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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:15640
Term: 5-formyltetrahydrofolic acid
Definition: A formyltetrahydrofolic acid in which the formyl group is located at position 5.
Chemical ID: MESH:D002955
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDFOLR1 protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein]; IL6ST protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein]; Leucovorin results in increased activity of and results in increased phosphorylation of STAT3 proteinPMID:25841994
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