Slc34a1 (solute carrier family 34 member 1) - Rat Genome Database

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Gene: Slc34a1 (solute carrier family 34 member 1) Rattus norvegicus
Analyze
Symbol: Slc34a1
Name: solute carrier family 34 member 1
RGD ID: 3708
Description: Enables PDZ domain binding activity and identical protein binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; ion transmembrane transport; and regulation of phosphate transport. Located in several cellular components, including apical plasma membrane; brush border membrane; and membrane raft. Is intrinsic component of plasma membrane. Biomarker of autosomal dominant polycystic kidney disease; chronic kidney disease (multiple); hyperthyroidism; hypophosphatemia; and hypothyroidism. Human ortholog(s) of this gene implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. Orthologous to human SLC34A1 (solute carrier family 34 member 1); PARTICIPATES IN phosphate transport pathway; INTERACTS WITH ammonium chloride; bisphenol A; buspirone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: na(+)-dependent phosphate cotransporter 2A; na(+)/Pi cotransporter 2A; NaPi-2; naPi-2a; NAPI2A; Npt2; Slc17a2; sodium-dependent phosphate transport protein 2A; sodium-phosphate co-transporter type II; sodium-phosphate transport protein 2A; sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium/hydrogen exchanger) member 2; solute carrier family 34 (sodium phosphate) member 1; Solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1; solute carrier family 34, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Slc34a1em1Mcwi  
Genetic Models: SS-Slc34a1em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,218,876 - 9,233,852 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl179,218,876 - 9,233,852 (-)Ensembl
Rnor_6.0179,747,766 - 9,762,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,747,752 - 9,762,813 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,856,946 - 11,872,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,262,929 - 15,277,902 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11715,262,928 - 15,277,902 (-)NCBI
Celera179,297,383 - 9,312,355 (-)NCBICelera
RH 3.4 Map1781.4RGD
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alcalde AI, etal., Endocrinology. 1999 Apr;140(4):1544-51.
2. Bacic D, etal., Kidney Int. 2006 Feb;69(3):495-503.
3. Beck L, etal., Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5372-7.
4. Breusegem SY, etal., Am J Physiol Renal Physiol. 2009 Jun 3.
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6. Dermaku-Sopjani M, etal., Cell Physiol Biochem. 2011;28(2):251-8. doi: 10.1159/000331737. Epub 2011 Aug 16.
7. Elhalel MD, etal., Pflugers Arch. 2004 Dec;449(3):265-70.
8. Faroqui S, etal., Kidney Int. 2008 May;73(10):1141-50. doi: 10.1038/ki.2008.33. Epub 2008 Feb 27.
9. Forster IC, etal., Am J Physiol. 1999 Apr;276(4):F644-9. doi: 10.1152/ajprenal.1999.276.4.F644.
10. Forster IC, etal., J Physiol. 1999 Jun 1;517 ( Pt 2):327-40.
11. Gattineni J, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F282-91. doi: 10.1152/ajprenal.90742.2008. Epub 2009 Jun 10.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. GOA data from the GO Consortium
14. Hioki H, etal., Neuroscience 2003;117(1):1-6.
15. Hu MC, etal., FASEB J. 2010 Sep;24(9):3438-50. doi: 10.1096/fj.10-154765. Epub 2010 May 13.
16. Inoue M, etal., J Biol Chem. 2004 Nov 19;279(47):49160-71. Epub 2004 Sep 7.
17. Iwaki T, etal., J Am Soc Nephrol. 2008 Sep;19(9):1753-62. doi: 10.1681/ASN.2007121360. Epub 2008 Jun 11.
18. Kamimoto M, etal., Biomed Res. 2009 Aug;30(4):251-8.
19. Kastner C, etal., Am J Physiol Renal Physiol. 2009 Apr;296(4):F902-11. doi: 10.1152/ajprenal.90451.2008. Epub 2009 Feb 4.
20. Katai K, etal., J Biochem. 1997 Jan;121(1):50-5. doi: 10.1093/oxfordjournals.jbchem.a021569.
21. Kempe DS, etal., Acta Physiol (Oxf). 2010 Sep;200(1):75-85. doi: 10.1111/j.1748-1716.2010.02109.x. Epub 2010 Mar 17.
22. Khan SR and Canales BK, J Urol. 2011 Sep;186(3):1107-13. doi: 10.1016/j.juro.2011.04.109. Epub 2011 Jul 23.
23. Khan SR and Glenton PA, Am J Physiol Renal Physiol. 2008 May;294(5):F1109-15. doi: 10.1152/ajprenal.00620.2007. Epub 2008 Mar 12.
24. Kohler K, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F687-96.
25. Kohler K, etal., Pflugers Arch. 2003 May;446(2):203-10. Epub 2003 Mar 26.
26. Kottgen A, etal., Nat Genet. 2010 May;42(5):376-84. doi: 10.1038/ng.568. Epub 2010 Apr 11.
27. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. Lambert G, etal., J Membr Biol. 2000 Jul 15;176(2):133-41.
29. Lambert G, etal., J Membr Biol. 2000 Jul 15;176(2):143-9.
30. Lambert G, etal., Pflugers Arch. 1999 May;437(6):972-8.
31. Lorenz-Depiereux B, etal., Am J Hum Genet. 2006 Feb;78(2):193-201. Epub 2005 Dec 9.
32. Lotscher M, etal., J Clin Invest. 1999 Aug;104(4):483-94.
33. Lundquist P, etal., Cell Physiol Biochem. 2007;19(1-4):43-56.
34. Lundquist P, etal., J Bone Miner Res. 2002 Oct;17(10):1801-13.
35. Lötscher M, etal., Kidney Int. 1996 Apr;49(4):1010-1. doi: 10.1038/ki.1996.145.
36. Magagnin S, etal., Proc Natl Acad Sci U S A 1993 Jul 1;90(13):5979-83.
37. Magen D, etal., N Engl J Med. 2010 Mar 25;362(12):1102-9. doi: 10.1056/NEJMoa0905647.
38. Marks J, etal., J Am Soc Nephrol. 2008 Dec;19(12):2313-20. doi: 10.1681/ASN.2008030315. Epub 2008 Nov 12.
39. Masuda M, etal., Biochem J. 2010 Aug 1;429(3):583-92. doi: 10.1042/BJ20100484.
40. McWilliams RR, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C1042-51. Epub 2005 May 25.
41. MGD data from the GO Consortium
42. Moe SM, etal., J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485.
43. Mohebbi N, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F416-27. Epub 2007 Apr 4.
44. Mohebbi N, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F499-509. doi: 10.1152/ajprenal.90489.2008. Epub 2009 May 13.
45. Muller D, etal., Toxicol Appl Pharmacol. 2006 Jul 15;214(2):166-77. Epub 2006 Feb 14.
46. Nakagawa T and Yamaguchi M, J Cell Biochem. 2006 Nov 1;99(4):1064-77.
47. Nakatani T, etal., FASEB J. 2009 Feb;23(2):433-41. doi: 10.1096/fj.08-114397. Epub 2008 Oct 3.
48. NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. Nowik M, etal., Pflugers Arch. 2008 Nov;457(2):539-49. doi: 10.1007/s00424-008-0530-5. Epub 2008 Jun 6.
50. Ohnishi M and Razzaque MS, FASEB J. 2010 Sep;24(9):3562-71. doi: 10.1096/fj.09-152488. Epub 2010 Apr 23.
51. OMIM Disease Annotation Pipeline
52. Picard N, etal., Pflugers Arch. 2010 Aug;460(3):677-87. doi: 10.1007/s00424-010-0841-1. Epub 2010 Jun 5.
53. Prie D, etal., Horm Res Paediatr. 2011;76 Suppl 1:71-5. doi: 10.1159/000329175. Epub 2011 Jul 21.
54. Prie D, etal., Kidney Int. 2001 Sep;60(3):1069-76.
55. RGD automated data pipeline
56. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
57. RGD automated import pipeline for gene-chemical interactions
58. Ritthaler T, etal., Kidney Int. 1999 Mar;55(3):976-83.
59. Rubinger D, etal., Nephron Physiol. 2005;100(1):p1-12. Epub 2005 Mar 17.
60. Segawa H, etal., Am J Physiol Renal Physiol. 2007 Jan;292(1):F395-403. Epub 2006 Sep 19.
61. Segawa H, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F671-8. doi: 10.1152/ajprenal.00156.2009. Epub 2009 Jul 1.
62. Segawa H, etal., J Biol Chem 2002 May 31;277(22):19665-72. Epub 2002 Mar 5.
63. Sorribas V, etal., Kidney Int. 2001 Mar;59(3):1024-36.
64. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
65. Takahashi F, etal., Biochem J. 1998 Jul 1;333 ( Pt 1):175-81.
66. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
67. Tatsumi S, etal., J Biol Chem 1998 Oct 30;273(44):28568-75.
68. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
69. Thumfart J, etal., Am J Physiol Renal Physiol. 2008 Oct;295(4):F1126-33. Epub 2008 Aug 13.
70. Traebert M, etal., J Am Soc Nephrol. 1999 Jul;10(7):1407-15.
71. Urabe Y, etal., PLoS Genet. 2012;8(3):e1002541. doi: 10.1371/journal.pgen.1002541. Epub 2012 Mar 1.
72. Villa-Bellosta R and Sorribas V, Toxicol Appl Pharmacol. 2010 Aug 15;247(1):36-40. doi: 10.1016/j.taap.2010.05.012. Epub 2010 May 25.
73. Vogel M, etal., J Am Soc Nephrol. 2000 Oct;11(10):1926-32.
74. Woda CB, etal., Am J Physiol Renal Physiol. 2004 Jul;287(1):F117-23. Epub 2004 Mar 2.
75. Xiao L, etal., J Biol Chem. 2010 Jan 22;285(4):2834-46. doi: 10.1074/jbc.M109.030577. Epub 2009 Nov 20.
76. Xiao Y, etal., Biochem J. 1997 Apr 15;323 ( Pt 2):401-8.
77. Xu L, etal., Biochim Biophys Acta. 2004 Dec 15;1667(2):114-21.
78. Zeng M, etal., Ren Fail. 2012;34(3):358-63. doi: 10.3109/0886022X.2011.647341. Epub 2012 Jan 20.
Additional References at PubMed
PMID:8898024   PMID:9465116   PMID:9530108   PMID:12606316   PMID:12851820   PMID:15489334   PMID:15618618   PMID:16710700   PMID:17206517   PMID:17574207   PMID:20119884   PMID:20810910  
PMID:23344572   PMID:23509734   PMID:23816829   PMID:23863468   PMID:24500689   PMID:25608964   PMID:26047794   PMID:26460967   PMID:26782594   PMID:30696771   PMID:32853180  


Genomics

Comparative Map Data
Slc34a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,218,876 - 9,233,852 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl179,218,876 - 9,233,852 (-)Ensembl
Rnor_6.0179,747,766 - 9,762,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,747,752 - 9,762,813 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,856,946 - 11,872,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,262,929 - 15,277,902 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11715,262,928 - 15,277,902 (-)NCBI
Celera179,297,383 - 9,312,355 (-)NCBICelera
RH 3.4 Map1781.4RGD
Cytogenetic Map17p14NCBI
SLC34A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,384,434 - 177,412,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5177,379,235 - 177,398,848 (+)EnsemblGRCh38hg38GRCh38
GRCh375176,811,435 - 176,825,849 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,744,041 - 176,758,455 (+)NCBINCBI36hg18NCBI36
Build 345176,744,060 - 176,758,454NCBI
Celera5171,675,605 - 171,689,835 (-)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5171,732,061 - 171,746,276 (+)NCBIHuRef
CHM1_15176,244,481 - 176,258,897 (+)NCBICHM1_1
Slc34a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,547,435 - 55,562,508 (+)NCBIGRCm39mm39
GRCm39 Ensembl1355,546,000 - 55,563,405 (+)Ensembl
GRCm381355,399,622 - 55,414,695 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,398,187 - 55,415,592 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,501,009 - 55,516,056 (+)NCBIGRCm37mm9NCBIm37
MGSCv361355,409,326 - 55,423,713 (+)NCBImm8
Celera1356,453,307 - 56,468,818 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.81NCBI
Slc34a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,626,775 - 29,640,875 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,626,775 - 29,640,811 (+)NCBIChiLan1.0ChiLan1.0
SLC34A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15179,748,492 - 179,762,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,748,492 - 179,762,975 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05172,685,862 - 172,700,440 (+)NCBIMhudiblu_PPA_v0panPan3
SLC34A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,961,394 - 35,973,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,961,958 - 35,973,657 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,928,819 - 35,941,165 (-)NCBI
ROS_Cfam_1.0436,327,621 - 36,339,965 (-)NCBI
ROS_Cfam_1.0 Ensembl436,328,185 - 36,339,882 (-)Ensembl
UMICH_Zoey_3.1436,152,845 - 36,165,191 (-)NCBI
UNSW_CanFamBas_1.0436,339,065 - 36,351,380 (-)NCBI
UU_Cfam_GSD_1.0436,848,297 - 36,860,641 (-)NCBI
Slc34a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,642,609 - 122,659,626 (+)NCBI
SpeTri2.0NW_0049365971,667,700 - 1,684,533 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC34A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,548,232 - 80,563,321 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,548,208 - 80,563,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC34A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,395,923 - 79,410,835 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,396,250 - 79,411,695 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607510,585,375 - 10,600,418 (+)NCBIVero_WHO_p1.0
Slc34a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473312,685,544 - 12,699,908 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Slc34a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,218,991 - 9,219,155 (+)MAPPERmRatBN7.2
Rnor_6.0179,747,882 - 9,748,045NCBIRnor6.0
Rnor_5.01711,857,062 - 11,857,225UniSTSRnor5.0
RGSC_v3.41715,263,045 - 15,263,208UniSTSRGSC3.4
Celera179,297,499 - 9,297,662UniSTS
RH 3.4 Map1781.4UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat


Genetic Models
This gene Slc34a1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000033749
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 13
Medium 16 1
Low 1 14 4 11 4 3 3 5 2 8 7 3
Below cutoff 1 17 12 6 7 6 5 5 52 4 22 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033749   ⟹   ENSRNOP00000031764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,218,876 - 9,233,852 (-)Ensembl
Rnor_6.0 Ensembl179,747,752 - 9,762,813 (-)Ensembl
RefSeq Acc Id: NM_013030   ⟹   NP_037162
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,218,876 - 9,233,852 (-)NCBI
Rnor_6.0179,747,766 - 9,762,739 (-)NCBI
Rnor_5.01711,856,946 - 11,872,100 (-)NCBI
RGSC_v3.41715,262,929 - 15,277,902 (-)RGD
Celera179,297,383 - 9,312,355 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037162   ⟸   NM_013030
- UniProtKB: Q06496 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031764   ⟸   ENSRNOT00000033749

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06496-F1-model_v2 AlphaFold Q06496 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700308
Promoter ID:EPDNEW_R10831
Type:single initiation site
Name:Slc34a1_1
Description:solute carrier family 34 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,762,750 - 9,762,810EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3708 AgrOrtholog
BioCyc Gene G2FUF-10202 BioCyc
Ensembl Genes ENSRNOG00000015262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000031764 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033749 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109613 IMAGE-MGC_LOAD
InterPro Na/Pi_transpt UniProtKB/Swiss-Prot
  Na/Pi_transpt_2A UniProtKB/Swiss-Prot
KEGG Report rno:25548 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93556 IMAGE-MGC_LOAD
NCBI Gene 25548 ENTREZGENE
PANTHER PTHR10010 UniProtKB/Swiss-Prot
  PTHR10010:SF21 UniProtKB/Swiss-Prot
Pfam Na_Pi_cotrans UniProtKB/Swiss-Prot
PhenoGen Slc34a1 PhenoGen
TIGR TC204997
TIGRFAMs 2a58 UniProtKB/Swiss-Prot
UniProt NPT2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-26 Slc34a1  solute carrier family 34 (type II sodium/phosphate cotransporter), member 1  Slc34a1  solute carrier family 34 (type II sodium/phosphate contransporter), member 1  Name changed 629549 APPROVED
2004-09-10 Slc34a1  solute carrier family 34 (sodium phosphate), member 1    solute carrier family 34, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc34a1  solute carrier family 34, member 1    Solute carrier family 34 (sodium phosphate), member 1  Name updated 629478 APPROVED
2001-06-22 Slc34a1  Solute carrier family 34 (sodium phosphate), member 1      Name updated 67952 APPROVED
2001-06-22 Slc17a2  Solute carrier family 17 (sodium/hydrogen exchanger), member 2      Symbol withdrawn, duplicate of Slc34a1 (RGD:3708) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains 3 putative transmembrane domains 730045
gene_expression mRNA expressed in kidney 730120
gene_process may be involved with sodium/phosphate cotransport in the renal brush border 730120
gene_protein predicted protein contains 337 aa residues and masses 36 kDa 730045