Gene: Cdk12 (cyclin-dependent kinase 12) Rattus norvegicus
Symbol: Cdk12
Name: cyclin-dependent kinase 12
Description: ENCODES a protein that exhibits cyclin binding; protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN regulation of RNA splicing; RNA splicing; negative regulation of stem cell differentiation (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog); Prostatic Neoplasms (ortholog); Smith-Magenis syndrome (ortholog); FOUND IN nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; cyclin K-CDK12 complex (ortholog); INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CDC2-related kinase 7; Cdc2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; Crk7; CrkRS; cyclin-dependent kinase 12 isoform; Pksc; protein kinase for splicing component; similar to human CrkRS: CDC2-related protein kinase 7
Homo sapiens (human) : CDK12 (cyclin dependent kinase 12)  HGNC  Alliance
Mus musculus (house mouse) : Cdk12 (cyclin-dependent kinase 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk12 (cyclin dependent kinase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK12 (cyclin dependent kinase 12)
Canis lupus familiaris (dog) : CDK12 (cyclin dependent kinase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk12 (cyclin dependent kinase 12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01086,157,186 - 86,210,657 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01085,953,855 - 86,019,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,972,428 - 87,027,794 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11086,986,797 - 87,036,966 (+)NCBI
Celera1081,950,642 - 82,003,549 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Cdk12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621111
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2018-08-14
Status: ACTIVE