Lrp2 (LDL receptor related protein 2) - Rat Genome Database

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Gene: Lrp2 (LDL receptor related protein 2) Ictidomys tridecemlineatus
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Symbol: Lrp2
Name: LDL receptor related protein 2
RGD ID: 12548240
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); calcium ion binding (ortholog); chaperone binding (ortholog); INVOLVED IN aging (ortholog); amyloid-beta clearance (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); autoimmune thyroiditis (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LDL receptor related protein 2, transcript variant X1; LDL receptor related protein 2, transcript variant X2; LDL receptor related protein 2, transcript variant X3; low-density lipoprotein receptor-related protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta clearance  (ISO)
animal organ regeneration  (ISO)
aorta development  (ISO)
cell population proliferation  (ISO)
cellular response to growth factor stimulus  (ISO)
chemoattraction of axon  (ISO)
coronary artery morphogenesis  (ISO)
coronary vasculature development  (ISO)
endocytic hemoglobin import into cell  (ISO)
endocytosis  (ISO)
endosomal transport  (ISO)
folate import across plasma membrane  (ISO)
forebrain development  (ISO)
heart development  (ISO)
hormone secretion  (ISO)
kidney development  (ISO)
male gonad development  (ISO)
metal ion transport  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (ISO)
neural tube closure  (ISO)
neuron projection arborization  (ISO)
outflow tract septum morphogenesis  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of lipoprotein transport  (ISO)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
protein transport  (ISO)
pulmonary artery morphogenesis  (ISO)
receptor-mediated endocytosis  (ISO)
response to drug  (ISO)
response to leptin  (ISO)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to X-ray  (ISO)
secondary heart field specification  (ISO)
sensory perception of sound  (ISO)
transcytosis  (ISO)
vagina development  (ISO)
ventricular compact myocardium morphogenesis  (ISO)
ventricular septum development  (ISO)
vitamin metabolic process  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh382169,127,109 - 169,362,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBImm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,189,305 - 54,346,769 (-)NCBI
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0panPan3
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBI
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBI
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBI
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBI
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBI
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,301 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBI
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)Ensembl
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBI
Lrp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021727033   ⟹   XP_021582708
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021727069   ⟹   XP_021582744
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021727121   ⟹   XP_021582796
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493646910,245,001 - 10,417,400 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040294431   ⟹   XP_040150365
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
RefSeq Acc Id: XM_040294432   ⟹   XP_040150366
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
RefSeq Acc Id: XR_002484096
RefSeq Status:
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493646910,245,001 - 10,414,037 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_021582708   ⟸   XM_021727033
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021582744   ⟸   XM_021727069
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021582796   ⟸   XM_021727121
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040150366   ⟸   XM_040294432
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040150365   ⟸   XM_040294431
- Peptide Label: isoform X3
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009904 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000008942 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000025766 UniProtKB/TrEMBL
  ENSSTOP00000029304 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009966 UniProtKB/TrEMBL
  ENSSTOT00000031229 UniProtKB/TrEMBL
  ENSSTOT00000041437 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  cEGF UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
NCBI Gene Lrp2 ENTREZGENE
Pfam cEGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A287CWV8_ICTTR UniProtKB/TrEMBL
  A0A287D6Y9_ICTTR UniProtKB/TrEMBL
  I3MEK3_ICTTR UniProtKB/TrEMBL