Stat3 (signal transducer and activator of transcription 3) - Rat Genome Database

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Gene: Stat3 (signal transducer and activator of transcription 3) Rattus norvegicus
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Symbol: Stat3
Name: signal transducer and activator of transcription 3
RGD ID: 3772
Description: Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; postsynapse to nucleus signaling pathway; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; mitochondrial inner membrane; and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Biomarker of atherosclerosis; colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3); PARTICIPATES IN Interleukin-10 signaling pathway; epidermal growth factor/neuregulin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-nicotine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93551; signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau3 Pia10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,811,206 - 85,863,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,847,511 - 90,899,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,326,207 - 90,377,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,719,368 - 85,771,150 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model