Bss43 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bss43 (Bone structure and strength QTL 43) Rattus norvegicus

Symbol: Bss43
Name: Bone structure and strength QTL 43
RGD ID: 2293698
Trait: lumbar vertebra size trait   (VT:0010518)    
Measurement Type: lumbar vertebra cross-sectional area   (CMO:0001689)    
LOD Score: 5.33
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21059,209,888 - 104,209,888RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01062,096,293 - 107,096,293RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01061,889,555 - 106,889,555RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41062,984,501 - 107,984,501RGD_MAPPER_PIPELINERGSC3.4
Cross Type: intercross
Strains Crossed: COP/OlaHsd DA/OlaHsd 




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bss43Ratosteoporosis susceptibilityIAGP 2293455 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bss43Ratabnormal bone strength susceptibilityIDA 2293455 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bss43Ratlumbar vertebra cross-sectional area  IDA 2293455 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bss43Ratcontrol condition  IDA 2293455 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bss43Ratex vivo peripheral quantitative computed tomography  IDA 2293455 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bss43RatCOP/OlaHsd  IEA 2293455 RGD 
Bss43RatDA/OlaHsd  IEA 2293455 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bss43Ratlumbar vertebra size trait  IDA 2293455 RGD 


#
Reference Title
Reference Citation
1. Genetic loci affecting bone structure and strength in inbred COP and DA rats. Sun Q, etal., Bone. 2008 Mar;42(3):547-53. Epub 2007 Nov 28.


1 to 20 of 1165 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1333845Or1d2olfactory receptor family 1 subfamily D member 2105921294759213882Rat
1563134Rpl29l6ribosomal protein L29 like 6105921793159218554Rat
1332930Olr1520olfactory receptor 1520105923700359237938Rat
1304590Rap1gap2RAP1 GTPase activating protein 2105925540059472536Rat
1562276Ccdc92bcoiled-coil domain containing 92B105947979859501486Rat
41260746LOC120095138ATP synthase subunit e, mitochondrial-like105950223859503061Rat
1307222Cluhclustered mitochondria homolog105950958059531345Rat
620331Pafah1b1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1105953304259591808Rat
41163241LOC120095365U6 spliceosomal RNA105959581859595922Rat
41388596LOC120095488U2 spliceosomal RNA105963677259636857Rat
1593242Mettl16methyltransferase 16, RNA N6-adenosine105964091559697291Rat
1308683MntMAX network transcriptional repressor105969920859714848Rat
1306957Sgsm2small G protein signaling modulator 2105971818059759822Rat
2322150Tsr1TSR1, ribosome maturation factor105976042059771868Rat
40996527LOC120095462small nucleolar RNA SNORD91 family105976825759768349Rat
41255405LOC120095461small nucleolar RNA SNORD91 family105976896759769057Rat
735094Srrserine racemase105976956359786688Rat
1595918Smg6SMG6 nonsense mediated mRNA decay factor105978625860014395Rat
40962770LOC120095370U6 spliceosomal RNA105979642959796515Rat
1307527Hic1HIC ZBTB transcriptional repressor 1106001452060019475Rat

1 to 20 of 1165 rows
1 to 20 of 1808 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
5081941BF415384135105925628659256421Ratregion
5075038RH138363186105927476259274948Ratregion
37720D10Rat80145105937813559378278Ratregion
1641402D10Got412234105948803159488265Ratregion
5073826RH137661126105950123359501359Ratregion
5500079UniSTS:236635168105953016859530336Ratregion
5025712RH129368201105953102559531226Ratregion
5050768RH134247180105953417859534358Ratregion
5044932RH130886201105953483559535036Ratregion
5082357BE119243182105968626559686447Ratregion
5079992RH141320196105968674859686944Ratregion
5055567RH143875101105969344159693542Ratregion
5500081UniSTS:236639252105971375459714006Ratregion
5036155D11Bhm872105971991359719986Ratregion
5502953Sgsm2621105972302959723650Ratregion
5503176ksks290457105972682359727280Ratregion
1630732D10Got227178105973294559733123Ratregion
1635815D10M11Nds199105973300459733103Ratregion
5058186BF386775150105976686259767012Ratregion
5028993RH143106121105976962859769749Ratregion
1 to 20 of 1808 rows

Peak: (D10Rat124)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21081,709,788 - 81,709,989 (+)MAPPER
Rnor_6.01084,596,193 - 84,596,393NCBI
Rnor_5.01084,389,455 - 84,389,655UniSTS
RGSC_v3.41085,484,402 - 85,484,602UniSTS
RGSC_v3.41085,484,401 - 85,484,602RGD
RGSC_v3.11085,498,771 - 85,498,972RGD
Celera1080,471,819 - 80,472,019UniSTS
RH 3.4 Map10744.2RGD
RH 3.4 Map10744.2UniSTS
RH 2.0 Map10906.5RGD
SHRSP x BN Map1058.54RGD
FHH x ACI Map1066.97RGD
Cytogenetic Map10q31UniSTS


1 to 10 of 179 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat

1 to 10 of 179 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general allele: DA alleles cause stronger skeletal structure and strength 2293455
qtl_general software package: MAPMAKER/EXP 2293455
qtl_general measurement method: at 26 weeks of age lumbar 5 vertebrae was removed and frozen at -20oC, later slices were cut from lumbar spine and neural arch and measurements taken from pQCT images 2293455
qtl_general number of animals used: 405 males and 423 females from F2 progeny 2293455