Stat3 (signal transducer and activator of transcription 3) - Rat Genome Database

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Gene: Stat3 (signal transducer and activator of transcription 3) Rattus norvegicus
Symbol: Stat3
Name: signal transducer and activator of transcription 3
RGD ID: 3772
Description: Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3); PARTICIPATES IN Interleukin-10 signaling pathway; epidermal growth factor/neuregulin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (R)-mevalonic acid; (R,R,R)-alpha-tocopherol; (S)-nicotine.
Type: protein-coding
Previously known as: MGC93551; signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau3 Pia10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21085,811,206 - 85,863,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,847,511 - 90,899,338 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01090,326,207 - 90,377,980 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01085,719,368 - 85,771,150 (-)NCBIRnor_WKY
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alzheimer's disease  (ISO)
anaplastic large cell lymphoma  (ISO)
angiomyolipoma  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
Atrophy  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IDA,IMP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cervix uteri carcinoma in situ  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic lymphocytic leukemia  (ISO)
Churg-Strauss syndrome  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISS)
colorectal carcinoma  (IEP)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
Copper-Overload Cirrhosis  (ISO)
Crohn's disease  (ISO)
Diabetic Nephropathies  (IDA)
duodenal ulcer  (IMP)
Endometrial Neoplasms  (ISO)
Epidermal Hyperplasia  (ISO)
esophageal carcinoma  (ISO)
Experimental Arthritis  (IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Experimental Neoplasms  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
growth hormone insensitivity syndrome with immune dysregulation 1  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (IEP)
hepatocellular carcinoma  (ISO)
hyper IgE recurrent infection syndrome 1  (ISO)
hyper IgE syndrome  (ISO)
Hyperalgesia  (IMP)
hyperuricemia  (IDA)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISS)
irritant dermatitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (IDA)
Liver Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
lymphoproliferative syndrome  (ISO)
medulloblastoma  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
Multisystem Autoimmune Disease, Infantile-Onset, 1  (ISO)
Myocardial Reperfusion Injury  (IDA)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neutropenia  (IAGP)
Niemann-Pick disease type C1  (ISO)
non-alcoholic fatty liver disease  (IDA)
obesity  (IDA)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
periodontitis  (ISO)
peripartum cardiomyopathy  (ISS)
pre-malignant neoplasm  (IEP,ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
Pyogenic Granuloma  (ISO)
rectum adenocarcinoma  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IDA)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (IDA)
Sepsis-Associated Encephalopathy  (IDA)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (IEP)
T-cell acute lymphoblastic leukemia  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IDA)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-cotinine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-lobeline  (ISO)
(-)-selegiline  (ISO)
(20R)-protopanaxadiol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-naphthoquinone  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
25-hydroxycholesterol  (EXP)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
abamectin  (EXP)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
Allylamine  (EXP)
alpinumisoflavone  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
amidotrizoic acid  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (EXP,ISO)
amphibole asbestos  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
aucubin  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
beraprost  (ISO)
berberine  (EXP)
Bergenin  (EXP)
beta-Elemonic acid  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
BQ 123  (ISO)
bucladesine  (ISO)
butein  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbidopa  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carnosine  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chitin  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
ciglitazone  (ISO)
Cirsimarin  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
columbamine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumermycin A1  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocin-1  (ISO)
Cryptotanshinone  (ISO)
crystal violet  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanidin cation  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
deguelin  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dinitrogen oxide  (ISO)
dioxygen  (EXP,ISO)
docebenone  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
emodin  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
eriocitrin  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP)
ethyl methanesulfonate  (ISO)
fisetin  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fraxetin  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
galangin  (ISO)
galaxolide  (ISO)
Ganoderic acid A  (ISO)
Garcinol  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK690693  (ISO)
GW 3965  (EXP)
halothane  (ISO)
hesperetin  (EXP)
hesperidin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (ISO)
Hexamethonium  (EXP,ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
Interferon beta-1b  (ISO)
iomeprol  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoliquiritigenin  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kurarinol  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (ISO)
L-mimosine  (EXP)
lapatinib  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
limonin  (ISO)
linagliptin  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lithium chloride  (ISO)
loganin  (EXP,ISO)
losartan  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lycorine  (ISO)
malaoxon  (EXP)
malathion  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
manumycin A  (ISO)
maslinic acid  (ISO)
masoprocol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
mercury dichloride  (ISO)
mesalamine  (EXP)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (EXP)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (ISO)
Methylthiouracil  (ISO)
microcystin-LR  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
morphine  (ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-phosphocreatine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naringin  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifuroxazide  (EXP)
nimesulide  (ISO)
nitrofen  (EXP)
nitrofurantoin  (EXP,ISO)
nitroglycerin  (EXP)
ochratoxin A  (ISO)
olanzapine  (EXP)
oleanolic acid  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (ISO)
paroxetine  (ISO)
pentachlorophenol  (ISO)
phenethyl caffeate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylpropanolamine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosphatidic acid  (ISO)
physostigmine  (ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
Ponicidin  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
Punicalagin  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reparixin  (ISO)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP)
rimonabant  (ISO)
risperidone  (EXP)
ritodrine  (ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salinomycin  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
stattic  (EXP,ISO)
staurosporine  (ISO)
stavudine  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
succinic acid  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theobromine  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
thyroxine  (ISO)
tofacitinib  (ISO)
tolcapone  (EXP)
toluene  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trametinib  (ISO)
trimethyltin  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (ISO)
tyrphostin B42  (ISO)
U50488  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
verapamil  (EXP)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
aging  (IEP)
astrocyte differentiation  (ISO,ISS)
cell differentiation  (ISO)
cell population proliferation  (ISO)
cellular response to cytokine stimulus  (IDA)
cellular response to hormone stimulus  (ISO)
cellular response to interleukin-17  (ISO)
cellular response to leptin stimulus  (ISO,ISS)
cellular response to organic cyclic compound  (IDA)
defense response  (IBA)
eating behavior  (ISO,ISS)
energy homeostasis  (ISO,ISS)
eye photoreceptor cell differentiation  (ISS)
gene expression  (ISO)
glucose homeostasis  (ISO,ISS)
growth hormone receptor signaling pathway  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,ISO,ISS)
inflammatory response  (ISO,ISS)
interleukin-11-mediated signaling pathway  (ISO)
interleukin-15-mediated signaling pathway  (ISO)
interleukin-2-mediated signaling pathway  (ISO)
interleukin-6-mediated signaling pathway  (ISO,ISS)
interleukin-9-mediated signaling pathway  (ISO)
intracellular receptor signaling pathway  (ISO)
leptin-mediated signaling pathway  (IBA,ISO,ISS)
modulation of chemical synaptic transmission  (EXP,IDA,IMP)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hydrogen peroxide biosynthetic process  (IMP)
negative regulation of inflammatory response  (ISO)
negative regulation of inflammatory response to wounding  (ISO)
negative regulation of neuron death  (IMP)
negative regulation of neuron migration  (ISO)
negative regulation of primary miRNA processing  (ISO)
negative regulation of stem cell differentiation  (ISO)
obsolete positive regulation of miRNA-mediated gene silencing by inhibition of translation  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
phosphorylation  (ISO,ISS)
positive regulation of angiogenesis  (ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of erythrocyte differentiation  (ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (IMP)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-6 production  (IGI)
positive regulation of interleukin-8 production  (ISO)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of miRNA-mediated gene silencing  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IGI)
positive regulation of Notch signaling pathway  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynapse to nucleus signaling pathway  (IDA,IEP)
protein import into nucleus  (ISO,ISS)
radial glial cell differentiation  (ISO,ISS)
receptor signaling pathway via JAK-STAT  (IBA,ISO,TAS)
regulation of cell cycle  (ISO)
regulation of cell cycle  (ISO)
regulation of cell cycle  (ISS)
regulation of cell population proliferation  (IBA)
regulation of cellular response to hypoxia  (IMP)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of feeding behavior  (ISO,ISS)
regulation of mitochondrial membrane permeability  (IMP)
regulation of multicellular organism growth  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISS)
response to cytokine  (IDA)
response to estradiol  (IEP,ISO)
response to ethanol  (IEP)
response to leptin  (ISO,ISS)
response to organic cyclic compound  (IEP)
response to organic substance  (IEA,IEP)
response to peptide hormone  (IBA,IEP)
response to xenobiotic stimulus  (IEP)
retinal rod cell differentiation  (ISO)
sexual reproduction  (ISO,ISS)
signal transduction  (IEA)
somatic stem cell population maintenance  (ISO)
T-helper 17 cell lineage commitment  (ISO,ISS)
T-helper 17 type immune response  (ISO)
temperature homeostasis  (ISO,ISS)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. Prevention of hypovolemic circulatory collapse by IL-6 activated stat3. Alten JA, etal., PLoS ONE. 2008 Feb 13;3(2):e1605.
3. NF-kappaB and STAT3 inhibition as a therapeutic strategy in psoriasis: in vitro and in vivo effects of BTH. Andres RM, etal., J Invest Dermatol. 2013 Oct;133(10):2362-71. doi: 10.1038/jid.2013.182. Epub 2013 Apr 17.
4. Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period. Anhe GF, etal., J Endocrinol. 2007 Oct;195(1):17-27.
5. Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. Arambasic J, etal., IUBMB Life. 2010 Mar;62(3):227-36.
6. STAT3 deletion sensitizes cells to oxidative stress. Barry SP, etal., Biochem Biophys Res Commun. 2009 Jul 31;385(3):324-9. doi: 10.1016/j.bbrc.2009.05.051. Epub 2009 May 18.
7. The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Boengler K, etal., Curr Pharm Des. 2013;19(39):6890-5.
8. ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Bong YS, etal., Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17305-10. Epub 2007 Oct 22.
9. Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1. Booz GW, etal., Mol Cell Biochem 2002 Nov;240(1-2):39-46.
10. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Cao H, etal., Circ Res. 2006 Apr 14;98(7):913-22. Epub 2006 Mar 9.
11. Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease. Cenit MC, etal., Hum Immunol. 2013 Feb;74(2):230-3. doi: 10.1016/j.humimm.2012.10.019. Epub 2012 Nov 2.
12. SH2B1beta interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. Chang YJ, etal., Mol Cell Biol. 2014 Mar;34(6):1003-19. doi: 10.1128/MCB.00940-13. Epub 2014 Jan 6.
13. [Expressions of VEGF/VEGFRs and activation of STATs in ovarian carcinoma] Chen BY, etal., Zhonghua Zhong Liu Za Zhi. 2005 Jan;27(1):33-7.
14. Stat3 activation in human endometrial and cervical cancers. Chen CL, etal., Br J Cancer. 2007 Feb 26;96(4):591-9.
15. Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. Chen JR, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):50-9. Epub 2007 Oct 4.
16. Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia. Chen N, etal., Oncol Rep. 2018 Jun;39(6):3064-3072. doi: 10.3892/or.2018.6367. Epub 2018 Apr 12.
17. Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. Chen SY, etal., J Cutan Pathol. 2008 Aug;35(8):722-30.
18. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Chen Y, etal., Diabetologia. 2012 Sep;55(9):2533-45. doi: 10.1007/s00125-012-2594-1. Epub 2012 Jun 4.
19. Clinicopathologic and prognostic significance of VEGF, JAK2 and STAT3 in patients with nasopharyngeal carcinoma. Cheng JZ, etal., Cancer Cell Int. 2018 Aug 13;18:110. doi: 10.1186/s12935-018-0605-0. eCollection 2018.
20. Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Chiba T, etal., Mol Psychiatry. 2009 Feb;14(2):206-22. doi: 10.1038/mp.2008.105. Epub 2008 Sep 23.
21. Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Choi JS, etal., Glia 2003 Feb;41(3):237-46.
22. Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells. Chung H, etal., J Endocrinol. 2013 Jun 1;218(1):49-59. doi: 10.1530/JOE-13-0045. Print 2013 Jul.
23. Stat3 activation in prostatic carcinomas. Dhir R, etal., Prostate. 2002 Jun 1;51(4):241-6.
24. Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target. El-Hashemite N and Kwiatkowski DJ, Am J Respir Cell Mol Biol. 2005 Sep;33(3):227-30. Epub 2005 Jun 30.
25. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. Farooqi IS, etal., N Engl J Med. 2007 Jan 18;356(3):237-47.
26. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
27. Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population. Ferguson LR, etal., Mutat Res. 2010 Aug 7;690(1-2):108-15. Epub 2010 Jan 28.
28. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
29. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
30. Opposite nuclear level and binding activity of STAT5B and STAT3 proteins with rat haptoglobin gene under normal and turpentine induced acute phase conditions. Grigorov I, etal., Mol Biol Rep 2001;28(4):217-22.
31. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
32. MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. Halkein J, etal., J Clin Invest. 2013 May 1;123(5):2143-54. doi: 10.1172/JCI64365. Epub 2013 Apr 24.
33. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. Harris TJ, etal., J Immunol. 2007 Oct 1;179(7):4313-7.
34. Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: a study of incidence and its association with pathological features and clinical outcome. Horiguchi A, etal., J Urol. 2002 Aug;168(2):762-5.
35. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
36. JAK2 and STAT3 polymorphisms in a Han Chinese population with Behcet's disease. Hu K, etal., Invest Ophthalmol Vis Sci. 2012 Jan 31;53(1):538-41. Print 2012 Jan.
37. Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway. Huang T, etal., Oxid Med Cell Longev. 2019 Jul 15;2019:5813985. doi: 10.1155/2019/5813985. eCollection 2019.
38. STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. Ito N, etal., J Clin Oncol. 2007 Jul 1;25(19):2785-91.
39. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Izumi-Nagai K, etal., Am J Pathol. 2007 Jun;170(6):2149-58.
40. Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients. Jakiela B, etal., Rheumatology (Oxford). 2012 Jul 5.
41. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T cell large granular lymphocyte leukemia. Jerez A, etal., Blood. 2012 Aug 2.
42. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-kappaB signaling pathways. Jia Y, etal., PLoS One. 2011;6(10):e27006. Epub 2011 Oct 31.
43. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Jing N, etal., Cancer Res. 2004 Sep 15;64(18):6603-9.
44. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
45. Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis. Kataoka K, etal., Carcinogenesis. 2008 Jun;29(6):1108-14. doi: 10.1093/carcin/bgn061. Epub 2008 May 2.
46. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Khomenko T, etal., Dig Dis Sci. 2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3.
47. Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis. Kim DJ, etal., Oncogene. 2009 Feb 19;28(7):950-60. doi: 10.1038/onc.2008.453. Epub 2009 Jan 12.
48. JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. Kim OS, etal., J Biol Chem 2002 Oct 25;277(43):40594-601. Epub 2002 Aug 20.
49. Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3. Kong F, etal., Shock 2002 Oct;18(4):374-9.
50. Somatic STAT3 mutations in large granular lymphocytic leukemia. Koskela HL, etal., N Engl J Med. 2012 May 17;366(20):1905-13.
51. Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting. Kurosaka M and Machida S, Cell Prolif. 2013 Aug;46(4):365-73. doi: 10.1111/cpr.12045.
52. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
53. Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression. Lee CS, etal., J Ethnopharmacol. 2011 Jun 1;135(3):747-53. doi: 10.1016/j.jep.2011.04.009. Epub 2011 Apr 12.
54. Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. Lejeune D, etal., J Biol Chem 2002 Sep 13;277(37):33676-82. Epub 2002 Jun 26.
55. Mangiferin ameliorates Porphyromonas gingivalis-induced experimental periodontitis by inhibiting phosphorylation of nuclear factor-κB and Janus kinase 1-signal transducer and activator of transcription signaling pathways. Li H, etal., J Periodontal Res. 2017 Feb;52(1):1-7. doi: 10.1111/jre.12360. Epub 2016 Jan 30.
56. Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells. Li X, etal., PLoS One. 2012;7(10):e47600. doi: 10.1371/journal.pone.0047600. Epub 2012 Oct 19.
57. Effects of propofol on invasion and migration of colon cancer cells and JAK2/STAT3 signaling pathway. Liang B and Dong T, Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28;45(3):290-296. doi: 10.11817/j.issn.1672-7347.2020.180704.
58. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
59. Ilex paraguariensis (yerba mate) improves endocrine and metabolic disorders in obese rats primed by early weaning. Lima Nda S, etal., Eur J Nutr. 2014 Feb;53(1):73-82. doi: 10.1007/s00394-013-0500-3. Epub 2013 Feb 9.
60. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Ling X, etal., Cancer Res. 2007 May 1;67(9):4210-8.
61. Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma. Liu HW, etal., Cancers (Basel). 2019 Nov 27;11(12). pii: cancers11121888. doi: 10.3390/cancers11121888.
62. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Liu JR, etal., Pathol Res Pract. 2015 Jun;211(6):426-34. doi: 10.1016/j.prp.2015.01.007. Epub 2015 Jan 24.
63. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. Liu X, etal., J Immunol. 2008 May 1;180(9):6070-6.
64. Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. Liu X, etal., PLoS One. 2013 Oct 3;8(10):e75804. doi: 10.1371/journal.pone.0075804. eCollection 2013.
65. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Liu YF, etal., Int J Mol Sci. 2015 Jan 12;16(1):1576-89. doi: 10.3390/ijms16011576.
66. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
67. Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. Ma H, etal., J Mol Cell Cardiol. 2012 Jun;52(6):1282-90. doi: 10.1016/j.yjmcc.2012.02.011. Epub 2012 Mar 6.
68. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Mashili F, etal., Diabetes. 2013 Feb;62(2):457-65. doi: 10.2337/db12-0337. Epub 2012 Oct 5.
69. Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinoma. Masuda M, etal., Oral Oncol. 2007 Sep;43(8):785-90. Epub 2006 Dec 13.
70. TNF-a-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between I¿B-NF¿B and JAK-STAT3 pathways. Matsumoto J, etal., Brain Res. 2018 Aug 1;1692:34-44. doi: 10.1016/j.brainres.2018.04.023. Epub 2018 Apr 24.
71. Expression and activation of STAT3 in ischemia-induced retinopathy. Mechoulam H and Pierce EA, Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4409-16.
72. Interleukin-17 Signaling in Inflammatory, Kupffer, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice. Meng F, etal., Gastroenterology. 2012 Jun 8.
73. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
74. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
75. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Minegishi Y, etal., Nature. 2007 Aug 30;448(7157):1058-62. Epub 2007 Aug 5.
76. Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. Miyoshi K, etal., J Invest Dermatol. 2011 Jan;131(1):108-17. doi: 10.1038/jid.2010.255. Epub 2010 Sep 2.
77. Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain. Murata S, etal., Brain Res Mol Brain Res. 2000 May 31;78(1-2):80-90.
78. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
79. Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Mutze J, etal., Neurosci Lett. 2007 May 7;417(3):286-91. Epub 2007 Mar 2.
80. JAK-STAT signaling pathway mediates astrogliosis in brains of scrapie-infected mice. Na YJ, etal., J Neurochem. 2007 Oct;103(2):637-49.
81. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
82. The Jak/STAT pathway is involved in synaptic plasticity. Nicolas CS, etal., Neuron. 2012 Jan 26;73(2):374-90. doi: 10.1016/j.neuron.2011.11.024.
83. [Expression of Stat3, HIF-1alpha and VEGF in Wilms' tumor] Niu ZB, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Oct;9(5):461-4.
84. Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. O'Donoghue RJ, etal., EMBO Mol Med. 2012 Jun 8. doi: 10.1002/emmm.201100604.
85. STAT3 signaling after traumatic brain injury. Oliva AA Jr, etal., J Neurochem. 2012 Mar;120(5):710-20. doi: 10.1111/j.1471-4159.2011.07610.x. Epub 2012 Jan 31.
86. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
87. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. Park EJ, etal., J Biol Chem 2003 Apr 25;278(17):14747-52. Epub 2003 Feb 12.
88. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. Parker-Athill E, etal., J Neuroimmunol. 2009 Dec 10;217(1-2):20-7. Epub 2009 Sep 18.
89. Interleukin (IL)-10 inhibits RANTES-, tumour necrosis factor (TNF)- and nerve growth factor (NGF)-induced mast cell migratory response but is not a mast cell chemoattractant. Pietrzak A, etal., Immunol Lett. 2009 Mar 24;123(1):46-51. Epub 2009 Feb 14.
90. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
91. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
92. Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease. Polgar N, etal., Int J Immunogenet. 2012 Jan 23. doi: 10.1111/j.1744-313X.2012.01084.x.
93. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Quinton LJ, etal., Am J Respir Cell Mol Biol. 2008 Jun;38(6):699-706. Epub 2008 Jan 10.
94. Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. Rai A, etal., Pharmacol Res. 2018 Jun;132:188-203. doi: 10.1016/j.phrs.2017.12.010. Epub 2017 Dec 8.
95. GABAA Receptor Regulation after Experimental Traumatic Brain Injury. Raible DJ, etal., J Neurotrauma. 2012 Jul 24.
96. 5,7,3'-Triacetyl hesperetin suppresses adjuvant-induced arthritis in rats through modulating JAK2/STAT3 pathway. Ren DY, etal., Am J Chin Med. 2013;41(3):601-14. doi: 10.1142/S0192415X13500420.
97. Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. Ren S, etal., Int J Biochem Cell Biol. 2020 Aug;125:105777. doi: 10.1016/j.biocel.2020.105777. Epub 2020 Jun 3.
98. Autosomal recessive hyperimmunoglobulin E syndrome: a distinct disease entity. Renner ED, etal., J Pediatr. 2004 Jan;144(1):93-9.
99. GOA pipeline RGD automated data pipeline
100. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
101. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
102. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. Ripperger JA, etal., J Biol Chem 1995 Dec 15;270(50):29998-30006.
103. Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. Robinson K, etal., J Am Coll Surg. 2006 May;202(5):788-96.
104. Oxysterol and diabetes activate STAT3, and control endothelial expression of profilin-1 via OSBP1. Romeo GR and Kazlauskas A, J Biol Chem. 2008 Jan 28;.
105. Biology of interleukin-10. Sabat R, etal., Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. doi: 10.1016/j.cytogfr.2010.09.002. Epub 2010 Nov 5.
106. Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage. Samraj AK, etal., J Cereb Blood Flow Metab. 2014 May;34(5):759-63. doi: 10.1038/jcbfm.2014.15. Epub 2014 Feb 12.
107. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Scarpace PJ, etal., Endocrinology 2002 Aug;143(8):3026-35.
108. Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia. Sehara Y, etal., J Neurosci. 2013 Jul 24;33(30):12364-74. doi: 10.1523/JNEUROSCI.1852-13.2013.
109. Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects. Sen M, etal., Mol Med. 2014 Mar 18;20:46-56. doi: 10.2119/molmed.2013.00104.
110. Human umbilical cord blood-derived mesenchymal stem cells protect against neuronal cell death and ameliorate motor deficits in Niemann Pick type C1 mice.