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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3affects response to substanceISOSTAT3 (Homo sapiens)6480464CTDSTAT3 protein affects the susceptibility to FluorouracilPMID:15682485 PMID:15730734
Stat3decreases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDFluorouracil results in decreased phosphorylation of STAT3 proteinPMID:18161298 PMID:18205257
Stat3increases expressionISOSTAT3 (Homo sapiens)6480464CTDFluorouracil results in increased expression of STAT3 mRNAPMID:16557594
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