LOC100989105 (signal transducer and activator of transcription 5B) - Rat Genome Database

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Gene: LOC100989105 (signal transducer and activator of transcription 5B) Pan paniscus
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Symbol: LOC100989105
Name: signal transducer and activator of transcription 5B
RGD ID: 11680809
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN acute-phase response (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN erythropoietin signaling pathway; fibroblast growth factor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); cutaneous T cell lymphoma (ortholog); Endotoxemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B; STAT5B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,306,412 - 15,338,973 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,306,418 - 15,336,463 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,040,303 - 15,116,682 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cytokine-mediated signaling pathway  (ISO)
development of secondary female sexual characteristics  (ISO)
development of secondary male sexual characteristics  (ISO)
female pregnancy  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (ISO)
lactation  (ISO)
lipid storage  (ISO)
liver development  (ISO)
luteinization  (ISO)
mast cell migration  (ISO)
natural killer cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of erythrocyte differentiation  (ISO)
Peyer's patch development  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular component movement  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of lymphocyte differentiation  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
progesterone metabolic process  (ISO)
receptor signaling pathway via JAK-STAT  (ISO)
regulation of cell adhesion  (ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of steroid metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to interleukin-15  (ISO)
response to interleukin-2  (ISO)
response to interleukin-4  (ISO)
response to lipopolysaccharide  (ISO)
response to peptide hormone  (ISO)
sex differentiation  (ISO)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
taurine metabolic process  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
nucleus  (ISO)

References

Genomics

Comparative Map Data
LOC100989105
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,306,412 - 15,338,973 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,306,418 - 15,336,463 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,040,303 - 15,116,682 (+)NCBIMhudiblu_PPA_v0panPan3
STAT5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,199,177 - 42,276,707 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,199,177 - 42,288,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,351,195 - 40,428,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,604,721 - 37,681,950 (-)NCBINCBI36hg18NCBI36
Build 341737,604,721 - 37,681,950NCBI
Celera1737,005,458 - 37,083,308 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,116,230 - 36,193,344 (-)NCBIHuRef
CHM1_11740,586,923 - 40,664,134 (-)NCBICHM1_1
Stat5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,671,557 - 100,741,407 (-)NCBIGRCm39mm39
GRCm39 Ensembl11100,671,557 - 100,741,550 (-)Ensembl
GRCm3811100,780,731 - 100,859,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,780,731 - 100,850,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,642,045 - 100,711,899 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,596,821 - 100,638,618 (-)NCBImm8
MGSCv3611101,557,264 - 101,599,060 (-)NCBImm8
Cytogenetic Map11DNCBI
cM Map1163.63NCBI
Stat5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,704,841 - 85,775,856 (-)NCBI
Rnor_6.0 Ensembl1088,686,207 - 88,754,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01088,686,207 - 88,712,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01088,480,377 - 88,506,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,716,624 - 89,743,134 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,730,993 - 89,757,504 (-)NCBI
Celera1084,424,576 - 84,451,052 (-)NCBICelera
RH 3.4 Map10837.39RGD
Cytogenetic Map10q31NCBI
Stat5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,253,645 - 16,295,337 (-)NCBIChiLan1.0ChiLan1.0
STAT5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,647,712 - 20,718,453 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,691,483 - 20,716,485 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,109,403 - 20,179,537 (+)NCBI
ROS_Cfam_1.0921,367,403 - 21,437,279 (+)NCBI
UMICH_Zoey_3.1920,152,431 - 20,222,600 (+)NCBI
UNSW_CanFamBas_1.0920,419,706 - 20,489,689 (+)NCBI
UU_Cfam_GSD_1.0920,522,505 - 20,592,735 (+)NCBI
LOC101954516
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,031,387 - 20,054,040 (+)NCBI
SpeTri2.0NW_00493649017,022,268 - 17,043,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,508,403 - 20,574,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,498,103 - 20,574,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,634,155 - 20,864,515 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243413
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,997,486 - 64,070,392 (+)NCBI
ChlSab1.1 Ensembl1663,997,441 - 64,070,445 (+)Ensembl
Vero_WHO_p1.0NW_02366607734,795,632 - 34,884,310 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000056806   ⟹   ENSPPAP00000033925
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1715,306,418 - 15,336,463 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056826   ⟹   ENSPPAP00000033945
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1715,306,418 - 15,336,463 (+)Ensembl
RefSeq Acc Id: XM_034941835   ⟹   XP_034797726
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01715,040,303 - 15,116,682 (+)NCBI
RefSeq Acc Id: XM_034941836   ⟹   XP_034797727
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01715,083,879 - 15,116,682 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034797726 (Get FASTA)   NCBI Sequence Viewer  
  XP_034797727 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034797726   ⟸   XM_034941835
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034797727   ⟸   XM_034941836
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000033925   ⟸   ENSPPAT00000056806
RefSeq Acc Id: ENSPPAP00000033945   ⟸   ENSPPAT00000056826
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039557 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000033925 UniProtKB/TrEMBL
  ENSPPAP00000033945 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056806 UniProtKB/TrEMBL
  ENSPPAT00000056826 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT5a/5b UniProtKB/TrEMBL
  STAT5b_SH2 UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
NCBI Gene STAT5B ENTREZGENE
PANTHER PTHR11801 UniProtKB/TrEMBL
  PTHR11801:SF47 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/TrEMBL
  SSF48092 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9BZK1_PANPA UniProtKB/TrEMBL
  A0A2R9BZM3_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 LOC100989105  signal transducer and activator of transcription 5B  STAT5B  signal transducer and activator of transcription 5B  Symbol and/or name change 5135510 APPROVED