LOC103243413 (signal transducer and activator of transcription 5B) - Rat Genome Database

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Pathways
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Gene: LOC103243413 (signal transducer and activator of transcription 5B) Chlorocebus sabaeus
Analyze
Symbol: LOC103243413 (Ensembl: STAT5B)
Name: signal transducer and activator of transcription 5B
RGD ID: 18774164
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN activated T cell proliferation (ortholog); acute-phase response (ortholog); B cell differentiation (ortholog); PARTICIPATES IN erythropoietin signaling pathway; fibroblast growth factor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); colon adenocarcinoma (ortholog); colorectal adenocarcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: STAT5B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,997,486 - 64,070,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,997,441 - 64,070,445 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,795,632 - 34,884,310 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
acute-phase response  (ISO)
B cell differentiation  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to organic substance  (IEA)
cytokine-mediated signaling pathway  (IEA,ISO)
defense response  (IEA)
development of secondary female sexual characteristics  (ISO)
development of secondary male sexual characteristics  (ISO)
eosinophil differentiation  (IEA)
erythrocyte differentiation  (ISO)
female pregnancy  (ISO)
gamma-delta T cell differentiation  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IEA)
interleukin-15-mediated signaling pathway  (IEA)
interleukin-2-mediated signaling pathway  (IEA)
interleukin-3-mediated signaling pathway  (IEA)
interleukin-4-mediated signaling pathway  (IEA)
interleukin-5-mediated signaling pathway  (IEA)
interleukin-9-mediated signaling pathway  (IEA)
lactation  (IEA,ISO)
lipid storage  (ISO)
liver development  (ISO)
luteinization  (ISO)
lymphocyte differentiation  (ISO)
mast cell migration  (ISO)
mitotic cell cycle  (ISO)
myeloid cell apoptotic process  (ISO)
natural killer cell differentiation  (ISO)
natural killer cell mediated cytotoxicity  (ISO)
natural killer cell proliferation  (ISO)
negative regulation of erythrocyte differentiation  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
Peyer's patch development  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of fibroblast growth factor production  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of lymphocyte differentiation  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
progesterone metabolic process  (ISO)
reelin-mediated signaling pathway  (IEA)
regulation of cell adhesion  (ISO)
regulation of cell population proliferation  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of steroid metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to interleukin-15  (ISO)
response to interleukin-2  (ISO)
response to interleukin-4  (ISO)
response to lipopolysaccharide  (ISO)
response to peptide hormone  (IEA,ISO)
sex differentiation  (ISO)
signal transduction  (IEA)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
taurine metabolic process  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LOC103243413
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,997,486 - 64,070,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,997,441 - 64,070,445 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,795,632 - 34,884,310 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
STAT5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,199,177 - 42,288,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,199,176 - 42,288,633 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,351,195 - 40,428,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,604,721 - 37,681,950 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,604,721 - 37,681,950NCBI
Celera1737,005,458 - 37,083,308 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,116,230 - 36,193,344 (-)NCBIHuRef
CHM1_11740,586,923 - 40,664,134 (-)NCBICHM1_1
T2T-CHM13v2.01743,055,661 - 43,144,521 (-)NCBIT2T-CHM13v2.0
Stat5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,671,557 - 100,741,407 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,671,557 - 100,741,550 (-)EnsemblGRCm39 Ensembl
GRCm3811100,780,731 - 100,859,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,780,731 - 100,850,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,642,045 - 100,711,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,596,821 - 100,638,618 (-)NCBIMGSCv36mm8
MGSCv3611101,557,264 - 101,599,060 (-)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1163.63NCBI
Stat5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,205,148 - 86,276,178 (-)NCBIGRCr8
mRatBN7.21085,704,841 - 85,775,856 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,705,670 - 85,775,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,743,399 - 90,812,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,222,166 - 90,290,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,615,217 - 85,683,927 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,686,207 - 88,712,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,686,207 - 88,754,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,480,377 - 88,506,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,716,624 - 89,743,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,730,993 - 89,757,504 (-)NCBI
Celera1084,424,576 - 84,451,052 (-)NCBICelera
RH 3.4 Map10837.39RGD
Cytogenetic Map10q31NCBI
Stat5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,253,645 - 16,295,337 (-)NCBIChiLan1.0ChiLan1.0
LOC100989105
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,696,139 - 22,784,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,586,321 - 24,674,917 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,040,303 - 15,116,682 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,306,412 - 15,338,973 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,306,418 - 15,336,463 (+)Ensemblpanpan1.1panPan2
STAT5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,647,712 - 20,718,453 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,691,483 - 20,716,485 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,109,403 - 20,179,537 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,367,403 - 21,437,279 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,367,403 - 21,437,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,152,431 - 20,222,600 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,419,706 - 20,489,689 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,522,505 - 20,592,735 (+)NCBIUU_Cfam_GSD_1.0
LOC101954516
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,031,387 - 20,054,040 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,021,051 - 17,043,941 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,022,268 - 17,043,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,508,404 - 20,574,266 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,498,103 - 20,574,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,634,155 - 20,864,515 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 37
Low 23
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000001159   ⟹   ENSCSAP00000014910
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1663,997,441 - 64,070,445 (+)Ensembl
RefSeq Acc Id: XM_008012649   ⟹   XP_008010840
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11663,997,486 - 64,070,392 (+)NCBI
Vero_WHO_p1.0NW_02366607734,806,694 - 34,884,310 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008012650   ⟹   XP_008010841
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11664,036,846 - 64,070,392 (+)NCBI
Vero_WHO_p1.0NW_02366607734,850,284 - 34,884,310 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037993182   ⟹   XP_037849110
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,806,391 - 34,884,310 (+)NCBI
RefSeq Acc Id: XM_037993183   ⟹   XP_037849111
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,795,632 - 34,884,310 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008010840 (Get FASTA)   NCBI Sequence Viewer  
  XP_008010841 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849110 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849111 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014906.1
  ENSCSAP00000014910
  ENSCSAP00000014910.1
Reference Protein Sequences
RefSeq Acc Id: XP_008010840   ⟸   XM_008012649
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S221 (UniProtKB/TrEMBL),   A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008010841   ⟸   XM_008012650
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000014910   ⟸   ENSCSAT00000001159
RefSeq Acc Id: XP_037849111   ⟸   XM_037993183
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S221 (UniProtKB/TrEMBL),   A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849110   ⟸   XM_037993182
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S221 (UniProtKB/TrEMBL),   A0A0D9S217 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCSAG00000003196 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001159.1 UniProtKB/TrEMBL
  ENSCSAT00000001166.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT5_CCD UniProtKB/TrEMBL
  STAT5a/5b UniProtKB/TrEMBL
  STAT5b_SH2 UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report csab:103243413 UniProtKB/TrEMBL
NCBI Gene STAT5B ENTREZGENE
PANTHER PTHR11801 UniProtKB/TrEMBL
  SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A UniProtKB/TrEMBL
  SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/TrEMBL
  SSF48092 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9S217 ENTREZGENE, UniProtKB/TrEMBL
  A0A0D9S221 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103243413  signal transducer and activator of transcription 5B  STAT5B  signal transducer and activator of transcription 5B  Symbol and/or name change 5135510 APPROVED