RGD Reference Report - Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats. - Rat Genome Database

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Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats.

Authors: Zhang, DM  Li, YC  Xu, D  Ding, XQ  Kong, LD 
Citation: Zhang DM, etal., Food Chem. 2012 Oct 15;134(4):2184-93. doi: 10.1016/j.foodchem.2012.04.026. Epub 2012 Apr 17.
RGD ID: 10411892
Pubmed: PMID:23442673   (View Abstract at PubMed)
DOI: DOI:10.1016/j.foodchem.2012.04.026   (Journal Full-text)

Increasing evidence has demonstrated that excess fructose consumption as a risk factor for metabolic syndrome causes hyperuricaemia and renal injury. Curcumin, a natural plant phenolic food additive, lowered serum urate, creatinine and blood urea nitrogen levels, and increased urinary urate and nitrate/nitrites levels, as well as renal nitric oxide (NO) production in fructose-fed rats. Moreover, curcumin regulated urate transport-related proteins and inhibited activation of the JAK2-STAT3 cascade and overexpression of SOCS3 and TGF-beta1 in the kidneys of fructose-fed rats. These results suggested that the anti-hyperuricaemic and renal protective actions of curcumin might be the result of renal NO-mediated JAK2-STAT3 signalling and TGF-beta1 normality, which ameliorated renal endothelial dysfunction to improve renal urate transporter system in this model. The present study may provide the evidence for the potential use of a functional food ingredient curcumin because of its action against hyperuricaemia and renal injury induced by high fructose intake.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
JAK2Humanhyperuricemia treatmentISOJak2 (Rattus norvegicus) RGD 
Jak2Rathyperuricemia treatmentIDA  RGD 
Jak2Mousehyperuricemia treatmentISOJak2 (Rattus norvegicus) RGD 
STAT3Humanhyperuricemia treatmentISOStat3 (Rattus norvegicus) RGD 
Stat3Rathyperuricemia treatmentIDA  RGD 
Stat3Mousehyperuricemia treatmentISOStat3 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Jak2  (Janus kinase 2)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Jak2  (Janus kinase 2)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
JAK2  (Janus kinase 2)
STAT3  (signal transducer and activator of transcription 3)


Additional Information