Stat6 (signal transducer and activator of transcription 6) - Rat Genome Database
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Gene: Stat6 (signal transducer and activator of transcription 6) Rattus norvegicus
Analyze
Symbol: Stat6
Name: signal transducer and activator of transcription 6
RGD ID: 1309063
Description: Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; and positive regulation of transcription by RNA polymerase II. Localizes to membrane raft and nucleus. Used to study asthma and renal fibrosis. Biomarker of asthma and myocarditis. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC362896; signal transducer and activator of transcription 6, interleukin-4 induced; signal transducer and transcription activator 6
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0770,946,228 - 70,963,542 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,946,228 - 70,964,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,118,725 - 71,135,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,623,534 - 67,642,283 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,622,590 - 67,662,987 (+)NCBI
Celera760,619,697 - 60,637,001 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpinumisoflavone  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyfluthrin  (ISO)
Deguelin  (ISO)
diclofenac  (ISO)
Diisodecyl phthalate  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
Fidarestat  (ISO)
flavonoids  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (EXP,ISO)
geraniol  (ISO)
glycidol  (EXP)
histamine  (ISO)
hydrogen peroxide  (ISO)
ketorolac  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
oxaliplatin  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium salicylate  (ISO)
sunitinib  (ISO)
synephrine  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
tofacitinib  (ISO)
trichostatin A  (EXP,ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)


Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,ISO)
membrane raft  (IDA)
nuclear chromatin  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Acharya B, etal., Am J Nephrol. 2005 Jan-Feb;25(1):30-5. Epub 2005 Feb 1.
2. Borner C, etal., J Neurochem. 2004 Dec;91(6):1493-500.
3. Chun KR, etal., Exp Mol Med. 2004 Aug 31;36(4):367-71.
4. Das S, etal., Prostate. 2007 Oct 1;67(14):1550-64.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. He H, etal., Genes Immun. 2008 Apr;9(3):195-206. doi: 10.1038/gene.2008.2. Epub 2008 Feb 14.
8. Ikeuchi Y, etal., Pediatr Nephrol. 2009 Mar;24(3):489-95. doi: 10.1007/s00467-008-1003-y. Epub 2008 Nov 15.
9. Jacob CO, etal., J Immunol. 2003 Aug 1;171(3):1564-71.
10. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
11. Kobayashi Y, etal., Am J Kidney Dis. 2003 Aug;42(2):271-6.
12. Land KJ, etal., Endocrinology. 2004 Aug;145(8):3724-30. Epub 2004 Apr 29.
13. Lau M, etal., J Autoimmun. 2012 Dec;39(4):388-97. doi: 10.1016/j.jaut.2012.06.003. Epub 2012 Aug 4.
14. Li CC, etal., Zhonghua Er Ke Za Zhi. 2005 Jul;43(7):521-5.
15. Liu ZC, etal., Zhonghua Yi Xue Za Zhi. 2008 Sep 9;88(34):2432-6.
16. Low SH, etal., Dev Cell. 2006 Jan;10(1):57-69.
17. Matsukawa A, etal., J Exp Med. 2001 Mar 19;193(6):679-88.
18. MGD data from the GO Consortium
19. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
20. Ni Z, etal., J Urol. 2002 Apr;167(4):1859-62.
21. Nishimura Y, etal., Circ J. 2008 Apr;72(4):647-53.
22. Olsan EE, etal., Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18067-72. doi: 10.1073/pnas.1111966108. Epub 2011 Oct 24.
23. Ong CJ, etal., Cell Immunol. 1999 Aug 25;196(1):60-8.
24. Ostrand-Rosenberg S, etal., J Immunol. 2000 Dec 1;165(11):6015-9.
25. Park SJ, etal., J Immunol. 2012 May 15;188(10):5132-41. doi: 10.4049/jimmunol.1101600. Epub 2012 Apr 13.
26. Pipeline to import KEGG annotations from KEGG into RGD
27. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Qiu Y, etal., Cell. 2014 Jun 5;157(6):1292-308. doi: 10.1016/j.cell.2014.03.066.
29. RGD automated data pipeline
30. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. RGD automated import pipeline for gene-chemical interactions
32. Robinson K, etal., J Am Coll Surg. 2006 May;202(5):788-96.
33. Summers SA, etal., Clin Exp Immunol. 2011 Nov;166(2):227-34. doi: 10.1111/j.1365-2249.2011.04437.x.
34. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
35. Yokota N, etal., Am J Physiol Renal Physiol. 2003 Aug;285(2):F319-25. Epub 2003 Apr 22.
36. Yukawa K, etal., Int J Mol Med. 2005 Feb;15(2):225-30.
37. Zhao J, etal., Toxicol Lett. 2012 Feb 5;208(3):225-31. doi: 10.1016/j.toxlet.2011.11.012. Epub 2011 Nov 23.
Additional References at PubMed
PMID:8810328   PMID:9110977   PMID:10438949   PMID:10490661   PMID:12093868   PMID:12634107   PMID:15187136   PMID:15659391   PMID:16728393   PMID:17210636   PMID:17658279   PMID:18997793  
PMID:19531027   PMID:20706986   PMID:20956546   PMID:21162243   PMID:21217760   PMID:21269961   PMID:22000020   PMID:22588720   PMID:24280217   PMID:24296793   PMID:24321062   PMID:29115389  


Genomics

Comparative Map Data
Stat6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0770,946,228 - 70,963,542 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,946,228 - 70,964,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0771,118,725 - 71,135,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,623,534 - 67,642,283 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,622,590 - 67,662,987 (+)NCBI
Celera760,619,697 - 60,637,001 (+)NCBICelera
Cytogenetic Map7q22NCBI
STAT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,095,408 - 57,132,139 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,095,408 - 57,111,413 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,489,187 - 57,505,196 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,775,458 - 55,791,428 (-)NCBINCBI36hg18NCBI36
Build 341255,775,461 - 55,791,428NCBI
Celera1257,143,115 - 57,159,124 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,527,593 - 54,543,593 (-)NCBIHuRef
CHM1_11257,456,871 - 57,472,880 (-)NCBICHM1_1
Stat6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,478,855 - 127,496,856 (+)NCBI
GRCm3810127,642,955 - 127,660,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,642,986 - 127,660,957 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,080,042 - 127,098,043 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610127,046,120 - 127,063,352 (+)NCBImm8
Celera10130,035,284 - 130,053,348 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.59NCBI
Stat6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,833,515 - 4,843,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,833,417 - 4,847,956 (-)NCBIChiLan1.0ChiLan1.0
STAT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl101,233,691 - 1,247,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1101,232,515 - 1,247,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Stat6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366461,297,530 - 1,312,508 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,406,364 - 22,421,990 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,406,356 - 22,422,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,206,059 - 24,221,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAT6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1153,006,145 - 53,021,203 (-)Ensembl
ChlSab1.11153,005,378 - 53,020,899 (-)NCBI
Stat6
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
AI451907  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0770,964,747 - 70,964,860NCBIRnor6.0
Rnor_5.0771,137,053 - 71,137,166UniSTSRnor5.0
RGSC_v3.4767,643,488 - 67,643,601UniSTSRGSC3.4
Celera760,638,214 - 60,638,327UniSTS
Cytogenetic Map7q22UniSTS
UniSTS:224451  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0770,963,655 - 70,963,824NCBIRnor6.0
Rnor_5.0771,135,961 - 71,136,130UniSTSRnor5.0
RGSC_v3.4767,642,396 - 67,642,565UniSTSRGSC3.4
Celera760,637,114 - 60,637,291UniSTS
Cytogenetic Map7q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72536563393155402Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72820465373204653Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)73138152976381529Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)73203505377035053Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)73257294277572942Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)73304444971352127Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)73586772980867729Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)73586772993155402Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73854770683547706Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)74087268285872682Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)74087268285872682Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74530157390301573Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)75025210395252103Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)75079381895793818Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)751252005111589099Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)75320034498200344Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)75425951299259512Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)75453499673293934Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)755495689100495689Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)755495689100495689Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)755495689100495689Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)755495689100495689Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)755495689100495689Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)755495689100495689Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)755495689100495689Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)761047589113228378Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)768518460113518460Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)769399586111043530Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)769399586111043530Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)770421228115421228Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:77
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000039306
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 53 37 19 37 1 1 6 35 34 11 1
Low 11 4 4 4 7 10 68 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039306   ⟹   ENSRNOP00000034983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl770,946,228 - 70,963,542 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085350   ⟹   ENSRNOP00000072301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl770,950,231 - 70,964,484 (+)Ensembl
RefSeq Acc Id: NM_001044250   ⟹   NP_001037715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,946,228 - 70,963,542 (+)NCBI
Rnor_5.0771,118,725 - 71,135,848 (+)NCBI
RGSC_v3.4767,623,534 - 67,642,283 (+)RGD
Celera760,619,697 - 60,637,001 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001037715 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC12759 (Get FASTA)   NCBI Sequence Viewer  
  ABE73454 (Get FASTA)   NCBI Sequence Viewer  
  EDM16459 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001037715   ⟸   NM_001044250
- UniProtKB: Q1KQ07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072301   ⟸   ENSRNOT00000085350
RefSeq Acc Id: ENSRNOP00000034983   ⟸   ENSRNOT00000039306
Protein Domains
SH2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695266
Promoter ID:EPDNEW_R5790
Type:initiation region
Name:Stat6_1
Description:signal transducer and activator of transcription 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,946,220 - 70,946,280EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309063 AgrOrtholog
Ensembl Genes ENSRNOG00000025023 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034983 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072301 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039306 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085350 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT6_C UniProtKB/TrEMBL
  STAT6_SH2 UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_core UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_sub UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report rno:362896 UniProtKB/TrEMBL
NCBI Gene 362896 ENTREZGENE
PANTHER STAT UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT6_C UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
PhenoGen Stat6 PhenoGen
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP P53_like_DNA_bnd UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
UniGene Rn.6880 ENTREZGENE
UniProt O70429_RAT UniProtKB/TrEMBL
  Q1KQ07 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Stat6  signal transducer and activator of transcription 6  Stat6  signal transducer and activator of transcription 6, interleukin-4 induced  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-01 Stat6  signal transducer and activator of transcription 6, interleukin-4 induced  Stat6  signal transducer and activator of transcription 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Stat6  signal transducer and activator of transcription 6   Stat6_predicted  signal transducer and activator of transcription 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stat6_predicted  signal transducer and activator of transcription 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.