Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Lrp2 (LDL receptor related protein 2) Rattus norvegicus
Symbol: Lrp2
Name: LDL receptor related protein 2
Description: Exhibits several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and signaling receptor binding activity. Involved in several processes, including endocytic hemoglobin import into cell; positive regulation of transport; and response to vitamin D. Localizes to several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: glycoprotein 330; gp330; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; LRP-2; megalin
Homo sapiens (human) : LRP2 (LDL receptor related protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Lrp2 (low density lipoprotein receptor-related protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp2 (LDL receptor related protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP2 (LDL receptor related protein 2)
Canis lupus familiaris (dog) : LRP2 (LDL receptor related protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp2 (LDL receptor related protein 2)
Sus scrofa (pig) : LRP2 (LDL receptor related protein 2)
Chlorocebus sabaeus (African green monkey) : LRP2 (LDL receptor related protein 2)
Heterocephalus glaber (naked mole-rat) : Lrp2 (LDL receptor related protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lrp2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68407
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.