Nherf1 (NHERF family PDZ scaffold protein 1) - Rat Genome Database

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Gene: Nherf1 (NHERF family PDZ scaffold protein 1) Mus musculus
Analyze
Symbol: Nherf1
Name: NHERF family PDZ scaffold protein 1
RGD ID: 732281
MGI Page MGI
Description: Enables dopamine receptor binding activity and phosphatase binding activity. Involved in several processes, including bile acid secretion; maintenance of epithelial cell apical/basal polarity; and negative regulation of signal transduction. Acts upstream of or within several processes, including G protein-coupled dopamine receptor signaling pathway; auditory receptor cell stereocilium organization; and cerebrospinal fluid circulation. Located in several cellular components, including brush border membrane; sperm midpiece; and stereocilium tip. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; pleura; and sensory organ. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EBP-5; EBP-50; EBP50; ezrin-radixin-moesin-binding phosphoprotein 50; MGC95776; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; NHE-; NHE-RF; NHER; NHERF-1; regulatory cofactor of Na(+)/H(+) exchanger; Slc9a3r1; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; solute carrier family 9 isoform A3 regulatory factor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,054,138 - 115,072,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,054,167 - 115,072,007 (+)EnsemblGRCm39 Ensembl
GRCm3811115,163,341 - 115,181,178 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,163,341 - 115,181,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711115,024,655 - 115,042,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611114,979,493 - 115,014,684 (+)NCBIMGSCv36mm8
Celera11126,928,560 - 126,946,416 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dibromoethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dioxane  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetonitrile  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromobenzene  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
etoposide  (EXP)
flavonoids  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
folpet  (EXP)
FR900359  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycidol  (EXP)
hydrogen peroxide  (ISO)
inulin  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
trovafloxacin  (EXP)
urethane  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IMP)
adenylate cyclase-activating dopamine receptor signaling pathway  (IMP)
auditory receptor cell stereocilium organization  (IMP)
bile acid secretion  (IMP)
cerebrospinal fluid circulation  (IDA,IMP)
cilium organization  (IMP)
establishment of epithelial cell apical/basal polarity  (IEA,ISO)
establishment of Golgi localization  (IEA,ISO)
establishment of localization in cell  (IMP)
fibroblast migration  (IGI)
gamma-aminobutyric acid import  (IEA,ISO)
gland morphogenesis  (IEA,ISO)
glutathione transport  (IMP)
import across plasma membrane  (IEA,ISO)
intracellular phosphate ion homeostasis  (IMP)
maintenance of epithelial cell apical/basal polarity  (IMP,ISO)
microvillus assembly  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell motility  (IMP)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of fibroblast migration  (IGI)
negative regulation of mitotic cell cycle  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IGI,IMP,ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IMP)
negative regulation of sodium ion transport  (IMP)
negative regulation of sodium:proton antiporter activity  (IMP)
nuclear migration  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IMP)
plasma membrane organization  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of monoatomic ion transmembrane transport  (IEA,ISO)
protein localization  (IMP)
protein localization to plasma membrane  (IBA,IEA,ISO)
regulation of cell shape  (IEA,ISO)
regulation of cell size  (IEA,ISO)
regulation of protein kinase activity  (IMP)
regulation of renal phosphate excretion  (IMP)
renal absorption  (IMP)
renal phosphate ion absorption  (ISO,ISS)
renal sodium ion transport  (IMP)
sensory perception of sound  (IMP)
sodium ion transport  (IMP)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats. Kobayashi K, etal., J Hypertens. 2004 Sep;22(9):1723-30.
2. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9560162   PMID:10349636   PMID:10500246   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11099500   PMID:11217851   PMID:11533036   PMID:11777944   PMID:12169661   PMID:12403779  
PMID:12477932   PMID:12586353   PMID:12606316   PMID:12780527   PMID:12819230   PMID:12952857   PMID:14531806   PMID:14580213   PMID:14596847   PMID:14610273   PMID:14996907   PMID:15177033  
PMID:15218020   PMID:15378723   PMID:15466885   PMID:15469991   PMID:15489334   PMID:15591354   PMID:15782199   PMID:15942053   PMID:16141072   PMID:16141073   PMID:16203733   PMID:16249272  
PMID:16339021   PMID:16410385   PMID:16456542   PMID:16602821   PMID:16615918   PMID:16705152   PMID:16916513   PMID:16987995   PMID:17110338   PMID:17114649   PMID:17325659   PMID:17390218  
PMID:17409311   PMID:17580307   PMID:17895247   PMID:17947234   PMID:17990980   PMID:18190691   PMID:18256311   PMID:18287559   PMID:18391535   PMID:18407958   PMID:18758809   PMID:18931049  
PMID:19170756   PMID:19221439   PMID:19515997   PMID:19857202   PMID:19889841   PMID:19995908   PMID:20200151   PMID:20404332   PMID:20571032   PMID:20706633   PMID:20736413   PMID:20802536  
PMID:21063698   PMID:21267068   PMID:21388960   PMID:21444686   PMID:21677750   PMID:21873635   PMID:21908609   PMID:21976599   PMID:22034511   PMID:22904329   PMID:22974528   PMID:22992649  
PMID:23046970   PMID:23109343   PMID:23208378   PMID:23341629   PMID:23474170   PMID:24108661   PMID:24196963   PMID:24297041   PMID:24920589   PMID:25756512   PMID:25775275   PMID:26183564  
PMID:26258413   PMID:26442671   PMID:27055101   PMID:27279487   PMID:27540115   PMID:27542690   PMID:27566107   PMID:27655939   PMID:27834195   PMID:28392297   PMID:28533091   PMID:29518331  
PMID:29712669   PMID:29899468   PMID:30333137   PMID:30581004   PMID:30926337   PMID:31087002   PMID:32325033   PMID:33361207   PMID:33500317   PMID:33952618   PMID:34168324   PMID:34321999  
PMID:36255053   PMID:37839992   PMID:38355793  


Genomics

Comparative Map Data
Nherf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,054,138 - 115,072,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,054,167 - 115,072,007 (+)EnsemblGRCm39 Ensembl
GRCm3811115,163,341 - 115,181,178 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,163,341 - 115,181,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711115,024,655 - 115,042,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611114,979,493 - 115,014,684 (+)NCBIMGSCv36mm8
Celera11126,928,560 - 126,946,416 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.65NCBI
NHERF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381774,748,628 - 74,769,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1774,748,628 - 74,769,353 (+)EnsemblGRCh38hg38GRCh38
GRCh371772,744,767 - 72,765,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,256,373 - 70,277,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 341770,256,378 - 70,277,089NCBI
Celera1769,337,944 - 69,358,679 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,155,124 - 68,175,866 (+)NCBIHuRef
CHM1_11772,809,571 - 72,830,338 (+)NCBICHM1_1
T2T-CHM13v2.01775,640,506 - 75,661,228 (+)NCBIT2T-CHM13v2.0
Nherf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810100,902,165 - 100,919,265 (+)NCBIGRCr8
mRatBN7.210100,403,189 - 100,420,290 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,403,069 - 100,420,598 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,463,056 - 105,480,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010104,926,121 - 104,943,248 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,324,177 - 100,341,277 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,713,045 - 103,730,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,713,045 - 103,730,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,573,624 - 104,590,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,237,637 - 105,254,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,252,140 - 105,269,254 (+)NCBI
Celera1098,979,637 - 98,995,900 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Nherf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,639,267 - 1,656,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555531,639,267 - 1,656,850 (+)NCBIChiLan1.0ChiLan1.0
NHERF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21990,785,997 - 90,806,905 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,608,707 - 95,629,599 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01768,694,468 - 68,715,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,250,406 - 74,271,234 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,250,406 - 74,271,234 (+)Ensemblpanpan1.1panPan2
NHERF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,661,792 - 5,679,783 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,662,464 - 5,679,570 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,341,827 - 6,358,910 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,333,687 - 6,351,685 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,333,688 - 6,351,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,371,237 - 6,388,311 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,481,877 - 6,498,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,542,206 - 6,559,311 (-)NCBIUU_Cfam_GSD_1.0
Nherf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,275,339 - 6,292,156 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594119,770 - 136,789 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594119,808 - 136,620 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHERF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,466,121 - 6,483,548 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,466,138 - 6,483,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,455,107 - 6,472,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NHERF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,889,454 - 46,910,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,888,942 - 46,910,842 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,675,824 - 17,696,157 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nherf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,612,849 - 4,630,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248014,612,890 - 4,630,454 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nherf1
739 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:247
Count of miRNA genes:200
Interacting mature miRNAs:210
Transcripts:ENSMUST00000021077
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
Slc9a3r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
cM Map11 UniSTS
Slc9a3r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E2UniSTS
cM Map11 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF154912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB660628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000021077   ⟹   ENSMUSP00000021077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11115,054,167 - 115,072,007 (+)Ensembl
GRCm38.p6 Ensembl11115,163,341 - 115,181,181 (+)Ensembl
RefSeq Acc Id: NM_012030   ⟹   NP_036160
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911115,054,167 - 115,072,004 (+)NCBI
GRCm3811115,163,341 - 115,181,178 (+)NCBI
MGSCv3711115,024,655 - 115,042,492 (+)RGD
Celera11126,928,560 - 126,946,416 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156735   ⟹   XP_036012628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911115,054,138 - 115,072,009 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036160   ⟸   NM_012030
- UniProtKB: Q8BYD8 (UniProtKB/Swiss-Prot),   P70441 (UniProtKB/Swiss-Prot),   Q3TG37 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000021077   ⟸   ENSMUST00000021077
RefSeq Acc Id: XP_036012628   ⟸   XM_036156735
- Peptide Label: isoform X1
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70441-F1-model_v2 AlphaFold P70441 1-355 view protein structure

Promoters
RGD ID:6822149
Promoter ID:MM_KWN:10504
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000007862
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611115,024,476 - 115,024,976 (+)MPROMDB
RGD ID:6822150
Promoter ID:MM_KWN:10505
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:UC007MGQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611115,037,341 - 115,037,841 (+)MPROMDB
RGD ID:8677312
Promoter ID:EPDNEW_M16687
Type:multiple initiation site
Name:Slc9a3r1_1
Description:Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),member 3 regulator 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811115,163,341 - 115,163,401EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1349482 AgrOrtholog
Ensembl Genes ENSMUSG00000020733 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021077 ENTREZGENE
  ENSMUST00000021077.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EBP50_C-term UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHERF-1/NHERF-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26941 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1349482 ENTREZGENE
NCBI Gene 26941 ENTREZGENE
PANTHER PDZ DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14191:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EBP50_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nherf1 PhenoGen
PIRSF EBP50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NHRF1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TG37 ENTREZGENE, UniProtKB/TrEMBL
  Q8BYD8 ENTREZGENE
UniProt Secondary Q8BYD8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-12 Nherf1  NHERF family PDZ scaffold protein 1  Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1  Symbol and/or name updated 27372883 PROVISIONAL