.1762,610,694 - 107,610,694RGD
Cross Type: F2
Strains Crossed: SS/Jr LEW/NCrl 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Tac3 is a candidate Gene for Bp38
Nxph4 is a candidate Gene for Bp38
Rdh16 is a candidate Gene for Bp38


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp38Rathypertension  IDA 61040 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp38Ratincreased systemic arterial blood pressure  QTM 61040 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp38Ratsystolic blood pressure  IDA 61040 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp38Ratcontrolled sodium content diet  IDA 61040 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp38Rattail cuff photoplethysmography  IDA 61040 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp38RatLEW/NCrl  IEA 61040 RGD 
Bp38RatSS/Jr  IEA 61040 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp38Ratarterial blood pressure trait  IDA 61040 RGD 


#
Reference Title
Reference Citation
1. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
2. Normotension in Lewis and Dahl salt-resistant rats is governed by different genes. Crespo K, etal., J Hypertens. 2011 Mar;29(3):460-5.
3. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23

Related QTL Description Reference
Bp279 interacts with RGD:7421500
Bp310 interacts with RGD:7421500



1 to 20 of 1003 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1305021Ppfia2PTPRF interacting protein alpha 274176571642240104Rat
1307051Acss3acyl-CoA synthetase short-chain family member 374224126142450209Rat
9417884LOC103692846sulfotransferase 1C2 pseudogene74225480842256182Rat
40969194LOC120094001small nucleolar RNA SNORA1774245986042459990Rat
621256Lin7alin-7 homolog A, crumbs cell polarity complex component74258670442742609Rat
41152665LOC120094046U5 spliceosomal RNA74265756642657674Rat
1308322Myf5myogenic factor 574280294642806177Rat
3134Myf6myogenic factor 674281300842814852Rat
41050361LOC120093580uncharacterized LOC12009358074281525443016555Rat
620779Ptprqprotein tyrosine phosphatase, receptor type, Q74283445543016807Rat
1589018Otoglotogelin-like74306580043211400Rat
620013Ppp1r12aprotein phosphatase 1, regulatory subunit 12A74348280843593689Rat
69065Pawrpro-apoptotic WT1 regulator74364502843725033Rat
41023123Rpl26-ps10ribosomal protein L26, pseudogene 1074370389943716963Rat
41368650LOC120093977small nucleolar RNA SNORA4874371172743711871Rat
41136792LOC120093582uncharacterized LOC12009358274374690243769702Rat
40962771LOC120093799uncharacterized LOC12009379974380844543814458Rat
3803Syt1synaptotagmin 174381320444358020Rat
7658882LOC102547595uncharacterized LOC10254759574397609244001594Rat
9447173Brcc3dcBRCA1/BRCA2-containing complex, subunit 3, domain containing74401488944016646Rat

1 to 20 of 1003 rows
1 to 20 of 1382 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10221D7Arb1722675811322458113450Ratregion
10252D7Mit121367114727471114727581Ratregion
10253D7Wox201447114727449114727593Ratregion
10427D7Wox192577106839225106839474Ratregion
10431D7Wox182507106741074106741295Ratregion
10431D7Wox182507106773255106773476Ratregion
10447D7Wox212717113938271113938544Ratregion
10448D7Mgh32447113915925113916171Ratregion
10449D7Mit161627113886156113886318Ratregion
10472D7Wox301987114321734114321932Ratregion
10880D7Mgh2212475288832652888450Ratregion
10935D7Wox1413179359564793595780Ratregion
10936D7Arb520479359562793595833Ratregion
10937D7Wox1515979359562093595781Ratregion
10938D7Wox2911979359563393595754Ratregion
10939D7Mit2721079359563193595843Ratregion
33816D7Mit11947116738749116738842Ratregion
33838D3Mit181887116932605116932728Ratregion
33969D7Mit423979481108594811326Ratregion
34096D7Mgh41487112729554112729683Ratregion
1 to 20 of 1382 rows

Flank 1: (D7Mgh1)
Rat AssemblyChrPosition (strand)Source
GRCr87123,682,399 - 123,682,549 (+)Marker Load Pipeline
Cytogenetic Map7 RGD
Peak: (D7Mit5)
Rat AssemblyChrPosition (strand)Source
GRCr8782,111,245 - 82,111,382 (+)Marker Load Pipeline
mRatBN7.2780,221,299 - 80,221,436 (+)MAPPER
Rnor_6.0788,365,265 - 88,365,401NCBI
Rnor_5.0788,393,619 - 88,393,755UniSTS
RGSC_v3.4785,089,895 - 85,090,032RGD
RGSC_v3.4785,089,896 - 85,090,032UniSTS
RGSC_v3.1785,110,626 - 85,110,762RGD
Celera777,115,894 - 77,116,030UniSTS
RH 3.4 Map7539.2UniSTS
RH 3.4 Map7539.2RGD
RH 2.0 Map7467.1RGD
SHRSP x BN Map747.81RGD
FHH x ACI Map736.72RGD
Cytogenetic Map7 RGD
Flank 2: (D7Uia3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2741,333,674 - 41,333,804 (+)MAPPER
Rnor_6.0748,118,835 - 48,118,964NCBI
Rnor_5.0748,134,589 - 48,134,718UniSTS
RGSC_v3.4744,698,822 - 44,698,952RGD
RGSC_v3.4744,698,823 - 44,698,952UniSTS
RGSC_v3.1744,719,093 - 44,719,223RGD
Celera738,210,224 - 38,210,353UniSTS
Cytogenetic Map7 RGD


1 to 10 of 96 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat

1 to 10 of 96 rows


Database
Acc Id
Source(s)
NCBI Gene Bp38

Note Type Note Reference
qtl_cand_genes Tac2, Nxph4 and Rdh16 were reported as candidate genes; but these do not lie within the QTL boundaries 4891049
qtl_gene Cyp11b1, Cyp11b2 and Cyp11b3 cannot be the candidate genes as these are identical in SS/Jr and LEW/Crlc 4891049
qtl_general hypertensive allele is of SS origin and normotensive allele is of LEW origin 4891049
qtl_general LOD score for heart weight was acceptable 61040
qtl_general LOD score for heart weight was acceptable 61040
qtl_general region confirmed by developing SS.LEW-(D7Rat73-D7Rat128)/Ayd reciprocal congenic LEW.SS-(D7Rat73-D7Rat128)/Ayd does not show change in blood pressure 4891049