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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309063
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat6
Name: signal transducer and activator of transcription 6
Acc ID: CHEBI:46680
Term: serpentine asbestos
Definition: null
Chemical ID: MESH:D017632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat6increases oxidationISOStat6 (Mus musculus)6480464CTDAsbestos, Serpentine results in increased oxidation of STAT6 proteinPMID:26699812
Stat6multiple interactionsISOStat6 (Mus musculus)6480464CTDAsbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Asbestos, Serpentine promotes the reaction [STAT6 protein binds to KDM6B promoter]; Asbestos, Serpentine results in increased oxidation of and results in increased phosphorylation of STAT6 protein; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]; leflunomide inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of STAT6 protein]; polyethylene glycol-superoxide dismutase affects the reaction [STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]]; SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of CHIL3 mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of CHIL3 protein]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of KDM6B mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of RETNLA mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TGFB1 protein]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TNF protein]PMID:26699812
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