Stat3 (signal transducer and activator of transcription 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Stat3 (signal transducer and activator of transcription 3) Chinchilla lanigera
Analyze
Symbol: Stat3
Name: signal transducer and activator of transcription 3
RGD ID: 9047623
Description: ENCODES a protein that exhibits CCR5 chemokine receptor binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); aging (ortholog); astrocyte differentiation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; Interleukin-10 signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,319,904 - 16,357,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,320,326 - 16,348,505 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adult T-cell leukemia  (ISO)
Alzheimer's disease  (ISO)
anaplastic large cell lymphoma  (ISO)
angiomyolipoma  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
Atrophy  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cervix uteri carcinoma in situ  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic lymphocytic leukemia  (ISO)
Churg-Strauss syndrome  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Copper-Overload Cirrhosis  (ISO)
Crohn's disease  (ISO)
Diabetic Nephropathies  (ISO)
duodenal ulcer  (ISO)
Endometrial Neoplasms  (ISO)
Epidermal Hyperplasia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
hyper IgE recurrent infection syndrome 1  (ISO)
hyper IgE syndrome  (ISO)
Hyperalgesia  (ISO)
hyperuricemia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
irritant dermatitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
lymphoproliferative syndrome  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (ISO)
Multisystem Autoimmune Disease, Infantile-Onset, 1  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neutropenia  (ISO)
Niemann-Pick disease type C1  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
periodontitis  (ISO)
pre-malignant neoplasm  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
Pyogenic Granuloma  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
Sepsis-Associated Encephalopathy  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (ISO)
T-cell lymphoblastic leukemia/lymphoma  (ISO)
T-Cell Lymphoma  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
aging  (ISO)
astrocyte differentiation  (ISO)
cell population proliferation  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to leptin stimulus  (ISO)
eating behavior  (ISO)
energy homeostasis  (ISO)
eye photoreceptor cell differentiation  (ISO)
glucose homeostasis  (ISO)
growth hormone receptor signaling pathway  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (ISO)
inflammatory response  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
intracellular receptor signaling pathway  (ISO)
leptin-mediated signaling pathway  (ISO)
modulation of chemical synaptic transmission  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hydrogen peroxide biosynthetic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron migration  (ISO)
negative regulation of primary miRNA processing  (ISO)
negative regulation of stem cell differentiation  (ISO)
phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gene silencing by miRNA  (ISO)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of metalloendopeptidase activity  (ISO)
positive regulation of miRNA mediated inhibition of translation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
protein import into nucleus  (ISO)
radial glial cell differentiation  (ISO)
regulation of cell cycle  (ISO)
regulation of feeding behavior  (ISO)
regulation of mitochondrial membrane permeability  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to leptin  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to peptide hormone  (ISO)
sexual reproduction  (ISO)
stem cell population maintenance  (ISO)
T-helper 17 cell lineage commitment  (ISO)
T-helper 17 type immune response  (ISO)
temperature homeostasis  (ISO)
transcription by RNA polymerase II  (ISO)

References


Genomics

Comparative Map Data
Stat3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,319,904 - 16,357,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,320,326 - 16,348,505 (-)NCBIChiLan1.0ChiLan1.0
STAT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,313,324 - 42,388,482 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1742,313,324 - 42,388,540 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1742,313,324 - 42,388,568 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,313,324 - 42,388,502 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,465,342 - 40,540,460 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,718,869 - 37,794,039 (-)NCBINCBI36hg18NCBI36
Build 341737,718,868 - 37,794,039NCBI
Celera1737,120,227 - 37,194,843 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,230,024 - 36,304,785 (-)NCBIHuRef
CHM1_11740,701,045 - 40,776,137 (-)NCBICHM1_1
Stat3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,777,632 - 100,830,447 (-)NCBIGRCm39mm39
GRCm39 Ensembl11100,775,924 - 100,830,366 (-)Ensembl
GRCm3811100,886,806 - 100,939,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,885,098 - 100,939,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,748,124 - 100,800,825 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,702,900 - 100,755,601 (-)NCBImm8
MGSCv3611101,663,341 - 101,716,042 (-)NCBImm8
Celera11112,235,347 - 112,235,602 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.82NCBI
Stat3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,811,206 - 85,863,057 (-)NCBI
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
STAT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,152,358 - 15,227,084 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,152,358 - 15,227,067 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01714,928,689 - 15,003,644 (+)NCBIMhudiblu_PPA_v0panPan3
STAT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,539,660 - 20,614,631 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,539,697 - 20,612,672 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,001,678 - 20,076,249 (+)NCBI
ROS_Cfam_1.0921,258,611 - 21,334,353 (+)NCBI
UMICH_Zoey_3.1920,044,250 - 20,119,519 (+)NCBI
UNSW_CanFamBas_1.0920,309,625 - 20,386,466 (+)NCBI
UU_Cfam_GSD_1.0920,413,942 - 20,489,100 (+)NCBI
Stat3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,877,467 - 19,955,950 (+)NCBI
SpeTri2.0NW_00493649017,119,189 - 17,178,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,407,233 - 20,472,993 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,407,316 - 20,471,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,709,840 - 20,775,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAT3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,877,884 - 63,957,894 (+)NCBI
ChlSab1.1 Ensembl1663,922,862 - 63,957,984 (+)Ensembl
Stat3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,648,235 - 1,680,788 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021700   ⟹   ENSCLAP00000021497
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545116,319,904 - 16,348,505 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021701   ⟹   ENSCLAP00000021498
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545116,320,353 - 16,357,687 (-)Ensembl
RefSeq Acc Id: XM_013519135   ⟹   XP_013374589
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545116,320,326 - 16,337,157 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013519137   ⟹   XP_013374591
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545116,320,326 - 16,348,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013519138   ⟹   XP_013374592
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545116,320,326 - 16,337,157 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013519139   ⟹   XP_013374593
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545116,320,326 - 16,337,157 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013374589 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374591 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374592 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374593 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013374591   ⟸   XM_013519137
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013374592   ⟸   XM_013519138
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013374589   ⟸   XM_013519135
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013374593   ⟸   XM_013519139
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSCLAP00000021498   ⟸   ENSCLAT00000021701
RefSeq Acc Id: ENSCLAP00000021497   ⟸   ENSCLAT00000021700


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014721 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000021497 ENTREZGENE
  ENSCLAP00000021498 ENTREZGENE
Ensembl Transcript ENSCLAT00000021700 ENTREZGENE
  ENSCLAT00000021701 ENTREZGENE
NCBI Gene Stat3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Stat3  signal transducer and activator of transcription 3    signal transducer and activator of transcription 3 (acute-phase response factor)  Symbol and/or name change 5135510 APPROVED