(+)-catechin decreases expression ISO RGD:1352729 6480464 Catechin results in decreased expression of TOP2A mRNA CTD PMID:15465739 (+)-dexrazoxane decreases activity ISO RGD:1352729 6480464 Dexrazoxane analog results in decreased activity of TOP2A protein, Dexrazoxane results in decreased activity of TOP2A protein CTD PMID:28941780 (+)-epicatechin-3-O-gallate decreases activity ISO RGD:1352729 6480464 epicatechin gallate results in decreased activity of TOP2A protein CTD PMID:16536579 (-)-demecolcine decreases expression ISO RGD:1352729 6480464 Demecolcine results in decreased expression of TOP2A mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate increases expression ISO RGD:1352729 6480464 epigallocatechin gallate results in increased expression of TOP2A mRNA CTD PMID:18851785 1,1-dichloroethene increases expression ISO RGD:62340 6480464 vinylidene chloride results in increased expression of TOP2A mRNA CTD PMID:26682919 1,2-dimethylhydrazine increases expression ISO RGD:62340 6480464 1, 2-Dimethylhydrazine results in increased expression of TOP2A mRNA CTD PMID:22206623 1,2-naphthoquinone multiple interactions ISO RGD:1352729 6480464 1, 2-naphthoquinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 , PMID:33760604 1,2-naphthoquinone affects activity ISO RGD:1352729 6480464 1, 2-naphthoquinone affects the activity of TOP2A protein CTD PMID:33760604 1,4-benzoquinone increases expression ISO RGD:1352729 6480464 quinone results in increased expression of TOP2A mRNA CTD PMID:18778717 1,4-benzoquinone decreases activity ISO RGD:62340 6480464 quinone results in decreased activity of TOP2A protein CTD PMID:31340051 1,4-benzoquinone increases activity ISO RGD:1352729 6480464 quinone results in increased activity of TOP2A protein CTD PMID:15833037 1,4-benzoquinone affects activity ISO RGD:1352729 6480464 quinone affects the activity of TOP2A protein, quinone metabolite affects the activity of TOP2A protein CTD PMID:16906772 , PMID:33760604 1,4-benzoquinone multiple interactions ISO RGD:1352729 6480464 MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA] more ... CTD PMID:15935817 more ... 1,4-benzoquinone decreases activity ISO RGD:1352729 6480464 quinone results in decreased activity of TOP2A protein CTD PMID:11468185 more ... 1,4-dithiothreitol multiple interactions ISO RGD:1352729 6480464 Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 1,4-naphthoquinone multiple interactions ISO RGD:1352729 6480464 1, 4-naphthoquinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 1-naphthyl isothiocyanate affects expression EXP 6480464 1-Naphthylisothiocyanate affects the expression of TOP2A protein CTD PMID:26011634 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of TOP2A mRNA CTD PMID:30723492 17alpha-ethynylestradiol multiple interactions ISO RGD:62340 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP2A mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of TOP2A mRNA CTD PMID:12655037 17alpha-ethynylestradiol increases expression ISO RGD:62340 6480464 Ethinyl Estradiol results in increased expression of TOP2A mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of TOP2A mRNA CTD PMID:17351261 17beta-estradiol increases expression ISO RGD:62340 6480464 Estradiol results in increased expression of TOP2A mRNA CTD PMID:19484750 more ... 17beta-estradiol multiple interactions ISO RGD:1352729 6480464 [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Cisplatin, [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Doxorubicin CTD PMID:28323900 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TOP2A mRNA, Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA] CTD PMID:26372666 , PMID:32741896 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of TOP2A mRNA CTD PMID:26372666 17beta-estradiol increases expression ISO RGD:1352729 6480464 Estradiol results in increased expression of TOP2A mRNA CTD PMID:16474171 , PMID:18310284 17beta-estradiol multiple interactions ISO RGD:62340 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of TOP2A mRNA] CTD PMID:25210133 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TOP2A mRNA CTD PMID:32741896 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:62340 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:20566336 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:62340 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:62340 6480464 Tetrachlorodibenzodioxin affects the expression of TOP2A mRNA CTD PMID:21570461 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of TOP2A mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:62340 6480464 Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA CTD PMID:25975270 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:62340 6480464 Tetrachlorodibenzodioxin results in increased expression of TOP2A mRNA CTD PMID:15667827 , PMID:21846477 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1352729 6480464 Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA CTD PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:62340 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP2A mRNA, Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of TOP2A protein] CTD PMID:17942748 , PMID:21846477 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4-diaminotoluene increases expression ISO RGD:62340 6480464 2, 4-diaminotoluene results in increased expression of TOP2A mRNA CTD PMID:20713471 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of TOP2A mRNA CTD PMID:22584684 2-amino-2-deoxy-D-glucopyranose decreases expression EXP 6480464 Glucosamine results in decreased expression of TOP2A mRNA CTD PMID:17109745 2-methylcholine affects expression ISO RGD:1352729 6480464 beta-methylcholine affects the expression of TOP2A mRNA CTD PMID:21179406 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of TOP2A mRNA CTD PMID:15890375 3-methylcholanthrene increases expression ISO RGD:62340 6480464 Methylcholanthrene results in increased expression of TOP2A mRNA CTD PMID:20713471 3-methylcholanthrene multiple interactions EXP 6480464 Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA] CTD PMID:26372666 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1, 2-dithiol-3-thione results in increased expression of TOP2A mRNA CTD PMID:19162173 4'-epidoxorubicin multiple interactions ISO RGD:1352729 6480464 TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil], TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16682728 , PMID:18465341 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TOP2A mRNA CTD PMID:15890375 4-hydroxynon-2-enal increases expression ISO RGD:62340 6480464 4-hydroxy-2-nonenal results in increased expression of TOP2A mRNA CTD PMID:19191707 4-hydroxynon-2-enal decreases expression ISO RGD:1352729 6480464 4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA CTD PMID:12419474 4-hydroxynon-2-enal decreases expression ISO RGD:62340 6480464 4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA CTD PMID:19191707 4-hydroxyphenyl retinamide increases expression ISO RGD:62340 6480464 Fenretinide results in increased expression of TOP2A mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO RGD:1352729 6480464 Decitabine affects the expression of TOP2A mRNA CTD PMID:23300844 5-azacytidine multiple interactions ISO RGD:1352729 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA, [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA CTD PMID:18348204 , PMID:18720364 5-fluorouracil decreases expression ISO RGD:1352729 6480464 Fluorouracil results in decreased expression of TOP2A mRNA CTD PMID:15205334 , PMID:16557594 5-fluorouracil decreases expression ISO RGD:62340 6480464 Fluorouracil results in decreased expression of TOP2A mRNA CTD PMID:19272435 5-fluorouracil multiple interactions ISO RGD:1352729 6480464 TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil] more ... CTD PMID:15016801 more ... 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of TOP2A mRNA CTD PMID:24780913 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of TOP2A mRNA CTD PMID:25825206 9,10-phenanthroquinone multiple interactions ISO RGD:1352729 6480464 9, 10-phenanthrenequinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 9-hydroxyellipticine affects response to substance ISO RGD:1352729 6480464 TOP2A protein affects the susceptibility to 9-hydroxyellipticine CTD PMID:23293027 acetamide increases expression EXP 6480464 acetamide results in increased expression of TOP2A mRNA CTD PMID:31881176 acetamiprid decreases expression ISO RGD:62340 6480464 acetamiprid results in decreased expression of TOP2A mRNA CTD PMID:30103633 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of TOP2A mRNA CTD PMID:28959563 acrylamide decreases expression ISO RGD:1352729 6480464 Acrylamide results in decreased expression of TOP2A mRNA CTD PMID:32763439 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of TOP2A mRNA CTD PMID:28606764 aflatoxin B1 affects expression ISO RGD:1352729 6480464 Aflatoxin B1 affects the expression of TOP2A protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:1352729 6480464 Aflatoxin B1 results in decreased methylation of TOP2A gene CTD PMID:27153756 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of TOP2A mRNA CTD PMID:23630614 , PMID:25378103 aflatoxin B1 decreases expression ISO RGD:62340 6480464 Aflatoxin B1 results in decreased expression of TOP2A mRNA CTD PMID:19770486 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of TOP2A mRNA CTD PMID:15890375 alachlor increases expression EXP 6480464 alachlor results in increased expression of TOP2A mRNA CTD PMID:12419858 aldehydo-D-glucosamine decreases expression EXP 6480464 Glucosamine results in decreased expression of TOP2A mRNA CTD PMID:17109745 all-trans-retinoic acid increases expression ISO RGD:1352729 6480464 Tretinoin results in increased expression of TOP2A protein CTD PMID:15059897 all-trans-retinoic acid decreases expression ISO RGD:1352729 6480464 Tretinoin results in decreased expression of TOP2A mRNA CTD PMID:15498508 more ... altenusin decreases activity ISO RGD:1352729 6480464 altenusin results in decreased activity of TOP2A protein CTD PMID:27682608 alternariol decreases activity ISO RGD:1352729 6480464 alternariol metabolite results in decreased activity of TOP2A protein, alternariol results in decreased activity of TOP2A protein CTD PMID:27422292 , PMID:27682608 amsacrine multiple interactions ISO RGD:1352729 6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine more ... CTD PMID:16969495 , PMID:21878638 amsacrine affects response to substance ISO RGD:1352729 6480464 TOP2A protein modified form affects the susceptibility to Amsacrine CTD PMID:12569090 amsacrine decreases response to substance ISO RGD:1352729 6480464 TOP2A gene mutant form results in decreased susceptibility to Amsacrine, TOP2A protein mutant form results in decreased susceptibility to Amsacrine CTD PMID:10727526 more ... anthracenes decreases activity ISO RGD:1352729 6480464 Anthracenes results in decreased activity of TOP2A protein CTD PMID:20561793 antimycin A increases expression ISO RGD:1352729 6480464 Antimycin A results in increased expression of TOP2A mRNA CTD PMID:33512557 arachidonic acid decreases expression ISO RGD:1352729 6480464 Arachidonic Acid results in decreased expression of TOP2A mRNA CTD PMID:16704987 aristolochic acid A decreases expression ISO RGD:1352729 6480464 aristolochic acid I results in decreased expression of TOP2A mRNA CTD PMID:33212167 arsane increases expression ISO RGD:1352729 6480464 Arsenic results in increased expression of TOP2A mRNA CTD PMID:11134558 arsenic atom increases expression ISO RGD:1352729 6480464 Arsenic results in increased expression of TOP2A mRNA CTD PMID:11134558 arsenite(3-) multiple interactions ISO RGD:1352729 6480464 arsenite inhibits the reaction [G3BP1 protein binds to TOP2A mRNA] CTD PMID:32406909 arsenite(3-) increases expression ISO RGD:1352729 6480464 arsenite results in increased expression of TOP2A mRNA CTD PMID:34425169 arsenous acid decreases expression ISO RGD:1352729 6480464 Arsenic Trioxide results in decreased expression of TOP2A protein CTD PMID:16884364 ATP increases hydrolysis ISO RGD:1352729 6480464 TOP2A protein results in increased hydrolysis of Adenosine Triphosphate, TOP2A results in increased hydrolysis of Adenosine Triphosphate CTD PMID:20855424 more ... ATP multiple interactions ISO RGD:1352729 6480464 Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] more ... CTD PMID:20855424 more ... aurofusarin decreases activity ISO RGD:1352729 6480464 aurofusarin results in decreased activity of TOP2A protein CTD PMID:29248571 azathioprine decreases expression ISO RGD:1352729 6480464 Azathioprine results in decreased expression of TOP2A mRNA CTD PMID:22623647 barium sulfate increases expression EXP 6480464 Barium Sulfate results in increased expression of TOP2A mRNA CTD PMID:29463257 benzene decreases expression ISO RGD:1352729 6480464 Benzene results in decreased expression of TOP2A mRNA, Benzene results in decreased expression of TOP2A protein CTD PMID:21382456 benzene-1,2,4-triol decreases activity ISO RGD:1352729 6480464 hydroxyhydroquinone results in decreased activity of TOP2A protein CTD PMID:7586126 benzimidazoles decreases activity ISO RGD:1352729 6480464 Benzimidazoles results in decreased activity of TOP2A protein CTD PMID:20884089 benzo[a]pyrene increases expression ISO RGD:1352729 6480464 Benzo(a)pyrene results in increased expression of TOP2A mRNA CTD PMID:20106945 benzo[a]pyrene decreases expression ISO RGD:1352729 6480464 Benzo(a)pyrene results in decreased expression of TOP2A mRNA CTD PMID:20064835 , PMID:21802500 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of TOP2A mRNA CTD PMID:21839799 benzo[a]pyrene decreases expression ISO RGD:62340 6480464 Benzo(a)pyrene results in decreased expression of TOP2A mRNA CTD PMID:19770486 benzo[a]pyrene increases expression ISO RGD:62340 6480464 Benzo(a)pyrene results in increased expression of TOP2A mRNA CTD PMID:20713471 , PMID:32417428 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1352729 6480464 7 more ... CTD PMID:20018196 more ... benzo[b]fluoranthene increases expression ISO RGD:62340 6480464 benzo(b)fluoranthene results in increased expression of TOP2A mRNA CTD PMID:26377693 berberine multiple interactions ISO RGD:1352729 6480464 TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form] CTD PMID:23747414 berberine affects response to substance ISO RGD:1352729 6480464 TOP2A protein affects the susceptibility to Berberine CTD PMID:23747414 beta-D-glucosamine decreases expression EXP 6480464 Glucosamine results in decreased expression of TOP2A mRNA CTD PMID:17109745 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TOP2A mRNA CTD PMID:18164116 beta-naphthoflavone decreases expression ISO RGD:1352729 6480464 beta-Naphthoflavone results in decreased expression of TOP2A mRNA CTD PMID:32858204 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of TOP2A mRNA CTD PMID:15651846 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1352729 6480464 Mustard Gas results in decreased expression of TOP2A mRNA CTD PMID:25102026 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1352729 6480464 Diethylhexyl Phthalate results in increased expression of TOP2A protein CTD PMID:31163220 bisphenol A increases expression ISO RGD:1352729 6480464 bisphenol A results in increased expression of TOP2A mRNA CTD PMID:16474171 bisphenol A affects expression ISO RGD:1352729 6480464 bisphenol A affects the expression of TOP2A mRNA CTD PMID:30903817 bisphenol A decreases expression ISO RGD:1352729 6480464 bisphenol A results in decreased expression of TOP2A mRNA CTD PMID:29275510 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TOP2A mRNA CTD PMID:25181051 more ... Boswellic acid multiple interactions ISO RGD:1352729 6480464 boswellic acid analog binds to and results in decreased activity of TOP2A protein CTD PMID:10860928 buta-1,3-diene increases expression ISO RGD:62340 6480464 1, 3-butadiene results in increased expression of TOP2A mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:1352729 6480464 butyraldehyde results in decreased expression of TOP2A mRNA CTD PMID:26079696 cadmium atom multiple interactions ISO RGD:1352729 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TOP2A mRNA CTD PMID:35301059 cadmium dichloride multiple interactions ISO RGD:1352729 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TOP2A mRNA, Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] CTD PMID:21497582 , PMID:35301059 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of TOP2A mRNA CTD PMID:25993096 cadmium dichloride multiple interactions ISO RGD:62340 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA CTD PMID:19840844 cadmium dichloride decreases activity ISO RGD:1352729 6480464 Cadmium Chloride results in decreased activity of TOP2A protein CTD PMID:21497582 caffeine decreases phosphorylation ISO RGD:1352729 6480464 Caffeine results in decreased phosphorylation of TOP2A protein CTD PMID:35688186 calcitriol decreases expression ISO RGD:1352729 6480464 Calcitriol results in decreased expression of TOP2A mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1352729 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TOP2A mRNA CTD PMID:21592394 cannabidiol multiple interactions ISO RGD:1352729 6480464 Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate], Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 cannabidiol decreases activity ISO RGD:1352729 6480464 Cannabidiol metabolite results in decreased activity of TOP2A protein CTD PMID:29272108 captafol decreases activity ISO RGD:62340 6480464 captafol results in decreased activity of TOP2A protein CTD PMID:12113771 captan decreases activity ISO RGD:62340 6480464 Captan results in decreased activity of TOP2A protein CTD PMID:12113771 Carbadox decreases expression EXP 6480464 Carbadox results in decreased expression of TOP2A protein CTD PMID:26558467 carbon nanotube affects expression ISO RGD:62340 6480464 Nanotubes, Carbon affects the expression of TOP2A mRNA CTD PMID:25554681 carbon nanotube increases expression ISO RGD:62340 6480464 Nanotubes, Carbon analog results in increased expression of TOP2A mRNA CTD PMID:25554681 carboplatin multiple interactions ISO RGD:1352729 6480464 TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] CTD PMID:11325482 cefaloridine decreases expression EXP 6480464 Cephaloridine results in decreased expression of TOP2A mRNA CTD PMID:18500788 CGP 52608 multiple interactions ISO RGD:1352729 6480464 CGP 52608 promotes the reaction [RORA protein binds to TOP2A gene] CTD PMID:28238834 chlorendic acid increases expression EXP 6480464 chlorendic acid results in increased expression of TOP2A mRNA CTD PMID:22584684 chloroacetaldehyde increases activity ISO RGD:1352729 6480464 chloroacetaldehyde results in increased activity of TOP2A protein CTD PMID:15751973 chloroethene increases activity ISO RGD:1352729 6480464 Vinyl Chloride metabolite results in increased activity of TOP2A protein CTD PMID:15751973 chlorpyrifos decreases activity ISO RGD:1352729 6480464 Chlorpyrifos results in decreased activity of TOP2A protein CTD PMID:26198043 ciprofloxacin affects binding ISO RGD:1352729 6480464 Ciprofloxacin binds to TOP2A protein CTD PMID:21413765 ciprofloxacin multiple interactions ISO RGD:1352729 6480464 [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein], [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein] CTD PMID:21413765 cisplatin decreases expression ISO RGD:1352729 6480464 Cisplatin results in decreased expression of TOP2A mRNA CTD PMID:27594783 cisplatin affects expression ISO RGD:1352729 6480464 Cisplatin affects the expression of TOP2A mRNA CTD PMID:23300844 cisplatin increases expression ISO RGD:62340 6480464 Cisplatin results in increased expression of TOP2A mRNA CTD PMID:21151649 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of TOP2A mRNA CTD PMID:22023808 cisplatin multiple interactions ISO RGD:1352729 6480464 [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Cisplatin more ... CTD PMID:11325482 , PMID:28323900 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of TOP2A mRNA CTD PMID:32741897 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of TOP2A mRNA CTD PMID:24386269 cobalt dichloride decreases expression ISO RGD:1352729 6480464 cobaltous chloride results in decreased expression of TOP2A mRNA CTD PMID:19320972 , PMID:19376846 copper atom multiple interactions ISO RGD:1352729 6480464 [NSC 689534 binds to Copper] which results in decreased expression of TOP2A mRNA CTD PMID:20971185 copper atom increases expression EXP 6480464 Copper results in increased expression of TOP2A mRNA CTD PMID:30556269 copper(0) multiple interactions ISO RGD:1352729 6480464 [NSC 689534 binds to Copper] which results in decreased expression of TOP2A mRNA CTD PMID:20971185 copper(0) increases expression EXP 6480464 Copper results in increased expression of TOP2A mRNA CTD PMID:30556269 copper(II) sulfate decreases expression ISO RGD:1352729 6480464 Copper Sulfate results in decreased expression of TOP2A mRNA CTD PMID:19549813 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of TOP2A mRNA CTD PMID:15755911 coumarin increases phosphorylation ISO RGD:1352729 6480464 coumarin results in increased phosphorylation of TOP2A protein CTD PMID:35688186 coumestrol multiple interactions ISO RGD:1352729 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:18310284 , PMID:19167446 Cryptotanshinone decreases expression ISO RGD:1352729 6480464 cryptotanshinone results in decreased expression of TOP2A mRNA CTD PMID:28716507 Cryptotanshinone multiple interactions ISO RGD:1352729 6480464 cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein CTD PMID:28716507 CU-O LINKAGE decreases expression ISO RGD:1352729 6480464 cupric oxide results in decreased expression of TOP2A mRNA CTD PMID:22077320 Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of TOP2A mRNA CTD PMID:26577399 curcumin multiple interactions ISO RGD:1352729 6480464 [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA, [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA CTD PMID:18348204 , PMID:18414057 curcumin decreases expression ISO RGD:1352729 6480464 Curcumin analog results in decreased expression of TOP2A mRNA, Curcumin results in decreased expression of TOP2A mRNA CTD PMID:18348204 more ... cyclophosphamide multiple interactions ISO RGD:1352729 6480464 TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil], TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:16682728 , PMID:18465341 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of TOP2A mRNA CTD PMID:11599041 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of TOP2A mRNA CTD PMID:19224547 cyclosporin A decreases expression ISO RGD:1352729 6480464 Cyclosporine results in decreased expression of TOP2A mRNA CTD PMID:20106945 more ... cyclosporin A decreases expression ISO RGD:62340 6480464 Cyclosporine results in decreased expression of TOP2A mRNA CTD PMID:19770486 deguelin increases expression ISO RGD:1352729 6480464 deguelin results in increased expression of TOP2A mRNA CTD PMID:33512557 delphinidin decreases activity ISO RGD:1352729 6480464 delphinidin results in decreased activity of TOP2A protein CTD PMID:19182879 delphinidin multiple interactions ISO RGD:1352729 6480464 delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein], delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein] CTD PMID:19182879 dexamethasone affects expression EXP 6480464 Dexamethasone affects the expression of TOP2A mRNA CTD PMID:15102944 dexamethasone increases expression ISO RGD:1352729 6480464 Dexamethasone results in increased expression of TOP2A mRNA CTD PMID:23137833 diarsenic trioxide decreases expression ISO RGD:1352729 6480464 Arsenic Trioxide results in decreased expression of TOP2A protein CTD PMID:16884364 dibenzofuran decreases expression EXP 6480464 dibenzofuran analog results in decreased expression of TOP2A mRNA CTD PMID:20566336 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of TOP2A mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:1352729 6480464 Dibutyl Phthalate results in decreased expression of TOP2A mRNA CTD PMID:28973377 dibutyl phthalate decreases expression ISO RGD:62340 6480464 Dibutyl Phthalate results in decreased expression of TOP2A mRNA CTD PMID:17361019 , PMID:21266533 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of TOP2A mRNA CTD PMID:18636392 dichloroacetic acid increases expression ISO RGD:62340 6480464 Dichloroacetic Acid results in increased expression of TOP2A mRNA CTD PMID:28962523 dicrotophos decreases expression ISO RGD:1352729 6480464 dicrotophos results in decreased expression of TOP2A mRNA CTD PMID:28302478 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of TOP2A mRNA CTD PMID:15890375 dimethylarsinic acid increases expression ISO RGD:62340 6480464 Cacodylic Acid results in increased expression of TOP2A mRNA CTD PMID:17441966 dimethylarsinic acid decreases expression EXP 6480464 Cacodylic Acid results in decreased expression of TOP2A mRNA CTD PMID:17720352 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of TOP2A mRNA CTD PMID:26476374 dioxygen multiple interactions EXP 6480464 [dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of TOP2A mRNA] more ... CTD PMID:26476374 , PMID:33729688 disodium selenite decreases expression ISO RGD:1352729 6480464 Sodium Selenite results in decreased expression of TOP2A mRNA CTD PMID:24383545 dorsomorphin multiple interactions ISO RGD:1352729 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA CTD PMID:27188386 doxorubicin multiple interactions ISO RGD:1352729 6480464 [Doxorubicin results in increased ribosylation of SP1 protein] affects the reaction [SP1 protein binds to TOP2A promoter] more ... CTD PMID:15486187 more ... doxorubicin increases expression ISO RGD:1352729 6480464 Doxorubicin results in increased expression of TOP2A protein CTD PMID:17351394 , PMID:22751436 doxorubicin decreases expression ISO RGD:62340 6480464 Doxorubicin results in decreased expression of TOP2A mRNA CTD PMID:25896364 doxorubicin increases expression ISO RGD:62340 6480464 Doxorubicin results in increased expression of TOP2A mRNA CTD PMID:22712078 doxorubicin multiple interactions ISO RGD:62340 6480464 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 doxorubicin affects activity ISO RGD:1352729 6480464 Doxorubicin affects the activity of TOP2A protein CTD PMID:19182879 doxorubicin decreases expression ISO RGD:1352729 6480464 Doxorubicin results in decreased expression of TOP2A mRNA CTD PMID:15205334 more ... doxorubicin decreases response to substance ISO RGD:1352729 6480464 TOP2A mRNA results in decreased susceptibility to Doxorubicin more ... CTD PMID:11470519 , PMID:15765123 doxorubicin affects response to substance ISO RGD:1352729 6480464 TOP2A protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin increases response to substance ISO RGD:1352729 6480464 TOP2A mRNA results in increased susceptibility to Doxorubicin, TOP2A results in increased susceptibility to Doxorubicin CTD PMID:15239142 , PMID:9862568 dronedarone decreases expression ISO RGD:1352729 6480464 dronedarone results in decreased expression of TOP2A mRNA, dronedarone results in decreased expression of TOP2A protein CTD PMID:29616291 dronedarone multiple interactions ISO RGD:1352729 6480464 CYP2D6 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein] more ... CTD PMID:29616291 emodin multiple interactions ISO RGD:1352729 6480464 Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate], TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form] CTD PMID:20855424 emodin increases activity ISO RGD:1352729 6480464 Emodin results in increased activity of TOP2A protein CTD PMID:20855424 Enterolactone multiple interactions ISO RGD:1352729 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TOP2A mRNA CTD PMID:19167446 ethylbenzene increases methylation ISO RGD:1352729 6480464 ethylbenzene results in increased methylation of TOP2A promoter CTD PMID:29217486 etoposide affects binding ISO RGD:1352729 6480464 Etoposide binds to TOP2A protein CTD PMID:21413765 etoposide multiple interactions ISO RGD:1352729 6480464 [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein] more ... CTD PMID:11325482 more ... etoposide decreases activity ISO RGD:1352729 6480464 Etoposide analog results in decreased activity of TOP2A protein more ... CTD PMID:21056033 more ... etoposide affects activity ISO RGD:1352729 6480464 Etoposide affects the activity of TOP2A protein CTD PMID:19182879 more ... etoposide decreases expression ISO RGD:62340 6480464 Etoposide results in decreased expression of TOP2A protein CTD PMID:10856430 etoposide decreases activity ISO RGD:62340 6480464 Etoposide results in decreased activity of TOP2A protein CTD PMID:15211611 etoposide increases response to substance ISO RGD:1352729 6480464 TOP2A protein results in increased susceptibility to Etoposide CTD PMID:11531262 etoposide affects response to substance ISO RGD:1352729 6480464 TOP2A protein modified form affects the susceptibility to Etoposide CTD PMID:12569090 etoposide decreases response to substance ISO RGD:1352729 6480464 TOP2A gene mutant form results in decreased susceptibility to Etoposide, TOP2A protein mutant form results in decreased susceptibility to Etoposide CTD PMID:11470519 , PMID:11676865 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of TOP2A mRNA CTD PMID:32741897 fenpyroximate increases expression ISO RGD:1352729 6480464 fenpyroximate results in increased expression of TOP2A mRNA CTD PMID:33512557 flavonoids decreases expression ISO RGD:1352729 6480464 Flavonoids results in decreased expression of TOP2A mRNA CTD PMID:15465739 folic acid multiple interactions ISO RGD:1352729 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TOP2A mRNA CTD PMID:24657277 fulvestrant increases expression ISO RGD:1352729 6480464 fulvestrant results in increased expression of TOP2A mRNA CTD PMID:12154049 furan increases expression EXP 6480464 furan results in increased expression of TOP2A mRNA CTD PMID:25539665 genistein increases expression ISO RGD:1352729 6480464 Genistein results in increased expression of TOP2A mRNA CTD PMID:16474171 genistein affects activity EXP 6480464 Genistein affects the activity of TOP2A protein CTD PMID:26723871 glutathione multiple interactions ISO RGD:1352729 6480464 Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] CTD PMID:21497582 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of TOP2A mRNA CTD PMID:24395379 Heliotrine increases expression EXP 6480464 heliotrine results in increased expression of TOP2A mRNA CTD PMID:32419051 hexadecanoic acid affects phosphorylation ISO RGD:1352729 6480464 Palmitic Acid affects the phosphorylation of TOP2A protein CTD PMID:28073184 hydrogen peroxide multiple interactions ISO RGD:1352729 6480464 [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] CTD PMID:15935818 hydroquinone affects activity ISO RGD:1352729 6480464 hydroquinone affects the activity of TOP2A protein CTD PMID:15833037 hydroquinone decreases activity ISO RGD:1352729 6480464 hydroquinone results in decreased activity of TOP2A protein CTD PMID:11468185 more ... hydroquinone multiple interactions ISO RGD:1352729 6480464 [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] CTD PMID:15935818 hydroquinone decreases activity ISO RGD:62340 6480464 hydroquinone results in decreased activity of TOP2A protein CTD PMID:15211611 hypericin decreases activity ISO RGD:1352729 6480464 hypericin results in decreased activity of TOP2A protein CTD PMID:11597574 ifosfamide multiple interactions ISO RGD:1352729 6480464 TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] CTD PMID:11325482 indirubin decreases expression ISO RGD:1352729 6480464 indirubin results in decreased expression of TOP2A mRNA CTD PMID:15056799 indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TOP2A mRNA CTD PMID:22129741 irinotecan increases response to substance ISO RGD:1352729 6480464 TOP2A mRNA results in increased susceptibility to Irinotecan CTD PMID:15239142 irinotecan decreases expression ISO RGD:1352729 6480464 Irinotecan metabolite results in decreased expression of TOP2A mRNA, Irinotecan results in decreased expression of TOP2A mRNA CTD PMID:15956246 isoflavones decreases expression ISO RGD:1352729 6480464 Isoflavones results in decreased expression of TOP2A mRNA CTD PMID:17374662 ivermectin decreases expression ISO RGD:1352729 6480464 Ivermectin results in decreased expression of TOP2A protein CTD PMID:32959892 L-1,4-dithiothreitol multiple interactions ISO RGD:1352729 6480464 Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 Lasiocarpine multiple interactions ISO RGD:1352729 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of TOP2A mRNA CTD PMID:33884520 lead diacetate decreases expression ISO RGD:62340 6480464 lead acetate results in decreased expression of TOP2A mRNA CTD PMID:22613225 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of TOP2A mRNA CTD PMID:24136188 leflunomide decreases expression ISO RGD:1352729 6480464 leflunomide results in decreased expression of TOP2A mRNA CTD PMID:28988120 lipopolysaccharide multiple interactions ISO RGD:1352729 6480464 Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TOP2A mRNA] CTD PMID:28070326 lipopolysaccharide increases expression ISO RGD:62340 6480464 Lipopolysaccharides results in increased expression of TOP2A mRNA CTD PMID:10975854 lipopolysaccharide affects expression ISO RGD:1352729 6480464 Lipopolysaccharides affects the expression of TOP2A mRNA CTD PMID:28070326 lithium atom increases expression EXP 6480464 Lithium results in increased expression of TOP2A mRNA CTD PMID:21711903 lithium hydride increases expression EXP 6480464 Lithium results in increased expression of TOP2A mRNA CTD PMID:21711903 lovastatin multiple interactions ISO RGD:62340 6480464 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 lucanthone decreases expression ISO RGD:1352729 6480464 Lucanthone results in decreased expression of TOP2A mRNA CTD PMID:21148553 MeIQx increases expression ISO RGD:1352729 6480464 2-amino-3 more ... CTD PMID:20816883 menadione affects expression ISO RGD:1352729 6480464 Vitamin K 3 affects the expression of TOP2A mRNA CTD PMID:20044591 methamphetamine decreases expression ISO RGD:1352729 6480464 Methamphetamine results in decreased expression of TOP2A mRNA CTD PMID:25290377 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of TOP2A mRNA, Methamphetamine results in decreased expression of TOP2A protein CTD PMID:28341135 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of TOP2A mRNA, Methapyrilene results in increased expression of TOP2A protein CTD PMID:15890375 more ... methotrexate multiple interactions ISO RGD:1352729 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TOP2A mRNA CTD PMID:24657277 methotrexate decreases expression ISO RGD:1352729 6480464 Methotrexate results in decreased expression of TOP2A mRNA CTD PMID:24657277 methylmercury chloride decreases expression ISO RGD:62340 6480464 methylmercuric chloride results in decreased expression of TOP2A mRNA CTD PMID:20061341 methylparaben decreases expression ISO RGD:1352729 6480464 methylparaben results in decreased expression of TOP2A mRNA CTD PMID:31745603 methylseleninic acid affects expression ISO RGD:1352729 6480464 methylselenic acid affects the expression of TOP2A mRNA CTD PMID:14617803 mycotoxin multiple interactions ISO RGD:1352729 6480464 [Mycotoxins co-treated with Oxidants] results in decreased activity of TOP2A protein CTD PMID:26894873 mycotoxin decreases activity ISO RGD:1352729 6480464 Mycotoxins results in decreased activity of TOP2A protein CTD PMID:26894873 myricetin decreases activity ISO RGD:1352729 6480464 myricetin results in decreased activity of TOP2A protein CTD PMID:16536579 N-acetyl-1,4-benzoquinone imine decreases activity ISO RGD:1352729 6480464 N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1352729 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] CTD PMID:17575151 N-butyl-N-(4-hydroxybutyl)nitrosamine multiple interactions EXP 6480464 [Butylhydroxybutylnitrosamine co-treated with Propolis analog] results in increased expression of TOP2A mRNA CTD PMID:26111810 N-methyl-4-phenylpyridinium decreases expression ISO RGD:1352729 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TOP2A mRNA CTD PMID:24810058 N-methyl-4-phenylpyridinium increases expression ISO RGD:62340 6480464 1-Methyl-4-phenylpyridinium results in increased expression of TOP2A protein CTD PMID:26558463 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:62340 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA more ... CTD PMID:19840844 N-methyl-N-nitrosourea increases expression ISO RGD:62340 6480464 Methylnitrosourea results in increased expression of TOP2A mRNA CTD PMID:25270620 N-nitrosodiethylamine increases expression ISO RGD:62340 6480464 Diethylnitrosamine results in increased expression of TOP2A mRNA CTD PMID:17854601 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of TOP2A mRNA CTD PMID:25242409 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TOP2A mRNA, [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TOP2A mRNA CTD PMID:18164116 , PMID:22129741 N-nitrosodiethylamine multiple interactions ISO RGD:62340 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOP2A mRNA, RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOP2A mRNA] CTD PMID:17854601 , PMID:24535843 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of TOP2A mRNA CTD PMID:15890375 N-Nitrosopyrrolidine decreases expression ISO RGD:1352729 6480464 N-Nitrosopyrrolidine results in decreased expression of TOP2A mRNA CTD PMID:32234424 naphthalene-1,2-diol affects activity ISO RGD:1352729 6480464 1, 2-dihydroxynaphthalene affects the activity of TOP2A protein CTD PMID:33760604 nevadensin decreases activity ISO RGD:1352729 6480464 nevadensin results in decreased activity of TOP2A protein CTD PMID:34635930 nickel subsulfide increases expression EXP 6480464 nickel subsulfide results in increased expression of TOP2A mRNA CTD PMID:24952340 Nitidine decreases expression ISO RGD:1352729 6480464 nitidine results in decreased expression of TOP2A mRNA, nitidine results in decreased expression of TOP2A protein CTD PMID:30132517 O-methyleugenol affects expression EXP 6480464 methyleugenol affects the expression of TOP2A protein CTD PMID:26011634 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of TOP2A mRNA, ochratoxin A results in increased expression of TOP2A protein CTD PMID:19237604 okadaic acid multiple interactions ISO RGD:62340 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TOP2A mRNA CTD PMID:19840844 oleanolic acid decreases activity ISO RGD:1352729 6480464 Oleanolic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 oleanolic acid decreases expression ISO RGD:1352729 6480464 Oleanolic Acid analog results in decreased expression of TOP2A protein CTD PMID:26612655 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2A mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of TOP2A mRNA CTD PMID:25729387 oxfendazole decreases expression EXP 6480464 oxfendazole results in decreased expression of TOP2A protein CTD PMID:26558467 ozone increases expression ISO RGD:62340 6480464 Ozone results in increased expression of TOP2A mRNA CTD PMID:12763052 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of TOP2A mRNA CTD PMID:18636392 ozone multiple interactions ISO RGD:62340 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TOP2A mRNA more ... CTD PMID:19555225 more ... p-menthan-3-ol decreases activity ISO RGD:1352729 6480464 Menthol results in decreased activity of TOP2A protein CTD PMID:16158947 p-menthan-3-ol increases expression ISO RGD:1352729 6480464 Menthol results in increased expression of TOP2A mRNA CTD PMID:26760959 paclitaxel increases response to substance ISO RGD:1352729 6480464 TOP2A mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 paclitaxel multiple interactions ISO RGD:1352729 6480464 TOP2A results in decreased susceptibility to [Cisplatin co-treated with Paclitaxel] CTD PMID:11325482 palbociclib decreases expression ISO RGD:1352729 6480464 palbociclib analog results in decreased expression of TOP2A mRNA more ... CTD PMID:15542782 more ... palbociclib multiple interactions ISO RGD:1352729 6480464 palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein], RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]] CTD PMID:22751436 paracetamol affects expression ISO RGD:62340 6480464 Acetaminophen affects the expression of TOP2A mRNA CTD PMID:17562736 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of TOP2A protein CTD PMID:26011634 paracetamol decreases expression ISO RGD:1352729 6480464 Acetaminophen results in decreased expression of TOP2A mRNA CTD PMID:29067470 paracetamol increases expression ISO RGD:1352729 6480464 Acetaminophen results in increased expression of TOP2A mRNA CTD PMID:22230336 paraquat multiple interactions ISO RGD:1352729 6480464 [Paraquat co-treated with Antigens, Dermatophagoides] results in decreased expression of TOP2A mRNA CTD PMID:34097952 PCB138 multiple interactions ISO RGD:62340 6480464 [2 more ... CTD PMID:25510870 perfluorooctanoic acid decreases expression ISO RGD:1352729 6480464 perfluorooctanoic acid results in decreased expression of TOP2A mRNA CTD PMID:25868421 phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of TOP2A mRNA CTD PMID:31324951 phenobarbital multiple interactions ISO RGD:62340 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOP2A mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TOP2A mRNA] CTD PMID:19482888 , PMID:24535843 phenobarbital increases expression ISO RGD:62340 6480464 Phenobarbital results in increased expression of TOP2A mRNA CTD PMID:19363144 more ... phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of TOP2A mRNA CTD PMID:19162173 phenylmercury acetate decreases expression ISO RGD:1352729 6480464 Phenylmercuric Acetate results in decreased expression of TOP2A mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1352729 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA CTD PMID:27188386 PhIP decreases expression ISO RGD:1352729 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of TOP2A mRNA CTD PMID:20816883 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of TOP2A mRNA CTD PMID:29877212 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:62340 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TOP2A mRNA CTD PMID:19840844 phytoestrogen increases expression ISO RGD:1352729 6480464 Phytoestrogens results in increased expression of TOP2A mRNA CTD PMID:18310284 picoxystrobin increases expression ISO RGD:1352729 6480464 picoxystrobin results in increased expression of TOP2A mRNA CTD PMID:33512557 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of TOP2A mRNA CTD PMID:15890375 pirinixic acid increases expression ISO RGD:62340 6480464 pirinixic acid results in increased expression of TOP2A mRNA CTD PMID:18301758 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of TOP2A mRNA CTD PMID:12832660 more ... pirinixic acid decreases expression ISO RGD:62340 6480464 pirinixic acid results in decreased expression of TOP2A mRNA CTD PMID:17426115 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of TOP2A mRNA CTD PMID:19162173 procyanidin B2 decreases activity ISO RGD:1352729 6480464 procyanidin B2 results in decreased activity of TOP2A protein CTD PMID:16536579 progesterone decreases expression ISO RGD:1352729 6480464 Progesterone results in decreased expression of TOP2A mRNA CTD PMID:21795739 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of TOP2A mRNA CTD PMID:20726854 progesterone increases expression ISO RGD:1352729 6480464 Progesterone results in increased expression of TOP2A mRNA CTD PMID:18070364 , PMID:21540246 promethazine affects expression EXP 6480464 Promethazine affects the expression of TOP2A protein CTD PMID:26011634 propanal decreases expression ISO RGD:1352729 6480464 propionaldehyde results in decreased expression of TOP2A mRNA CTD PMID:26079696 propiconazole increases expression ISO RGD:62340 6480464 propiconazole results in increased expression of TOP2A mRNA CTD PMID:21278054 Pyrenophorol decreases activity ISO RGD:1352729 6480464 pyrenophorol results in decreased activity of TOP2A protein CTD PMID:27682608 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of TOP2A mRNA] CTD PMID:26476374 quercetin decreases expression ISO RGD:1352729 6480464 Quercetin results in decreased expression of TOP2A mRNA CTD PMID:21632981 raloxifene increases expression ISO RGD:1352729 6480464 Raloxifene Hydrochloride results in increased expression of TOP2A mRNA CTD PMID:12154049 razoxane affects binding ISO RGD:1352729 6480464 Razoxane binds to TOP2A protein CTD PMID:17875725 Rebamipide increases expression EXP 6480464 rebamipide results in increased expression of TOP2A mRNA CTD PMID:18299717 resveratrol decreases activity ISO RGD:1352729 6480464 resveratrol results in decreased activity of TOP2A protein CTD PMID:16536579 resveratrol decreases expression ISO RGD:1352729 6480464 resveratrol results in decreased expression of TOP2A mRNA CTD PMID:15767336 , PMID:23137833 resveratrol decreases expression ISO RGD:62340 6480464 resveratrol results in decreased expression of TOP2A protein CTD PMID:25505154 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of TOP2A mRNA CTD PMID:19228061 riddelliine multiple interactions ISO RGD:1352729 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA CTD PMID:33884520 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of TOP2A mRNA CTD PMID:28374803 rotenone increases expression ISO RGD:1352729 6480464 Rotenone results in increased expression of TOP2A mRNA CTD PMID:33512557 sarin decreases expression ISO RGD:1352729 6480464 Sarin results in decreased expression of TOP2A mRNA CTD PMID:19522546 SB 431542 multiple interactions ISO RGD:1352729 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA CTD PMID:27188386 senecionine increases expression EXP 6480464 senecionine results in increased expression of TOP2A mRNA CTD PMID:32419051 Senkirkine increases expression EXP 6480464 senkirkine results in increased expression of TOP2A mRNA CTD PMID:32419051 silicon dioxide increases expression ISO RGD:1352729 6480464 Silicon Dioxide results in increased expression of TOP2A mRNA CTD PMID:25351596 silicon dioxide increases expression ISO RGD:62340 6480464 Silicon Dioxide results in increased expression of TOP2A mRNA CTD PMID:29341224 sodium arsenite decreases expression ISO RGD:1352729 6480464 sodium arsenite results in decreased expression of TOP2A mRNA CTD PMID:12760830 , PMID:32844245 sodium arsenite affects expression ISO RGD:1352729 6480464 sodium arsenite affects the expression of TOP2A mRNA CTD PMID:29301061 sodium arsenite increases expression ISO RGD:1352729 6480464 sodium arsenite results in increased expression of TOP2A mRNA CTD PMID:12016162 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of TOP2A mRNA CTD PMID:22561333 sodium dichromate decreases expression ISO RGD:62340 6480464 sodium bichromate results in decreased expression of TOP2A mRNA CTD PMID:31558096 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of TOP2A mRNA CTD PMID:11960910 succimer multiple interactions ISO RGD:1352729 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TOP2A mRNA CTD PMID:26378955 sunitinib decreases expression ISO RGD:1352729 6480464 Sunitinib results in decreased expression of TOP2A mRNA CTD PMID:31533062 T-2 toxin decreases expression ISO RGD:1352729 6480464 T-2 Toxin results in decreased expression of TOP2A mRNA CTD PMID:34581912 tamibarotene affects expression ISO RGD:1352729 6480464 tamibarotene affects the expression of TOP2A mRNA CTD PMID:15498508 tamoxifen decreases expression ISO RGD:1352729 6480464 Tamoxifen results in decreased expression of TOP2A protein CTD PMID:10785588 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of TOP2A mRNA CTD PMID:19224547 teniposide multiple interactions ISO RGD:1352729 6480464 TOP2A results in decreased susceptibility to [Cisplatin co-treated with Teniposide] CTD PMID:11325482 testosterone multiple interactions ISO RGD:1352729 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TOP2A mRNA CTD PMID:21592394 testosterone multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TOP2A mRNA CTD PMID:32741896 testosterone increases expression ISO RGD:62340 6480464 Testosterone results in increased expression of TOP2A mRNA CTD PMID:19693291 testosterone decreases expression ISO RGD:1352729 6480464 Testosterone results in decreased expression of TOP2A mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO RGD:62340 6480464 Carbon Tetrachloride results in increased expression of TOP2A mRNA CTD PMID:27339419 more ... tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of TOP2A mRNA CTD PMID:31150632 tetracycline decreases expression EXP 6480464 Tetracycline results in decreased expression of TOP2A mRNA CTD PMID:19224547 tetracycline decreases expression ISO RGD:1352729 6480464 Tetracycline results in decreased expression of TOP2A protein CTD PMID:23293027 thalidomide multiple interactions ISO RGD:1352729 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA CTD PMID:18720364 thapsigargin increases expression ISO RGD:62340 6480464 Thapsigargin results in increased expression of TOP2A protein CTD PMID:24648495 thapsigargin decreases expression EXP 6480464 Thapsigargin results in decreased expression of TOP2A protein CTD PMID:35544339 thifluzamide increases expression ISO RGD:1352729 6480464 thifluzamide results in increased expression of TOP2A mRNA CTD PMID:33512557 thimerosal decreases activity ISO RGD:1352729 6480464 Thimerosal results in decreased activity of TOP2A protein CTD PMID:18197631 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of TOP2A mRNA, Thioacetamide results in increased expression of TOP2A protein CTD PMID:22659510 more ... thymoquinone affects activity ISO RGD:1352729 6480464 thymoquinone affects the activity of TOP2A protein CTD PMID:24650156 titanium dioxide increases expression ISO RGD:62340 6480464 titanium dioxide results in increased expression of TOP2A mRNA CTD PMID:23557971 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of TOP2A mRNA CTD PMID:30012374 titanium dioxide multiple interactions ISO RGD:1352729 6480464 [Vitallium analog binds to titanium dioxide] which results in decreased expression of TOP2A mRNA CTD PMID:23825117 titanium dioxide affects expression ISO RGD:62340 6480464 titanium dioxide affects the expression of TOP2A mRNA CTD PMID:17656681 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of TOP2A mRNA CTD PMID:25729387 topotecan decreases expression ISO RGD:1352729 6480464 Topotecan results in decreased expression of TOP2A mRNA CTD PMID:16026610 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2A mRNA CTD PMID:25729387 tremolite asbestos increases expression ISO RGD:62340 6480464 tremolite results in increased expression of TOP2A mRNA CTD PMID:29279043 triacsin C decreases expression ISO RGD:1352729 6480464 triacsin C results in decreased expression of TOP2A mRNA CTD PMID:16704987 triclosan decreases expression ISO RGD:1352729 6480464 Triclosan results in decreased expression of TOP2A mRNA CTD PMID:30510588 trimellitic anhydride increases expression ISO RGD:62340 6480464 trimellitic anhydride results in increased expression of TOP2A mRNA CTD PMID:19042947 triptonide decreases expression ISO RGD:62340 6480464 triptonide results in decreased expression of TOP2A mRNA CTD PMID:33045310 troglitazone decreases expression ISO RGD:1352729 6480464 troglitazone results in decreased expression of TOP2A mRNA CTD PMID:19140230 trovafloxacin decreases activity ISO RGD:1352729 6480464 trovafloxacin results in decreased activity of TOP2A protein CTD PMID:24817034 trovafloxacin decreases expression ISO RGD:62340 6480464 trovafloxacin results in decreased expression of TOP2A mRNA CTD PMID:35537566 tungsten decreases expression ISO RGD:62340 6480464 Tungsten results in decreased expression of TOP2A mRNA CTD PMID:30912803 ursolic acid decreases activity ISO RGD:1352729 6480464 ursolic acid results in decreased activity of TOP2A protein CTD PMID:10860928 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of TOP2A mRNA CTD PMID:19224547 valproic acid decreases expression ISO RGD:1352729 6480464 Valproic Acid results in decreased expression of TOP2A mRNA CTD PMID:20585447 , PMID:28001369 vincaleukoblastine affects response to substance ISO RGD:1352729 6480464 TOP2A protein affects the susceptibility to Vinblastine CTD PMID:16217747 vincristine decreases expression ISO RGD:1352729 6480464 Vincristine results in decreased expression of TOP2A mRNA CTD PMID:23649840 Xanthatin decreases activity ISO RGD:1352729 6480464 xanthatin results in decreased activity of TOP2A protein CTD PMID:23313378 Xanthatin multiple interactions ISO RGD:1352729 6480464 [xanthatin results in decreased expression of TOP2A] which results in increased expression of GADD45G mRNA CTD PMID:23824011 Xanthatin decreases expression ISO RGD:1352729 6480464 xanthatin results in decreased expression of TOP2A CTD PMID:23824011 zaragozic acid A decreases expression ISO RGD:62340 6480464 squalestatin 1 results in decreased expression of TOP2A mRNA CTD PMID:27225895 zaragozic acid A decreases expression EXP 6480464 squalestatin 1 results in decreased expression of TOP2A mRNA CTD PMID:27225895 zinc atom increases expression ISO RGD:1352729 6480464 Zinc deficiency results in increased expression of TOP2A mRNA CTD PMID:22171008 zinc(0) increases expression ISO RGD:1352729 6480464 Zinc deficiency results in increased expression of TOP2A mRNA CTD PMID:22171008 zoledronic acid decreases expression ISO RGD:1352729 6480464 zoledronic acid results in decreased expression of TOP2A mRNA CTD PMID:24714768
