RGD Reference Report - Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma. - Rat Genome Database

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Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma.

Authors: Wang, Xiangkun  Liao, Xiwen  Yu, Tingdong  Gong, Yizhen  Zhang, Linbo  Huang, Jianlu  Yang, Chengkun  Han, Chuangye  Yu, Long  Zhu, Guangzhi  Qin, Wei  Liu, Zhengqian  Zhou, Xin  Liu, Junqi  Han, Quanfa  Peng, Tao 
Citation: Wang X, etal., Int J Oncol. 2019 Oct;55(4):805-822. doi: 10.3892/ijo.2019.4862. Epub 2019 Aug 27.
RGD ID: 153298932
Pubmed: PMID:31485610   (View Abstract at PubMed)
PMCID: PMC6741847   (View Article at PubMed Central)
DOI: DOI:10.3892/ijo.2019.4862   (Journal Full-text)

Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor prognosis in patients. The aim of the present study is to explore the clinical significance of the main genes involved in the Janus kinase (JAK)‑signal transducer and activator of transcription (STAT) pathway in HCC. GSE14520, a training cohort containing 212 hepatitis B virus‑infected HCC patients from the Gene Expression Omnibus database, and data from The Cancer Genome Atlas as a validation cohort containing 370 HCC patients, were used to analyze the diagnostic and prognostic significance for HCC. Joint‑effect analyses were performed to determine diagnostic and prognostic significance. Nomograms and risk score models were constructed to predict HCC prognosis using the two cohorts. Additionally, molecular mechanism analysis was performed for the two cohorts. Prognosis‑associated genes in the two cohorts were further validated for differential expression using reverse transcription‑quantitative polymerase chain reaction of 21 pairs of hepatitis B virus‑infected HCC samples. JAK2, TYK2, STAT3, STAT4 and STAT5B had diagnostic significance in the two cohorts (all area under curves >0.5; P<=0.05). In addition, JAK2, STAT5A, STAT6 exhibited prognostic significance in both cohorts (all adjusted P<=0.05). Furthermore, joint‑effect analysis had advantages over using one gene alone. Molecular mechanism analyses confirmed that STAT6 was enriched in pathways and terms associated with the cell cycle, cell division and lipid metabolism. Nomograms and risk score models had advantages for HCC prognosis prediction. When validated in 21 pairs of HCC and non‑tumor tissue, STAT6 was differentially expressed, whereas JAK2 was not differentially expressed. In conclusion, JAK2, STAT5A and STAT6 may be potential prognostic biomarkers for HCC. JAK2, TYK2, STAT3, STAT4 and STAT5B may be potential diagnostic biomarkers for HCC. STAT6 has a role in HCC that may be mediated via effects on the cell cycle, cell division and lipid metabolism.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma amelioratesIEP 153298932mRNA:increased expression:liver (human)RGD 
hepatocellular carcinoma amelioratesISOSTAT5B (Homo sapiens)153298932; 153298932mRNA:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Stat5b  (signal transducer and activator of transcription 5B)

Genes (Mus musculus)
Stat5b  (signal transducer and activator of transcription 5B)

Genes (Homo sapiens)
STAT5B  (signal transducer and activator of transcription 5B)


Additional Information