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Gene: Stat3 (signal transducer and activator of transcription 3) Rattus norvegicus
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Symbol: Stat3
Name: signal transducer and activator of transcription 3
Description: Exhibits CCR5 chemokine receptor binding activity; glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including aging; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; and regulation of cellular biosynthetic process. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; intracellular membrane-bounded organelle; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; nonalcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of heart disease and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Job's syndrome; carcinoma (multiple); inflammatory bowel disease (multiple); and psoriatic arthritis. Orthologous to human STAT3 (signal transducer and activator of transcription 3); PARTICIPATES IN Interleukin-10 signaling pathway; epidermal growth factor/neuregulin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (R)-mevalonic acid; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC93551; signal transducer and activator of transcription 3 (acute-phase response factor)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
Cytogenetic Map10q31NCBI
RH 3.4 Map10837.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)