Gsdmdl1 (gasdermin D like 1) - Rat Genome Database

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Gene: Gsdmdl1 (gasdermin D like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gsdmdl1 (Ensembl: RGD1359449)
Name: gasdermin D like 1 (Ensembl:gasdermin domain containing protein RGD1359449)
RGD ID: 1359449
Description: Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to be located in cytosol and plasma membrane; INTERACTS WITH 6-propyl-2-thiouracil; copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gasdermin domain containing protein RGD1359449; LOC314959; RGD1359449; similar to gasdermin
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8797,509,288 - 97,519,788 (+)NCBIGRCr8
mRatBN7.2795,620,052 - 95,630,546 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl795,620,061 - 95,630,532 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx797,391,160 - 97,401,646 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0799,592,826 - 99,603,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0799,514,792 - 99,525,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07104,500,564 - 104,511,236 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7104,501,014 - 104,511,234 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0791,504,091 - 91,514,581 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,134,842 - 101,145,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,169,071 - 101,179,555 (+)NCBI
Celera792,217,932 - 92,228,417 (+)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Gsdmdl1
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:97
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000006823
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 23 7 19 7 5 5 8 8 7 8 5
Below cutoff 3 9 5 5 5 3 6 3 16 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000090226   ⟹   ENSRNOP00000074359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,620,061 - 95,630,532 (+)Ensembl
Rnor_6.0 Ensembl7104,501,014 - 104,511,234 (+)Ensembl
RefSeq Acc Id: NM_001014084   ⟹   NP_001014106
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,303 - 97,519,788 (+)NCBI
mRatBN7.2795,620,061 - 95,630,546 (+)NCBI
Rnor_6.07104,500,751 - 104,511,236 (+)NCBI
Rnor_5.0791,504,091 - 91,514,581 (+)NCBI
RGSC_v3.47101,134,842 - 101,145,327 (+)RGD
Celera792,217,932 - 92,228,417 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241642   ⟹   XP_006241704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,290 - 97,519,788 (+)NCBI
mRatBN7.2795,620,052 - 95,630,546 (+)NCBI
Rnor_6.07104,500,566 - 104,511,236 (+)NCBI
Rnor_5.0791,504,091 - 91,514,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079164   ⟹   XP_038935092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,290 - 97,519,788 (+)NCBI
mRatBN7.2795,620,061 - 95,630,546 (+)NCBI
RefSeq Acc Id: XM_039079167   ⟹   XP_038935095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,294 - 97,519,788 (+)NCBI
mRatBN7.2795,620,052 - 95,630,546 (+)NCBI
RefSeq Acc Id: XM_039079168   ⟹   XP_038935096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,294 - 97,519,788 (+)NCBI
mRatBN7.2795,620,052 - 95,629,803 (+)NCBI
RefSeq Acc Id: XM_063263517   ⟹   XP_063119587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,290 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263518   ⟹   XP_063119588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,294 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263520   ⟹   XP_063119590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,303 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263521   ⟹   XP_063119591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,288 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263522   ⟹   XP_063119592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,301 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263523   ⟹   XP_063119593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,961 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263524   ⟹   XP_063119594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,291 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263525   ⟹   XP_063119595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,291 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263526   ⟹   XP_063119596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,301 - 97,519,788 (+)NCBI
RefSeq Acc Id: XM_063263528   ⟹   XP_063119598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,301 - 97,519,788 (+)NCBI
RefSeq Acc Id: XR_010052972
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,291 - 97,519,016 (+)NCBI
RefSeq Acc Id: XR_010052973
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,509,291 - 97,519,538 (+)NCBI
RefSeq Acc Id: NP_001014106   ⟸   NM_001014084
- UniProtKB: Q6AY10 (UniProtKB/TrEMBL),   A0A0G2K7V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241704   ⟸   XM_006241642
- Peptide Label: isoform X2
- UniProtKB: Q6AY10 (UniProtKB/TrEMBL),   A0A0G2K7V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074359   ⟸   ENSRNOT00000090226
RefSeq Acc Id: XP_038935095   ⟸   XM_039079167
- Peptide Label: isoform X2
- UniProtKB: Q6AY10 (UniProtKB/TrEMBL),   A0A0G2K7V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935096   ⟸   XM_039079168
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K7V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935092   ⟸   XM_039079164
- Peptide Label: isoform X2
- UniProtKB: Q6AY10 (UniProtKB/TrEMBL),   A0A0G2K7V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119591   ⟸   XM_063263521
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119587   ⟸   XM_063263517
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119595   ⟸   XM_063263525
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119594   ⟸   XM_063263524
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119588   ⟸   XM_063263518
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119596   ⟸   XM_063263526
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119592   ⟸   XM_063263522
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119598   ⟸   XM_063263528
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119590   ⟸   XM_063263520
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119593   ⟸   XM_063263523
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY10-F1-model_v2 AlphaFold Q6AY10 1-460 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359449 AgrOrtholog
BioCyc Gene G2FUF-33150 BioCyc
Ensembl Genes ENSRNOG00000059240 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090226.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132649 IMAGE-MGC_LOAD
InterPro DFNA5 UniProtKB/TrEMBL
  Gasdermin_pore UniProtKB/TrEMBL
  Gasdermin_PUB UniProtKB/TrEMBL
KEGG Report rno:314959 UniProtKB/TrEMBL
MGC_CLONE MGC:94321 IMAGE-MGC_LOAD
NCBI Gene 314959 ENTREZGENE
PANTHER DFNA5 UniProtKB/TrEMBL
  GASDERMIN DOMAIN-CONTAINING PROTEIN RGD1359449 UniProtKB/TrEMBL
Pfam Gasdermin UniProtKB/TrEMBL
  Gasdermin_C UniProtKB/TrEMBL
PhenoGen Gsdmdl1 PhenoGen
RatGTEx ENSRNOG00000059240 RatGTEx
UniProt A0A0G2K7V2 ENTREZGENE, UniProtKB/TrEMBL
  Q6AY10 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Gsdmdl1  gasdermin D like 1  RGD1359449  gasdermin domain containing protein RGD1359449  Symbol and Name Changed 1299863 APPROVED
2005-11-17 RGD1359449  gasdermin domain containing protein RGD1359449      Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC314959  similar to gasdermin      Symbol and Name status set to provisional 70820 PROVISIONAL