Lasp1 (LIM and SH3 protein 1) - Rat Genome Database

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Gene: Lasp1 (LIM and SH3 protein 1) Rattus norvegicus
Analyze
Symbol: Lasp1
Name: LIM and SH3 protein 1
RGD ID: 68408
Description: Enables monoatomic ion transmembrane transporter activity. Involved in monoatomic ion transport. Located in cortical actin cytoskeleton. Is active in postsynapse. Orthologous to human LASP1 (LIM and SH3 protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LASP-1; LIM and SH3 domain protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,290,820 - 83,331,989 (+)NCBIGRCr8
mRatBN7.21082,795,177 - 82,835,659 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,795,137 - 82,943,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,743,471 - 87,783,948 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,241,560 - 87,282,036 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,634,149 - 82,674,629 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,744,662 - 85,785,130 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,744,568 - 85,785,133 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,533,431 - 85,573,899 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,552,612 - 86,593,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11086,567,067 - 86,605,176 (+)NCBI
Celera1081,549,996 - 81,590,495 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lasp1Rathereditary breast ovarian cancer syndrome  ISOLASP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lasp1Ratautistic disorder  ISOLASP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17376794
Lasp1RatEndometrial Neoplasms  ISOLASP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28232485

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lasp1Rat1,2-dichloroethane increases expressionISOLasp1 (Mus musculus)6480464ethylene dichloride results in increased expression of LASP1 mRNACTDPMID:28960355
Lasp1Rat1,2-dimethylhydrazine affects expressionISOLasp1 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of LASP1 mRNACTDPMID:22206623
Lasp1Rat1,2-dimethylhydrazine multiple interactionsISOLasp1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LASP1 mRNACTDPMID:22206623
Lasp1Rat17alpha-ethynylestradiol multiple interactionsISOLasp1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LASP1 mRNACTDPMID:17942748
Lasp1Rat17beta-estradiol affects expressionISOLASP1 (Homo sapiens)6480464Estradiol affects the expression of LASP1 mRNACTDPMID:22574217
Lasp1Rat17beta-estradiol increases expressionISOLasp1 (Mus musculus)6480464Estradiol results in increased expression of LASP1 mRNACTDPMID:39298647
Lasp1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOLASP1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Lasp1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOLasp1 (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of LASP1 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LASP1 mRNACTDPMID:16214954 and PMID:17942748
Lasp1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of LASP1 mRNACTDPMID:15644576 more ...
Lasp1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOLasp1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of LASP1 mRNACTDPMID:18796159 and PMID:26290441
Lasp1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLasp1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of LASP1 mRNACTDPMID:21570461
Lasp1Rat2,4,6-tribromophenol decreases expressionISOLASP1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Lasp1Rat2,4,6-trinitrotoluene affects expressionEXP 6480464Trinitrotoluene affects the expression of LASP1 mRNACTDPMID:21346803
Lasp1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionEXP 64804642 more ...CTDPMID:19954255
Lasp1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of LASP1 mRNACTDPMID:21346803
Lasp1Rat2,6-dimethoxyphenol multiple interactionsISOLASP1 (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in decreased expression of LASP1 proteinCTDPMID:38598786
Lasp1Rat2-methylcholine affects expressionISOLASP1 (Homo sapiens)6480464beta-methylcholine affects the expression of LASP1 mRNACTDPMID:21179406
Lasp1Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOLASP1 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of LASP1 proteinCTDPMID:31675489
Lasp1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOLASP1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LASP1 mRNACTDPMID:28628672
Lasp1Rat4,4'-sulfonyldiphenol affects expressionISOLasp1 (Mus musculus)6480464bisphenol S affects the expression of LASP1 mRNACTDPMID:39298647

1 to 20 of 141 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lasp1Ratmonoatomic ion transmembrane transport involved_inIEAGO:00150751600115GO_REF:0000108GOCGO_REF:0000108
Lasp1Ratmonoatomic ion transport involved_inIDA 8553950PMID:10806114UniProt 
Lasp1Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lasp1Ratcell cortex located_inIEAUniProtKB-SubCell:SL-01381600115GO_REF:0000044UniProtGO_REF:0000044
Lasp1Ratcortical actin cytoskeleton located_inIDA 8553950PMID:10806114UniProt 
Lasp1Ratcytoplasm located_inISOLASP1 (Homo sapiens)1624291 PMID:25468996RGDPMID:25468996
Lasp1Ratcytoplasm located_inIEAUniProtKB:Q14847 and ensembl:ENSP000003252401600115GO_REF:0000107EnsemblGO_REF:0000107
Lasp1Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Lasp1Ratcytoplasm located_inISOLasp1 (Mus musculus)1624291 PMID:15465019RGDPMID:15465019
Lasp1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Lasp1Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Lasp1Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Lasp1Ratfocal adhesion is_active_inIBAFB:FBgn0063485 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lasp1Ratfocal adhesion located_inISOLasp1 (Mus musculus)1624291 PMID:15465019RGDPMID:15465019
Lasp1Ratpostsynapse is_active_inIDA 155230797PMID:15372503SynGO 
Lasp1Ratpostsynapse is_active_inIEP 155230797PMID:15372503SynGO 
1 to 13 of 13 rows

Molecular Function

  


1 to 9 of 9 rows
#
Reference Title
Reference Citation
1. The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. Chew CS, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2035-45.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines. Phillips GR, etal., J Neurosci Res. 2004 Oct 1;78(1):38-48. doi: 10.1002/jnr.20224.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 9 of 9 rows
PMID:12477932   PMID:15465019   PMID:19726686   PMID:21423176   PMID:22514729   PMID:23376485   PMID:24625528   PMID:25468996   PMID:25931508   PMID:28235806   PMID:29739492   PMID:32997597  
PMID:33144090  



Lasp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,290,820 - 83,331,989 (+)NCBIGRCr8
mRatBN7.21082,795,177 - 82,835,659 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,795,137 - 82,943,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,743,471 - 87,783,948 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,241,560 - 87,282,036 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,634,149 - 82,674,629 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,744,662 - 85,785,130 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,744,568 - 85,785,133 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,533,431 - 85,573,899 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,552,612 - 86,593,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11086,567,067 - 86,605,176 (+)NCBI
Celera1081,549,996 - 81,590,495 (+)NCBICelera
Cytogenetic Map10q31NCBI
LASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381738,870,058 - 38,921,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1738,869,859 - 38,921,770 (+)EnsemblGRCh38hg38GRCh38
GRCh371737,026,311 - 37,078,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,279,894 - 34,331,541 (+)NCBINCBI36Build 36hg18NCBI36
Build 341734,279,893 - 34,331,541NCBI
Celera1733,687,074 - 33,739,007 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1732,821,270 - 32,873,230 (+)NCBIHuRef
CHM1_11737,261,377 - 37,313,322 (+)NCBICHM1_1
T2T-CHM13v2.01739,733,108 - 39,784,846 (+)NCBIT2T-CHM13v2.0
Lasp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391197,689,748 - 97,729,591 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1197,689,826 - 97,729,590 (+)EnsemblGRCm39 Ensembl
GRCm381197,799,005 - 97,838,765 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1197,799,000 - 97,838,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv371197,660,986 - 97,700,078 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361197,615,762 - 97,654,854 (+)NCBIMGSCv36mm8
Celera11107,449,132 - 107,487,995 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.1NCBI
Lasp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,910,889 - 13,932,506 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545113,910,891 - 13,932,506 (+)NCBIChiLan1.0ChiLan1.0
LASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21926,026,693 - 26,078,986 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,910,292 - 27,962,126 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01718,350,002 - 18,401,693 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11718,623,071 - 18,674,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1718,623,071 - 18,674,731 (-)Ensemblpanpan1.1panPan2
LASP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1923,345,226 - 23,397,058 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl923,347,881 - 23,396,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,816,905 - 22,868,891 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0924,139,876 - 24,191,899 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl924,139,879 - 24,180,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,911,898 - 22,963,837 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,172,943 - 23,224,901 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0923,297,911 - 23,350,411 (-)NCBIUU_Cfam_GSD_1.0
Lasp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,779,042 - 22,807,935 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,263,973 - 14,298,951 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,267,185 - 14,296,114 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,222,708 - 23,267,855 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11223,222,706 - 23,267,209 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LASP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11667,268,442 - 67,320,473 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1667,267,940 - 67,320,373 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607738,264,217 - 38,316,231 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lasp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,842,242 - 3,868,217 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,842,244 - 3,868,208 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Lasp1
180 total Variants

Predicted Target Of
Summary Value
Count of predictions:561
Count of miRNA genes:245
Interacting mature miRNAs:319
Transcripts:ENSRNOT00000005522
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 80 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat

1 to 10 of 80 rows
RH133294  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81083,331,621 - 83,331,823 (+)Marker Load Pipeline
mRatBN7.21082,835,291 - 82,835,493 (+)MAPPERmRatBN7.2
Rnor_6.01085,784,763 - 85,784,964NCBIRnor6.0
Rnor_5.01085,573,532 - 85,573,733UniSTSRnor5.0
RGSC_v3.41086,592,963 - 86,593,164UniSTSRGSC3.4
Celera1081,590,130 - 81,590,331UniSTS
RH 3.4 Map10878.09UniSTS
Cytogenetic Map10q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005522   ⟹   ENSRNOP00000005522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,795,137 - 82,943,292 (+)Ensembl
Rnor_6.0 Ensembl1085,744,568 - 85,785,133 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102880   ⟹   ENSRNOP00000078535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,795,237 - 82,835,564 (+)Ensembl
RefSeq Acc Id: NM_032613   ⟹   NP_116002
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,291,518 - 83,331,987 (+)NCBI
mRatBN7.21082,795,177 - 82,835,657 (+)NCBI
Rnor_6.01085,744,662 - 85,785,128 (+)NCBI
Rnor_5.01085,533,431 - 85,573,899 (+)NCBI
RGSC_v3.41086,552,612 - 86,593,328 (+)RGD
Celera1081,549,996 - 81,590,495 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247288   ⟹   XP_006247350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,292,097 - 83,331,989 (+)NCBI
mRatBN7.21082,795,784 - 82,835,659 (+)NCBI
Rnor_6.01085,745,258 - 85,785,130 (+)NCBI
Rnor_5.01085,533,431 - 85,573,899 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268798   ⟹   XP_063124868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,290,820 - 83,331,989 (+)NCBI
RefSeq Acc Id: XM_063268799   ⟹   XP_063124869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,298,972 - 83,331,989 (+)NCBI
RefSeq Acc Id: NP_116002   ⟸   NM_032613
- UniProtKB: Q499R9 (UniProtKB/Swiss-Prot),   Q99MZ8 (UniProtKB/Swiss-Prot),   A6HIN2 (UniProtKB/TrEMBL),   A0A8I6G1X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247350   ⟸   XM_006247288
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G1X8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005522   ⟸   ENSRNOT00000005522
Ensembl Acc Id: ENSRNOP00000078535   ⟸   ENSRNOT00000102880
RefSeq Acc Id: XP_063124868   ⟸   XM_063268798
- Peptide Label: isoform X1
- UniProtKB: Q99MZ8 (UniProtKB/Swiss-Prot),   Q499R9 (UniProtKB/Swiss-Prot),   A6HIN2 (UniProtKB/TrEMBL),   A0A8I6G1X8 (UniProtKB/TrEMBL)
LIM zinc-binding   SH3

Name Modeler Protein Id AA Range Protein Structure
AF-Q99MZ8-F1-model_v2 AlphaFold Q99MZ8 1-263 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697651
Promoter ID:EPDNEW_R8176
Type:initiation region
Name:Lasp1_1
Description:LIM and SH3 protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01085,744,620 - 85,744,680EPDNEW


1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23395 BioCyc
Ensembl Genes ENSRNOG00000004132 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005522 ENTREZGENE
  ENSRNOT00000005522.8 UniProtKB/Swiss-Prot
  ENSRNOT00000120676 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7934892 IMAGE-MGC_LOAD
InterPro Lasp1_SH3 UniProtKB/Swiss-Prot
  LIM-SH3_domain_protein UniProtKB/Swiss-Prot
  Nebulin_repeat UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report rno:29278 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124593 IMAGE-MGC_LOAD
NCBI Gene 29278 ENTREZGENE
PANTHER LASP UniProtKB/Swiss-Prot
  LIM AND SH3 DOMAIN PROTEIN 1 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  Nebulin UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Lasp1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
  NEBULIN UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004132 RatGTEx
SMART LIM UniProtKB/Swiss-Prot
  NEBU UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
TIGR TC216636
UniProt A0A8I6G1X8 ENTREZGENE, UniProtKB/TrEMBL
  A6HIN2 ENTREZGENE, UniProtKB/TrEMBL
  A6HIN4_RAT UniProtKB/TrEMBL
  LASP1_RAT UniProtKB/Swiss-Prot
  Q499R9 ENTREZGENE
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lasp1  LIM and SH3 protein 1      Name updated 70584 APPROVED

Note Type Note Reference