Lrp2 (LDL receptor related protein 2) - Rat Genome Database

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Gene: Lrp2 (LDL receptor related protein 2) Rattus norvegicus
Analyze
Symbol: Lrp2
Name: LDL receptor related protein 2
RGD ID: 68407
Description: Exhibits several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and signaling receptor binding activity. Involved in several processes, including cation transport; positive regulation of transport; and response to vitamin D. Localizes to several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glycoprotein 330; gp330; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; LRP-2; megalin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,189,305 - 54,346,769 (-)NCBI
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
aflatoxin B2  (ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
aspartame  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
cholic acid  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
guggulsterone  (ISO)
hydrogen peroxide  (ISO)
lithocholic acid  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
O-methyleugenol  (ISO)
panobinostat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phosgene  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
sulforaphane  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
amyloid-beta clearance  (IMP)
animal organ regeneration  (IEP)
aorta development  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to growth factor stimulus  (IMP)
chemoattraction of axon  (IMP)
coronary artery morphogenesis  (IEA,ISO,ISS)
coronary vasculature development  (ISO)
endocytic hemoglobin import into cell  (IMP)
endocytosis  (IMP)
endosomal transport  (IMP)
folate import across plasma membrane  (IEA,ISO,ISS)
forebrain development  (IEA,ISO)
heart development  (ISO)
hormone secretion  (IMP)
kidney development  (IEA,ISO)
male gonad development  (IEA,ISO,ISS)
metal ion transport  (IDA,IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO,ISS)
negative regulation of endopeptidase activity  (IC)
neural tube closure  (IEA,ISO,ISS)
neuron projection arborization  (IEA,ISO,ISS)
outflow tract septum morphogenesis  (IEA,ISO,ISS)
positive regulation of endocytosis  (IMP)
positive regulation of lipoprotein transport  (IMP)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neurogenesis  (ISO,ISS)
positive regulation of oligodendrocyte progenitor proliferation  (IEA,ISO,ISS)
positive regulation of protein kinase B signaling  (IEA,ISO)
protein transport  (IEA,ISO)
pulmonary artery morphogenesis  (IEA,ISO,ISS)
receptor-mediated endocytosis  (IBA,IDA,IEA,IMP,ISO)
response to drug  (IEP)
response to leptin  (IEA,IMP,ISO)
response to retinoic acid  (IEP)
response to vitamin D  (IEP)
response to X-ray  (IDA)
secondary heart field specification  (IEA,ISO,ISS)
sensory perception of sound  (IEA,ISO,ISS)
transcytosis  (IMP)
vagina development  (IEA,ISO,ISS)
ventricular compact myocardium morphogenesis  (IEA,ISO,ISS)
ventricular septum development  (IEA,ISO)
vitamin metabolic process  (IEA,ISO,TAS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bento-Abreu A, etal., J Neurochem. 2008 Aug;106(3):1149-59. doi: 10.1111/j.1471-4159.2008.05462.x. Epub 2008 May 5.
2. Carro E, etal., J Neurosci. 2005 Nov 23;25(47):10884-93. doi: 10.1523/JNEUROSCI.2909-05.2005.
3. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
4. Dietrich MO, etal., Neurobiol Aging. 2008 Jun;29(6):902-12. Epub 2007 Feb 26.
5. Faber K, etal., Mol Endocrinol. 2006 Jan;20(1):212-8. Epub 2005 Aug 11.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gburek J, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F451-8. Epub 2003 Apr 29.
8. Gburek J, etal., J Am Soc Nephrol. 2002 Feb;13(2):423-30.
9. GOA data from the GO Consortium
10. Gonzalez-Villalobos R, etal., Am J Physiol Renal Physiol. 2005 Feb;288(2):F420-7. Epub 2004 Oct 5.
11. Gonzalez-Villalobos R, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1270-5. Epub 2005 Dec 27.
12. Hama H, etal., Endocrinology. 2004 Aug;145(8):3935-40. Epub 2004 May 6.
13. Hammad SM, etal., J Biol Chem. 2000 Apr 21;275(16):12003-8.
14. Hammes A, etal., Cell. 2005 Sep 9;122(5):751-62.
15. Hammond TG, etal., Am J Physiol. 1997 Jan;272(1 Pt 2):F117-23.
16. Hosaka K, etal., Kidney Int. 2009 Jun;75(12):1308-15. Epub 2009 Apr 1.
17. Hryciw DH, etal., Int J Biochem Cell Biol. 2012 May;44(5):815-23. doi: 10.1016/j.biocel.2012.02.007. Epub 2012 Feb 13.
18. Hvidberg V, etal., FEBS Lett. 2005 Jan 31;579(3):773-7.
19. Ishida T, etal., Cell Struct Funct. 2006;31(2):77-85. Epub 2006 Oct 23.
20. Johanns M, etal., Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.
21. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
22. Kaseda R, etal., Biochem Biophys Res Commun. 2007 Jun 15;357(4):1130-4. Epub 2007 Apr 19.
23. Kerjaschki D and Farquhar MG, Proc Natl Acad Sci U S A. 1982 Sep;79(18):5557-61.
24. Klassen RB, etal., Am J Physiol Renal Physiol. 2004 Sep;287(3):F393-403. Epub 2004 May 4.
25. Kohler K, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F687-96.
26. Landowski LM, etal., J Biol Chem. 2016 Jan 15;291(3):1092-102. doi: 10.1074/jbc.M115.668996. Epub 2015 Nov 23.
27. Lisi S, etal., Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14858-63. Epub 2003 Dec 1.
28. Liu W, etal., Eur J Clin Invest. 1998 Feb;28(2):100-7.
29. Lou X, etal., J Am Soc Nephrol. 2002 Apr;13(4):918-27.
30. Magyar CE, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F358-69.
31. Marino M, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2468-74.
32. McCarthy RA, etal., J Biol Chem. 2002 Jul 12;277(28):25660-7. Epub 2002 Apr 18.
33. MGD data from the GO Consortium
34. Morales CR, etal., J Histochem Cytochem. 2006 Oct;54(10):1115-27. Epub 2006 Jun 26.
35. Nagai M, etal., Mol Biol Cell. 2003 Dec;14(12):4984-96. Epub 2003 Oct 3.
36. NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Odera K, etal., Biogerontology. 2007 Apr 24;.
38. Oleinikov AV, etal., Biochem J. 2000 May 1;347 Pt 3:613-21.
39. OMIM Disease Annotation Pipeline
40. Pipeline to import KEGG annotations from KEGG into RGD
41. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. RGD automated data pipeline
43. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. RGD automated import pipeline for gene-chemical interactions
45. Saito A, etal., Proc Natl Acad Sci U S A 1994 Oct 11;91(21):9725-9.
46. Slattery C, etal., Cell Physiol Biochem. 2011;27(2):171-8. doi: 10.1159/000325219. Epub 2011 Feb 11.
47. Stefansson S, etal., J Biol Chem. 1996 Apr 5;271(14):8215-20.
48. Takeda T, etal., Am J Physiol Cell Physiol. 2003 May;284(5):C1105-13. Epub 2003 Jan 8.
49. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
50. Tauris J, etal., Audiol Neurootol. 2009;14(4):267-78. doi: 10.1159/000199446. Epub 2009 Feb 6.
51. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
52. Tojo A, etal., Histochem Cell Biol. 2001 Sep;116(3):269-76.
53. Vonend O, etal., Nephrol Dial Transplant. 2004 Sep;19(9):2217-22. Epub 2004 Jul 20.
54. Witzgall R, etal., Kidney Int. 2002 Jan;61(1 Suppl):132-7.
55. Xu C, etal., Sci Signal. 2012 May 29;5(226):ra39. doi: 10.1126/scisignal.2002979.
56. Yammani RR, etal., Am J Physiol Endocrinol Metab 2001 Nov;281(5):E900-7.
57. Yammani RR, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R339-46.
58. Zhao J, etal., Gene 2001 Mar 7;265(1-2):123-31.
Additional References at PubMed
PMID:7510321   PMID:7544804   PMID:9228033   PMID:10052453   PMID:10662735   PMID:12707383   PMID:12809172   PMID:12815097   PMID:12846736   PMID:14764706   PMID:15082773   PMID:15286052  
PMID:15342463   PMID:15616221   PMID:15623804   PMID:16027047   PMID:17228368   PMID:17245526   PMID:17457373   PMID:17846082   PMID:17897319   PMID:17990981   PMID:18174160   PMID:18927221  
PMID:19056867   PMID:20460439   PMID:20637285   PMID:20966072   PMID:21938401   PMID:22354480   PMID:23275343   PMID:23376485   PMID:23382219   PMID:23533145   PMID:23677864   PMID:23825075  
PMID:23836931   PMID:24586199   PMID:24639464   PMID:25807483   PMID:26025362   PMID:26173747   PMID:26248135   PMID:26822476   PMID:27241555   PMID:28289043   PMID:29187367   PMID:29286200  
PMID:29949391   PMID:32200675  


Genomics

Comparative Map Data
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,189,305 - 54,346,769 (-)NCBI
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh382169,127,109 - 169,362,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBImm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0panPan3
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBI
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBI
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBI
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBI
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBI
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,301 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBI
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)Ensembl
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBI
Lrp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBI

Position Markers
D3Rat239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2354,319,500 - 54,319,800 (+)MAPPER
Rnor_6.0355,795,318 - 55,795,617NCBIRnor6.0
Rnor_5.0362,407,260 - 62,407,559UniSTSRnor5.0
RGSC_v3.4351,697,009 - 51,697,309RGDRGSC3.4
RGSC_v3.4351,697,010 - 51,697,309UniSTSRGSC3.4
RGSC_v3.1351,593,353 - 51,593,777RGD
Celera353,880,411 - 53,880,710UniSTS
FHH x ACI Map339.47UniSTS
FHH x ACI Map339.47RGD
Cytogenetic Map3q21UniSTS
RH140983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2354,190,634 - 54,190,983 (+)MAPPER
Rnor_6.0355,666,480 - 55,666,828NCBIRnor6.0
Rnor_5.0362,272,606 - 62,272,954UniSTSRnor5.0
RGSC_v3.4351,565,091 - 51,565,439UniSTSRGSC3.4
Celera353,752,758 - 53,753,106UniSTS
Cytogenetic Map3q21UniSTS
UniSTS:485602  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22024,385,485 - 24,385,544 (+)MAPPER
mRatBN7.2354,309,254 - 54,309,840 (+)MAPPER
Rnor_6.0355,785,073 - 55,785,657NCBIRnor6.0
Rnor_6.02025,862,227 - 25,862,285NCBIRnor6.0
Rnor_5.0362,397,014 - 62,397,599UniSTSRnor5.0
Rnor_5.02027,932,273 - 27,932,331UniSTSRnor5.0
RGSC_v3.4351,686,764 - 51,687,349UniSTSRGSC3.4
Celera353,870,165 - 53,870,750UniSTS
Celera2025,718,227 - 25,718,285UniSTS
Cytogenetic Map20p11-q11UniSTS
Cytogenetic Map3q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31009408193415837Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31011931879772001Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31802366463023664Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32122380366223803Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32122380366223803Rat
631685Bp118Blood pressure QTL 1183.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)32465522569655225Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32932171474321714Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32968273274682732Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32968273274682732Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32968273274682732Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32968273274682732Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32968273274682732Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32990825574908255Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32990825574908255Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33110358972989078Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33110358972989078Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33110358972989078Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33110358972989078Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33110358972989078Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33110358972989078Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33213099777130997Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33213099777130997Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33347735462922975Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33347735481136227Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333477354108914061Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)334394121103141944Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)34042292185422921Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)34052359364880586Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)34052359392654473Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)34052359392654473Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)343295930108914061Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34540605894467785Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)351822008120917851Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35463094866711785Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)354630948119830094Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35463104693415673Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35524527695176874Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 1 1 1 14 29 5 11
Low 22 40 24 19 24 7 7 58 2 36 7
Below cutoff 2 18 16 16 16 1 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082624   ⟹   ENSRNOP00000075159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)Ensembl
RefSeq Acc Id: NM_030827   ⟹   NP_110454
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2354,189,308 - 54,346,708 (-)NCBI
Rnor_6.0355,665,153 - 55,822,484 (-)NCBI
Rnor_5.0362,271,279 - 62,434,959 (-)NCBI
RGSC_v3.4351,563,764 - 51,724,478 (-)RGD
Celera353,751,431 - 53,907,374 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104427   ⟹   XP_038960355
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2354,189,305 - 54,346,769 (-)NCBI
Protein Sequences
Protein RefSeqs NP_110454 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960355 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA51369 (Get FASTA)   NCBI Sequence Viewer  
  P98158 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_110454   ⟸   NM_030827
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000075159   ⟸   ENSRNOT00000082624
RefSeq Acc Id: XP_038960355   ⟸   XM_039104427
- Peptide Label: isoform X1
Protein Domains
EGF-like   LDL-receptor class A

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692114
Promoter ID:EPDNEW_R2639
Type:multiple initiation site
Name:Lrp2_1
Description:LDL receptor related protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0355,822,498 - 55,822,558EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68407 AgrOrtholog
BIND 133316
Ensembl Genes ENSRNOG00000056184 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075159 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082624 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29216 UniProtKB/Swiss-Prot
NCBI Gene 29216 ENTREZGENE
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LRP2 RGD
PhenoGen Lrp2 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229506
UniProt A0A0G2K9W7_RAT UniProtKB/TrEMBL
  LRP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp2  LDL receptor related protein 2  Lrp2  low density lipoprotein receptor-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Lrp2  low density lipoprotein receptor-related protein 2  Lrp2  low density lipoprotein-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Lrp2  low density lipoprotein-related protein 2  Lrp2  low density lipoprotein receptor-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lrp2  low density lipoprotein receptor-related protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the rat yolk sac carcinoma cells and in the distal intestine 628443
gene_physical_interaction binds with cubilin to bring about endocytosis and cobalamin transportation through the endoplasmic reticulum 628443
gene_process may be involved in the process of receptor-mediated endocytosis 68274
gene_process may be involved in the process of receptor-mediated endocytosis 68711