Stat5b (signal transducer and activator of transcription 5B) - Rat Genome Database

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Gene: Stat5b (signal transducer and activator of transcription 5B) Rattus norvegicus
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Symbol: Stat5b
Name: signal transducer and activator of transcription 5B
RGD ID: 3774
Description: Enables several functions, including DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; receptor signaling pathway via JAK-STAT; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B); PARTICIPATES IN Jak-Stat signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Signal transducer and activator of transcription 5a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Eau3 Pia10 Ciaa2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,704,841 - 85,775,856 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,705,670 - 85,775,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,743,399 - 90,812,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,222,166 - 90,290,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,615,217 - 85,683,927 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,686,207 - 88,712,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,686,207 - 88,754,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,480,377 - 88,506,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,716,624 - 89,743,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,730,993 - 89,757,504 (-)NCBI
Celera1084,424,576 - 84,451,052 (-)NCBICelera
RH 3.4 Map10837.39RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-benzofuran  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-tert-Butoxy-2-propanol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-nitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
AP20187  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciprofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coumarin  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
furan  (EXP,ISO)
gentamycin  (EXP)
GW 501516  (ISO)
hexachlorobenzene  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
ketoconazole  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(1-naphthyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-Methylolacrylamide  (ISO)
naphthalene  (ISO)
naphthalene-1,5-diamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (ISO)
NORCANTHARIDIN  (ISO)
oxazepam  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenanthrolines  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quizartinib  (ISO)
resveratrol  (ISO)
ruxolitinib  (ISO)
SB 431542  (ISO)
sebacic acid  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (IEA,ISO)
acute-phase response  (IDA)
B cell differentiation  (IEA,ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IBA,IDA,IEA,ISO)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to growth factor stimulus  (IEA,ISO,ISS)
cellular response to hormone stimulus  (ISO)
cytokine-mediated signaling pathway  (IBA,IEA,ISO)
defense response  (IBA,IEA)
development of secondary female sexual characteristics  (IEA,ISO)
development of secondary male sexual characteristics  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
female pregnancy  (IEA,ISO)
gamma-delta T cell differentiation  (IEA,ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO)
lactation  (IEA,ISO)
lipid storage  (IEA,ISO)
liver development  (IDA)
luteinization  (IDA,IEA,ISO)
lymphocyte differentiation  (ISO)
mast cell migration  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
myeloid cell apoptotic process  (IEA,ISO)
natural killer cell differentiation  (IEA,ISO)
natural killer cell mediated cytotoxicity  (IEA,ISO)
natural killer cell proliferation  (IEA,ISO)
negative regulation of erythrocyte differentiation  (IEA,ISO)
negative regulation of myeloid cell apoptotic process  (IEA,ISO)
Peyer's patch development  (IEA,ISO)
positive regulation of activated T cell proliferation  (IEA,ISO)
positive regulation of B cell differentiation  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO,ISS)
positive regulation of fibroblast growth factor production  (IMP)
positive regulation of gamma-delta T cell differentiation  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of lymphocyte differentiation  (ISO)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of natural killer cell differentiation  (IEA,ISO)
positive regulation of natural killer cell mediated cytotoxicity  (IEA,ISO)
positive regulation of natural killer cell proliferation  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
progesterone metabolic process  (IEA,ISO)
regulation of cell adhesion  (ISO)
regulation of cell population proliferation  (IBA,IEA)
regulation of DNA-templated transcription  (IDA,IEA)
regulation of epithelial cell differentiation  (IEA,ISO)
regulation of multicellular organism growth  (ISO)
regulation of steroid metabolic process  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to estradiol  (IEA,ISO)
response to ethanol  (IEP)
response to hypoxia  (IEP)
response to interleukin-15  (IEA,ISO)
response to interleukin-2  (IEA,ISO)
response to interleukin-4  (IEA,ISO)
response to lipopolysaccharide  (IDA)
response to peptide hormone  (IBA,IDA,IEP)
sex differentiation  (ISO)
T cell differentiation in thymus  (IEA,ISO)
T cell homeostasis  (IEA,ISO)
taurine metabolic process  (IEA,ISO)
transcription by RNA polymerase II  (IDA,IEA,ISO)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (TAS)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Effects of chronic ethanol on hepatic and renal CYP2C11 in the male rat: interactions with the Janus-kinase 2-signal transducer and activators of transcription proteins 5b pathway. Badger TM, etal., Endocrinology. 2003 Sep;144(9):3969-76.
2. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Cao H, etal., Circ Res. 2006 Apr 14;98(7):913-22. Epub 2006 Mar 9.
3. ENDOTOXIN ATTENUATES GROWTH HORMONE INDUCED HEPATIC INSULIN-LIKE GROWTH FACTOR-1 EXPRESSION BY INHIBITING JAK2/STAT5 SIGNAL TRANSDUCTION AND STAT5b DNA BINDING. Chen Y, etal., Am J Physiol Endocrinol Metab. 2007 Feb 27;.
4. STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species. Du W, etal., J Cell Physiol. 2012 Jun;227(6):2421-9. doi: 10.1002/jcp.22977.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. Gebert CA, etal., Mol Endocrinol. 1997 Apr;11(4):400-14.
7. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Gerland K, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Opposite nuclear level and binding activity of STAT5B and STAT3 proteins with rat haptoglobin gene under normal and turpentine induced acute phase conditions. Grigorov I, etal., Mol Biol Rep 2001;28(4):217-22.
10. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
11. Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth. Hu X, etal., Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10213-8. doi: 10.1073/pnas.1221243110. Epub 2013 Jun 3.
12. STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes. Jackerott M, etal., Diabetes. 2006 Oct;55(10):2705-12.
13. Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway. Ji S, etal., J Biol Chem. 1999 May 7;274(19):13434-42.
14. Activation of signal transducer and activator of transcription 5 is required for progression of autochthonous prostate cancer: evidence from the transgenic adenocarcinoma of the mouse prostate system. Kazansky AV, etal., Cancer Res. 2003 Dec 15;63(24):8757-62.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. Lee TK, etal., Cancer Res. 2006 Oct 15;66(20):9948-56. doi: 10.1158/0008-5472.CAN-06-1092.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response. Mihailovic M, etal., Acta Biochim Pol. 2007;54(2):331-40. Epub 2007 Jun 12.
19. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Genetic background determines if Stat5b suppresses or enhances murine hepatocarcinogenesis. Oberley CC, etal., Mol Carcinog. 2015 Oct;54(10):959-70. doi: 10.1002/mc.22165. Epub 2014 May 17.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression. Park SH and Waxman DJ, J Biol Chem 2001 Nov 16;276(46):43031-9.
24. Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. Pastuszak-Lewandoska D, etal., PLoS One. 2014 Aug 19;9(8):e104265. doi: 10.1371/journal.pone.0104265. eCollection 2014.
25. A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. Peng SC, etal., Nucleic Acids Res. 2010 Nov;38(21):7446-57. doi: 10.1093/nar/gkq634. Epub 2010 Jul 17.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells. Rhodes J, etal., Exp Hematol. 2000 Mar;28(3):305-10.
32. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. Ripperger JA, etal., J Biol Chem 1995 Dec 15;270(50):29998-30006.
33. Differentiation-dependent prolactin responsiveness and stat (signal transducers and activators of transcription) signaling in rat ovarian cells. Russell DL and Richards JS, Mol Endocrinol. 1999 Dec;13(12):2049-64.
34. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Slattery ML, etal., Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
35. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
36. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
37. Stimulation of hepatic signal transducer and activator of transcription 5b by GH is not altered by 3-methylcholanthrene. Timsit YE and Riddick DS, Endocrinology 2002 Sep;143(9):3284-94.
38. Low levels of eosinophil cationic proteins in patients with asthma. Venge P, etal., Lancet 1977 Aug 20;2(8034):373-5.
39. Chronic intermittent hypoxia alters hypothalamic transcription of genes involved in metabolic regulation. Volgin DV and Kubin L, Auton Neurosci. 2006 Jun 30;126-127:93-9. Epub 2006 May 26.
40. Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma. Wang X, etal., Int J Oncol. 2019 Oct;55(4):805-822. doi: 10.3892/ijo.2019.4862. Epub 2019 Aug 27.
41. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
Additional References at PubMed
PMID:8923468   PMID:9341127   PMID:9630227   PMID:9841920   PMID:10072077   PMID:10485657   PMID:10652277   PMID:10979977   PMID:11706048   PMID:12147240   PMID:12552091   PMID:12634107  
PMID:12682066   PMID:12767047   PMID:14532269   PMID:14761873   PMID:15062567   PMID:15142985   PMID:15253383   PMID:15294943   PMID:15471942   PMID:16303763   PMID:16339156   PMID:16857756  
PMID:17008382   PMID:17332060   PMID:17412818   PMID:18648510   PMID:19666510   PMID:20378540   PMID:20702587   PMID:21106534   PMID:21592969   PMID:22801370   PMID:23064763   PMID:23071812  
PMID:23185594   PMID:24068671  


Genomics

Comparative Map Data
Stat5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,704,841 - 85,775,856 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,705,670 - 85,775,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,743,399 - 90,812,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,222,166 - 90,290,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,615,217 - 85,683,927 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,686,207 - 88,712,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,686,207 - 88,754,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,480,377 - 88,506,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,716,624 - 89,743,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,730,993 - 89,757,504 (-)NCBI
Celera1084,424,576 - 84,451,052 (-)NCBICelera
RH 3.4 Map10837.39RGD
Cytogenetic Map10q31NCBI
STAT5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,199,177 - 42,288,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,199,176 - 42,288,633 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,351,195 - 40,428,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,604,721 - 37,681,950 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,604,721 - 37,681,950NCBI
Celera1737,005,458 - 37,083,308 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,116,230 - 36,193,344 (-)NCBIHuRef
CHM1_11740,586,923 - 40,664,134 (-)NCBICHM1_1
T2T-CHM13v2.01743,055,661 - 43,144,521 (-)NCBIT2T-CHM13v2.0
Stat5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,671,557 - 100,741,407 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,671,557 - 100,741,550 (-)EnsemblGRCm39 Ensembl
GRCm3811100,780,731 - 100,859,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,780,731 - 100,850,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,642,045 - 100,711,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,596,821 - 100,638,618 (-)NCBIMGSCv36mm8
MGSCv3611101,557,264 - 101,599,060 (-)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1163.63NCBI
Stat5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,253,645 - 16,295,337 (-)NCBIChiLan1.0ChiLan1.0
LOC100989105
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11724,586,321 - 24,674,917 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,040,303 - 15,116,682 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,306,412 - 15,338,973 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,306,418 - 15,336,463 (+)Ensemblpanpan1.1panPan2
STAT5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,647,712 - 20,718,453 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,691,483 - 20,716,485 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,109,403 - 20,179,537 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,367,403 - 21,437,279 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,367,403 - 21,437,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,152,431 - 20,222,600 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,419,706 - 20,489,689 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,522,505 - 20,592,735 (+)NCBIUU_Cfam_GSD_1.0
LOC101954516
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,031,387 - 20,054,040 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,021,051 - 17,043,941 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,022,268 - 17,043,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,508,404 - 20,574,266 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,498,103 - 20,574,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,634,155 - 20,864,515 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243413
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,997,486 - 64,070,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,997,441 - 64,070,445 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,795,632 - 34,884,310 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Stat5b
296 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000026354
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat

Markers in Region
RH94818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,707,128 - 85,707,298 (+)MAPPERmRatBN7.2
Rnor_6.01088,686,350 - 88,686,519NCBIRnor6.0
Rnor_5.01088,480,520 - 88,480,689UniSTSRnor5.0
RGSC_v3.41089,716,767 - 89,716,936UniSTSRGSC3.4
Celera1084,424,719 - 84,424,888UniSTS
RH 3.4 Map10837.39UniSTS
Cytogenetic Map10q32.1UniSTS
RH142912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,728,820 - 85,729,025 (+)MAPPERmRatBN7.2
Rnor_6.01088,708,017 - 88,708,221NCBIRnor6.0
Rnor_5.01088,502,592 - 88,502,796UniSTSRnor5.0
RGSC_v3.41089,738,838 - 89,739,042UniSTSRGSC3.4
Celera1084,446,756 - 84,446,960UniSTS
RH 3.4 Map10860.6UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 11 70 35 34 11 8
Low 1 4 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000026354   ⟹   ENSRNOP00000026354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,706,986 - 85,747,156 (-)Ensembl
Rnor_6.0 Ensembl1088,686,207 - 88,754,829 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081247   ⟹   ENSRNOP00000070284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,706,986 - 85,775,630 (-)Ensembl
Rnor_6.0 Ensembl1088,686,208 - 88,712,309 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104227   ⟹   ENSRNOP00000095287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,705,670 - 85,775,668 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107303   ⟹   ENSRNOP00000092900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,707,116 - 85,775,668 (-)Ensembl
RefSeq Acc Id: NM_022380   ⟹   NP_071775
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,706,986 - 85,775,630 (-)NCBI
Rnor_6.01088,686,207 - 88,712,313 (-)NCBI
Rnor_5.01088,480,377 - 88,506,888 (-)NCBI
RGSC_v3.41089,716,624 - 89,743,134 (-)RGD
Celera1084,424,576 - 84,451,052 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085256   ⟹   XP_038941184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,704,841 - 85,747,890 (-)NCBI
RefSeq Acc Id: XM_039085257   ⟹   XP_038941185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,704,841 - 85,747,424 (-)NCBI
RefSeq Acc Id: XM_039085258   ⟹   XP_038941186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,704,841 - 85,775,856 (-)NCBI
RefSeq Acc Id: XM_039085259   ⟹   XP_038941187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,704,841 - 85,747,425 (-)NCBI
RefSeq Acc Id: XM_039085260   ⟹   XP_038941188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,704,841 - 85,747,890 (-)NCBI
RefSeq Acc Id: NP_071775   ⟸   NM_022380
- UniProtKB: P52632 (UniProtKB/Swiss-Prot),   A6HJ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026354   ⟸   ENSRNOT00000026354
RefSeq Acc Id: ENSRNOP00000070284   ⟸   ENSRNOT00000081247
RefSeq Acc Id: XP_038941186   ⟸   XM_039085258
- Peptide Label: isoform X2
- UniProtKB: P52632 (UniProtKB/Swiss-Prot),   A6HJ61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941188   ⟸   XM_039085260
- Peptide Label: isoform X3
- UniProtKB: P52632 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038941184   ⟸   XM_039085256
- Peptide Label: isoform X1
- UniProtKB: P52632 (UniProtKB/Swiss-Prot),   A0A0G2JSR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941187   ⟸   XM_039085259
- Peptide Label: isoform X2
- UniProtKB: P52632 (UniProtKB/Swiss-Prot),   A6HJ61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941185   ⟸   XM_039085257
- Peptide Label: isoform X2
- UniProtKB: P52632 (UniProtKB/Swiss-Prot),   A6HJ61 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092900   ⟸   ENSRNOT00000107303
RefSeq Acc Id: ENSRNOP00000095287   ⟸   ENSRNOT00000104227
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52632-F1-model_v2 AlphaFold P52632 1-786 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3774 AgrOrtholog
BioCyc Gene G2FUF-23212 BioCyc
Ensembl Genes ENSRNOG00000019075 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026354 ENTREZGENE
  ENSRNOT00000026354.4 UniProtKB/TrEMBL
  ENSRNOT00000081247 ENTREZGENE
  ENSRNOT00000081247.2 UniProtKB/TrEMBL
  ENSRNOT00000104227 ENTREZGENE
  ENSRNOT00000104227.1 UniProtKB/TrEMBL
  ENSRNOT00000107303.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT5_CCD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT5a/5b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT5b_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25126 ENTREZGENE
PANTHER PTHR11801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stat5b PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019075 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JXI4_RAT UniProtKB/TrEMBL
  A0A8I6GK04_RAT UniProtKB/TrEMBL
  A0A8I6GLJ7_RAT UniProtKB/TrEMBL
  A6HJ61 ENTREZGENE, UniProtKB/TrEMBL
  P52632 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Stat5b  signal transducer and activator of transcription 5B    signal transducer and activator of transcription 5b  Name updated 629478 APPROVED
2002-06-10 Stat5b  signal transducer and activator of transcription 5b      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs independent of the effects of 3-methylcholanthrene in growth hormone induced chain of reactions on CYP2C11 gene expression 628356
gene_function binds to the GAS element and activates prl-induced transcription 70587
gene_homology aa sequence shows 26.7% identity with rat Stat3, 87.7% with sheep Stat5a, 92.5% with mouse Stat5a, and 98.7% with mouse Stat5b 729990
gene_process involved in signal transduction and activation of transcription 70587
gene_process may be a key intracellular mediator in the GH-pulse induced masculinization of liver CYP expression 628356
gene_regulation HNF3beta inhibits Stat5b activation at the level of Stat5b tyrosine phosphorylation; Stat5b inhibits HNF3beta by an unknown mechanism; neither inhibition is dependent on DNA binding 70587
gene_regulation growth hormone activation of Stat5b inhibits the transcription factor HNF3beta resulting in downregulation of Cyp2c11 70587
gene_regulation induced in hepatic nucleus by growth hormone 628356
gene_regulation exposure of H4 hepatoma cells to growth hormone (GH) results in a reversible time-, concentration- and growth hormone receptor concentration-dependent increase in tyrosine phosphorylation of STAT5 625493
gene_regulation translocated to the nucleus in most subpopulations of hypothalamic dopaminergic neurons following ovine prolactin activation of prolactin receptors 632713