Stat3 (signal transducer and activator of transcription 3) - Rat Genome Database

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Gene: Stat3 (signal transducer and activator of transcription 3) Rattus norvegicus
Symbol: Stat3
Name: signal transducer and activator of transcription 3
RGD ID: 3772
Description: Enables CCR5 chemokine receptor binding activity; glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3); PARTICIPATES IN Interleukin-10 signaling pathway; epidermal growth factor/neuregulin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (R)-mevalonic acid; (R,R,R)-alpha-tocopherol; (S)-nicotine.
Type: protein-coding
Also known as: MGC93551; signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21085,811,206 - 85,863,057 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)Ensembl
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adult T-cell leukemia  (ISO)
Alzheimer's disease  (ISO)
anaplastic large cell lymphoma  (ISO)
angiomyolipoma  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
Atrophy  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IDA,IMP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cervix uteri carcinoma in situ  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic lymphocytic leukemia  (ISO)
Churg-Strauss syndrome  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISS)
colorectal carcinoma  (IEP)
congenital diaphragmatic hernia  (ISO)
Copper-Overload Cirrhosis  (ISO)
Crohn's disease  (ISO)
Diabetic Nephropathies  (IDA)
duodenal ulcer  (IMP)
Endometrial Neoplasms  (ISO)
Epidermal Hyperplasia  (ISO)
esophageal carcinoma  (ISO)
Experimental Arthritis  (IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (IEP)
hepatocellular carcinoma  (ISO)
hyper IgE recurrent infection syndrome 1  (ISO)
hyper IgE syndrome  (ISO)
Hyperalgesia  (IMP)
hyperuricemia  (IDA)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISS)
irritant dermatitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (IDA)
Liver Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
lymphoproliferative syndrome  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
Multisystem Autoimmune Disease, Infantile-Onset, 1  (ISO)
Myocardial Reperfusion Injury  (IDA)
Nasal Polyps  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neutropenia  (IAGP)
Niemann-Pick disease type C1  (ISO)
non-alcoholic fatty liver disease  (IDA)
obesity  (IDA)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
periodontitis  (ISO)
peripartum cardiomyopathy  (ISS)
pre-malignant neoplasm  (IEP,ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
Pyogenic Granuloma  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IDA)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (IDA)
Sepsis-Associated Encephalopathy  (IDA)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (IEP)
T-cell lymphoblastic leukemia/lymphoma  (ISO)
T-Cell Lymphoma  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IDA)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-cotinine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-lobeline  (ISO)
(-)-selegiline  (ISO)
(20R)-protopanaxadiol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-naphthoquinone  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
25-hydroxycholesterol  (EXP)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
alpinumisoflavone  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
amidotrizoic acid  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (EXP,ISO)
amphibole asbestos  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
aucubin  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
beraprost  (ISO)
Bergenin  (EXP)
beta-Elemonic acid  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
BQ 123  (ISO)
bucladesine  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calyculin a  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbidopa  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carnosine  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
ceruletide  (ISO)
cetrorelix  (ISO)
chitin  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
columbamine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocin-1  (ISO)
Cryptotanshinone  (ISO)
crystal violet  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanidin cation  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dinitrogen oxide  (ISO)
dioxygen  (EXP,ISO)
docebenone  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
emodin  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (EXP)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP)
ethyl methanesulfonate  (ISO)
fisetin  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fraxetin  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
galangin  (ISO)
Ganoderic acid A  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK690693  (ISO)
GW 3965  (EXP)
halothane  (ISO)
hesperetin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (ISO)
Hexamethonium  (EXP,ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
Interferon beta-1b  (ISO)
iomeprol  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoliquiritigenin  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kurarinol  (ISO)
L-ascorbic acid  (ISO)
L-mimosine  (EXP)
lapatinib  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
linagliptin  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lithium chloride  (ISO)
losartan  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
lycorine  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
manumycin A  (ISO)
maslinic acid  (ISO)
masoprocol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
mercury dichloride  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (ISO)
Methylthiouracil  (ISO)
microcystin-LR  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
morphine  (ISO)
morusin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naringin  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifuroxazide  (EXP)
nimesulide  (ISO)
nitrofen  (EXP)
nitrofurantoin  (EXP,ISO)
nitroglycerin  (EXP)
ochratoxin A  (ISO)
olanzapine  (EXP)
oleanolic acid  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paroxetine  (ISO)
phenethyl caffeate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylpropanolamine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosphatidic acid  (ISO)
physostigmine  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
Ponicidin  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reparixin  (ISO)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP)
rimonabant  (ISO)
risperidone  (EXP)
ritodrine  (ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salinomycin  (ISO)
salubrinal  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
stattic  (EXP,ISO)
staurosporine  (ISO)
stavudine  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
succinic acid  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theobromine  (EXP)
theophylline  (ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
tofacitinib  (ISO)
tolcapone  (EXP)
toluene  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trametinib  (ISO)
trimethyltin  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (ISO)
tyrphostin B42  (ISO)
U50488  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
verapamil  (EXP)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
aging  (IEP)
astrocyte differentiation  (ISO,ISS)
cell population proliferation  (ISO)
cellular response to cytokine stimulus  (IDA)
cellular response to hormone stimulus  (ISO)
cellular response to leptin stimulus  (ISO,ISS)
cellular response to organic cyclic compound  (IDA)
cytokine-mediated signaling pathway  (IBA)
defense response  (IBA)
eating behavior  (ISO,ISS)
energy homeostasis  (ISO,ISS)
eye photoreceptor cell differentiation  (ISO,ISS)
glucose homeostasis  (ISO,ISS)
growth hormone receptor signaling pathway  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,ISO,ISS)
inflammatory response  (ISO,ISS)
interleukin-6-mediated signaling pathway  (ISO,ISS)
intracellular receptor signaling pathway  (ISO)
leptin-mediated signaling pathway  (IBA,ISO,ISS)
modulation of chemical synaptic transmission  (EXP,IDA,IMP)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell death  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hydrogen peroxide biosynthetic process  (IMP)
negative regulation of neuron death  (IMP)
negative regulation of neuron migration  (ISO)
negative regulation of primary miRNA processing  (ISO)
negative regulation of stem cell differentiation  (ISO)
phosphorylation  (ISO,ISS)
positive regulation of angiogenesis  (ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of erythrocyte differentiation  (ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of gene silencing by miRNA  (ISO)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (IMP)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-6 production  (IGI)
positive regulation of interleukin-8 production  (ISO)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of miRNA-mediated gene silencing by inhibition of translation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IGI)
positive regulation of Notch signaling pathway  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynapse to nucleus signaling pathway  (IDA)
protein import into nucleus  (ISO,ISS)
radial glial cell differentiation  (ISO,ISS)
receptor signaling pathway via JAK-STAT  (IBA,TAS)
regulation of cell cycle  (ISO,ISS)
regulation of cell population proliferation  (IBA)
regulation of feeding behavior  (ISO,ISS)
regulation of mitochondrial membrane permeability  (IMP)
regulation of multicellular organism growth  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISS)
regulation of transcription, DNA-templated  (ISO,ISS)
response to cytokine  (IDA)
response to estradiol  (IEP,ISO)
response to ethanol  (IEP)
response to leptin  (ISO,ISS)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to peptide hormone  (IBA,IEP)
response to xenobiotic stimulus  (IEP)
sexual reproduction  (ISO,ISS)
stem cell population maintenance  (ISO)
T-helper 17 cell lineage commitment  (ISO,ISS)
T-helper 17 type immune response  (ISO)
temperature homeostasis  (ISO,ISS)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component


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