Top2a (DNA topoisomerase II alpha) - Rat Genome Database

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Gene: Top2a (DNA topoisomerase II alpha) Rattus norvegicus
Analyze
Symbol: Top2a
Name: DNA topoisomerase II alpha
RGD ID: 62048
Description: Enables several functions, including ATP binding activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and chromatin binding activity. Involved in several processes, including DNA topological change; cerebellar cortex formation; and response to parathyroid hormone. Part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Orthologous to human TOP2A (DNA topoisomerase II alpha); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; topoisomerase (DNA) 2 alpha; topoisomerase (DNA) II alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,441,954 - 84,473,093 (-)NCBIGRCr8
mRatBN7.21083,945,731 - 83,976,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,889,659 - 88,920,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,387,764 - 88,418,905 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,780,312 - 83,811,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Celera1082,687,594 - 82,716,976 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9,10-phenanthroquinone  (ISO)
9-hydroxyellipticine  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
altenusin  (ISO)
alternariol  (ISO)
Altertoxin I  (ISO)
Altertoxin II  (ISO)
amsacrine  (ISO)
anthracenes  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (EXP)
aurofusarin  (ISO)
azathioprine  (ISO)
barium sulfate  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Boswellic acid  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captafol  (ISO)
captan  (ISO)
Carbadox  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorendic acid  (EXP)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
Cryptotanshinone  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
Heliotrine  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypericin  (ISO)
ifosfamide  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
lucanthone  (ISO)
Macrosporin  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mycotoxin  (ISO)
myricetin  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene-1,2-diol  (ISO)
nevadensin  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
Nitidine  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleanolic acid  (ISO)
orotic acid  (EXP)
oxaliplatin  (EXP)
oxfendazole  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pectolinarigenin  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propanal  (ISO)
propiconazole  (ISO)
Pyrenophorol  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
razoxane  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Stemphyltoxin III  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
tremolite asbestos  (ISO)
triacsin C  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
Xanthatin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy. Albadine R, etal., J Urol. 2009 Aug;182(2):735-40. Epub 2009 Jun 18.
2. Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays. Baker VA, etal., Environ Health Perspect. 2004 Mar;112(4):428-38.
3. Substrate specificity plays an important role in uncoupling the catalytic and scaffolding activities of rat testis DNA topoisomerase IIalpha. Bakshi R, etal., J Biomol Struct Dyn. 2001 Apr;18(5):749-60.
4. DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity. Berney DM, etal., BJU Int. 2008 Sep;102(8):1040-4. Epub 2008 May 16.
5. Gene expression changes are age-dependent and lobe-specific in the brown Norway rat model of prostatic hyperplasia. Bethel CR, etal., Prostate. 2009 Jun 1;69(8):838-50.
6. Prognostic markers of low-grade squamous intraepithelial lesions: the role of topoisomerase IIalpha and active caspase-3. Coelho RA, etal., Eur J Gynaecol Oncol. 2008;29(5):499-501.
7. Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis. Faggad A, etal., Mod Pathol. 2009 Apr;22(4):579-88. Epub 2009 Mar 6.
8. The expression of the nuclear matrix proteins NuMA, topoisomerase II-alpha, and -beta in bone and osseous cell culture: regulation by parathyroid hormone. Feister HA, etal., Bone. 2000 Mar;26(3):227-34.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Glucose-regulated protein 75 overexpression attenuates ionizing radiation-mediated injury in PC12 cells by inducing the expression of topoisomerase IIa. Guo W, etal., Mol Med Rep. 2012 Dec;6(6):1423-7. doi: 10.3892/mmr.2012.1070. Epub 2012 Sep 10.
11. Clinical Implications and Prognostic Values of Topoisomerase-II Alpha Expression in Primary Non-Muscle-Invasive Bladder Cancer. Kim EJ, etal., Urology. 2009 Nov 12.
12. Identification of prognostic biomarkers for prostate cancer. Kosari F, etal., Clin Cancer Res. 2008 Mar 15;14(6):1734-43.
13. Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy. Martin CM, etal., Methods Mol Biol. 2009;511:333-59.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Structural homology between molecular probes binding site of DNA polymerase beta and DNA topoisomerase II Mizushina Y, etal., Tanpakushitsu Kakusan Koso 2002 May;47(6):708-14.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D. Nielsen KV, etal., Acta Oncol. 2008;47(4):725-34.
18. Nucleotide sequence analysis of the CDNA for rat DNA topoisomerase II. Park SH, etal., Biochem Biophys Res Commun 1993 Jun 15;193(2):787-93.
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms. Rochette L, etal., Trends Pharmacol Sci. 2015 Jun;36(6):326-48. doi: 10.1016/j.tips.2015.03.005. Epub 2015 Apr 17.
24. Topoisomerase IIalpha expression in ductal carcinoma in situ of the breast: a preliminary study. Shpitz B, etal., Hum Pathol. 2000 Oct;31(10):1249-54.
25. Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer. Sparano JA, etal., Clin Cancer Res. 2009 Dec 15;15(24):7693-7700. Epub .
26. Gene expression profiling of favorable histology Wilms tumors and its correlation with clinical features. Takahashi M, etal., Cancer Res. 2002 Nov 15;62(22):6598-605.
27. Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression. Tretiakova M, etal., J Clin Pathol. 2006 Dec;59(12):1272-7. Epub 2006 Mar 23.
28. Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum. Tsutsui K, et al., J Comp Neurol. 2001 Mar 5;431(2):228-39.
29. Molecular cloning of partial cDNAs for rat DNA topoisomerase II isoforms and their differential expression in brain development. Tsutsui K, etal., J Biol Chem 1993 Sep 5;268(25):19076-83.
30. Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts. Usha L, etal., J Hematol Oncol. 2008 Aug 14;1:12.
31. Differential expressions of the topoisomerase II alpha and II beta mRNAs in developing rat brain. Watanabe M, et al., Neurosci Res. 1994 Feb;19(1):51-7.
32. Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta. Yamauchi H, etal., Biol Reprod. 2004 Jun;70(6):1762-7. Epub 2004 Feb 6.
Additional References at PubMed
PMID:1331984   PMID:1683482   PMID:7842491   PMID:7937150   PMID:9049244   PMID:9094096   PMID:9224616   PMID:10473615   PMID:10666337   PMID:10788521   PMID:10959840   PMID:11062478  
PMID:11136718   PMID:11835579   PMID:11835580   PMID:12079377   PMID:12711669   PMID:15013075   PMID:15456904   PMID:15491148   PMID:15965487   PMID:16611985   PMID:16712776   PMID:16914642  
PMID:17567603   PMID:21795393   PMID:22323612   PMID:22681889   PMID:23012366   PMID:24029230   PMID:24116135   PMID:24321095   PMID:24625528   PMID:25961503   PMID:26319574   PMID:26527691  
PMID:30053369   PMID:31505169   PMID:35352799  


Genomics

Comparative Map Data
Top2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,441,954 - 84,473,093 (-)NCBIGRCr8
mRatBN7.21083,945,731 - 83,976,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,889,659 - 88,920,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,387,764 - 88,418,905 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,780,312 - 83,811,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Celera1082,687,594 - 82,716,976 (-)NCBICelera
Cytogenetic Map10q31NCBI
TOP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,388,525 - 40,417,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,388,525 - 40,417,896 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,544,777 - 38,574,148 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,798,321 - 35,827,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 341735,798,320 - 35,827,695NCBI
Celera1735,204,916 - 35,234,352 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,337,633 - 34,367,123 (-)NCBIHuRef
CHM1_11738,780,085 - 38,809,522 (-)NCBICHM1_1
T2T-CHM13v2.01741,252,019 - 41,281,395 (-)NCBIT2T-CHM13v2.0
Top2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,883,773 - 98,915,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,883,769 - 98,915,015 (-)EnsemblGRCm39 Ensembl
GRCm381198,992,947 - 99,024,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,992,943 - 99,024,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,854,261 - 98,885,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,809,493 - 98,840,205 (-)NCBIMGSCv36mm8
Celera11108,658,802 - 108,690,006 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.91NCBI
Top2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,929,136 - 14,964,723 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,928,273 - 14,964,855 (-)NCBIChiLan1.0ChiLan1.0
TOP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,537,882 - 24,567,338 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,432,885 - 26,462,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,872,169 - 16,901,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,097,619 - 17,127,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,097,778 - 17,126,207 (+)Ensemblpanpan1.1panPan2
TOP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,207,501 - 22,237,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,207,638 - 22,237,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,679,941 - 21,709,943 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,000,244 - 23,030,254 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,000,269 - 23,029,980 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,774,298 - 21,804,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,033,150 - 22,063,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,157,897 - 22,187,909 (+)NCBIUU_Cfam_GSD_1.0
Top2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,608,163 - 21,633,139 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,441,575 - 15,466,978 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,441,463 - 15,465,692 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,001,282 - 22,028,450 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,001,300 - 22,028,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,310,214 - 22,337,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,761,391 - 65,792,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,761,416 - 65,792,701 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,662,555 - 36,693,082 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Top2a
229 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:86
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000050725
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
PMC207566P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,959,743 - 83,960,392 (+)MAPPERmRatBN7.2
Rnor_6.01086,914,986 - 86,915,634NCBIRnor6.0
Rnor_5.01086,712,635 - 86,713,283UniSTSRnor5.0
RGSC_v3.41087,784,898 - 87,785,546UniSTSRGSC3.4
Celera1082,701,028 - 82,701,676UniSTS
Cytogenetic Map10q31UniSTS
RH128311  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,945,870 - 83,946,082 (+)MAPPERmRatBN7.2
Rnor_6.01086,901,152 - 86,901,363NCBIRnor6.0
Rnor_5.01086,698,962 - 86,699,173UniSTSRnor5.0
RGSC_v3.41087,771,022 - 87,771,233UniSTSRGSC3.4
Celera1082,687,279 - 82,687,490UniSTS
RH 3.4 Map10874.8UniSTS
Cytogenetic Map10q31UniSTS
PMC207566P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,976,767 - 83,976,982 (+)MAPPERmRatBN7.2
Rnor_6.01086,932,021 - 86,932,235NCBIRnor6.0
Rnor_5.01086,729,384 - 86,729,598UniSTSRnor5.0
RGSC_v3.41087,802,034 - 87,802,248UniSTSRGSC3.4
Celera1082,718,050 - 82,718,264UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000081440   ⟹   ENSRNOP00000069083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,945,908 - 83,975,696 (-)Ensembl
Rnor_6.0 Ensembl1086,901,467 - 86,930,947 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085344   ⟹   ENSRNOP00000069963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)Ensembl
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096403   ⟹   ENSRNOP00000091216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,945,735 - 83,976,744 (-)Ensembl
RefSeq Acc Id: NM_001393768   ⟹   NP_001380697
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81084,441,954 - 84,473,093 (-)NCBI
mRatBN7.21083,945,731 - 83,976,874 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001380697 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA03132 (Get FASTA)   NCBI Sequence Viewer  
  CAA79611 (Get FASTA)   NCBI Sequence Viewer  
  EDM05966 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069083.2
  ENSRNOP00000069963.2
  ENSRNOP00000091216.1
GenBank Protein P41516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000069963   ⟸   ENSRNOT00000085344
Ensembl Acc Id: ENSRNOP00000069083   ⟸   ENSRNOT00000081440
Ensembl Acc Id: ENSRNOP00000091216   ⟸   ENSRNOT00000096403
RefSeq Acc Id: NP_001380697   ⟸   NM_001393768
- UniProtKB: A0A0G2JWP8 (UniProtKB/TrEMBL),   A6HIW1 (UniProtKB/TrEMBL),   A0A8I6ADA9 (UniProtKB/TrEMBL)
Protein Domains
Topo IIA-type catalytic   Toprim

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41516-F1-model_v2 AlphaFold P41516 1-1526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697681
Promoter ID:EPDNEW_R8199
Type:multiple initiation site
Name:Top2a_1
Description:DNA topoisomerase II alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,932,115 - 86,932,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62048 AgrOrtholog
BioCyc Gene G2FUF-23330 BioCyc
Ensembl Genes ENSRNOG00000053047 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081440.2 UniProtKB/TrEMBL
  ENSRNOT00000085344.2 UniProtKB/TrEMBL
  ENSRNOT00000096403.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.268.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1360.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.199.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA_Topoisomerase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DTHCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_A/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_A/C_ab UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_A_a_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topo_IIA_bsu_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoII_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoIIA_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_TopoII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 360243 ENTREZGENE
PANTHER DNA TOPOISOMERASE 2-ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA TOPOISOMERASE/GYRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DNA_gyraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_topoisoIV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DTHCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toprim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TOP2A RGD
PhenoGen Top2a PhenoGen
PRINTS TOPISMRASEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPI2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TOPO_IIA UniProtKB/Swiss-Prot
  TOPOISOMERASE_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOPRIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053047 RatGTEx
SMART TOP2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOP4c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JUF8_RAT UniProtKB/TrEMBL
  A0A0G2JWP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADA9 ENTREZGENE, UniProtKB/TrEMBL
  A6HIW1 ENTREZGENE, UniProtKB/TrEMBL
  P41516 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Top2a  DNA topoisomerase II alpha  Top2a  topoisomerase (DNA) II alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-28 Top2a  topoisomerase (DNA) II alpha  Top2a  topoisomerase (DNA) 2 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Top2a  topoisomerase (DNA) 2 alpha      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Top2a  topoisomerase (DNA) 2 alpha      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains conains three functional domains for ATPase activity, DNA break-reunion activity and DNA binding activity, as well as a leucine zipper motif and two putative nuclear targeting sequences 61772
gene_protein putative protein consists of 1526 aa residues 61772