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Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats. |
Alcalde AI, etal., Endocrinology. 1999 Apr;140(4):1544-51.
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2. |
The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. |
Bacic D, etal., Kidney Int. 2006 Feb;69(3):495-503.
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3. |
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. |
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4. |
Differential Regulation of the Renal Sodium/Phosphate Co-Transporters NaPi-IIa, NaPi-IIc and PiT-2 in Dietary Potassium Deficiency. |
Breusegem SY, etal., Am J Physiol Renal Physiol. 2009 Jun 3.
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Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene Npt2. |
Chau H, etal., J Bone Miner Res. 2003 Apr;18(4):644-57.
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Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. |
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Elhalel MD, etal., Pflugers Arch. 2004 Dec;449(3):265-70.
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8. |
Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. |
Faroqui S, etal., Kidney Int. 2008 May;73(10):1141-50. doi: 10.1038/ki.2008.33. Epub 2008 Feb 27.
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9. |
Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters. |
Forster IC, etal., Am J Physiol. 1999 Apr;276(4):F644-9. doi: 10.1152/ajprenal.1999.276.4.F644.
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10. |
Protein kinase C activators induce membrane retrieval of type II Na+-phosphate cotransporters expressed in Xenopus oocytes. |
Forster IC, etal., J Physiol. 1999 Jun 1;517 ( Pt 2):327-40.
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11. |
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. |
Gattineni J, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F282-91. doi: 10.1152/ajprenal.90742.2008. Epub 2009 Jun 10.
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12. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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13. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
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14. |
Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex. |
Hioki H, etal., Neuroscience 2003;117(1):1-6.
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15. |
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. |
Hu MC, etal., FASEB J. 2010 Sep;24(9):3438-50. doi: 10.1096/fj.10-154765. Epub 2010 May 13.
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16. |
Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity. |
Inoue M, etal., J Biol Chem. 2004 Nov 19;279(47):49160-71. Epub 2004 Sep 7.
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17. |
A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. |
Iwaki T, etal., J Am Soc Nephrol. 2008 Sep;19(9):1753-62. doi: 10.1681/ASN.2007121360. Epub 2008 Jun 11.
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18. |
Type 2a sodium-phosphate co-transporter serves as a histological predictor of renal dysfunction and tubular apical damage in the kidneys of septic mice. |
Kamimoto M, etal., Biomed Res. 2009 Aug;30(4):251-8.
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19. |
Effects of receptor-mediated endocytosis and tubular protein composition on volume retention in experimental glomerulonephritis. |
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20. |
Acute regulation by dietary phosphate of the sodium-dependent phosphate transporter (NaP(i)-2) in rat kidney. |
Katai K, etal., J Biochem. 1997 Jan;121(1):50-5. doi: 10.1093/oxfordjournals.jbchem.a021569.
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21. |
Akt2/PKBbeta-sensitive regulation of renal phosphate transport. |
Kempe DS, etal., Acta Physiol (Oxf). 2010 Sep;200(1):75-85. doi: 10.1111/j.1748-1716.2010.02109.x. Epub 2010 Mar 17.
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22. |
Ultrastructural investigation of crystal deposits in Npt2a knockout mice: are they similar to human Randall's plaques? |
Khan SR and Canales BK, J Urol. 2011 Sep;186(3):1107-13. doi: 10.1016/j.juro.2011.04.109. Epub 2011 Jul 23.
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Calcium oxalate crystal deposition in kidneys of hypercalciuric mice with disrupted type IIa sodium-phosphate cotransporter. |
Khan SR and Glenton PA, Am J Physiol Renal Physiol. 2008 May;294(5):F1109-15. doi: 10.1152/ajprenal.00620.2007. Epub 2008 Mar 12.
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24. |
Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter. |
Kohler K, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F687-96.
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25. |
Essential cysteine residues of the type IIa Na+/Pi cotransporter. |
Kohler K, etal., Pflugers Arch. 2003 May;446(2):203-10. Epub 2003 Mar 26.
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26. |
New loci associated with kidney function and chronic kidney disease. |
Kottgen A, etal., Nat Genet. 2010 May;42(5):376-84. doi: 10.1038/ng.568. Epub 2010 Apr 11.
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27. |
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
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28. |
Cysteine residues and the structure of the rat renal proximal tubular type II sodium phosphate cotransporter (rat NaPi IIa). |
Lambert G, etal., J Membr Biol. 2000 Jul 15;176(2):133-41.
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29. |
Cleavage of disulfide bonds leads to inactivation and degradation of the type IIa, but not type IIb sodium phosphate cotransporter expressed in Xenopus laevis oocytes. |
Lambert G, etal., J Membr Biol. 2000 Jul 15;176(2):143-9.
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30. |
Studies on the topology of the renal type II NaPi-cotransporter. |
Lambert G, etal., Pflugers Arch. 1999 May;437(6):972-8.
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31. |
Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. |
Lorenz-Depiereux B, etal., Am J Hum Genet. 2006 Feb;78(2):193-201. Epub 2005 Dec 9.
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32. |
Rapid downregulation of rat renal Na/P(i) cotransporter in response to parathyroid hormone involves microtubule rearrangement. |
Lotscher M, etal., J Clin Invest. 1999 Aug;104(4):483-94.
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Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate. |
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34. |
Phosphate and calcium uptake by rat odontoblast-like MRPC-1 cells concomitant with mineralization. |
Lundquist P, etal., J Bone Miner Res. 2002 Oct;17(10):1801-13.
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Regulation of rat renal Na/Pi-cotransporter by parathyroid hormone: immunohistochemistry. |
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36. |
Expression cloning of human and rat renal cortex Na/Pi cotransport. |
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A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome. |
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Matrix extracellular phosphoglycoprotein inhibits phosphate transport. |
Marks J, etal., J Am Soc Nephrol. 2008 Dec;19(12):2313-20. doi: 10.1681/ASN.2008030315. Epub 2008 Nov 12.
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Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors. |
Masuda M, etal., Biochem J. 2010 Aug 1;429(3):583-92. doi: 10.1042/BJ20100484.
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Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells. |
McWilliams RR, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C1042-51. Epub 2005 May 25.
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41. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
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42. |
The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. |
Moe SM, etal., J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485.
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Thyroid hormone deficiency alters expression of acid-base transporters in rat kidney. |
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The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. |
Mohebbi N, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F499-509. doi: 10.1152/ajprenal.90489.2008. Epub 2009 May 13.
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Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells. |
Muller D, etal., Toxicol Appl Pharmacol. 2006 Jul 15;214(2):166-77. Epub 2006 Feb 14.
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46. |
Overexpression of regucalcin enhances its nuclear localization and suppresses L-type Ca2+ channel and calcium-sensing receptor mRNA expressions in cloned normal rat kidney proximal tubular epithelial NRK52E cells. |
Nakagawa T and Yamaguchi M, J Cell Biochem. 2006 Nov 1;99(4):1064-77.
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In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. |
Nakatani T, etal., FASEB J. 2009 Feb;23(2):433-41. doi: 10.1096/fj.08-114397. Epub 2008 Oct 3.
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48. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
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49. |
Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption. |
Nowik M, etal., Pflugers Arch. 2008 Nov;457(2):539-49. doi: 10.1007/s00424-008-0530-5. Epub 2008 Jun 6.
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Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. |
Ohnishi M and Razzaque MS, FASEB J. 2010 Sep;24(9):3562-71. doi: 10.1096/fj.09-152488. Epub 2010 Apr 23.
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51. |
OMIM Disease Annotation Pipeline |
OMIM Disease Annotation Pipeline
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Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters. |
Picard N, etal., Pflugers Arch. 2010 Aug;460(3):677-87. doi: 10.1007/s00424-010-0841-1. Epub 2010 Jun 5.
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Phosphate handling: new genes, new molecules. |
Prie D, etal., Horm Res Paediatr. 2011;76 Suppl 1:71-5. doi: 10.1159/000329175. Epub 2011 Jul 21.
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P-glycoprotein inhibitors stimulate renal phosphate reabsorption in rats. |
Prie D, etal., Kidney Int. 2001 Sep;60(3):1069-76.
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55. |
GOA pipeline |
RGD automated data pipeline
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56. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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57. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
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58. |
Effects of phosphate intake on distribution of type II Na/Pi cotransporter mRNA in rat kidney. |
Ritthaler T, etal., Kidney Int. 1999 Mar;55(3):976-83.
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Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. |
Segawa H, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F671-8. doi: 10.1152/ajprenal.00156.2009. Epub 2009 Jul 1.
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Growth-related renal type II Na/Pi cotransporter. |
Segawa H, etal., J Biol Chem 2002 May 31;277(22):19665-72. Epub 2002 Mar 5.
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Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2). |
Sorribas V, etal., Kidney Int. 2001 Mar;59(3):1024-36.
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats. |
Takahashi F, etal., Biochem J. 1998 Jul 1;333 ( Pt 1):175-81.
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Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. |
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Identification of three isoforms for the Na+-dependent phosphate cotransporter (NaPi-2) in rat kidney. |
Tatsumi S, etal., J Biol Chem 1998 Oct 30;273(44):28568-75.
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Tentative Sequence Identification Numbers |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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Magnesium stimulates renal phosphate reabsorption. |
Thumfart J, etal., Am J Physiol Renal Physiol. 2008 Oct;295(4):F1126-33. Epub 2008 Aug 13.
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Distribution of the sodium/phosphate transporter during postnatal ontogeny of the rat kidney. |
Traebert M, etal., J Am Soc Nephrol. 1999 Jul;10(7):1407-15.
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A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. |
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Arsenate transport by sodium/phosphate cotransporter type IIb. |
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Altered expression of type II sodium/phosphate cotransporter in polycystic kidney disease. |
Vogel M, etal., J Am Soc Nephrol. 2000 Oct;11(10):1926-32.
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Regulation of renal NaPi-2 expression and tubular phosphate reabsorption by growth hormone in the juvenile rat. |
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Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. |
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Involvement of disulphide bonds in the renal sodium/phosphate co-transporter NaPi-2. |
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