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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3affects localizationISOSTAT3 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate affects the localization of STAT3 proteinPMID:30133131
Stat3increases expressionISOStat3 (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased expression of STAT3PMID:26100520
Stat3increases phosphorylationISOStat3 (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 proteinPMID:22986104 PMID:26513295
Stat3increases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 proteinPMID:20523355 PMID:24496235
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTDbisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRKCE protein binds to STAT3 protein]]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of STAT3 protein]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; Phycocyanin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; Tetradecanoylphorbol Acetate promotes the reaction [PRKCE protein binds to STAT3 protein]; Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of STAT3 protein; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]PMID:22986104 PMID:24496235 PMID:26100520 PMID:26513295
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[Tetradecanoylphorbol Acetate co-treated with bisphenol A] results in decreased phosphorylation of STAT3 protein; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]PMID:20523355 PMID:25128825
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