Slc34a2 (solute carrier family 34 member 2)

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Gene: Slc34a2 (solute carrier family 34 member 2) Rattus norvegicus

Analyze

Symbol:

Slc34a2

Name:

solute carrier family 34 member 2

RGD ID:

620889

Description:

Enables protein domain specific binding activity and sodium:phosphate symporter activity. Involved in response to estradiol; response to fructose; and sodium-dependent phosphate transport. Located in apical plasma membrane; brush border membrane; and microvillus membrane. Human ortholog(s) of this gene implicated in pulmonary alveolar microlithiasis. Orthologous to human SLC34A2 (solute carrier family 34 member 2); PARTICIPATES IN phosphate transport pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

na(+)-dependent phosphate cotransporter 2B; na(+)/Pi cotransporter 2B; naPi-2b; rNaPi IIb; sodium-dependent phosphate transport protein 2B; sodium-phosphate transport protein 2B; sodium/phosphate cotransporter 2B; solute carrier family 34 (sodium phosphate), member 2; solute carrier family 34 (type II sodium/phosphate contransporter), member 2; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2; type IIb sodium-phosphate transporter

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	57,910,931 - 57,930,236 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	57,910,480 - 57,930,436 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	62,312,729 - 62,331,995 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	63,631,450 - 63,650,714 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	60,028,211 - 60,047,475 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	60,257,211 - 60,276,516 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	60,256,712 - 60,276,794 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	60,375,980 - 60,395,841 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	62,660,006 - 62,679,311 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	62,661,945 - 62,674,066 (-)	NCBI
Celera	14	57,011,613 - 57,030,915 (-)	NCBI		Celera
Cytogenetic Map	14	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

lung non-small cell carcinoma (ISO)

pulmonary alveolar microlithiasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

all-trans-retinoic acid (EXP,ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

buspirone (EXP)

calcitriol (ISO)

chlorohydrocarbon (EXP)

clofibrate (EXP)

cyclosporin A (EXP)

dextran sulfate (ISO)

dieldrin (EXP)

dimethylarsinic acid (ISO)

dioxygen (ISO)

endosulfan (EXP)

fenofibrate (EXP)

flutamide (EXP)

fonofos (ISO)

formaldehyde (ISO)

fructose (EXP)

fulvestrant (ISO)

furan (EXP)

heptachlor (EXP)

indole-3-methanol (EXP)

iron atom (EXP)

iron(0) (EXP)

leflunomide (EXP)

methotrexate (ISO)

methylarsonic acid (ISO)

methylmercury chloride (EXP)

mirex (EXP)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nevirapine (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

nimesulide (EXP)

nitrofen (EXP)

oxycodone (EXP)

paracetamol (EXP)

paraquat (EXP)

parathion (ISO)

perfluorooctanoic acid (EXP)

phenformin (EXP)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

pravastatin (EXP,ISO)

propiconazole (ISO)

prothioconazole (ISO)

rotenone (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

tacrolimus hydrate (EXP)

tamoxifen (ISO)

terbufos (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichloroethene (ISO)

triclosan (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (EXP)

trovafloxacin (EXP)

tungstate (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

in utero embryonic development (IEA,ISO)

intracellular phosphate ion homeostasis (IBA,IEA,ISO)

phosphate ion transport (ISO)

response to estradiol (IEP)

response to estrogen (IEA,ISO)

response to fructose (IEP)

sodium ion transmembrane transport (IEA)

sodium-dependent phosphate transport (IBA,IEA,IMP)

Cellular Component

apical plasma membrane (IBA,IDA,IEA,ISO)

brush border (IBA,IEA,ISO)

brush border membrane (IDA)

membrane (ISO)

microvillus membrane (IDA)

vesicle (IBA)

Molecular Function

phosphate ion binding (IEA,ISO)

protein binding (ISO)

protein domain specific binding (IPI)

sodium ion binding (IEA,ISO)

sodium:phosphate symporter activity (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phosphate transport pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver.	Frei P, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G771-8. Epub 2004 Nov 24.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli.	Giral H, etal., J Biol Chem. 2012 Oct 12;287(42):35047-56. doi: 10.1074/jbc.M112.392415. Epub 2012 Aug 17.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung.	Hashimoto M, etal., Am J Pathol 2000 Jul;157(1):21-7.
6.	Luminal fructose inhibits rat intestinal sodium-phosphate cotransporter gene expression and phosphate uptake.	Kirchner S, etal., Am J Clin Nutr. 2008 Apr;87(4):1028-38.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	Phosphate handling: new genes, new molecules.	Prie D, etal., Horm Res Paediatr. 2011;76 Suppl 1:71-5. doi: 10.1159/000329175. Epub 2011 Jul 21.
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Role of rat sodium/phosphate cotransporters in the cell membrane transport of arsenate.	Villa-Bellosta R and Sorribas V, Toxicol Appl Pharmacol. 2008 Oct 1;232(1):125-34. Epub 2008 Jun 10.
16.	Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen.	Xu H, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1317-24. Epub 2003 Jul 31.

Additional References at PubMed

PMID:9826740	PMID:10329428	PMID:10610722	PMID:11706048	PMID:12121891	PMID:12488042	PMID:12773415	PMID:15489334	PMID:15970207	PMID:17310099	PMID:17574207	PMID:19190083
PMID:19233126	PMID:19806400	PMID:22235299	PMID:28179233	PMID:33846411

Genomics

Comparative Map Data

Slc34a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	57,910,931 - 57,930,236 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	57,910,480 - 57,930,436 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	62,312,729 - 62,331,995 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	63,631,450 - 63,650,714 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	60,028,211 - 60,047,475 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	60,257,211 - 60,276,516 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	60,256,712 - 60,276,794 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	60,375,980 - 60,395,841 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	62,660,006 - 62,679,311 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	62,661,945 - 62,674,066 (-)	NCBI
Celera	14	57,011,613 - 57,030,915 (-)	NCBI		Celera
Cytogenetic Map	14	q11	NCBI

SLC34A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	25,655,851 - 25,678,748 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	25,648,011 - 25,678,748 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	25,657,473 - 25,680,370 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	25,266,533 - 25,289,468 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	25,333,741 - 25,354,773	NCBI
Celera	4	26,105,505 - 26,128,442 (+)	NCBI		Celera
Cytogenetic Map	4	p15.2	NCBI
HuRef	4	24,995,885 - 25,018,820 (+)	NCBI		HuRef
CHM1_1	4	25,657,246 - 25,680,195 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	25,637,821 - 25,660,720 (+)	NCBI		T2T-CHM13v2.0

Slc34a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	53,206,695 - 53,229,006 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	53,195,423 - 53,229,006 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	53,049,353 - 53,071,664 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	53,038,081 - 53,071,664 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	53,440,592 - 53,462,903 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	53,337,630 - 53,359,912 (+)	NCBI		MGSCv36	mm8
Celera	5	50,429,966 - 50,452,261 (+)	NCBI		Celera
Cytogenetic Map	5	C1	NCBI
cM Map	5	28.92	NCBI

Slc34a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955443	19,452,306 - 19,467,129 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955443	19,452,373 - 19,467,129 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC34A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	26,099,982 - 26,122,815 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	20,056,254 - 20,079,012 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	25,336,538 - 25,359,381 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	25,336,538 - 25,359,381 (+)	Ensembl	panpan1.1		panPan2

SLC34A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	84,686,505 - 84,717,579 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	84,686,425 - 84,742,038 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	87,197,404 - 87,228,556 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	85,655,124 - 85,686,281 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	85,655,645 - 85,714,088 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	84,777,180 - 84,808,314 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	84,897,108 - 84,928,226 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	85,280,888 - 85,312,032 (-)	NCBI		UU_Cfam_GSD_1.0

Slc34a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	50,252,670 - 50,273,639 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	3,956,061 - 3,966,392 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936477	3,954,377 - 3,975,259 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC34A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	19,481,198 - 19,509,666 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	19,481,127 - 19,507,903 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	19,819,341 - 19,847,993 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC34A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	24,674,419 - 24,698,844 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	24,674,584 - 24,690,984 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	71,188,809 - 71,212,116 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc34a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	6,830,056 - 6,842,910 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	6,829,197 - 6,849,898 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc34a2
63 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	181
Count of miRNA genes:	138
Interacting mature miRNAs:	158
Transcripts:	ENSRNOT00000048509
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18541332	63541332	Rat
10755459	Coatc15	Coat color QTL 15		0.01681	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	14	19836944	64836944	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	30883777	68757901	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	37669719	82669719	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	37669719	82669719	Rat
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	37669719	82669719	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	37669719	82669719	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39057237	83368335	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39998251	75582726	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42262529	95023211	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	50023211	95023211	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat

Markers in Region

RH127919

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	57,910,622 - 57,910,810 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	60,256,903 - 60,257,090	NCBI	Rnor6.0
Rnor_5.0	14	60,376,126 - 60,376,313	UniSTS	Rnor5.0
RGSC_v3.4	14	62,659,698 - 62,659,885	UniSTS	RGSC3.4
Celera	14	57,011,305 - 57,011,492	UniSTS
Cytogenetic Map	14	q11	UniSTS

RH133883

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	57,911,020 - 57,911,235 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	60,257,301 - 60,257,515	NCBI	Rnor6.0
Rnor_5.0	14	60,376,524 - 60,376,738	UniSTS	Rnor5.0
RGSC_v3.4	14	62,660,096 - 62,660,310	UniSTS	RGSC3.4
Celera	14	57,011,703 - 57,011,917	UniSTS
Cytogenetic Map	14	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High												1
Medium			18	18		18				17	4	10
Low			25	15	12	15	5	6	1	14	28		5
Below cutoff	3	17	14	8	7	8	3	3	26	2	8		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF157026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF247725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000048509 ⟹ ENSRNOP00000050889

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	57,910,931 - 57,930,436 (-)	Ensembl
Rnor_6.0 Ensembl	14	60,256,712 - 60,276,794 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111481 ⟹ ENSRNOP00000083766

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	57,910,480 - 57,930,244 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117888 ⟹ ENSRNOP00000096758

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	57,910,931 - 57,930,436 (-)	Ensembl

RefSeq Acc Id:

NM_053380 ⟹ NP_445832

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	57,910,931 - 57,930,236 (-)	NCBI
Rnor_6.0	14	60,257,211 - 60,276,516 (-)	NCBI
Rnor_5.0	14	60,375,980 - 60,395,841 (-)	NCBI
RGSC_v3.4	14	62,660,006 - 62,679,311 (-)	RGD
Celera	14	57,011,613 - 57,030,915 (-)	RGD

Sequence:

show sequence

CTGTCCCTTACCTGCGAAGGGAGCGCTGACCATGGCTCCTTGGCCCGAGTTGGAAAATGCCCAC
CCCAACCCCAATAAATTCATCGAAGGGGCCTCAGGTCCACAGTCTAGCATACCAGACAAAGACA
AGGGGACCAGCAAAACAAATGACAGCGGGACTCCTGTAGCCAAGATTGAACTTCTACCCTCATA
TTCCGCCCTGGTTCTCATAGAGGAGCCCCCTGAGGGGAACGACCCCTGGGACCTGCCTGAACTC
CAAGACAATGGGATCAAATGGTCAGAGAGAGACTCCAAAGGGAAGATTCTCTGCATTTTCCAGG
GGATTGGGAAATTCATCCTTCTCCTGGGGTTTCTCTACTTGTTTGTGTGCTCCCTGGATGTACT
CAGTAGTGCCTTCCAGCTTGTTGGAGGAAAAATGGCCGGCCAGTTCTTCAGCAACAACTCCATT
ATGTCTAATCCTGTGGCTGGACTTGTGATAGGGGTGCTGGTGACAGTCATGGTGCAAAGCTCCA
GCACGTCCTCGTCAATCATCGTCAGCATGGTTGCCTCCTCCTTGCTGTCAGTCCGCGCTGCCAT
CCCCATCATCATGGGTGCTAACATCGGGACCTCCATCACCAACACGATTGTGGCACTTATGCAG
GCAGGAGACAGAAATGAGTTCAGAAGGGCATTTGCAGGAGCTACTGTCCATGACTTCTTCAACT
GGCTCTCTGTGTTGGTGCTCTTACCTCTGGAGGCTGCCACCCATTACCTGGAGAAACTGACCAA
CCTTGTGTTGGAAACCTTCAGCTTCCAGAATGGAGAAGATGCCCCAGACATTCTGAAAGTCATA
ACAGACCCCTTCACAAAGCTCATCATCCAGCTGGATAAAAAAGTCATCCAACAAATTGCAATGG
GTGACTCAGAAGCCCAGAACAAGAGCCTGATCAAGATCTGGTGTAAAACTATAAGCAATGTGAT
TGAGGAGAATGTCACTGTCCCCTCGCCTGATAACTGCACCTCTCCTTCATATTGCTGGACTGAT
GGCATACAGACCTGGACCATCCAGAATGTGACCGAGAAGGAGAACATTGCTAAATGCCAGCACA
TCTTCGTGAATTTCAGCCTCCCAGACCTCGCTGTGGGCATCATCCTGCTCACTGTCTCCCTGCT
GATCCTTTGCGGCTGTCTGATCATGATTGTCAAACTGTTGGGTTCTGTGCTCAGGGGACAGGTT
GCCACTGTCATCAAGAAGACCCTTAATACTGATTTCCCCTTTCCCTTTGCCTGGCTGACTGGCT
ACCTGGCCATCCTTGTGGGGGCAGGCATGACCTTCATAGTGCAAAGCAGCTCTGTGTTCACTTC
TGCCATGACGCCACTCATCGGTATTGGGGTGATCAGCATCGAGAGGGCATATCCACTCACGCTG
GGCTCCAACATTGGCACCACCACGACTGCCATTCTGGCTGCCTTGGCCAGCCCAGGCAACACAT
TGAGGAGTTCCCTCCAGATTGCCCTGTGCCATTTTTTCTTCAACATCTCTGGAATATTGCTGTG
GTACCCAATCCCATTCACCCGTCTGCCCATCCGTCTGGCTAAAGGCCTGGGCAACATCTCTGCC
AAGTATCGCTGGTTCGCAGTCTTCTATCTCATCTTCTTCTTCCTCCTGACCCCGCTGACAGTGT
TTGGCCTGTCCCTGGCTGGCTGGCCAGTGCTGGTGGGCGTGGGTGTGCCCATCATTCTGCTGAT
CCTCCTGGTCCTGTGCCTCCGGATGCTGCAGGCCCGCTGCCCTCGCATCCTGCCCCTGAAGCTC
CGGGACTGGAATTTCCTACCCTTGTGGATGCACTCTCTGAAACCCTGGGACAACATCATCTCCC
TGGCCACCTCCTGCTTCCAGAGGCGCTGTTGCTGCTGTTGCCGTGTGTGCTGCCGTGTCTGCTG
CATGGTGTGTGGCTGCAAGTGCTGCCGCTGCAGCAAGTGCTGCAAGAACCTGGAGGAGGAGGAA
AAGGAGCAGGACGTCCCAGTCAAGGCTTCTGGGGGCTTTGACAATACAGCTATGAGCAAAGAAT
GCCAAGATGAGGGCAAGGGCCAAGTGGAAGTTCTGGGCATGAAGGCCCTGTCCAACACTACAGT
GTTCTAGGAGCACCTAGGAGTCAGGGGTGCCTCCCTCCCATAAGACAGAACAGAGATGTAGACT
GTGAACATGGCCCACAGATGACCACATCCACCCATGGCCTATAATGCCTTCAAAGTCCATCCTC
ACCCAAAGACATTAAGAGGGAGGCATTAGGGAAGGTTCTGGAAAGATCCAATGTAAAGAGTATT
TGTAAATATATGTACAAAGCAGTTGTTTCTTGGTATAAAACCTCAGCCACATCTCTCATTTTAT
AAGTCCACTCCTACCCAATAACTTCTCCTACTCACCCCTGCCCCAGAGCAGCCAAGTTCAAACA
CACTGAATGTTTGTAGCCCATAGGTGTGAGCCTTTCTAGCTCACACTGCAGGGCATGTTCTATT
AAGGCATCGTCTGGTATAGTCAGGCCAAGCAGCTGACCACAGTGTCCTCTGAAGTCCGTGGTGC
TCAGCTTCCTAGGATGGAGTGAATGGGGTTCACGACGTGTTTGGCACATTGTTGGTTTTTCTAT
GCCTAGGGCTGGACTAGAATAGGAGACATTGTTGCTACATATTTCTGATGGAACTTGTAAGACC
TGTGTCCCAGGCCTTCTCTCCATTGCTACTGCCTGGGTCATCTGCTGGTGAAGGGTCTGCCTAT
CTTTCTCTTTTGTGCAAGGAGACTTTCCGGGCCAGCTTTTCATGCTCTGTTTCATCCACCCCCT
CACCCTCCTGCTCATGTATTCATTTCAAACCCATCGTCTTACACAGATGAGCTTCCTACCCCTT
CCATGCCTACAAAGTTCCAAGGGATTGCTTAGGAGGGAGGAGATGGGAAATGGCTAAAATGCCC
TTAGAATCAAGATGAAGCCAGTAAGTAGGGTTGGGAGTGTGCATGTGGGAGCCTGTATGGCACA
GGATGCCATAGTCATACGCTGTGCTCATGTGCAGTCCCCATGGTGGCTCTGCAAGCATTCCCAT
CCCATCCCCCTCCCCACAAGAACGGGCCTCAGCTTGACTTGGGTCAGGCTGTGTGGTTCCACGG
CCATCCTCTTCCATCATACTGCATGGGAAGAGGCTGAGGGCCAGCCCGAGCCCCTCTGTAGATA
AACGTTCCCCAAGAGCCATTTATGCGGCATAATTTATAGCCATGCATCTGTACAGAATACTTCA
TAACTTATAGTAAATAGTGACTTGTTTTATAGTGTCTCATTTGGAAATGAGGCAGGGTTCTTTT
ATGTACTGTGAACAGAAAGAACACCTTTGTATATTTTGTAATACTGCCTTTAAACACAACTCTC
GAGGTCATGCTACACCTCCCCCTGTAAATATGTAAGGTACACCCCAGGAAGTGGCTTTGCCCTC
TGTTGATTACTTTTTTTAAAAAAAATGGGATCTTTGAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445832	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF76291	(Get FASTA)	NCBI Sequence Viewer
	AAH70898	(Get FASTA)	NCBI Sequence Viewer
	AAL55704	(Get FASTA)	NCBI Sequence Viewer
	EDL99876	(Get FASTA)	NCBI Sequence Viewer
	EDL99877	(Get FASTA)	NCBI Sequence Viewer
	Q9JJ09	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_445832 ⟸ NM_053380

- UniProtKB:

Q8VI55 (UniProtKB/Swiss-Prot), Q9JJ09 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAPWPELENAHPNPNKFIEGASGPQSSIPDKDKGTSKTNDSGTPVAKIELLPSYSALVLIEEPP
EGNDPWDLPELQDNGIKWSERDSKGKILCIFQGIGKFILLLGFLYLFVCSLDVLSSAFQLVGGK
MAGQFFSNNSIMSNPVAGLVIGVLVTVMVQSSSTSSSIIVSMVASSLLSVRAAIPIIMGANIGT
SITNTIVALMQAGDRNEFRRAFAGATVHDFFNWLSVLVLLPLEAATHYLEKLTNLVLETFSFQN
GEDAPDILKVITDPFTKLIIQLDKKVIQQIAMGDSEAQNKSLIKIWCKTISNVIEENVTVPSPD
NCTSPSYCWTDGIQTWTIQNVTEKENIAKCQHIFVNFSLPDLAVGIILLTVSLLILCGCLIMIV
KLLGSVLRGQVATVIKKTLNTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGV
ISIERAYPLTLGSNIGTTTTAILAALASPGNTLRSSLQIALCHFFFNISGILLWYPIPFTRLPI
RLAKGLGNISAKYRWFAVFYLIFFFLLTPLTVFGLSLAGWPVLVGVGVPIILLILLVLCLRMLQ
ARCPRILPLKLRDWNFLPLWMHSLKPWDNIISLATSCFQRRCCCCCRVCCRVCCMVCGCKCCRC
SKCCKNLEEEEKEQDVPVKASGGFDNTAMSKECQDEGKGQVEVLGMKALSNTTVF

hide sequence

RefSeq Acc Id:

ENSRNOP00000050889 ⟸ ENSRNOT00000048509

RefSeq Acc Id:

ENSRNOP00000083766 ⟸ ENSRNOT00000111481

RefSeq Acc Id:

ENSRNOP00000096758 ⟸ ENSRNOT00000117888

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JJ09-F1-model_v2	AlphaFold	Q9JJ09	1-695	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620889	AgrOrtholog
BioCyc Gene	G2FUF-15607	BioCyc
Ensembl Genes	ENSRNOG00000004626	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000050889.2	UniProtKB/TrEMBL
	ENSRNOP00000083766	ENTREZGENE
	ENSRNOP00000083766.1	UniProtKB/TrEMBL
	ENSRNOP00000096758.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000048509.3	UniProtKB/TrEMBL
	ENSRNOT00000111481	ENTREZGENE
	ENSRNOT00000111481.1	UniProtKB/TrEMBL
	ENSRNOT00000117888.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099656	IMAGE-MGC_LOAD
InterPro	Na/Pi_transpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:84395	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:91585	IMAGE-MGC_LOAD
NCBI Gene	84395	ENTREZGENE
PANTHER	PTHR10010	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10010:SF23	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Na_Pi_cotrans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc34a2	PhenoGen
TIGRFAMs	2a58	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UHZ0_RAT	UniProtKB/TrEMBL
	A0A8I5ZXN1_RAT	UniProtKB/TrEMBL
	A0A8I6AQW9_RAT	UniProtKB/TrEMBL
	NPT2B_RAT	UniProtKB/Swiss-Prot
	Q8VI55	ENTREZGENE
	Q9JJ09	ENTREZGENE
UniProt Secondary	Q8VI55	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc34a2	solute carrier family 34 member 2	Slc34a2	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-11-26	Slc34a2	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2	Slc34a2	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	Name changed	629549	APPROVED
2013-08-02	Slc34a2	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	Slc34a2	solute carrier family 34 (sodium phosphate), member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Slc34a2	solute carrier family 34 (sodium phosphate), member 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Slc34a2	solute carrier family 34 (sodium phosphate), member 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in type II alveolar cells of the developing lung	634065

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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