PARATHYROID HORMONE SIGNALING PATHWAY (PW:0001135)

View Ontology Report

Description

The signaling initiated by the parathyroid hormone (PTH) plays a central role in calcium (Ca2+) and phosphate homeostasis. In response to low Ca2+, the hormone is secreted from the parathyroid glands; high Ca2+ levels activate the Ca2+ sensing receptor whose signaling inhibits its secretion. In the kidney, PTH regulates Ca2+ and phosphate reabsorption: specifically, it increases Ca2+ reabsorption leading to increased release of the metal into the circulation; it diminishes phosphate absorption

Pathway Diagram:

Ariadne Genomics Inc. Pth --+> Ca2+ reabsorption Pth ---> anabolic, catabolic effects on bone phosphate reabsoprtion activation of adenylyl cyclases/increased cAMP --+> protein kinase A (PKA) signaling pathway cAMP increased DAG/IP3 via PLC activation --+> protein kinase C (PKC) signaling pathway IP3 DAG Slc34a1 phosphate transport pathway anabolic, catabolic effects on bone Pth1r partners G protein mediated signaling pathway via Galphas family ---> activation of adenylyl cyclases/increased cAMP Arrb1 ---- Pth1r Arrb2 ---- Pth1r Arrb1 Adrbk1 Pth1r ---- Pth1r partners Pth1r ---- Slc9a3r2 Slc9a3r2 Ezr ---- Pth1r Ezr Ezr ---- Slc9a3r1 Pth1r ---- Slc9a3r1 Slc9a3r1 calcium signaling pathway via the calcium-sensing receptor ---| Pth protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphaq family activation of adenylyl cyclases/increased cAMP protein kinase C (PKC) signaling pathway Adrbk1 ---| Pth1r Arrb2 Ca2+ G protein mediated signaling pathway via Galphaq family ---> increased DAG/IP3 via PLC activation Pth ---- Pth1r Ca2+ --+> Pth calcium signaling pathway via the calcium-sensing receptor Ca2+ --+> calcium signaling pathway via the calcium-sensing receptor increased DAG/IP3 via PLC activation Pth ---| phosphate reabsoprtion Pth ---| phosphate transport pathway Pth Ca2+ reabsorption Slc34a1 ---- Slc9a3r1 Pth1r --+> G protein mediated signaling pathway via Galphas family Pth1r Pth1r --+> G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphas family
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
parathyroid hormone signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:7207469
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:7207469
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:7207465
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:7207470
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7207455
RGD:7207470
RGD:7207465
G Pth1r parathyroid hormone 1 receptor JBrowse link 8 118,984,531 119,012,803 RGD:7207455
RGD:7207470
RGD:7207469
RGD:7207465
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:7207465
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link 10 14,003,330 14,015,066 RGD:7207465

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupPth1r partners

Pathway Gene Annotations

Disease Annotations Associated with Genes in the parathyroid hormone signaling pathway
Disease TermsGene Symbols
albuminuriaPth
Amphetamine-Related DisordersArrb2
AnemiaPth
Aortic Valve, Calcification ofPth
Arteriovenous FistulaArrb1 , Arrb2
Arthritis, ExperimentalArrb1 , Arrb2 , Grk2
Arthritis, RheumatoidGrk2
Atrial FibrillationPth
atrophic gastritisPth
autosomal dominant hypocalcemiaPth
Basal Cell Nevus SyndromePth
Bone Diseases, EndocrinePth
Bone ResorptionPth
BurnsGrk2
CarcinomaEzr
Carcinoma, Ductal, BreastSlc9a3r1
CardiomegalyGrk2
cardiomyopathyGrk2
cardiovascular system diseaseGrk2
chondrodysplasia, Blomstrand typePth1r
ColitisArrb1
Congenital AbnormalitiesGrk2
Coronary Artery DiseasePth
Dermatitis, Allergic ContactGrk2
Diabetic NephropathiesPth
Eiken Skeletal DysplasiaPth1r
Embryo LossGrk2
Failure of Tooth Eruption, PrimaryPth1r
Fractures, BonePth
Heart FailureArrb1 , Grk2 , Pth
hereditary hypophosphatemic rickets with hypercalciuriaPth
HyperalgesiaGrk2
HypercalcemiaPth , Pth1r
HypercalciuriaPth
HyperglycemiaGrk2
hyperostosisPth
HyperparathyroidismPth1r
Hyperparathyroidism, PrimaryPth
Hyperparathyroidism, SecondaryPth
hyperphosphatemiaPth
HypertensionArrb2 , Grk2 , Pth , Slc9a3r1 , Slc9a3r2
Hypertrophy, Left VentricularGrk2 , Pth
HypocalcemiaPth
Hypoparathyroidism Familial IsolatedPth
Hypoparathyroidism, Autosomal RecessivePth
Insulin ResistanceGrk2
Jansen Type Metaphyseal ChondrodysplasiaPth1r
Kidney Failure, ChronicPth
Limb IschemiaGrk2
Liver CirrhosisArrb1
Liver Cirrhosis, ExperimentalArrb2 , Ezr , Grk2
Liver Neoplasms, ExperimentalArrb2
Lung DiseasesPth1r
major depressive disorderArrb1
Mammary Neoplasms, AnimalEzr
Mammary Neoplasms, ExperimentalEzr
metaphyseal chondrodysplasiaPth1r
Myocardial Reperfusion InjuryArrb2 , Grk2
Neoplasm MetastasisEzr
NephrocalcinosisPth
Nephrolithiasis, Calcium OxalatePth
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2Slc9a3r1
OsteoarthritisEzr
OsteochondrodysplasiasPth1r
OsteoporosisPth
Osteoporosis, PostmenopausalPth
OsteosarcomaPth
otitis mediaPth
Parathyroid NeoplasmsPth
Parkinson's DiseaseGrk2
PhosphaturiaPth
portal hypertensionArrb2 , Grk2
prostatic neoplasmsEzr
PruritusGrk2
Renal FibrosisArrb2
Renal Insufficiency, ChronicPth
renal osteodystrophyPth
RicketsPth , Pth1r
SepsisGrk2
Smith-Magenis syndromeSlc9a3r1
StrokePth
Tibial FracturesPth
Transplant RejectionArrb1 , Arrb2
type 1 diabetes mellitusPth
type 2 diabetes mellitusArrb2 , Pth
UremiaPth
Vascular CalcificationPth
Vascular System InjuriesGrk2
Pathway Annotations Associated with Genes in the parathyroid hormone signaling pathway
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2
aldosterone signaling pathwaySlc9a3r2
angiotensin II signaling pathway via AT1 receptorArrb1 , Arrb2 , Grk2
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Grk2
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Grk2
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2
eicosanoid signaling pathwayArrb2 , Grk2 , Slc9a3r1
endocytosis pathwayArrb1 , Arrb2 , Grk2
epinephrine signaling pathway via adrenergic receptor betaArrb1 , Arrb2 , Grk2
FasL mediated signaling pathwayEzr
G protein mediated signaling pathwayGrk2
G protein mediated signaling pathway via Galphaq familyPth1r
G protein mediated signaling pathway via Galphas familyGrk2 , Pth1r
glutamate signaling pathwayGrk2
Hedgehog signaling pathwayArrb2 , Grk2
kinin signaling pathwayArrb1 , Arrb2
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2
nuclear factor kappa B signaling pathwayArrb2
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Ezr , Grk2 , Pth , Pth1r , Slc9a3r1 , Slc9a3r2
platelet-derived growth factor signaling pathwaySlc9a3r1
protein kinase A (PKA) signaling pathwayEzr
syndecan signaling pathwayEzr
transforming growth factor-beta Smad dependent signaling pathwayArrb2
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling, non-canonical pathwayArrb2

References Associated with the parathyroid hormone signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: