STAT5A (signal transducer and activator of transcription 5A) - Rat Genome Database

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Gene: STAT5A (signal transducer and activator of transcription 5A) Homo sapiens
Analyze
Symbol: STAT5A
Name: signal transducer and activator of transcription 5A
RGD ID: 737523
HGNC Page HGNC:11366
Description: Enables DNA-binding transcription factor activity and DNA-binding transcription factor binding activity. Involved in several processes, including cytokine-mediated signaling pathway; eosinophil differentiation; and positive regulation of blood vessel endothelial cell migration. Acts upstream of or within reelin-mediated signaling pathway. Located in cytosol and nucleoplasm. Is active in nucleus. Implicated in colon adenocarcinoma. Biomarker of several diseases, including ductal carcinoma in situ; gastric adenocarcinoma; invasive lobular carcinoma; leukemia (multiple); and prostate cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGF; STAT5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,287,439 - 42,311,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,287,547 - 42,311,943 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,439,565 - 40,463,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,693,091 - 37,717,484 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,693,090 - 37,717,484NCBI
Celera1737,094,449 - 37,118,845 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBIHuRef
CHM1_11740,675,279 - 40,699,663 (+)NCBICHM1_1
T2T-CHM13v2.01743,143,926 - 43,168,430 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
alpinumisoflavone  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bromocriptine  (ISO)
calcitriol  (EXP)
chelerythrine  (ISO)
cholesterol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
cypermethrin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (EXP)
dichloromethane  (ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
epoxiconazole  (ISO)
estriol  (ISO)
fluorescein 5-isothiocyanate  (ISO)
Garcinol  (EXP)
genistein  (ISO)
gentamycin  (ISO)
Goe 6976  (ISO)
immunological adjuvant  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (ISO)
metam  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methylphenidate  (ISO)
mycophenolic acid  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
NORCANTHARIDIN  (EXP)
oxybenzone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pevonedistat  (EXP)
phenylmercury acetate  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphane  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
ponatinib  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (ISO)
quizartinib  (EXP)
resveratrol  (EXP)
rifampicin  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sorafenib  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP,ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
zearalenone  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
B cell differentiation  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (IEA)
cell surface receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO,NAS,TAS)
cellular response to cytokine stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (IEA)
cytokine-mediated signaling pathway  (IBA,IEA,ISO)
defense response  (IBA,IEA)
development of secondary female sexual characteristics  (ISO)
development of secondary male sexual characteristics  (ISO)
eosinophil differentiation  (IDA)
epithelial cell differentiation involved in prostate gland development  (ISO)
erythrocyte differentiation  (ISO)
female pregnancy  (ISO)
gamma-delta T cell differentiation  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,IEA)
interleukin-15-mediated signaling pathway  (IDA)
interleukin-2-mediated signaling pathway  (IDA)
interleukin-3-mediated signaling pathway  (IDA)
interleukin-4-mediated signaling pathway  (IDA)
interleukin-5-mediated signaling pathway  (IDA)
interleukin-9-mediated signaling pathway  (IDA)
lactation  (IEA,ISO)
lipid storage  (ISO)
luteinization  (ISO)
lymphocyte differentiation  (ISO)
mammary gland development  (ISO)
mammary gland epithelium development  (ISO)
mammary gland involution  (ISO)
mast cell apoptotic process  (ISO)
mast cell differentiation  (ISO)
mast cell proliferation  (ISO)
mitotic cell cycle  (ISO)
multicellular organismal reproductive process  (ISO)
myeloid cell apoptotic process  (ISO)
natural killer cell differentiation  (ISO)
natural killer cell mediated cytotoxicity  (ISO)
negative regulation of erythrocyte differentiation  (ISO)
negative regulation of mast cell apoptotic process  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
Peyer's patch development  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of blood vessel endothelial cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of lymphocyte differentiation  (ISO)
positive regulation of mast cell differentiation  (ISO)
positive regulation of mast cell proliferation  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO,NAS)
prostate gland epithelium morphogenesis  (ISO)
reelin-mediated signaling pathway  (IDA)
regulation of cell adhesion  (ISO)
regulation of cell population proliferation  (IBA,IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell differentiation  (ISO)
regulation of multicellular organism growth  (ISS)
regulation of steroid metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO,TAS)
response to ethanol  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (IBA,ISO)
signal transduction  (IEA)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
T cell proliferation  (ISO)
taurine metabolic process  (ISS)
transcription by RNA polymerase II  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. STAT 5a expression in various lesions of the breast. Bratthauer GL, etal., Virchows Arch. 2006 Feb;448(2):165-71. Epub 2005 Aug 19.
2. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
3. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Gerland K, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
6. STAT5A/B gene locus undergoes amplification during human prostate cancer progression. Haddad BR, etal., Am J Pathol. 2013 Jun;182(6):2264-75. doi: 10.1016/j.ajpath.2013.02.044. Epub 2013 May 7.
7. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
8. Interleukin-15 is associated with disease severity in viral bronchiolitis. Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5.
9. Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma. Liu HW, etal., Cancers (Basel). 2019 Nov 27;11(12). pii: cancers11121888. doi: 10.3390/cancers11121888.
10. Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis. Miermont AM, etal., Carcinogenesis. 2010 Jun;31(6):1124-31. doi: 10.1093/carcin/bgq048. Epub 2010 Feb 24.
11. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
12. De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance. Nie ZY, etal., J Exp Clin Cancer Res. 2020 Jan 17;39(1):17. doi: 10.1186/s13046-019-1502-7.
13. Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a. Papaconstantinou AD and Snyderwine EG, FEBS Lett. 2007 Jan 9;581(1):29-33. Epub 2006 Dec 5.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Loss of Stat5a delays mammary cancer progression in a mouse model. Ren S, etal., Oncogene. 2002 Jun 20;21(27):4335-9.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Possible role of Stat5a in rat mammary gland carcinogenesis. Shan L, etal., Breast Cancer Res Treat. 2004 Dec;88(3):263-72.
19. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
20. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
21. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
22. JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. Slattery ML, etal., Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.
23. Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential. Standke GJ, etal., Mol Endocrinol. 1994 Apr;8(4):469-77. doi: 10.1210/mend.8.4.7519723.
24. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
25. STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. Tsuruyama T, etal., J Cell Biochem. 2016 Nov;117(11):2630-42. doi: 10.1002/jcb.25558. Epub 2016 Apr 14.
26. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Ye D, etal., Blood. 2006 Jun 15;107(12):4917-25. doi: 10.1182/blood-2005-10-4110. Epub 2006 Mar 7.
Additional References at PubMed
PMID:7568001   PMID:7719937   PMID:7719938   PMID:7925280   PMID:8580378   PMID:8617237   PMID:8631883   PMID:8702683   PMID:8732682   PMID:8878484   PMID:8977232   PMID:9030599  
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PMID:9989503   PMID:10037026   PMID:10037796   PMID:10194762   PMID:10358045   PMID:10358079   PMID:10374881   PMID:10428030   PMID:10570284   PMID:10594041   PMID:10602027   PMID:10617656  
PMID:10652277   PMID:10825200   PMID:10919676   PMID:10996427   PMID:11030348   PMID:11097834   PMID:11158330   PMID:11167825   PMID:11413148   PMID:11418623   PMID:11418668   PMID:11440634  
PMID:11485409   PMID:11682624   PMID:11722592   PMID:11726519   PMID:11756417   PMID:11779872   PMID:11861304   PMID:11867689   PMID:11923474   PMID:11973644   PMID:11997457   PMID:12039059  
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PMID:17639043   PMID:17666591   PMID:17703412   PMID:17726024   PMID:17846080   PMID:17867599   PMID:17913706   PMID:17922009   PMID:17938255   PMID:18023521   PMID:18029348   PMID:18063684  
PMID:18172316   PMID:18250158   PMID:18270368   PMID:18271926   PMID:18296629   PMID:18378698   PMID:18413343   PMID:18436865   PMID:18460645   PMID:18483262   PMID:18616510   PMID:18660489  
PMID:18779318   PMID:18830265   PMID:18838617   PMID:18927468   PMID:19036881   PMID:19258923   PMID:19262752   PMID:19274049   PMID:19276230   PMID:19309697   PMID:19362457   PMID:19423540  
PMID:19423653   PMID:19491198   PMID:19571317   PMID:19675167   PMID:19779039   PMID:19797429   PMID:19817957   PMID:19864382   PMID:19923221   PMID:19956772   PMID:19966185   PMID:20065083  
PMID:20075866   PMID:20113333   PMID:20124477   PMID:20196786   PMID:20214633   PMID:20233708   PMID:20331378   PMID:20339093   PMID:20388848   PMID:20406964   PMID:20415542   PMID:20438785  
PMID:20489169   PMID:20503287   PMID:20508164   PMID:20530519   PMID:20716621   PMID:20816854   PMID:20849385   PMID:20952588   PMID:20974963   PMID:21079973   PMID:21220747   PMID:21233313  
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PMID:30923103   PMID:30948494   PMID:30961617   PMID:30988120   PMID:31123029   PMID:31263070   PMID:31292140   PMID:31409773   PMID:31415393   PMID:31434952   PMID:31545408   PMID:31646566  
PMID:31732153   PMID:31843895   PMID:31980649   PMID:32024640   PMID:32041920   PMID:32155324   PMID:32246817   PMID:32667731   PMID:32790723   PMID:33086498   PMID:33155364   PMID:33429916  
PMID:33502684   PMID:33589921   PMID:33767425   PMID:33862068   PMID:33948920   PMID:33961781   PMID:34148062   PMID:34157051   PMID:34188118   PMID:34197875   PMID:34482361   PMID:34743736  
PMID:34825975   PMID:34914211   PMID:35075244   PMID:35140242   PMID:35314791   PMID:35526080   PMID:35887269   PMID:35939714   PMID:35944360   PMID:36045346   PMID:36215168   PMID:36232600  
PMID:36261627   PMID:36724073   PMID:36755813   PMID:36905318   PMID:37106040   PMID:37196931   PMID:37345979   PMID:37616578   PMID:37802467   PMID:38360140  


Genomics

Comparative Map Data
STAT5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,287,439 - 42,311,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,287,547 - 42,311,943 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,439,565 - 40,463,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,693,091 - 37,717,484 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,693,090 - 37,717,484NCBI
Celera1737,094,449 - 37,118,845 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBIHuRef
CHM1_11740,675,279 - 40,699,663 (+)NCBICHM1_1
T2T-CHM13v2.01743,143,926 - 43,168,430 (+)NCBIT2T-CHM13v2.0
Stat5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,750,177 - 100,775,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,750,177 - 100,775,995 (+)EnsemblGRCm39 Ensembl
GRCm3811100,859,351 - 100,885,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,859,351 - 100,885,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,720,665 - 100,746,483 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,675,494 - 100,701,259 (+)NCBIMGSCv36mm8
MGSCv3611101,635,936 - 101,661,700 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1163.77NCBI
Stat5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,285,859 - 86,310,187 (+)NCBIGRCr8
mRatBN7.21085,785,537 - 85,809,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,821,886 - 90,846,156 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,300,534 - 90,324,854 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,693,771 - 85,718,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,764,732 - 88,789,060 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,764,732 - 88,789,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,558,936 - 88,583,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,795,404 - 89,819,732 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,809,773 - 89,834,099 (+)NCBI
Celera1084,503,376 - 84,527,708 (+)NCBICelera
Cytogenetic Map10q31NCBI
Stat5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,305,363 - 16,319,219 (+)NCBIChiLan1.0ChiLan1.0
LOC100988550
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,673,101 - 22,696,260 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,563,275 - 24,586,438 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,005,025 - 15,029,110 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,228,465 - 15,251,783 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,228,465 - 15,251,783 (-)Ensemblpanpan1.1panPan2
STAT5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,616,041 - 20,638,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,617,151 - 20,638,103 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,077,547 - 20,099,955 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,335,685 - 21,357,957 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,288,139 - 21,357,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,120,814 - 20,142,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,387,762 - 20,409,305 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,490,411 - 20,512,845 (-)NCBIUU_Cfam_GSD_1.0
STAT5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,474,227 - 20,499,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,474,221 - 20,498,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,563,982 - 24,581,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAT5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,959,265 - 63,986,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,960,515 - 63,985,026 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,956 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in STAT5A
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31		 pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_001288718.2(STAT5A):c.2060T>G (p.Leu687Arg) single nucleotide variant Inborn genetic diseases [RCV003276994] Chr17:42308331 [GRCh38]
Chr17:40460349 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.341A>G (p.Tyr114Cys) single nucleotide variant Inborn genetic diseases [RCV003248123] Chr17:42292027 [GRCh38]
Chr17:40444045 [GRCh37]
Chr17:17q21.2		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_001288718.2(STAT5A):c.626T>C (p.Val209Ala) single nucleotide variant not provided [RCV000967453] Chr17:42299826 [GRCh38]
Chr17:40451844 [GRCh37]
Chr17:17q21.2		 benign
NM_001288718.2(STAT5A):c.465G>A (p.Thr155=) single nucleotide variant not provided [RCV000906183] Chr17:42295708 [GRCh38]
Chr17:40447726 [GRCh37]
Chr17:17q21.2		 benign
NM_001288718.2(STAT5A):c.2063-4A>G single nucleotide variant not provided [RCV000947823] Chr17:42309043 [GRCh38]
Chr17:40461061 [GRCh37]
Chr17:17q21.2		 benign
NM_001288718.2(STAT5A):c.2229C>T (p.Asp743=) single nucleotide variant not provided [RCV000971650] Chr17:42310513 [GRCh38]
Chr17:40462531 [GRCh37]
Chr17:17q21.2		 benign
NM_001288718.2(STAT5A):c.1279G>A (p.Ala427Thr) single nucleotide variant Esophageal atresia [RCV000984687] Chr17:42304551 [GRCh38]
Chr17:40456569 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.2238C>T (p.Leu746=) single nucleotide variant not provided [RCV000967454] Chr17:42310522 [GRCh38]
Chr17:40462540 [GRCh37]
Chr17:17q21.2		 benign
NM_001288718.2(STAT5A):c.1794G>C (p.Val598=) single nucleotide variant not provided [RCV000910519] Chr17:42307611 [GRCh38]
Chr17:40459629 [GRCh37]
Chr17:17q21.2		 benign
NC_000017.10:g.(?_40376777)_(40575115_?)dup duplication Growth hormone insensitivity with immune dysregulation 1, autosomal recessive [RCV003116609]|Hyper-IgE recurrent infection syndrome 1, autosomal dominant [RCV003116610] Chr17:40376777..40575115 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.2344C>T (p.Pro782Ser) single nucleotide variant Inborn genetic diseases [RCV002749627] Chr17:42310628 [GRCh38]
Chr17:40462646 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.581C>T (p.Pro194Leu) single nucleotide variant Inborn genetic diseases [RCV002683833] Chr17:42299781 [GRCh38]
Chr17:40451799 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.1072G>A (p.Gly358Arg) single nucleotide variant Inborn genetic diseases [RCV002823567] Chr17:42301357 [GRCh38]
Chr17:40453375 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.1528G>A (p.Ala510Thr) single nucleotide variant Inborn genetic diseases [RCV002950645] Chr17:42306295 [GRCh38]
Chr17:40458313 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.2152G>A (p.Ala718Thr) single nucleotide variant Inborn genetic diseases [RCV002782652] Chr17:42309414 [GRCh38]
Chr17:40461432 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.27G>C (p.Gln9His) single nucleotide variant Inborn genetic diseases [RCV002641200] Chr17:42289438 [GRCh38]
Chr17:40441456 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.1255A>G (p.Met419Val) single nucleotide variant Inborn genetic diseases [RCV002803465] Chr17:42304427 [GRCh38]
Chr17:40456445 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.1686C>G (p.Asn562Lys) single nucleotide variant Inborn genetic diseases [RCV002892292] Chr17:42307407 [GRCh38]
Chr17:40459425 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.944A>C (p.Glu315Ala) single nucleotide variant Inborn genetic diseases [RCV002745169] Chr17:42300825 [GRCh38]
Chr17:40452843 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.1734G>A (p.Met578Ile) single nucleotide variant Inborn genetic diseases [RCV002941398] Chr17:42307455 [GRCh38]
Chr17:40459473 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.881G>A (p.Arg294His) single nucleotide variant Inborn genetic diseases [RCV002703478] Chr17:42300762 [GRCh38]
Chr17:40452780 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.1277G>A (p.Arg426His) single nucleotide variant Inborn genetic diseases [RCV002940816] Chr17:42304549 [GRCh38]
Chr17:40456567 [GRCh37]
Chr17:17q21.2		 uncertain significance
NM_001288718.2(STAT5A):c.563A>C (p.Gln188Pro) single nucleotide variant Inborn genetic diseases [RCV003183397] Chr17:42299763 [GRCh38]
Chr17:40451781 [GRCh37]
Chr17:17q21.2		 likely benign
NM_001288718.2(STAT5A):c.560C>G (p.Ala187Gly) single nucleotide variant Inborn genetic diseases [RCV003183398] Chr17:42299760 [GRCh38]
Chr17:40451778 [GRCh37]
Chr17:17q21.2		 likely benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR222hsa-miR-222-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20489169

Predicted Target Of
Summary Value
Count of predictions:4210
Count of miRNA genes:1051
Interacting mature miRNAs:1320
Transcripts:ENST00000345506, ENST00000444283, ENST00000452307, ENST00000468096, ENST00000469124, ENST00000478897, ENST00000479417, ENST00000546010, ENST00000587646, ENST00000588868, ENST00000590726, ENST00000590949, ENST00000591556
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH122165  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,462,311 - 40,462,582UniSTSGRCh37
Build 361737,715,837 - 37,716,108RGDNCBI36
Celera1737,117,195 - 37,117,466RGD
Cytogenetic Map17q11.2UniSTS
HuRef1736,226,992 - 36,227,263UniSTS
TNG Radiation Hybrid Map1718873.0UniSTS
PMC262552P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,456,370 - 40,456,611UniSTSGRCh37
Build 361737,709,896 - 37,710,137RGDNCBI36
Celera1737,111,254 - 37,111,495RGD
Cytogenetic Map17q11.2UniSTS
HuRef1736,221,051 - 36,221,292UniSTS
STAT5A_260  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,463,220 - 40,464,080UniSTSGRCh37
Build 361737,716,746 - 37,717,606RGDNCBI36
Celera1737,118,104 - 37,118,964RGD
HuRef1736,227,901 - 36,228,761UniSTS
RH71461  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,463,750 - 40,463,884UniSTSGRCh37
Build 361737,717,276 - 37,717,410RGDNCBI36
Celera1737,118,634 - 37,118,768RGD
Cytogenetic Map17q11.2UniSTS
HuRef1736,228,431 - 36,228,565UniSTS
GeneMap99-GB4 RH Map17307.8UniSTS
NCBI RH Map17431.3UniSTS
RH12579  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,463,735 - 40,463,884UniSTSGRCh37
Build 361737,717,261 - 37,717,410RGDNCBI36
Celera1737,118,619 - 37,118,768RGD
Cytogenetic Map17q11.2UniSTS
HuRef1736,228,416 - 36,228,565UniSTS
GeneMap99-GB4 RH Map17309.83UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2168 2292 1284 205 1793 56 3894 1489 1097 225 1058 1412 155 1204 2529 1
Low 253 693 432 413 127 403 460 685 2600 177 370 161 15 259 1
Below cutoff 7 4 3 21 4 2 17 12 10 16 26 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001288718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB208972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ412886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ815789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ471288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000345506   ⟹   ENSP00000341208
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,287,547 - 42,311,943 (+)Ensembl
RefSeq Acc Id: ENST00000444283   ⟹   ENSP00000407327
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,501 - 42,292,061 (+)Ensembl
RefSeq Acc Id: ENST00000468096
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,306,114 - 42,310,523 (+)Ensembl
RefSeq Acc Id: ENST00000469124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,489 - 42,290,179 (+)Ensembl
RefSeq Acc Id: ENST00000478897
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,289,213 - 42,292,037 (+)Ensembl
RefSeq Acc Id: ENST00000479417
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,304,179 - 42,306,326 (+)Ensembl
RefSeq Acc Id: ENST00000546010   ⟹   ENSP00000443107
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,076 - 42,310,927 (+)Ensembl
RefSeq Acc Id: ENST00000587646   ⟹   ENSP00000466320
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,306,170 - 42,311,903 (+)Ensembl
RefSeq Acc Id: ENST00000588868   ⟹   ENSP00000465437
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,543 - 42,311,940 (+)Ensembl
RefSeq Acc Id: ENST00000590726   ⟹   ENSP00000464730
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,469 - 42,311,943 (+)Ensembl
RefSeq Acc Id: ENST00000590949   ⟹   ENSP00000468749
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,498 - 42,311,943 (+)Ensembl
RefSeq Acc Id: ENST00000591556
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,306,116 - 42,308,759 (+)Ensembl
RefSeq Acc Id: ENST00000676585   ⟹   ENSP00000504449
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,501 - 42,311,943 (+)Ensembl
RefSeq Acc Id: ENST00000676631   ⟹   ENSP00000503484
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,441 - 42,311,903 (+)Ensembl
RefSeq Acc Id: ENST00000677301   ⟹   ENSP00000503262
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,289,213 - 42,311,943 (+)Ensembl
RefSeq Acc Id: ENST00000677893   ⟹   ENSP00000504833
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,441 - 42,311,923 (+)Ensembl
RefSeq Acc Id: ENST00000678903   ⟹   ENSP00000503304
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,288,496 - 42,311,924 (+)Ensembl
RefSeq Acc Id: NM_001288718   ⟹   NP_001275647
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,288,498 - 42,311,943 (+)NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBI
CHM1_11740,675,599 - 40,699,663 (+)NCBI
T2T-CHM13v2.01743,144,985 - 43,168,430 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288719   ⟹   NP_001275648
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,288,498 - 42,311,943 (+)NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBI
CHM1_11740,675,788 - 40,699,663 (+)NCBI
T2T-CHM13v2.01743,144,985 - 43,168,430 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288720   ⟹   NP_001275649
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,288,498 - 42,311,943 (+)NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBI
CHM1_11740,675,788 - 40,699,663 (+)NCBI
T2T-CHM13v2.01743,144,985 - 43,168,430 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001411103   ⟹   NP_001398032
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,287,439 - 42,311,943 (+)NCBI
T2T-CHM13v2.01743,143,926 - 43,168,430 (+)NCBI
RefSeq Acc Id: NM_003152   ⟹   NP_003143
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,287,547 - 42,311,943 (+)NCBI
GRCh371740,439,565 - 40,463,961 (+)ENTREZGENE
Build 361737,693,091 - 37,717,484 (+)NCBI Archive
HuRef1736,204,247 - 36,228,642 (+)ENTREZGENE
CHM1_11740,675,279 - 40,699,663 (+)NCBI
T2T-CHM13v2.01743,144,034 - 43,168,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047436588   ⟹   XP_047292544
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,288,498 - 42,311,943 (+)NCBI
RefSeq Acc Id: XM_047436589   ⟹   XP_047292545
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,287,547 - 42,311,943 (+)NCBI
RefSeq Acc Id: XM_047436590   ⟹   XP_047292546
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,287,547 - 42,311,943 (+)NCBI
RefSeq Acc Id: XM_047436591   ⟹   XP_047292547
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,287,547 - 42,311,943 (+)NCBI
RefSeq Acc Id: XM_054316994   ⟹   XP_054172969
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01743,144,985 - 43,168,430 (+)NCBI
RefSeq Acc Id: XM_054316995   ⟹   XP_054172970
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01743,144,034 - 43,168,430 (+)NCBI
RefSeq Acc Id: XM_054316996   ⟹   XP_054172971
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01743,144,034 - 43,168,430 (+)NCBI
RefSeq Acc Id: XM_054316997   ⟹   XP_054172972
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01743,144,034 - 43,168,430 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001275647 (Get FASTA)   NCBI Sequence Viewer  
  NP_001275648 (Get FASTA)   NCBI Sequence Viewer  
  NP_001275649 (Get FASTA)   NCBI Sequence Viewer  
  NP_001398032 (Get FASTA)   NCBI Sequence Viewer  
  NP_003143 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292544 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292545 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292546 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292547 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172969 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172970 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172971 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172972 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA73962 (Get FASTA)   NCBI Sequence Viewer  
  AAB06589 (Get FASTA)   NCBI Sequence Viewer  
  AAH27036 (Get FASTA)   NCBI Sequence Viewer  
  ABF17939 (Get FASTA)   NCBI Sequence Viewer  
  ADO22164 (Get FASTA)   NCBI Sequence Viewer  
  BAD92209 (Get FASTA)   NCBI Sequence Viewer  
  BAF84339 (Get FASTA)   NCBI Sequence Viewer  
  BAH13486 (Get FASTA)   NCBI Sequence Viewer  
  CAD19637 (Get FASTA)   NCBI Sequence Viewer  
  CAG32953 (Get FASTA)   NCBI Sequence Viewer  
  CBX53841 (Get FASTA)   NCBI Sequence Viewer  
  EAW60819 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000341208
  ENSP00000341208.4
  ENSP00000443107
  ENSP00000443107.1
  ENSP00000464730.3
  ENSP00000465437
  ENSP00000465437.1
  ENSP00000468749
  ENSP00000468749.1
  ENSP00000503262.1
  ENSP00000503304.1
  ENSP00000503484
  ENSP00000503484.1
  ENSP00000504449.1
  ENSP00000504833.1
GenBank Protein P42229 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_003143   ⟸   NM_003152
- Peptide Label: isoform 1
- UniProtKB: Q1KLZ6 (UniProtKB/Swiss-Prot),   P42229 (UniProtKB/Swiss-Prot),   A0A384N5W4 (UniProtKB/TrEMBL),   A0A7I2YQY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275647   ⟸   NM_001288718
- Peptide Label: isoform 1
- UniProtKB: Q1KLZ6 (UniProtKB/Swiss-Prot),   P42229 (UniProtKB/Swiss-Prot),   A0A384N5W4 (UniProtKB/TrEMBL),   A0A7I2YQY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275649   ⟸   NM_001288720
- Peptide Label: isoform 3
- UniProtKB: K7EK35 (UniProtKB/TrEMBL),   Q59GY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275648   ⟸   NM_001288719
- Peptide Label: isoform 2
- UniProtKB: A0A7I2YQY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000341208   ⟸   ENST00000345506
RefSeq Acc Id: ENSP00000443107   ⟸   ENST00000546010
RefSeq Acc Id: ENSP00000466320   ⟸   ENST00000587646
RefSeq Acc Id: ENSP00000465437   ⟸   ENST00000588868
RefSeq Acc Id: ENSP00000407327   ⟸   ENST00000444283
RefSeq Acc Id: ENSP00000464730   ⟸   ENST00000590726
RefSeq Acc Id: ENSP00000468749   ⟸   ENST00000590949
RefSeq Acc Id: ENSP00000503484   ⟸   ENST00000676631
RefSeq Acc Id: ENSP00000504449   ⟸   ENST00000676585
RefSeq Acc Id: ENSP00000503262   ⟸   ENST00000677301
RefSeq Acc Id: ENSP00000504833   ⟸   ENST00000677893
RefSeq Acc Id: ENSP00000503304   ⟸   ENST00000678903
RefSeq Acc Id: XP_047292546   ⟸   XM_047436590
- Peptide Label: isoform X2
- UniProtKB: A0A7I2YQY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047292545   ⟸   XM_047436589
- Peptide Label: isoform X1
- UniProtKB: P42229 (UniProtKB/Swiss-Prot),   Q1KLZ6 (UniProtKB/Swiss-Prot),   A0A384N5W4 (UniProtKB/TrEMBL),   A0A7I2YQY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047292547   ⟸   XM_047436591
- Peptide Label: isoform X3
- UniProtKB: A0A8V8TP21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047292544   ⟸   XM_047436588
- Peptide Label: isoform X1
- UniProtKB: P42229 (UniProtKB/Swiss-Prot),   Q1KLZ6 (UniProtKB/Swiss-Prot),   A0A384N5W4 (UniProtKB/TrEMBL),   A0A7I2YQY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398032   ⟸   NM_001411103
- Peptide Label: isoform 4
- UniProtKB: A0A7I2YQF1 (UniProtKB/TrEMBL),   A0A8V8TP21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172971   ⟸   XM_054316996
- Peptide Label: isoform X2
- UniProtKB: A0A7I2YQY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172970   ⟸   XM_054316995
- Peptide Label: isoform X1
- UniProtKB: P42229 (UniProtKB/Swiss-Prot),   Q1KLZ6 (UniProtKB/Swiss-Prot),   A0A384N5W4 (UniProtKB/TrEMBL),   A0A7I2YQY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172972   ⟸   XM_054316997
- Peptide Label: isoform X3
- UniProtKB: A0A8V8TP21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172969   ⟸   XM_054316994
- Peptide Label: isoform X1
- UniProtKB: P42229 (UniProtKB/Swiss-Prot),   Q1KLZ6 (UniProtKB/Swiss-Prot),   A0A384N5W4 (UniProtKB/TrEMBL),   A0A7I2YQY3 (UniProtKB/TrEMBL)
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42229-F1-model_v2 AlphaFold P42229 1-794 view protein structure

Promoters
RGD ID:6794589
Promoter ID:HG_KWN:26183
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000319804,   OTTHUMT00000319805,   OTTHUMT00000319807,   UC010CYA.1,   UC010CYB.1,   UC010CYC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,692,106 - 37,694,032 (+)MPROMDB
RGD ID:6794591
Promoter ID:HG_KWN:26184
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000319806
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,694,584 - 37,695,084 (+)MPROMDB
RGD ID:6794592
Promoter ID:HG_KWN:26185
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562
Transcripts:OTTHUMT00000319808
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,709,496 - 37,709,996 (+)MPROMDB
RGD ID:6794593
Promoter ID:HG_KWN:26186
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat,   K562,   NB4
Transcripts:OTTHUMT00000319809,   UC010CYD.1,   UC010CYE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,711,174 - 37,711,674 (+)MPROMDB
RGD ID:7235071
Promoter ID:EPDNEW_H23281
Type:initiation region
Name:STAT5A_3
Description:signal transducer and activator of transcription 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23282  EPDNEW_H23284  EPDNEW_H23283  EPDNEW_H23286  EPDNEW_H23287  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,287,439 - 42,287,499EPDNEW
RGD ID:7235073
Promoter ID:EPDNEW_H23282
Type:initiation region
Name:STAT5A_6
Description:signal transducer and activator of transcription 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23281  EPDNEW_H23284  EPDNEW_H23283  EPDNEW_H23286  EPDNEW_H23287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,287,938 - 42,287,998EPDNEW
RGD ID:7235077
Promoter ID:EPDNEW_H23283
Type:initiation region
Name:STAT5A_2
Description:signal transducer and activator of transcription 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23281  EPDNEW_H23282  EPDNEW_H23284  EPDNEW_H23286  EPDNEW_H23287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,288,165 - 42,288,225EPDNEW
RGD ID:7235075
Promoter ID:EPDNEW_H23284
Type:initiation region
Name:STAT5A_1
Description:signal transducer and activator of transcription 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23281  EPDNEW_H23282  EPDNEW_H23283  EPDNEW_H23286  EPDNEW_H23287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,288,498 - 42,288,558EPDNEW
RGD ID:7235079
Promoter ID:EPDNEW_H23286
Type:initiation region
Name:STAT5A_5
Description:signal transducer and activator of transcription 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23281  EPDNEW_H23282  EPDNEW_H23284  EPDNEW_H23283  EPDNEW_H23287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,289,356 - 42,289,416EPDNEW
RGD ID:7235083
Promoter ID:EPDNEW_H23287
Type:initiation region
Name:STAT5A_4
Description:signal transducer and activator of transcription 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23281  EPDNEW_H23282  EPDNEW_H23284  EPDNEW_H23283  EPDNEW_H23286  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,306,114 - 42,306,174EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11366 AgrOrtholog
COSMIC STAT5A COSMIC
Ensembl Genes ENSG00000126561 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000345506 ENTREZGENE
  ENST00000345506.8 UniProtKB/Swiss-Prot
  ENST00000546010 ENTREZGENE
  ENST00000546010.6 UniProtKB/Swiss-Prot
  ENST00000588868 ENTREZGENE
  ENST00000588868.5 UniProtKB/TrEMBL
  ENST00000590726.7 UniProtKB/TrEMBL
  ENST00000590949 ENTREZGENE
  ENST00000590949.6 UniProtKB/Swiss-Prot
  ENST00000676585.1 UniProtKB/Swiss-Prot
  ENST00000676631 ENTREZGENE
  ENST00000676631.1 UniProtKB/TrEMBL
  ENST00000677301.1 UniProtKB/Swiss-Prot
  ENST00000677893.1 UniProtKB/TrEMBL
  ENST00000678903.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000126561 GTEx
HGNC ID HGNC:11366 ENTREZGENE
Human Proteome Map STAT5A Human Proteome Map
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT5_CCD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT5a/5b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6776 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 6776 ENTREZGENE
OMIM 601511 OMIM
PANTHER PTHR11801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11801:SF47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_linker UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA338 PharmGKB
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A384N5W4 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V380_HUMAN UniProtKB/TrEMBL
  A0A7I2YQF1 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2YQY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8V8TP21 ENTREZGENE
  A8K6I5_HUMAN UniProtKB/TrEMBL
  K7EIF9_HUMAN UniProtKB/TrEMBL
  K7EK35 ENTREZGENE, UniProtKB/TrEMBL
  P42229 ENTREZGENE
  Q1KLZ6 ENTREZGENE
  Q59GY7 ENTREZGENE, UniProtKB/TrEMBL
  Q8WWS9_HUMAN UniProtKB/TrEMBL
  STA5A_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q1KLZ6 UniProtKB/Swiss-Prot