Nherf1 (NHERF family PDZ scaffold protein 1) - Rat Genome Database

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Gene: Nherf1 (NHERF family PDZ scaffold protein 1) Rattus norvegicus
Analyze
Symbol: Nherf1 (Ensembl: Slc9a3r1)
Name: NHERF family PDZ scaffold protein 1 (Ensembl:SLC9A3 regulator 1)
RGD ID: 708538
Description: Enables several functions, including PDZ domain binding activity; myosin II binding activity; and transmembrane transporter binding activity. Contributes to gamma-aminobutyric acid transmembrane transporter activity. Involved in gamma-aminobutyric acid import; import across plasma membrane; and positive regulation of monoatomic ion transmembrane transport. Located in several cellular components, including apical plasma membrane; membrane raft; and microvillus membrane. Part of plasma membrane protein complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1); PARTICIPATES IN eicosanoid signaling pathway; parathyroid hormone signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 14-Deoxy-11,12-didehydroandrographolide (ortholog); 17alpha-ethynylestradiol (ortholog); 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EBP50; ERM-binding phosphoprotein; ezrin-radixin-moesin-binding phosphoprotein 50; LOC59114; na(+)/H(+) exchange regulatory cofactor NHE-RF1; NHERF-1; regulatory cofactor of Na(+)/H(+) exchanger; SLC9A3 regulator 1; Slc9a3r1; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210100,403,189 - 100,420,290 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,403,069 - 100,420,598 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,463,056 - 105,480,181 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010104,926,121 - 104,943,248 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010100,324,177 - 100,341,277 (+)NCBIRnor_WKY
Rnor_6.010103,713,045 - 103,730,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,713,045 - 103,730,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,573,624 - 104,590,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,237,637 - 105,254,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,252,140 - 105,269,254 (+)NCBI
Celera1098,979,637 - 98,995,900 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
auditory receptor cell stereocilium organization  (ISO)
bile acid secretion  (ISO,ISS)
cerebrospinal fluid circulation  (ISO)
cilium organization  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment of Golgi localization  (ISO)
establishment of localization in cell  (ISO)
fibroblast migration  (ISO)
gamma-aminobutyric acid import  (IGI)
gland morphogenesis  (ISO)
glutathione transport  (ISO,ISS)
import across plasma membrane  (IGI)
intracellular phosphate ion homeostasis  (ISO)
maintenance of epithelial cell apical/basal polarity  (ISO)
microvillus assembly  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell motility  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of phosphatidylinositol 3-kinase signaling  (ISO,ISS)
negative regulation of platelet-derived growth factor receptor signaling pathway  (ISO,ISS)
negative regulation of protein kinase B signaling  (ISO,ISS)
negative regulation of sodium ion transport  (ISO)
negative regulation of sodium:proton antiporter activity  (ISO)
nuclear migration  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (ISO)
plasma membrane organization  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of monoatomic ion transmembrane transport  (IDA)
protein localization  (ISO)
protein localization to plasma membrane  (IBA,ISO)
regulation of cell shape  (ISO)
regulation of cell size  (ISO)
regulation of protein kinase activity  (ISO,ISS)
regulation of renal phosphate excretion  (ISO)
renal absorption  (ISO,ISS)
renal phosphate ion absorption  (ISO,ISS)
renal sodium ion transport  (ISO)
sensory perception of sound  (ISO)
sodium ion transport  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. EBP50 is involved in the regulation of vascular smooth muscle cell migration and cytokinesis. Baeyens N, etal., J Cell Biochem. 2011 Sep;112(9):2574-84. doi: 10.1002/jcb.23183.
2. Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium. Bonilha VL and Rodriguez-Boulan E, Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3274-82.
3. Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. Deval E, etal., J Biol Chem. 2006 Jan 20;281(3):1796-807. Epub 2005 Oct 17.
4. Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions. Fouassier L, etal., J Biol Chem 2000 Aug 11;275(32):25039-45.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. Giral H, etal., J Biol Chem. 2012 Oct 12;287(42):35047-56. doi: 10.1074/jbc.M112.392415. Epub 2012 Aug 17.
7. Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats. Kobayashi K, etal., J Hypertens. 2004 Sep;22(9):1723-30.
8. Subcellular redistribution of NHERF1 in response to dehydroepiandrosterone (DHEA) administration in endometrial glands of Wistar rats. Kreimann EL and Cabrini RL, Reprod Sci. 2013 Jan;20(1):103-11. doi: 10.1177/1933719112451148. Epub 2012 Aug 7.
9. Ezrin and EBP50 redistribute apically in rat uterine epithelial cells at the time of implantation and in response to cell contact. Lecce L, etal., Cell Tissue Res. 2011 Feb;343(2):445-53. doi: 10.1007/s00441-010-1088-z. Epub 2010 Dec 1.
10. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. Li M, etal., J Biol Chem. 2010 Jun 18;285(25):19299-307. doi: 10.1074/jbc.M109.096081. Epub 2010 Apr 19.
11. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin. Slattery C, etal., Cell Physiol Biochem. 2011;27(2):171-8. doi: 10.1159/000325219. Epub 2011 Feb 11.
19. Assembly of Taurine Transporter (Slc6a6) with Na+-H+ Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity. Tachikawa M, etal., Biol Pharm Bull. 2018;41(3):338-341. doi: 10.1248/bpb.b17-00664.
20. Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.
21. Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
Additional References at PubMed
PMID:9560162   PMID:12169661   PMID:12586353   PMID:12881487   PMID:12952857   PMID:14996907   PMID:15591354   PMID:15878350   PMID:16160858   PMID:16236806   PMID:16249272   PMID:16456542  
PMID:16641100   PMID:16987995   PMID:17110338   PMID:17242191   PMID:17895247   PMID:18055461   PMID:18190691   PMID:18784102   PMID:19056867   PMID:19188335   PMID:19190083   PMID:19199708  
PMID:19857202   PMID:20012548   PMID:20124415   PMID:20200151   PMID:20458337   PMID:20736378   PMID:20843475   PMID:20926777   PMID:20937695   PMID:21079987   PMID:21832055   PMID:21976599  
PMID:22855531   PMID:22871113   PMID:23376485   PMID:23482569   PMID:23533145   PMID:24862762   PMID:24920589   PMID:25775275   PMID:26173747   PMID:28392297   PMID:28515088   PMID:28669731  


Genomics

Comparative Map Data
Nherf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210100,403,189 - 100,420,290 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,403,069 - 100,420,598 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,463,056 - 105,480,181 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010104,926,121 - 104,943,248 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010100,324,177 - 100,341,277 (+)NCBIRnor_WKY
Rnor_6.010103,713,045 - 103,730,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,713,045 - 103,730,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,573,624 - 104,590,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,237,637 - 105,254,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,252,140 - 105,269,254 (+)NCBI
Celera1098,979,637 - 98,995,900 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
NHERF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381774,748,628 - 74,769,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1774,748,628 - 74,769,353 (+)EnsemblGRCh38hg38GRCh38
GRCh371772,744,767 - 72,765,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,256,373 - 70,277,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 341770,256,378 - 70,277,089NCBI
Celera1769,337,944 - 69,358,679 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,155,124 - 68,175,866 (+)NCBIHuRef
CHM1_11772,809,571 - 72,830,338 (+)NCBICHM1_1
T2T-CHM13v2.01775,640,506 - 75,661,228 (+)NCBIT2T-CHM13v2.0
Nherf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,054,138 - 115,072,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,054,167 - 115,072,007 (+)EnsemblGRCm39 Ensembl
GRCm3811115,163,341 - 115,181,178 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,163,341 - 115,181,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711115,024,655 - 115,042,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611114,979,493 - 115,014,684 (+)NCBIMGSCv36mm8
Celera11126,928,560 - 126,946,416 (+)NCBICelera
Cytogenetic Map11E2NCBI
Slc9a3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,639,267 - 1,656,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555531,639,267 - 1,656,850 (+)NCBIChiLan1.0ChiLan1.0
SLC9A3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11774,250,406 - 74,271,234 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,250,406 - 74,271,234 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01768,694,468 - 68,715,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NHERF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,661,792 - 5,679,783 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,662,464 - 5,679,570 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,341,827 - 6,358,910 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,333,687 - 6,351,685 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,333,688 - 6,351,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,371,237 - 6,388,311 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,481,877 - 6,498,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,542,206 - 6,559,311 (-)NCBIUU_Cfam_GSD_1.0
Slc9a3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,275,339 - 6,292,156 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594119,770 - 136,789 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936594119,808 - 136,620 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHERF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,466,121 - 6,483,548 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,466,138 - 6,483,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,455,107 - 6,472,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A3R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,889,454 - 46,910,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,888,942 - 46,910,842 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,675,824 - 17,696,157 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a3r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,612,849 - 4,630,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248014,612,890 - 4,630,454 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nherf1
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:325
Count of miRNA genes:184
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000004351
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
RH132852  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,401,733 - 100,401,935 (+)MAPPERmRatBN7.2
Rnor_6.010103,711,590 - 103,711,791NCBIRnor6.0
Rnor_5.010104,591,680 - 104,591,881UniSTSRnor5.0
RGSC_v3.410105,236,182 - 105,236,383UniSTSRGSC3.4
Celera1098,978,181 - 98,978,382UniSTS
Cytogenetic Map10q32.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 51 41 19 41 74 35 41 11
Low 35 6 8 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004351   ⟹   ENSRNOP00000004351
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,403,069 - 100,420,598 (+)Ensembl
Rnor_6.0 Ensembl10103,713,045 - 103,730,145 (+)Ensembl
RefSeq Acc Id: NM_021594   ⟹   NP_067605
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210100,403,189 - 100,420,290 (+)NCBI
Rnor_6.010103,713,045 - 103,730,145 (+)NCBI
Rnor_5.010104,573,624 - 104,590,426 (-)NCBI
RGSC_v3.410105,237,637 - 105,254,750 (+)RGD
Celera1098,979,637 - 98,995,900 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067605 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF73258 (Get FASTA)   NCBI Sequence Viewer  
  EDM06563 (Get FASTA)   NCBI Sequence Viewer  
  Q9JJ19 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_067605   ⟸   NM_021594
- UniProtKB: Q9JJ19 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004351   ⟸   ENSRNOT00000004351
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ19-F1-model_v2 AlphaFold Q9JJ19 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708538 AgrOrtholog
BioCyc Gene G2FUF-22697 BioCyc
Ensembl Genes ENSRNOG00000003232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004351 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004351 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
InterPro EBP50_C-term UniProtKB/Swiss-Prot
  NHERF-1 UniProtKB/Swiss-Prot
  NHERF-1/NHERF-2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:59114 UniProtKB/Swiss-Prot
NCBI Gene 59114 ENTREZGENE
PANTHER PTHR14191:SF7 UniProtKB/Swiss-Prot
Pfam EBP50_C UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
PhenoGen Nherf1 PhenoGen
PIRSF EBP50 UniProtKB/Swiss-Prot
PROSITE PDZ UniProtKB/Swiss-Prot
SMART PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
UniProt NHRF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-11-28 Nherf1  NHERF family PDZ scaffold protein 1  Slc9a3r1  SLC9A3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-24 Slc9a3r1  SLC9A3 regulator 1  Slc9a3r1  solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc9a3r1  solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1  Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1  Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1    ERM-binding phosphoprotein  Name updated 1299863 APPROVED
2004-09-10 Slc9a3r1  ERM-binding phosphoprotein  LOC59114    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference