Gene: Ccr5 (C-C motif chemokine receptor 5) Rattus norvegicus
Analyze
Symbol:
Ccr5
Name:
C-C motif chemokine receptor 5
Description:
Exhibits protein kinase binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of neuron differentiation; and response to bacterium. Localizes to cell surface and endosome. Used to study Alzheimer's disease; plague; and visual epilepsy. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; orchitis; and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Kawasaki disease; autoimmune hypersensitivity disease (multiple); rheumatoid arthritis (multiple); and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5); PARTICIPATES IN interleukin-12 signaling pathway; chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; Ckr5; Cmkbr5; MIP-1 alpha receptor
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 8 133,192,398 - 133,215,599 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 133,197,032 - 133,215,614 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 132,362,664 - 132,367,779 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 128,907,157 - 128,912,272 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 8 128,929,594 - 128,932,000 (+) NCBI Celera 8 122,847,673 - 122,852,786 (+) NCBI Celera Cytogenetic Map 8 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Acute Hepatitis disease_progression ISO RGD:733487 14401740 RGD Alcoholic Fatty Liver disease_progression ISO RGD:733487 14401742 RGD allergic contact dermatitis IEP 2325935 mRNA:increased expression:skin, lymph node (rat) RGD Alzheimer's disease ISO RGD:1351344 4890447 protein:increased expression:brain, microglia (human) RGD Alzheimer's disease IMP 4890446 RGD anterior uveitis IEP 4890448 mRNA:increased expression:iris, ciliary body (rat) RGD Arterial Injury IEP 8552233 RGD arteriosclerosis ISO RGD:733487 4890431 RGD asthma ISO RGD:1351344 4145638 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD asthma no_association ISO RGD:1351344 8551842 DNA:polymorphism, frameshift mutation: :-59029G>A, p.S185_T195del (rs333) (human) RGD asthma ISO RGD:733487 4892093 RGD asthma ISO RGD:1351344 4892108 protein:decreased expression:blood, lymphocyte (human) RGD asthma ISO RGD:733487 4892088 mRNA:increased expression:lung (mouse) RGD atherosclerosis treatment ISO RGD:733487 8549763 RGD atopic dermatitis ISO RGD:1351344 6893391 RGD Behcet's disease ISO RGD:1351344 4892106 protein:increased expression:blood, T cell (human) RGD Behcet's disease no_association ISO RGD:1351344 8551827 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD Behcet's disease ISO RGD:1351344 8551814 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD berylliosis disease_progression ISO RGD:1351344 4892065 DNA:polymorphisms:5' utr:multiple (human) RGD Birth Injuries IEP 4890426 mRNA:increased expression:multiple organs (rat) RGD Brain Injuries IEP 8552265 mRNA:increased expression:hippocampus RGD brain ischemia IEP 632396 mRNA:increased expression:brain (rat) RGD breast cancer disease_progression ISO RGD:1351344 8551810 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD breast cancer ISO RGD:1351344 8551816 mRNA:increased expression:breast RGD cerebral infarction ISO RGD:733487 8552262 RGD Chemical and Drug Induced Liver Injury susceptibility ISO RGD:733487 14401733 acetaminophen RGD chlamydia ISO RGD:733487 8549760 RGD Chronic Hepatitis C disease_progression ISO RGD:1351344 14401729 DNA:deletion:cds: RGD Chronic Hepatitis C treatment ISO RGD:1351344 14401737 DNA:deletion:cds: RGD chronic obstructive pulmonary disease ISO RGD:1351344 4892070 protein:increased expression:blood (human) RGD corneal neovascularization ISO RGD:733487 734790 RGD coronary artery disease IEP 4890438 mRNA:increased expression:heart (rat) RGD Coronary Disease resistance ISO RGD:1351344 1581176 DNA:polymorphisms:multiple (human) RGD Coronavirus infectious disease ISO RGD:733487 4891446 Respiratory Syndrome, Severe Acute, mRNA:increased expression:lung (mouse) RGD Coronavirus infectious disease ISO RGD:733487 14401732 RGD cutaneous leishmaniasis ISO RGD:1351344 8549764 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD cutaneous leishmaniasis no_association ISO RGD:1351344 8549765 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD Diabetes Mellitus, Experimental IEP 11533943 protein:increased expression:retina RGD Diabetic Nephropathies ISO RGD:1351344 8549756 associated with Diabetes Mellitus, Type 2, DNA:SNP: :59029G>A (human) RGD Diabetic Nephropathies susceptibility ISO RGD:1351344 2307107 associated with Diabetes Mellitus, Non-Insulin-Dependent, DNA:polymorphism:promoter:59029G>A (human) RGD diabetic retinopathy ISO RGD:733487 8551828 associated with Diabetes Mellitus, Experimental RGD dry eye syndrome ISO RGD:1351344 8549761 mRNA, protein:increased expression:conjunctiva, epithelial cell RGD end stage renal disease IEP 4889989 mRNA:increased expression:kidney cortex (rat) RGD Experimental Arthritis IEP 1582346 mRNA:increased expression:ankle (rat) RGD Experimental Arthritis treatment IEP 5687744 RGD Experimental Autoimmune Encephalomyelitis IEP 4890436 mRNA:increased expression:spinal cord, macrophage, microglia (rat) RGD Experimental Liver Cirrhosis treatment ISO RGD:733487 14401743 RGD Experimental Liver Cirrhosis ISO RGD:733487 14401743 mRNA, protein:increased expression:liver RGD fallopian tube disease ISO RGD:1351344 8549760 associated with Chlamydia Infections, DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD Fever IMP 2307192 RGD Fever ISO RGD:733487 8552232 RGD Flaviviridae Infections ISO RGD:1351344 14401734 associated with hepatitis G virus infection, protein:decreased expression: T lymphocyte:hepatitis G virus infection RGD gallbladder cancer onset ISO RGD:1351344 2317570 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD glaucoma ISO RGD:1351344 8549757 RGD Graft vs Host Disease ISO RGD:733487 4892067 mRNA:increased expression:lung, liver, intestine (mouse) RGD granulomatosis with polyangiitis ISO RGD:1351344 4892114 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD hepatitis B susceptibility ISO RGD:1351344 14401575 DNA:polymorphism: :DNA:deletion:Cds: RGD hepatitis B disease_progression ISO RGD:1351344 14401727 DNA:polymorphism:promoter:59029A>G, 59353C>T RGD hepatitis B susceptibility ISO RGD:1351344 14401574 DNA:SNP: : rs1799987(human) RGD hepatitis C no_association ISO RGD:1351344 14401731 DNA:deletion:cds: RGD hepatitis C susceptibility ISO RGD:1351344 14401735 RGD Herpes Simplex Encephalitis ISO RGD:733487 8551839 RGD herpes simplex virus keratitis ISO RGD:733487 8551837 ; 8551819 RGD human immunodeficiency virus infectious disease ISO RGD:1351344 4892094 protein:decreased expression:blood, T cell (human) RGD Human Influenza ISO RGD:733487 4892119 ; 4892122 RGD Human Influenza severity ISO RGD:1351344 4892063 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD Hyperalgesia IMP 8551795 associated with Spinal Cord Injuries RGD Hyperalgesia ISO RGD:733487 8551820 ; 8551809 RGD Hyperalgesia IEP 4890034 mRNA:increased expression:dorsal root ganglion (rat) RGD hypertension IEP 4890416 mRNA:increased expression:aorta (rat) RGD hypertension ISO RGD:1351344 1581182 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD Hypoxia-Ischemia, Brain IEP 4890442 mRNA:increased expression:cerebral hemisphere (rat) RGD Inflammation IEP 4144893 associated with Arthritis, Experimental, protein:increased expression:synovial tissue, macrophage (rat) RGD interstitial lung disease ISO RGD:135344 4892085 associated with Scleroderma, Systemic, protein:increased expression:blood, T cell (human) RGD juvenile rheumatoid arthritis no_association ISO RGD:1351344 1626283 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD juvenile rheumatoid arthritis ISO RGD:1351344 1626284 DNA:polymorphisms: :multiple (human) RGD Kawasaki disease treatment ISO RGD:1351344 8551812 DNA:polymorphisms, haplotype:multiple RGD Kawasaki disease susceptibility ISO RGD:1351344 8551811 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD Kawasaki disease susceptibility ISO RGD:1351344 8551815 DNA:frameshift mutation, haplotypes: :p.S185_T195del (rs333) (human) RGD keratoconjunctivitis sicca ISO RGD:1351344 8549757 RGD leishmaniasis disease_progression ISO RGD:733487 8551832 RGD leishmaniasis ISO RGD:1351344 8551841 associated with HIV Infections, protein:increased expression:blood, T cell RGD Liver Injury IMP 8552264 RGD Lymphatic Metastasis ISO RGD:1351344 8551816 associated with Breast Neoplasms, mRNA:increased expression:lymph node RGD Mammary Neoplasms, Experimental ISO RGD:1351344 8551813 ; 8551810 RGD multiple sclerosis ISO RGD:1351344 1358460 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD multiple sclerosis ISO RGD:1351344 8551829 protein:increased expression:blood, cerebrospinal fluid RGD Mycoplasma Infections ISO RGD:1351344 4892129 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD Mycoplasma pneumoniae pneumonia ISO RGD:733487 4892091 protein:increased expression:lung, T-helper cell (mouse) RGD Myocardial Reperfusion Injury ISO RGD:1351344 4892017 protein:decreased expression:blood, monocyte (human) RGD Myocardial Reperfusion Injury treatment IEP 8552227 RGD optic neuritis ISO RGD:1351344 8551840 RGD Oral Lichen Planus ISO RGD:1351344 8551821 protein:increased expression:blood, T cell RGD orchitis severity IEP 6767571 RGD ovarian carcinoma ISO RGD:1351344 4892092 protein:increased expression:peritoneal fluid, leukocyte (human) RGD pancreatic cancer ISO RGD:733487 2317567 RGD paracoccidioidomycosis ISO RGD:733487 4892087 RGD Perennial Allergic Rhinitis ISO RGD:1351344 4145109 mRNA:increased expression:nasal mucosa (human) RGD plague resistance IAGP 4890425 DNA:polymorphism:cds:p.H184R (rat) RGD pleural tuberculosis ISO RGD:1351344 4145106 protein:increased expression:pleural fluid, natural killer cell (human) RGD pneumonia ISO RGD:733487 4892103 Idiopathic Pneumonia Syndrome, mRNA:increased expression:lung (mouse) RGD posterior uveitis ISO RGD:1351344 8551817 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD psoriasis ISO RGD:1351344 8551838 protein:decreased expression:T cell RGD pulmonary emphysema ISO RGD:733487 4892098 mRNA, protein:increased expression:lung (mouse) RGD pulmonary emphysema ISO RGD:733487 4892090 RGD pulmonary emphysema ISO RGD:1351344 4892104 protein:increased expression:lung, lymphocyte (human) RGD pulmonary fibrosis ISO RGD:1351344 4892101 protein:decreased expression:lung, lymphocyte (human) RGD pulmonary fibrosis ISO RGD:733487 4145622 mRNA:increased expression:lung (mouse) RGD pulmonary sarcoidosis ISO RGD:1351344 4892066 DNA:polymorphisms:5' utr:multiple (human) RGD pulmonary sarcoidosis disease_progression ISO RGD:1351344 4892099 protein:altered expression:lung, lymphocyte, macrophage (human) RGD pulmonary tuberculosis ISO RGD:1351344 4892094 protein:decreased expression:blood, T cell (human) RGD respiratory syncytial virus infectious disease ISO RGD:1351344 4892113 DNA:snps:5' utr:g.-2459A>G, g.-2554G>T (human) RGD respiratory syncytial virus infectious disease ISO RGD:1351344 4892079 protein:increased expression:blood, monocyte (human) RGD Respirovirus Infections ISO RGD:733487 4892127 RGD rheumatoid arthritis no_association ISO RGD:1351344 1626283 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD rheumatoid arthritis resistance ISO RGD:1351344 1626290 DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) RGD sarcoidosis ISO RGD:1351344 4892086 Lofgren Syndrome, DNA:polymorphisms:5' utr:multiple (human) RGD Sjogren's syndrome ISO RGD:1351344 8551796 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD Sjogren's syndrome no_association ISO RGD:1351344 8551818 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD status epilepticus IEP 8552226 RGD syphilis ISO RGD:1351344 8551830 RGD systemic lupus erythematosus ISO RGD:1351344 6893428 mRNA:increased expression:blood, mononuclear cell RGD Transplant Rejection IEP 8552228 RGD Transplant Rejection treatment IEP 8552231 RGD type 1 diabetes mellitus ISO RGD:1351344 2317571 protein:decreased expression:blood, mononuclear cell RGD type 1 diabetes mellitus no_association ISO RGD:1351344 8551818 DNA:frameshift mutation: :p.S185_T195del (rs333) (human) RGD type 1 diabetes mellitus IEP 4890459 mRNA:increased expression:splenocyte (rat) RGD type 2 diabetes mellitus treatment IEP 8552229 RGD type 2 diabetes mellitus ISO RGD:1351344 2307064 protein:increased expression:monocyte RGD Ulcer ISO RGD:1351344 8551830 associated with Herpes Genitalis RGD urticaria ISO RGD:1351344 8551831 DNA:frameshift mutation, haplotype: :p.S185_T195del (rs333) (human) RGD uveitis IEP 2306302 mRNA, protein:increased expression:conjunctiva, ciliary body RGD visceral leishmaniasis treatment ISO RGD:733487 14401738 RGD visual epilepsy resistance IMP 4889880 RGD
Imported Annotations - ClinVar
acquired immunodeficiency syndrome ISO RGD:1351344 8554872 ClinVar Annotator: match by term: Acquired immunodeficiency syndrome, delayed progression to ClinVar PMID:12610055 more ... hepatitis C ISO RGD:1351344 8554872 ClinVar Annotator: match by term: HCV, RESISTANCE TO ClinVar PMID:10520641 more ... human immunodeficiency virus infectious disease ISO RGD:1351344 8554872 ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to ClinVar PMID:12610055 more ... human immunodeficiency virus infectious disease ISO RGD:1351344 8554872 ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to ClinVar PMID:10520641 more ... human immunodeficiency virus infectious disease ISO RGD:1351344 8554872 ClinVar Annotator: match by term: Human immunodeficiency virus type 1, increased perinatal transmission of ClinVar PMID:10559343 human immunodeficiency virus infectious disease ISO RGD:1351344 8554872 ClinVar Annotator: match by synonym: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO ClinVar PMID:11369664 , PMID:9399903 human immunodeficiency virus infectious disease ISO RGD:1351344 8554872 ClinVar Annotator: match by synonym: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO ClinVar PMID:9433423 multiple sclerosis ISO RGD:1351344 8554872 ClinVar Annotator: match by term: Multiple sclerosis modifier of disease progression ClinVar PMID:10520641 more ... West Nile fever ISO RGD:1351344 8554872 ClinVar Annotator: match by term: West nile virus, susceptibility to ClinVar PMID:10520641 more ...
Imported Annotations - CTD
acute kidney failure ISO RGD:1351344 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26055553 atopic dermatitis ISO RGD:1351344 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18249437 hepatitis C ISO RGD:1351344 11554173 CTD Direct Evidence: marker/mechanism CTD nephritis ISO RGD:1351344 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26055553 West Nile fever ISO RGD:1351344 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - OMIM
hepatitis C susceptibility ISO RGD:1351344 7240710 OMIM type 1 diabetes mellitus 22 ISO RGD:1351344 7240710 OMIM West Nile fever susceptibility ISO RGD:1351344 7240710 OMIM
(R)-mevalonic acid multiple interactions ISO RGD:1351344 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] CTD PMID:16321392 (S)-nicotine increases expression ISO RGD:1351344 6480464 Nicotine results in increased expression of CCR5 mRNA CTD PMID:18247414 1,3-benzothiazole-2-thiol increases expression ISO RGD:1351344 6480464 captax results in increased expression of CCR5 mRNA CTD PMID:20713136 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:1351344 6480464 Dinitrochlorobenzene results in increased expression of CCR5 mRNA CTD PMID:20713136 17alpha-ethynylestradiol multiple interactions ISO RGD:1351344 6480464 [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein CTD PMID:10770211 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CCR5 mRNA CTD PMID:15834898 17alpha-ethynylestradiol multiple interactions ISO RGD:733487 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:733487 6480464 Ethinyl Estradiol results in increased expression of CCR5 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:733487 6480464 Ethinyl Estradiol results in decreased expression of CCR5 mRNA CTD PMID:12538720 , PMID:15885639 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO RGD:733487 6480464 2 more ... CTD PMID:21851831 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:733487 6480464 2 more ... CTD PMID:21851831 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:733487 6480464 2 more ... CTD PMID:17942748 , PMID:21851831 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CCR5 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733487 6480464 Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA CTD PMID:18684927 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733487 6480464 Tetrachlorodibenzodioxin affects the expression of CCR5 mRNA CTD PMID:21570461 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:733487 6480464 Trinitrobenzenesulfonic Acid results in increased expression of CCR5 mRNA CTD PMID:15973123 , PMID:17982090 2-naphthylamine increases expression ISO RGD:1351344 6480464 2-Naphthylamine results in increased expression of CCR5 mRNA CTD PMID:18247414 3-chlorophenol decreases expression ISO RGD:1351344 6480464 3-chlorophenol results in decreased expression of CCR5 mRNA CTD PMID:18486366 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of CCR5 mRNA CTD PMID:21346803 4-hydroxyphenyl retinamide decreases expression ISO RGD:733487 6480464 Fenretinide results in decreased expression of CCR5 mRNA CTD PMID:28973697 acetamide increases expression EXP 6480464 acetamide results in increased expression of CCR5 mRNA CTD PMID:31881176 aflatoxin B1 increases expression ISO RGD:733487 6480464 Aflatoxin B1 results in increased expression of CCR5 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1351344 6480464 Aflatoxin B1 results in increased methylation of CCR5 gene CTD PMID:27153756 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CCR5 mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of CCR5 mRNA CTD PMID:30779732 antirheumatic drug decreases expression ISO RGD:1351344 6480464 Antirheumatic Agents results in decreased expression of CCR5 mRNA CTD PMID:24449571 benzalkonium chloride increases expression ISO RGD:733487 6480464 Benzalkonium Compounds results in increased expression of CCR5 mRNA CTD PMID:30171875 benzene increases expression ISO RGD:1351344 6480464 Benzene results in increased expression of CCR5 mRNA CTD PMID:19162166 benzo[a]pyrene increases expression ISO RGD:1351344 6480464 Benzo(a)pyrene results in increased expression of CCR5 mRNA CTD PMID:18247414 benzo[a]pyrene increases expression ISO RGD:733487 6480464 Benzo(a)pyrene results in increased expression of CCR5 mRNA CTD PMID:30165701 benzo[a]pyrene multiple interactions ISO RGD:733487 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CCR5 mRNA], Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CCR5 mRNA] CTD PMID:22228805 , PMID:30165701 benzo[a]pyrene decreases expression ISO RGD:733487 6480464 Benzo(a)pyrene results in decreased expression of CCR5 mRNA CTD PMID:21569818 bis(2-chloroethyl) sulfide increases expression ISO RGD:733487 6480464 Mustard Gas results in increased expression of CCR5 mRNA CTD PMID:18955075 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CCR5 mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CCR5 mRNA CTD PMID:30816183 bisphenol F increases expression ISO RGD:733487 6480464 bisphenol F results in increased expression of CCR5 mRNA CTD PMID:30951980 bleomycin A2 affects expression ISO RGD:733487 6480464 Bleomycin affects the expression of CCR5 mRNA CTD PMID:26345256 buta-1,3-diene decreases expression ISO RGD:733487 6480464 1, 3-butadiene results in decreased expression of CCR5 mRNA CTD PMID:29038090 carbon nanotube increases expression ISO RGD:733487 6480464 Nanotubes, Carbon analog results in increased expression of CCR5 mRNA, Nanotubes, Carbon results in increased expression of CCR5 mRNA CTD PMID:25554681 , PMID:25620056 carbon nanotube affects response to substance ISO RGD:733487 6480464 CCR5 gene mutant form affects the susceptibility to Nanotubes, Carbon CTD PMID:22438032 celecoxib decreases expression ISO RGD:733487 6480464 Celecoxib results in decreased expression of CCR5 mRNA CTD PMID:12902868 chloroprene decreases expression ISO RGD:733487 6480464 Chloroprene results in decreased expression of CCR5 mRNA CTD PMID:23125180 cisplatin increases expression ISO RGD:733487 6480464 Cisplatin results in increased expression of CCR5 mRNA CTD PMID:15814532 cisplatin multiple interactions ISO RGD:733487 6480464 pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA] CTD PMID:15814532 clofibrate increases expression ISO RGD:733487 6480464 Clofibrate results in increased expression of CCR5 mRNA CTD PMID:17585979 cocaine increases expression ISO RGD:1351344 6480464 Cocaine results in increased expression of CCR5 protein CTD PMID:16204638 cyclophosphamide increases expression ISO RGD:733487 6480464 Cyclophosphamide results in increased expression of CCR5 mRNA CTD PMID:15331540 cyclosporin A increases expression ISO RGD:733487 6480464 Cyclosporine results in increased expression of CCR5 protein CTD PMID:21292993 cyproterone acetate multiple interactions ISO RGD:1351344 6480464 [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein CTD PMID:10770211 D-penicillamine increases expression EXP 6480464 Penicillamine results in increased expression of CCR5 mRNA CTD PMID:19575532 D-penicillamine decreases expression EXP 6480464 Penicillamine results in decreased expression of CCR5 mRNA CTD PMID:19575532 dextran sulfate multiple interactions ISO RGD:733487 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CCR5 mRNA CTD PMID:29950665 diclofenac increases expression ISO RGD:733487 6480464 Diclofenac results in increased expression of CCR5 mRNA CTD PMID:26934552 dioxygen increases expression ISO RGD:733487 6480464 Oxygen deficiency results in increased expression of CCR5 mRNA, Oxygen deficiency results in increased expression of CCR5 protein CTD PMID:20880076 dioxygen multiple interactions ISO RGD:733487 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CCR5 mRNA, HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of CCR5 mRNA] CTD PMID:20880076 , PMID:30529165 disulfiram multiple interactions ISO RGD:733487 6480464 Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] more ... CTD PMID:19016906 ethyl methanesulfonate decreases expression ISO RGD:1351344 6480464 Ethyl Methanesulfonate results in decreased expression of CCR5 mRNA CTD PMID:23649840 eugenol increases expression ISO RGD:1351344 6480464 Eugenol results in increased expression of CCR5 mRNA CTD PMID:17936526 , PMID:20713136 formaldehyde decreases expression ISO RGD:1351344 6480464 Formaldehyde results in decreased expression of CCR5 mRNA CTD PMID:23649840 indole-3-methanol increases expression ISO RGD:1351344 6480464 indole-3-carbinol results in increased expression of CCR5 protein CTD PMID:27783115 isopentenyl diphosphate decreases expression ISO RGD:1351344 6480464 isopentenyl pyrophosphate results in decreased expression of CCR5 protein CTD PMID:11994442 ketamine increases expression EXP 6480464 Ketamine results in increased expression of CCR5 mRNA CTD PMID:20080153 lipopolysaccharide multiple interactions ISO RGD:1351344 6480464 methyl 2-cyano-3 more ... CTD PMID:26918785 lipopolysaccharide increases response to substance ISO RGD:733487 6480464 CCR5 gene mutant form results in increased susceptibility to Lipopolysaccharides CTD PMID:26055553 lipopolysaccharide multiple interactions ISO RGD:733487 6480464 [CCR5 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased cleavage of CASP3 protein more ... CTD PMID:26055553 lipopolysaccharide increases expression ISO RGD:1351344 6480464 Lipopolysaccharides results in increased expression of CCR5 mRNA CTD PMID:26918785 maraviroc multiple interactions ISO RGD:1351344 6480464 maraviroc binds to and results in decreased activity of CCR5 protein more ... CTD PMID:15644495 , PMID:21128663 mechlorethamine increases expression EXP 6480464 Mechlorethamine results in increased expression of CCR5 mRNA CTD PMID:26273949 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of CCR5 mRNA, Mercuric Chloride results in increased expression of CCR5 protein CTD PMID:12834626 mercury dichloride increases response to substance EXP 6480464 CCR5 protein results in increased susceptibility to Mercuric Chloride CTD PMID:12834626 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of CCR5 mRNA CTD PMID:19564919 methamphetamine multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in decreased expression of CCR5 mRNA CTD PMID:19564919 methyl methanesulfonate decreases expression ISO RGD:1351344 6480464 Methyl Methanesulfonate results in decreased expression of CCR5 mRNA CTD PMID:23649840 mycotoxin increases expression ISO RGD:733487 6480464 Mycotoxins results in increased expression of CCR5 mRNA CTD PMID:19818335 mycotoxin decreases expression ISO RGD:733487 6480464 Mycotoxins results in decreased expression of CCR5 mRNA CTD PMID:19818335 nickel atom affects expression ISO RGD:1351344 6480464 Nickel affects the expression of CCR5 mRNA CTD PMID:14575637 nickel atom increases expression ISO RGD:1351344 6480464 Nickel results in increased expression of CCR5 mRNA CTD PMID:25583101 nickel atom multiple interactions ISO RGD:1351344 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of CCR5 mRNA] CTD PMID:14575637 nicotine increases expression ISO RGD:1351344 6480464 Nicotine results in increased expression of CCR5 mRNA CTD PMID:18247414 nitric oxide multiple interactions ISO RGD:733487 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] more ... CTD PMID:19016906 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of CCR5 mRNA CTD PMID:25729387 paracetamol increases response to substance ISO RGD:733487 6480464 CCR5 protein results in increased susceptibility to Acetaminophen CTD PMID:24770590 pentachlorophenol decreases expression ISO RGD:1351344 6480464 Pentachlorophenol results in decreased expression of CCR5 mRNA CTD PMID:18486366 phenobarbital affects expression ISO RGD:733487 6480464 Phenobarbital affects the expression of CCR5 mRNA CTD PMID:23091169 pirinixic acid multiple interactions ISO RGD:733487 6480464 pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA] CTD PMID:15814532 proanthocyanidin decreases expression ISO RGD:1351344 6480464 proanthocyanidin results in decreased expression of CCR5 mRNA CTD PMID:12462994 prostaglandin E2 decreases expression ISO RGD:1351344 6480464 Dinoprostone results in decreased expression of CCR5 mRNA, Dinoprostone results in decreased expression of CCR5 protein CTD PMID:16303787 protein kinase inhibitor multiple interactions ISO RGD:1351344 6480464 Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CCR5 mRNA] CTD PMID:28003376 reactive oxygen species multiple interactions ISO RGD:733487 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:19016906 resveratrol multiple interactions ISO RGD:733487 6480464 Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CCR5 mRNA] CTD PMID:30165701 SCH 23390 multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in decreased expression of CCR5 mRNA CTD PMID:19564919 silicon dioxide increases expression ISO RGD:733487 6480464 Silicon Dioxide results in increased expression of CCR5 mRNA CTD PMID:29341224 simvastatin multiple interactions ISO RGD:1351344 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]], Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA] CTD PMID:16321392 simvastatin decreases expression EXP 6480464 Simvastatin results in decreased expression of CCR5 protein CTD PMID:17449418 simvastatin decreases expression ISO RGD:1351344 6480464 Simvastatin results in decreased expression of CCR5 mRNA CTD PMID:17112859 sodium dodecyl sulfate decreases expression ISO RGD:1351344 6480464 Sodium Dodecyl Sulfate results in decreased expression of CCR5 mRNA CTD PMID:17936526 Soman increases expression EXP 6480464 Soman results in increased expression of CCR5 mRNA CTD PMID:19281266 staurosporine multiple interactions EXP 6480464 Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein] CTD PMID:12594210 tetrachloromethane multiple interactions ISO RGD:733487 6480464 PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR5 mRNA] CTD PMID:18038451 tetrachloromethane increases expression ISO RGD:733487 6480464 Carbon Tetrachloride results in increased expression of CCR5 mRNA CTD PMID:23288052 titanium dioxide increases expression ISO RGD:733487 6480464 titanium dioxide results in increased expression of CCR5 mRNA CTD PMID:21259345 more ... titanium dioxide multiple interactions ISO RGD:733487 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CCR5 mRNA CTD PMID:29950665 topotecan increases expression EXP 6480464 Topotecan results in increased expression of CCR5 mRNA CTD PMID:25729387 trichostatin A multiple interactions ISO RGD:1351344 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of CCR5 mRNA] CTD PMID:14575637 trimellitic anhydride increases expression ISO RGD:733487 6480464 trimellitic anhydride results in increased expression of CCR5 mRNA CTD PMID:16141432 troglitazone increases expression ISO RGD:733487 6480464 troglitazone results in increased expression of CCR5 mRNA CTD PMID:28973697 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CCR5 mRNA CTD PMID:23034163 wortmannin multiple interactions ISO RGD:733487 6480464 wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] CTD PMID:19016906 zidovudine multiple interactions ISO RGD:1351344 6480464 [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA CTD PMID:20370541
Biological Process aging IEP 2307163 RGD calcium ion transport ISO RGD:1351344 1624291 (PMID:8699119) RGD PMID:8699119 calcium-mediated signaling ISO RGD:1351344 1624291 (PMID:10679098), (PMID:19523456) RGD PMID:10679098 , PMID:19523456 calcium-mediated signaling IBA PANTHER:PTN001200797 more ... 13792537 PMID:21873635 GO_Central calcium-mediated signaling IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell chemotaxis IBA MGI:MGI:103567 more ... 13792537 PMID:21873635 GO_Central cell-cell signaling ISO RGD:1351344 1624291 (PMID:10679098) RGD PMID:10679098 cell-cell signaling IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to lipopolysaccharide ISO RGD:1351344 1624291 (PMID:10679098) RGD PMID:10679098 cellular response to lipopolysaccharide IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 chemokine-mediated signaling pathway IEA GO:0004950 1600115 GO_REF:0000108 GOC GO_REF:0000108 chemokine-mediated signaling pathway IEA GO:0016493 1600115 GO_REF:0000108 GOC GO_REF:0000108 chemotaxis IEA InterPro:IPR000355 , InterPro:IPR002240 1600115 GO_REF:0000002 InterPro GO_REF:0000002 chemotaxis IBA MGI:MGI:103011 more ... 13792537 PMID:21873635 GO_Central defense response ISO RGD:733487 1624291 MGI:MGI:1861911 (MGI:MGI:1889062 , PMID:10528159) RGD MGI:MGI:1889062 , PMID:10528159 defense response to bacterium IEP 632396 RGD fat cell differentiation IEP 2307036 RGD forebrain development IEP 4890442 RGD G protein-coupled receptor signaling pathway ISO RGD:1351344 1624291 (PMID:19523456) RGD PMID:19523456 G protein-coupled receptor signaling pathway IEA UniProtKB-KW:KW-0297 1600115 GO_REF:0000043 UniProt GO_REF:0000043 G protein-coupled receptor signaling pathway IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 immune response IEA InterPro:IPR002240 1600115 GO_REF:0000002 InterPro GO_REF:0000002 immune response IBA MGI:MGI:103011 more ... 13792537 PMID:21873635 GO_Central inflammatory response IEA InterPro:IPR002240 1600115 GO_REF:0000002 InterPro GO_REF:0000002 inflammatory response IEP 2303104 RGD inflammatory response IBA MGI:MGI:104618 more ... 13792537 PMID:21873635 GO_Central inflammatory response to antigenic stimulus IEP 1582346 RGD leukocyte migration TAS 632395 RGD MAPK cascade ISO RGD:1351344 1624291 (PMID:12032188) RGD PMID:12032188 MAPK cascade IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of axon extension IMP 4890441 RGD negative regulation of cell migration IMP 4889880 bone marrow cell migration to the brain RGD negative regulation of macrophage apoptotic process ISO RGD:733487 1624291 (MGI:MGI:3608189, PMID:16208318) RGD MGI:MGI:3608189 , PMID:16208318 negative regulation of macrophage apoptotic process IEA UniProtKB:P51682 , ensembl:ENSMUSP000001070691600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neural precursor cell proliferation IMP 4889880 RGD neuron death IMP 4889880 positive regulation RGD positive regulation of apoptotic process by virus IMP 4890424 HIV-1 RGD positive regulation of cell-cell adhesion IMP 4890440 RGD positive regulation of cytosolic calcium ion concentration IMP 8552232 RGD positive regulation of cytosolic calcium ion concentration IBA MGI:MGI:1096320 more ... 13792537 PMID:21873635 GO_Central positive regulation of fever generation IMP 2307192 RGD positive regulation of gene expression IMP 4889880 Ccl5 RGD positive regulation of gene expression IMP 4889986 Nestin, Neun RGD positive regulation of inflammatory response IMP 4889880 RGD positive regulation of interleukin-1 beta production IMP 1598562 RGD positive regulation of interleukin-6 production IMP 1598562 RGD positive regulation of neuron differentiation IMP 4889986 RGD positive regulation of tumor necrosis factor production IMP 1598562 RGD release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO RGD:1351344 1624291 (PMID:19523456) RGD PMID:19523456 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to cholesterol ISO RGD:1351344 1624291 (PMID:19523456) RGD PMID:19523456 response to cholesterol IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to ionizing radiation IEP 2298916 RGD response to lipopolysaccharide IEP 2306302 RGD signaling ISO RGD:1351344 1624291 (PMID:12032188) RGD PMID:12032188 Cellular Component cell surface ISO RGD:733487 1624291 (MGI:MGI:5506989, PMID:23620790) RGD MGI:MGI:5506989 , PMID:23620790 cell surface ISO RGD:1351344 1624291 (PMID:10521508) RGD PMID:10521508 cell surface IDA 4144893 RGD cytoplasm IDA 4144893 RGD cytoplasm IBA PANTHER:PTN001628676 more ... 13792537 PMID:21873635 GO_Central endosome IDA 632389 RGD endosome IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 endosome ISO RGD:1351344 1624291 (PMID:10679098) RGD PMID:10679098 external side of plasma membrane ISO RGD:733487 1624291 (MGI:MGI:3700459 more ... RGD MGI:MGI:3700459 more ... external side of plasma membrane IBA MGI:MGI:103011 more ... 13792537 PMID:21873635 GO_Central external side of plasma membrane ISO RGD:1351344 1624291 (PMID:10383387), (PMID:10679098), (PMID:11278962), (PMID:19523456) RGD PMID:10383387 more ... external side of plasma membrane IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 external side of plasma membrane IEA UniProtKB:P51682 , ensembl:ENSMUSP000001070691600115 GO_REF:0000107 Ensembl GO_REF:0000107 external side of plasma membrane ISS UniProtKB:P51681 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Molecular Function actin binding ISO RGD:1351344 1624291 (PMID:12421915) RGD PMID:12421915 actin binding IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 C-C chemokine binding ISO RGD:733487 1624291 UniProtKB:P13501 (MGI:MGI:87663 , PMID:9139699) RGD MGI:MGI:87663 , PMID:9139699 C-C chemokine binding IBA MGI:MGI:104616 more ... 13792537 PMID:21873635 GO_Central C-C chemokine binding ISO RGD:1351344 1624291 UniProtKB:P10147 more ... RGD PMID:10383387 more ... C-C chemokine receptor activity TAS 632395 RGD C-C chemokine receptor activity ISO RGD:1351344 1624291 (PMID:10383387), (PMID:11278962) RGD PMID:10383387 , PMID:11278962 C-C chemokine receptor activity IBA MGI:MGI:103011 more ... 13792537 PMID:21873635 GO_Central C-C chemokine receptor activity IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 C-C chemokine receptor activity IEA UniProtKB:P51682 , ensembl:ENSMUSP000001070691600115 GO_REF:0000107 Ensembl GO_REF:0000107 C-C chemokine receptor activity IEA InterPro:IPR002240 1600115 GO_REF:0000002 InterPro GO_REF:0000002 C-C chemokine receptor activity ISS UniProtKB:P51681 1600115 GO_REF:0000024 UniProt GO_REF:0000024 C-C chemokine receptor activity ISO RGD:733487 1624291 (MGI:MGI:79768, PMID:8631787) RGD MGI:MGI:79768 , PMID:8631787 chemokine (C-C motif) ligand 5 binding ISO RGD:1351344 1624291 UniProtKB:P13501 (PMID:8699119) RGD PMID:8699119 chemokine (C-C motif) ligand 5 binding IBA PANTHER:PTN000659270 , UniProtKB:P51681 13792537 PMID:21873635 GO_Central chemokine (C-C motif) ligand 5 binding IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 chemokine binding IBA MGI:MGI:104616 more ... 13792537 PMID:21873635 GO_Central identical protein binding ISO RGD:1351344 1624291 UniProtKB:P51681 (PMID:18230715), (PMID:18632580) RGD PMID:18230715 , PMID:18632580 identical protein binding IEA UniProtKB:P51681 , ensembl:ENSP000002923031600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI RGD:3162 4889986 RGD protein binding IPI InterPro:IPR000777 4890441 RGD protein binding ISO RGD:1351344 1624291 UniProtKB:O43889-2 more ... RGD PMID:10816381 more ... protein binding IPI RGD:3771 , RGD:3772 1582346 RGD protein kinase binding IPI RGD:69056 1582346 RGD
Gene-Chemical Interaction Annotations
