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Gene: Ccr5 (C-C motif chemokine receptor 5) Rattus norvegicus
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Symbol: Ccr5
Name: C-C motif chemokine receptor 5
Description: Exhibits protein kinase binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of neuron differentiation; and response to bacterium. Localizes to cell surface and endosome. Used to study Alzheimer's disease; plague; and visual epilepsy. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; orchitis; and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Kawasaki disease; autoimmune hypersensitivity disease (multiple); rheumatoid arthritis (multiple); and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5); PARTICIPATES IN interleukin-12 signaling pathway; chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; Ckr5; Cmkbr5; MIP-1 alpha receptor
Orthologs:
Homo sapiens (human) : CCR5 (C-C motif chemokine receptor 5)  HGNC  Alliance
Mus musculus (house mouse) : Ccr5 (chemokine (C-C motif) receptor 5)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CCR5 (C-C motif chemokine receptor 5)
Canis lupus familiaris (dog) : CCR5 (C-C motif chemokine receptor 5)
Sus scrofa (pig) : CCR5 (chemokine (C-C motif) receptor 5)
Chlorocebus sabaeus (African green monkey) : CCR5 (C-C motif chemokine receptor 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08133,192,398 - 133,215,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,197,032 - 133,215,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,362,664 - 132,367,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,907,157 - 128,912,272 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,929,594 - 128,932,000 (+)NCBI
Celera8122,847,673 - 122,852,786 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ccr5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620596
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.