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Gene: LRP2 (LDL receptor related protein 2) Homo sapiens
Symbol: LRP2
Name: LDL receptor related protein 2
Description: Exhibits calcium ion binding activity and chaperone binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of protein kinase B signaling; and receptor-mediated endocytosis. Localizes to the apical plasma membrane and receptor complex. Implicated in Donnai-Barrow syndrome and autoimmune thyroiditis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: calcium sensor protein; DBS; glycoprotein 330; GP330; Heymann nephritis antigen homolog; low density lipoprotein receptor-related protein 2; low-density lipoprotein receptor-related protein 2; LRP-2; megalin
Mus musculus (house mouse) : Lrp2 (low density lipoprotein receptor-related protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrp2 (LDL receptor related protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp2 (LDL receptor related protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP2 (LDL receptor related protein 2)
Canis lupus familiaris (dog) : LRP2 (LDL receptor related protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp2 (LDL receptor related protein 2)
Sus scrofa (pig) : LRP2 (LDL receptor related protein 2)
Chlorocebus sabaeus (African green monkey) : LRP2 (LDL receptor related protein 2)
Heterocephalus glaber (naked mole-rat) : Lrp2 (LDL receptor related protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2169,127,109 - 169,362,534 (-)Ensembl
GRCh382169,127,109 - 169,362,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LRP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68599
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.