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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:27418
Term: 1,4-naphthoquinone
Definition: The parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties.
Chemical ID: MESH:C035342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases phosphorylationISOSTAT3 (Homo sapiens)6480464CTD1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 proteinPMID:30871965
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; FR 180204 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]PMID:30871965
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