(+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23365609 (+)-catechin decreases expression ISO Lep (Mus musculus) 6480464 Catechin results in decreased expression of LEP protein CTD PMID:30445784 (+)-catechin multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (+)-epicatechin-3-O-gallate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (-)-epigallocatechin 3-gallate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (R)-lipoic acid decreases secretion ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 (R)-lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA and Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 (R)-lipoic acid decreases expression ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 and PMID:29155039 (S)-nicotine decreases response to substance EXP 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 1,4-bis(2-ethylhexyl) sulfosuccinate increases expression ISO Lep (Mus musculus) 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of LEP mRNA CTD PMID:30728429 1,4-bis(2-ethylhexyl) sulfosuccinate multiple interactions ISO Lep (Mus musculus) 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of and results in increased secretion of LEP protein CTD PMID:30728429 1,8-cineole multiple interactions ISO Lep (Mus musculus) 6480464 Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein] more ... CTD PMID:31483951 1-(3-chlorophenyl)piperazine multiple interactions ISO Lep (Mus musculus) 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 1-naphthyl isothiocyanate affects expression EXP 6480464 1-Naphthylisothiocyanate affects the expression of LEP protein CTD PMID:25051504 15-deoxy-Delta(12,14)-prostaglandin J2 increases secretion ISO LEP (Homo sapiens) 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased secretion of LEP protein CTD PMID:11092516 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO LEP (Homo sapiens) 6480464 [Dexamethasone co-treated with 15-deoxy-delta(12 and 14)-prostaglandin J2] results in decreased secretion of LEP protein CTD PMID:11092516 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of LEP protein CTD PMID:25051504 17beta-estradiol increases expression ISO Lep (Mus musculus) 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:18359623 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:26164745 17beta-estradiol multiple interactions ISO LEP (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO LEP (Homo sapiens) 6480464 Dihydrotestosterone results in decreased expression of LEP mRNA CTD PMID:18801408 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:23618531 more ... 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:24978599 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:24559133 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LEP protein more ... CTD PMID:19063610 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Lep (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of LEP mRNA CTD PMID:21570461 and PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA more ... CTD PMID:15977195 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Lep (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA CTD PMID:19063610 2,4-dinitrophenol multiple interactions ISO Lep (Mus musculus) 6480464 [2 and 4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA CTD PMID:24872412 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO Lep (Mus musculus) 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of LEP protein CTD PMID:25051504 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Lep (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA more ... CTD PMID:19913045 2-amino-2-deoxy-D-galactopyranose increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Galactosamine CTD PMID:19913045 2-amino-2-deoxy-D-glucopyranose 6-phosphate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 2-aminopurine multiple interactions ISO Lep (Mus musculus) 6480464 2-Aminopurine affects the reaction [LEP protein affects the expression of ADGRE1 mRNA] more ... CTD PMID:24150608 2-arachidonoylglycerol multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with LEP protein] results in increased chemical synthesis of glyceryl 2-arachidonate CTD PMID:27071101 2-deoxy-D-glucose multiple interactions EXP 6480464 [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 2-deoxy-D-glucose decreases secretion EXP 6480464 Deoxyglucose results in decreased secretion of LEP protein CTD PMID:10780946 2-hydroxypropanoic acid affects expression ISO LEP (Homo sapiens) 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 2-methyl-4-chlorophenoxybutyric acid multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO Lep (Mus musculus) 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] and geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 24,25-Dihydroxyvitamin D decreases expression ISO LEP (Homo sapiens) 6480464 24 and 25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein CTD PMID:18379402 3',5'-cyclic AMP increases abundance ISO LEP (Homo sapiens) 6480464 LEP protein results in increased abundance of Cyclic AMP CTD PMID:11342529 3',5'-cyclic AMP multiple interactions ISO Lep (Mus musculus) 6480464 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA] CTD PMID:27381457 3',5'-cyclic AMP increases expression ISO Lep (Mus musculus) 6480464 Cyclic AMP analog results in increased expression of LEP mRNA CTD PMID:27381457 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:28973532 3,3',5,5'-tetrabromobisphenol A increases expression ISO Lep (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of LEP mRNA CTD PMID:30496566 3,4-methylenedioxymethamphetamine affects expression EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine affects the expression of LEP protein CTD PMID:17910739 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases expression ISO Lep (Mus musculus) 6480464 3 more ... CTD PMID:20512997 3-aminobenzamide increases expression EXP 6480464 3-aminobenzamide results in increased expression of LEP mRNA CTD PMID:18815186 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of LEP mRNA CTD PMID:20409345 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO LEP (Homo sapiens) 6480464 4 more ... CTD PMID:19186324 more ... 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Lep (Mus musculus) 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... 4,4'-sulfonyldiphenol increases secretion ISO Lep (Mus musculus) 6480464 bisphenol S results in increased secretion of LEP protein CTD PMID:25111128 and PMID:31820560 4,4'-sulfonyldiphenol decreases methylation ISO Lep (Mus musculus) 6480464 bisphenol S results in decreased methylation of LEP promoter CTD PMID:33297965 4,4'-sulfonyldiphenol multiple interactions ISO Lep (Mus musculus) 6480464 bisphenol S affects the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27241191 4,4'-sulfonyldiphenol decreases expression ISO LEP (Homo sapiens) 6480464 bisphenol S results in decreased expression of LEP mRNA CTD PMID:27685785 4-hydroxy-17beta-estradiol increases abundance ISO LEP (Homo sapiens) 6480464 LEP protein results in increased abundance of 4-hydroxyestradiol CTD PMID:24631339 4-hydroxy-TEMPO multiple interactions EXP 6480464 tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 4-hydroxybenzoic acid decreases expression ISO LEP (Homo sapiens) 6480464 4-hydroxybenzoic acid results in decreased expression of LEP mRNA CTD PMID:22956630 4-hydroxyphenyl retinamide decreases expression ISO Lep (Mus musculus) 6480464 Fenretinide results in decreased expression of LEP mRNA CTD PMID:28973697 4-nonylphenol increases expression EXP 6480464 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 5-aza-2'-deoxycytidine increases expression ISO LEP (Homo sapiens) 6480464 [Decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA and Decitabine results in increased expression of LEP mRNA CTD PMID:17502362 5-aza-2'-deoxycytidine multiple interactions ISO LEP (Homo sapiens) 6480464 trichostatin A promotes the reaction [Decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 5-aza-2'-deoxycytidine decreases methylation ISO LEP (Homo sapiens) 6480464 Decitabine results in decreased methylation of LEP promoter CTD PMID:17502362 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of LEP mRNA CTD PMID:24534949 8-Br-cAMP multiple interactions ISO LEP (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] more ... CTD PMID:19849856 8-Br-cAMP decreases response to substance ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased susceptibility to 8-Bromo Cyclic Adenosine Monophosphate CTD PMID:19849856 9-cis-retinoic acid multiple interactions EXP 6480464 [Alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 AACOCF3 multiple interactions ISO Lep (Mus musculus) 6480464 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 acarbose decreases expression EXP 6480464 Acarbose results in decreased expression of LEP protein CTD PMID:18290871 acetaldehyde multiple interactions ISO Lep (Mus musculus) 6480464 Acetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein] more ... CTD PMID:15130784 and PMID:17949463 acetylsalicylic acid multiple interactions EXP 6480464 [lipopolysaccharide and Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein CTD PMID:15024038 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] decreases response to substance ISO LEP (Homo sapiens) 6480464 adenosine-3' and 5'-cyclic phosphorothioate results in decreased susceptibility to LEP protein CTD PMID:11342529 Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] multiple interactions ISO LEP (Homo sapiens) 6480464 adenosine-3' more ... CTD PMID:11342529 aflatoxin B1 increases methylation ISO LEP (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of LEP gene CTD PMID:27153756 AH23848 multiple interactions ISO LEP (Homo sapiens) 6480464 AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 aldehydo-D-glucosamine 6-phosphate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 aldehydo-D-glucose multiple interactions ISO LEP (Homo sapiens) 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 aldehydo-D-glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 aldehydo-D-glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... aldehydo-D-glucose increases response to substance ISO LEP (Homo sapiens) 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 aldehydo-D-glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... all-trans-retinoic acid multiple interactions ISO LEP (Homo sapiens) 6480464 Tretinoin results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:32929351 all-trans-retinol multiple interactions EXP 6480464 LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 AM-251 multiple interactions ISO Lep (Mus musculus) 6480464 AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA] more ... CTD PMID:27071101 Amibegron decreases expression EXP 6480464 amibegron results in decreased expression of LEP mRNA CTD PMID:9718277 Amibegron multiple interactions EXP 6480464 3-(2-ethylphenoxy)-1-(1 more ... CTD PMID:9718277 amlodipine decreases expression ISO LEP (Homo sapiens) 6480464 Amlodipine results in decreased expression of LEP and Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 and PMID:19059660 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of LEP mRNA CTD PMID:16483693 anandamide decreases abundance ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:16154199 anandamide multiple interactions ISO Lep (Mus musculus) 6480464 Dietary Fats inhibits the reaction [LEP protein results in decreased abundance of anandamide] CTD PMID:29967158 anandamide decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:29967158 anandamide decreases activity ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased activity of anandamide CTD PMID:16154199 anandamide decreases transport ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased transport of anandamide CTD PMID:16154199 androst-4-ene-3,17-dione multiple interactions EXP 6480464 LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione] CTD PMID:14657608 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO LEP (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 apigenin increases expression ISO Lep (Mus musculus) 6480464 Apigenin results in increased expression of LEP mRNA and Apigenin results in increased expression of LEP protein CTD PMID:18359623 apocynin multiple interactions ISO Lep (Mus musculus) 6480464 acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 arachidonic acid multiple interactions ISO Lep (Mus musculus) 6480464 Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 arsane affects expression ISO LEP (Homo sapiens) 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 arsane multiple interactions ISO LEP (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 arsenic atom affects expression ISO LEP (Homo sapiens) 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 arsenic atom multiple interactions ISO LEP (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 arsenite(3-) decreases methylation ISO LEP (Homo sapiens) 6480464 arsenite results in decreased methylation of LEP promoter CTD PMID:23974009 arsenous acid multiple interactions ISO LEP (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein and Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 aspartame decreases expression EXP 6480464 Aspartame results in decreased expression of LEP protein CTD PMID:11890951 aspartame multiple interactions ISO Lep (Mus musculus) 6480464 [Fats more ... CTD PMID:23783067 atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein] CTD PMID:21122807 ATP multiple interactions EXP 6480464 [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein and [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 Aurothioglucose multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP mRNA and [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP protein CTD PMID:9794456 Aurothioglucose increases expression ISO Lep (Mus musculus) 6480464 Aurothioglucose results in increased expression of LEP mRNA and Aurothioglucose results in increased expression of LEP protein CTD PMID:15809509 more ... azoxystrobin multiple interactions ISO Lep (Mus musculus) 6480464 [azoxystrobin co-treated with Dietary Fats] affects the expression of LEP protein CTD PMID:24726979 Bardoxolone methyl multiple interactions ISO Lep (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein] and bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27417254 benzo[a]pyrene affects methylation ISO LEP (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of LEP intron CTD PMID:30157460 Benzyl parahydroxybenzoate increases expression ISO Lep (Mus musculus) 6480464 benzylparaben results in increased expression of LEP mRNA CTD PMID:22956630 Benzyl parahydroxybenzoate decreases expression ISO LEP (Homo sapiens) 6480464 benzylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 beta-D-glucosamine 6-sulfate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-O-sulfate results in decreased expression of LEP mRNA CTD PMID:19520133 beta-naphthoflavone decreases expression ISO LEP (Homo sapiens) 6480464 beta-Naphthoflavone results in decreased expression of LEP mRNA CTD PMID:32858204 bezafibrate decreases expression ISO LEP (Homo sapiens) 6480464 Bezafibrate results in decreased expression of LEP CTD PMID:10726910 bezafibrate multiple interactions ISO Lep (Mus musculus) 6480464 Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein] CTD PMID:21549692 bezafibrate decreases expression EXP 6480464 Bezafibrate results in decreased expression of LEP mRNA CTD PMID:11216866 and PMID:11473052 bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] CTD PMID:17379010 bis(2-ethylhexyl) phthalate increases expression ISO Lep (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of LEP mRNA and Diethylhexyl Phthalate results in increased expression of LEP protein CTD PMID:22588786 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of LEP protein CTD PMID:33309551 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP mRNA and [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP protein CTD PMID:33166671 bis(2-ethylhexyl) phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:29175711 and PMID:30660623 bis(2-ethylhexyl) phthalate increases expression EXP 25330351 bis(2-ethylhexyl) phthalate increased expression of LEP in adipose tissue (rat) RGD bisphenol A increases expression ISO Lep (Mus musculus) 6480464 bisphenol A results in increased expression of LEP more ... CTD PMID:18359623 more ... bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of LEP mRNA and bisphenol A results in increased expression of LEP protein CTD PMID:34947998 and PMID:37570835 bisphenol A decreases secretion ISO LEP (Homo sapiens) 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:29223775 bisphenol A multiple interactions EXP 6480464 bisphenol A results in increased expression of and results in increased secretion of LEP protein and Resveratrol inhibits the reaction [bisphenol A results in decreased expression of LEP protein] CTD PMID:32339907 and PMID:37570835 bisphenol A decreases secretion EXP 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:31697385 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LEP mRNA CTD PMID:30816183 and PMID:32528016 bisphenol A increases secretion ISO Lep (Mus musculus) 6480464 bisphenol A results in increased secretion of LEP protein CTD PMID:31820560 bisphenol A decreases expression ISO LEP (Homo sapiens) 6480464 bisphenol A results in decreased expression of LEP mRNA and bisphenol A results in decreased expression of LEP protein CTD PMID:24349194 more ... bisphenol A increases expression ISO LEP (Homo sapiens) 6480464 bisphenol A results in increased expression of LEP mRNA and bisphenol A results in increased expression of LEP protein CTD PMID:25878060 more ... bisphenol A multiple interactions ISO LEP (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 bisphenol A multiple interactions ISO Lep (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23493373 more ... Bisphenol A diglycidyl ether increases expression ISO Lep (Mus musculus) 6480464 2 and 2-bis(4-glycidyloxyphenyl)propane results in increased expression of LEP mRNA CTD PMID:22763116 Bisphenol A diglycidyl ether multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 Bisphenol B increases secretion ISO Lep (Mus musculus) 6480464 bisphenol B results in increased secretion of LEP protein CTD PMID:31820560 bisphenol F increases secretion ISO Lep (Mus musculus) 6480464 bisphenol F results in increased secretion of LEP protein CTD PMID:31820560 bleomycin A2 increases expression ISO Lep (Mus musculus) 6480464 Bleomycin results in increased expression of LEP protein CTD PMID:29175452 boric acid multiple interactions ISO Lep (Mus musculus) 6480464 boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA] and boric acid results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:28285642 boron atom multiple interactions EXP 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 BQ 123 multiple interactions ISO Lep (Mus musculus) 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 bromodichloromethane increases expression ISO Lep (Mus musculus) 6480464 bromodichloromethane results in increased expression of LEP mRNA CTD PMID:23640861 bromodichloromethane multiple interactions ISO Lep (Mus musculus) 6480464 bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA] more ... CTD PMID:23438451 and PMID:24211274 bromodichloromethane decreases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in decreased susceptibility to bromodichloromethane CTD PMID:23640861 bucladesine decreases expression ISO Lep (Mus musculus) 6480464 Bucladesine results in decreased expression of LEP mRNA CTD PMID:9002984 Butylparaben decreases expression ISO LEP (Homo sapiens) 6480464 butylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 Butylparaben increases expression ISO Lep (Mus musculus) 6480464 butylparaben results in increased expression of LEP mRNA CTD PMID:22956630 butyric acid multiple interactions ISO Lep (Mus musculus) 6480464 Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of LEP mRNA CTD PMID:36278208 cadmium atom multiple interactions ISO LEP (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 cadmium dichloride decreases expression ISO Lep (Mus musculus) 6480464 Cadmium Chloride results in decreased expression of LEP mRNA and Cadmium Chloride results in decreased expression of LEP protein CTD PMID:23921151 cadmium dichloride multiple interactions ISO LEP (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 cadmium dichloride decreases expression ISO LEP (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of LEP mRNA CTD PMID:19847775 cadmium dichloride increases expression ISO Lep (Mus musculus) 6480464 Cadmium Chloride results in increased expression of LEP protein CTD PMID:27634282 cadmium dichloride multiple interactions ISO Lep (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:23921151 and PMID:27814245 caffeine decreases expression ISO Lep (Mus musculus) 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:23727198 caffeine decreases expression ISO LEP (Homo sapiens) 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:26367767 caffeine multiple interactions ISO LEP (Homo sapiens) 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] and Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of LEP mRNA and Caffeine results in decreased expression of LEP protein CTD PMID:23727198 and PMID:26367767 calcitriol decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcitriol CTD PMID:14657008 calcium atom multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 and PMID:20107083 calcium atom multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium atom affects secretion EXP 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium atom affects expression EXP 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium atom decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium atom affects abundance ISO Lep (Mus musculus) 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium atom increases transport ISO Lep (Mus musculus) 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 calcium(0) multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 and PMID:20107083 calcium(0) multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium(0) affects secretion EXP 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium(0) affects expression EXP 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium(0) decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium(0) affects abundance ISO Lep (Mus musculus) 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium(0) increases transport ISO Lep (Mus musculus) 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 candesartan multiple interactions ISO LEP (Homo sapiens) 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP] and Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 candesartan increases response to substance EXP 6480464 LEP protein results in increased susceptibility to candesartan CTD PMID:21287150 candesartan decreases expression ISO LEP (Homo sapiens) 6480464 candesartan results in decreased expression of LEP CTD PMID:19059660 cannabidiol multiple interactions ISO Lep (Mus musculus) 6480464 Cannabidiol analog inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:30382123 capsaicin decreases expression ISO Lep (Mus musculus) 6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:17295509 and PMID:19798065 capsaicin multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] more ... CTD PMID:20359164 and PMID:22150557 capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of LEP mRNA and Capsaicin results in increased expression of LEP protein CTD PMID:16278290 and PMID:22150557 capsazepine multiple interactions ISO Lep (Mus musculus) 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 carbon nanotube increases expression ISO Lep (Mus musculus) 6480464 Nanotubes and Carbon results in increased expression of LEP protein CTD PMID:20381574 carvacrol multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 CCCP multiple interactions ISO LEP (Homo sapiens) 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 CCCP decreases response to substance ISO LEP (Homo sapiens) 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein CTD PMID:11342529 cerulenin affects response to substance ISO Lep (Mus musculus) 6480464 LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 CGP 52608 multiple interactions ISO LEP (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to LEP gene] CTD PMID:28238834 CGS-21680 multiple interactions ISO LEP (Homo sapiens) 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 chlorohydrocarbon multiple interactions ISO Lep (Mus musculus) 6480464 [LEP protein co-treated with Hydrocarbons more ... CTD PMID:31313498 chloroquine multiple interactions ISO Lep (Mus musculus) 6480464 Chloroquine inhibits the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of LEP protein CTD PMID:33994353 chlorpyrifos increases expression ISO LEP (Homo sapiens) 6480464 Chlorpyrifos results in increased expression of LEP mRNA CTD PMID:30879083 choline multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:24384915 more ... chromium atom decreases expression EXP 6480464 Chromium results in decreased expression of LEP protein CTD PMID:17114815 chromium atom increases expression EXP 6480464 Chromium deficiency results in increased expression of LEP mRNA and Chromium deficiency results in increased expression of LEP protein CTD PMID:19846803 chromium atom multiple interactions ISO Lep (Mus musculus) 6480464 [Linoleic Acids and Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 chrysin decreases expression ISO Lep (Mus musculus) 6480464 chrysin results in decreased expression of LEP protein CTD PMID:30445784 cisplatin affects expression EXP 6480464 Cisplatin affects the expression of LEP protein CTD PMID:25051504 clofibrate multiple interactions ISO Lep (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 clofibrate multiple interactions EXP 6480464 [alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 clozapine affects response to substance ISO LEP (Homo sapiens) 6480464 LEP protein affects the susceptibility to Clozapine CTD PMID:17502770 clozapine increases expression EXP 6480464 Clozapine results in increased expression of LEP protein CTD PMID:16402076 cobalt dichloride increases expression ISO LEP (Homo sapiens) 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride increases secretion EXP 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion ISO LEP (Homo sapiens) 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion ISO Lep (Mus musculus) 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:22019852 colforsin daropate hydrochloride decreases secretion ISO Lep (Mus musculus) 6480464 Colforsin results in decreased secretion of LEP protein CTD PMID:27381457 colforsin daropate hydrochloride multiple interactions ISO LEP (Homo sapiens) 6480464 Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 colforsin daropate hydrochloride decreases expression ISO Lep (Mus musculus) 6480464 Colforsin results in decreased expression of LEP mRNA CTD PMID:27381457 and PMID:9002984 conjugated linoleic acid multiple interactions ISO Lep (Mus musculus) 6480464 [Linoleic Acids and Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 conjugated linoleic acid decreases expression ISO Lep (Mus musculus) 6480464 Linoleic Acids and Conjugated results in decreased expression of LEP protein CTD PMID:16933788 conjugated linoleic acid increases expression ISO Lep (Mus musculus) 6480464 Linoleic Acids and Conjugated results in increased expression of LEP protein CTD PMID:17322064 corn oil multiple interactions EXP 6480464 Corn Oil inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:29165388 corticosterone multiple interactions ISO Lep (Mus musculus) 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 and PMID:29751049 corticosterone decreases expression ISO Lep (Mus musculus) 6480464 Corticosterone results in decreased expression of LEP protein CTD PMID:28186389 crocidolite asbestos decreases expression ISO Lep (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of LEP mRNA CTD PMID:23917077 cycloheximide multiple interactions ISO Lep (Mus musculus) 6480464 LEP protein inhibits the reaction [Cycloheximide results in decreased expression of LEPR protein] CTD PMID:31199479 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of LEP protein CTD PMID:25051504 cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of LEP protein CTD PMID:27348886 cyromazine multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 D-glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... D-glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 D-glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... D-glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 D-glucose increases response to substance ISO LEP (Homo sapiens) 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 D-glucose multiple interactions ISO LEP (Homo sapiens) 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 dantrolene decreases expression EXP 6480464 Dantrolene results in decreased expression of LEP protein CTD PMID:25051504 DDE increases secretion ISO Lep (Mus musculus) 6480464 Dichlorodiphenyl Dichloroethylene results in increased secretion of LEP protein CTD PMID:21044676 DDE multiple interactions ISO LEP (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:26200599 DDT increases expression ISO LEP (Homo sapiens) 6480464 DDT results in increased expression of LEP mRNA CTD PMID:25014179 dehydroepiandrosterone decreases expression EXP 6480464 Dehydroepiandrosterone results in decreased expression of LEP protein CTD PMID:12659879 deoxycholic acid decreases expression ISO Lep (Mus musculus) 6480464 Deoxycholic Acid results in decreased expression of LEP mRNA CTD PMID:23911798 desferrioxamine B increases expression ISO LEP (Homo sapiens) 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 desferrioxamine B increases secretion EXP 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases secretion ISO LEP (Homo sapiens) 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 dexamethasone multiple interactions ISO LEP (Homo sapiens) 6480464 4 more ... CTD PMID:10946865 more ... dexamethasone multiple interactions ISO Lep (Mus musculus) 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... dexamethasone increases secretion ISO LEP (Homo sapiens) 6480464 Dexamethasone results in increased secretion of LEP protein CTD PMID:10946865 dexamethasone increases expression ISO LEP (Homo sapiens) 6480464 Dexamethasone results in increased expression of LEP mRNA CTD PMID:10946865 and PMID:32976960 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of LEP mRNA and Dexamethasone results in increased expression of LEP protein CTD PMID:15824971 and PMID:23166830 dextran sulfate multiple interactions ISO Lep (Mus musculus) 6480464 [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA and [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein CTD PMID:19931517 diarsenic trioxide multiple interactions ISO LEP (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein and Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 diazoxide multiple interactions EXP 6480464 Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 diazoxide decreases secretion EXP 6480464 Diazoxide results in decreased secretion of LEP protein CTD PMID:10780946 dibenziodolium multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] more ... CTD PMID:17668557 dibutylstannane multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with di-n-butyltin] results in increased expression of LEP protein CTD PMID:29787037 diethylstilbestrol decreases secretion ISO Lep (Mus musculus) 6480464 Diethylstilbestrol results in decreased secretion of LEP protein CTD PMID:25111128 diethylstilbestrol multiple interactions ISO Lep (Mus musculus) 6480464 Diethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23493373 diiodine multiple interactions EXP 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 dioxygen increases secretion ISO LEP (Homo sapiens) 6480464 Oxygen deficiency results in increased secretion of LEP protein CTD PMID:12032628 dioxygen increases expression ISO LEP (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of LEP mRNA CTD PMID:12032628 and PMID:23466666 dioxygen decreases expression ISO Lep (Mus musculus) 6480464 Oxygen deficiency results in decreased expression of LEP mRNA and Oxygen deficiency results in decreased expression of LEP protein CTD PMID:21531777 and PMID:23539316 dipyridamole multiple interactions EXP 6480464 1 and 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 dipyridamole increases expression EXP 6480464 Dipyridamole results in increased expression of LEP protein CTD PMID:10746648 disodium selenite decreases expression ISO Lep (Mus musculus) 6480464 Sodium Selenite results in decreased expression of LEP mRNA CTD PMID:23274088 dobutamine decreases secretion ISO LEP (Homo sapiens) 6480464 Dobutamine results in decreased secretion of LEP protein CTD PMID:11022189 dobutamine decreases expression ISO Lep (Mus musculus) 6480464 Dobutamine results in decreased expression of LEP mRNA and Dobutamine results in decreased expression of LEP protein CTD PMID:9002984 DPCPX multiple interactions EXP 6480464 1 and 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 edelfosine multiple interactions ISO Lep (Mus musculus) 6480464 edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 efavirenz decreases expression ISO LEP (Homo sapiens) 6480464 efavirenz results in decreased expression of LEP mRNA CTD PMID:21619898 elemental boron multiple interactions EXP 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 elemental selenium decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 Elemicin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 enalapril increases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 ethambutol decreases expression EXP 6480464 Ethambutol results in decreased expression of LEP protein CTD PMID:25051504 ethanol multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:18227024 ethanol multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 ethionamide decreases expression EXP 6480464 Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 Ethyl icosapentate multiple interactions ISO Lep (Mus musculus) 6480464 Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA] and Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein] CTD PMID:10753628 Ethyl icosapentate increases secretion ISO Lep (Mus musculus) 6480464 eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein CTD PMID:10753628 Ethyl icosapentate increases expression ISO Lep (Mus musculus) 6480464 eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA CTD PMID:10753628 ethylparaben decreases expression ISO LEP (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA CTD PMID:22956630 fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] and Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA] CTD PMID:26973390 fenofibrate multiple interactions ISO LEP (Homo sapiens) 6480464 Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 fenoterol decreases secretion ISO LEP (Homo sapiens) 6480464 Fenoterol results in decreased secretion of LEP protein CTD PMID:11022189 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of LEP mRNA CTD PMID:30307764 flufenamic acid multiple interactions ISO Lep (Mus musculus) 6480464 Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of LEP protein CTD PMID:25051504 fonofos increases methylation ISO LEP (Homo sapiens) 6480464 Fonofos results in increased methylation of LEP promoter CTD PMID:22847954 fructose multiple interactions EXP 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:21122807 more ... fructose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of LEP mRNA CTD PMID:37567420 fructose increases secretion EXP 6480464 Fructose results in increased secretion of LEP protein CTD PMID:10780946 more ... fructose increases expression EXP 6480464 Fructose results in increased expression of LEP mRNA and Fructose results in increased expression of LEP protein CTD PMID:11741341 more ... furan decreases expression EXP 6480464 furan results in decreased expression of LEP mRNA CTD PMID:25539665 gallocatechin multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 gamma-hexachlorocyclohexane affects expression EXP 6480464 Hexachlorocyclohexane affects the expression of LEP mRNA CTD PMID:17785943 Ganoderic acid A multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of LEP mRNA CTD PMID:29852127 gemcitabine decreases expression ISO LEP (Homo sapiens) 6480464 Gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 gemfibrozil decreases expression EXP 6480464 Gemfibrozil results in decreased expression of LEP protein CTD PMID:25051504 gemfibrozil increases expression EXP 6480464 Gemfibrozil results in increased expression of LEP protein CTD PMID:25051504 genistein decreases expression ISO Lep (Mus musculus) 6480464 Genistein results in decreased expression of LEP mRNA and Genistein results in decreased expression of LEP protein CTD PMID:18359623 genistein decreases response to substance ISO LEP (Homo sapiens) 6480464 Genistein results in decreased susceptibility to LEP protein CTD PMID:11342529 genistein multiple interactions ISO LEP (Homo sapiens) 6480464 Genistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and Genistein inhibits the reaction [LEP protein results in increased expression of CCL2] CTD PMID:11342529 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of LEP mRNA CTD PMID:33387578 gingerol multiple interactions ISO Lep (Mus musculus) 6480464 gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] and gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 glucagon multiple interactions ISO Lep (Mus musculus) 6480464 Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein] and Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein] CTD PMID:29988851 glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 glucose increases response to substance ISO LEP (Homo sapiens) 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 glucose multiple interactions ISO LEP (Homo sapiens) 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 glycine multiple interactions ISO Lep (Mus musculus) 6480464 Glycine affects the reaction [Sodium Glutamate affects the expression of LEP protein] CTD PMID:18930730 hesperidin decreases expression EXP 6480464 Hesperidin results in decreased expression of LEP protein CTD PMID:21820093 hesperidin multiple interactions EXP 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein CTD PMID:21820093 hexadecanoic acid decreases expression ISO Lep (Mus musculus) 6480464 Palmitic Acid results in decreased expression of LEP mRNA and Palmitic Acid results in decreased expression of LEP protein CTD PMID:34968464 hexadecanoic acid multiple interactions ISO Lep (Mus musculus) 6480464 [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of LEP mRNA more ... CTD PMID:34968464 hydrogen peroxide affects expression ISO LEP (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of LEP mRNA CTD PMID:21179406 hydrogen peroxide decreases expression ISO LEP (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of LEP mRNA CTD PMID:26339600 imidacloprid multiple interactions ISO Lep (Mus musculus) 6480464 Dietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein] and imidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein] CTD PMID:27960282 imidacloprid increases secretion ISO Lep (Mus musculus) 6480464 imidacloprid results in increased secretion of LEP protein CTD PMID:27960282 indinavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] CTD PMID:17668557 indinavir multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 indinavir decreases expression ISO LEP (Homo sapiens) 6480464 Indinavir results in decreased expression of LEP protein CTD PMID:17668557 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of LEP protein CTD PMID:16280098 and PMID:25051504 indometacin multiple interactions ISO LEP (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA more ... CTD PMID:23086663 and PMID:28628672 indometacin multiple interactions EXP 6480464 BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein] more ... CTD PMID:16280098 and PMID:18181030 inulin decreases expression EXP 6480464 Inulin results in decreased expression of LEP protein CTD PMID:27760213 iodide salt increases expression EXP 6480464 Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 iron(2+) sulfate (anhydrous) increases expression ISO LEP (Homo sapiens) 6480464 ferrous sulfate results in increased expression of LEP mRNA CTD PMID:21540303 isoflavones increases expression EXP 6480464 Isoflavones results in increased expression of LEP protein CTD PMID:22155228 isoprenaline increases secretion ISO Lep (Mus musculus) 6480464 Isoproterenol results in increased secretion of LEP protein CTD PMID:25111128 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of LEP protein CTD PMID:20307649 isoprenaline multiple interactions EXP 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] CTD PMID:20307649 isoprenaline multiple interactions ISO LEP (Homo sapiens) 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 isoprenaline decreases secretion ISO LEP (Homo sapiens) 6480464 Isoproterenol results in decreased secretion of LEP protein CTD PMID:11022189 isoscutellarein decreases expression ISO Lep (Mus musculus) 6480464 isoscutellarein results in decreased expression of LEP protein CTD PMID:30445784 isotretinoin increases expression EXP 6480464 Isotretinoin results in increased expression of LEP mRNA CTD PMID:19212007 kaempferol decreases expression ISO Lep (Mus musculus) 6480464 kaempferol results in decreased expression of LEP protein CTD PMID:30445784 kainic acid decreases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 ketamine decreases expression ISO LEP (Homo sapiens) 6480464 Ketamine results in decreased expression of LEP protein CTD PMID:36907275 ketamine multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of BCL2 protein]] more ... CTD PMID:36907275 L-ascorbic acid decreases secretion EXP 6480464 Ascorbic Acid results in decreased secretion of LEP protein CTD PMID:20400526 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [INS1 protein results in increased secretion of LEP protein] CTD PMID:20400526 L-methionine multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:24384915 more ... lamivudine multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA and [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 lanthanum atom multiple interactions ISO Lep (Mus musculus) 6480464 Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 lead(0) multiple interactions ISO LEP (Homo sapiens) 6480464 Lead results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24709140 Licarin A multiple interactions ISO Lep (Mus musculus) 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA CTD PMID:29288687 lipoic acid decreases secretion ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA and Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 lipoic acid decreases expression ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 lipopolysaccharide multiple interactions ISO LEP (Homo sapiens) 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of LEP protein CTD PMID:17379010 lipopolysaccharide multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] and Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17379010 and PMID:17621560 lipopolysaccharide multiple interactions ISO Lep (Mus musculus) 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein and TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 lipopolysaccharide increases expression ISO Lep (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of LEP mRNA CTD PMID:12057914 lipopolysaccharide decreases expression ISO Lep (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of LEP mRNA CTD PMID:12057914 loganin affects expression ISO Lep (Mus musculus) 6480464 loganin affects the expression of LEP protein CTD PMID:21864639 lopinavir decreases expression ISO LEP (Homo sapiens) 6480464 Lopinavir results in decreased expression of LEP protein CTD PMID:17668557 lopinavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein] CTD PMID:17668557 LY294002 decreases expression ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA CTD PMID:19254925 and PMID:21351249 LY294002 multiple interactions ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein] CTD PMID:29248466 LY294002 multiple interactions ISO LEP (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 LY294002 decreases secretion ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein CTD PMID:19254925 and PMID:21351249 manganese atom decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 manganese(0) decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 melatonin decreases expression ISO LEP (Homo sapiens) 6480464 Melatonin results in decreased expression of LEP mRNA CTD PMID:20738756 melatonin decreases expression EXP 6480464 Melatonin results in decreased expression of LEP protein CTD PMID:19028472 menadione multiple interactions ISO LEP (Homo sapiens) 6480464 1 more ... CTD PMID:16996477 menadione increases expression ISO LEP (Homo sapiens) 6480464 Vitamin K 3 results in increased expression of LEP mRNA CTD PMID:16996477 mercury dichloride decreases expression ISO Lep (Mus musculus) 6480464 Mercuric Chloride results in decreased expression of LEP mRNA CTD PMID:22019852 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of LEP mRNA CTD PMID:30807803 mercury dichloride decreases secretion ISO Lep (Mus musculus) 6480464 Mercuric Chloride results in decreased secretion of LEP protein CTD PMID:22019852 metformin increases expression ISO Lep (Mus musculus) 6480464 Metformin results in increased expression of LEP protein CTD PMID:20869956 metformin multiple interactions ISO Lep (Mus musculus) 6480464 Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 methacholine chloride increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 methadone increases expression ISO LEP (Homo sapiens) 6480464 Methadone results in increased expression of LEP protein CTD PMID:15717844 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of LEP protein CTD PMID:25051504 methotrexate affects expression ISO Lep (Mus musculus) 6480464 Methotrexate affects the expression of LEP mRNA CTD PMID:18502557 methylmercury chloride multiple interactions ISO Lep (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:27814245 and PMID:33338554 methylmercury chloride decreases expression ISO Lep (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of LEP mRNA CTD PMID:29850906 methylparaben decreases expression ISO LEP (Homo sapiens) 6480464 methylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 metronidazole multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 metyrapone multiple interactions EXP 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA CTD PMID:37088303 mevalonic acid multiple interactions ISO Lep (Mus musculus) 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] and Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 MK-2206 multiple interactions ISO Lep (Mus musculus) 6480464 MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3' and 5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein] CTD PMID:27381457 mono(2-ethylhexyl) phthalate decreases secretion ISO LEP (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in decreased secretion of LEP protein CTD PMID:29223775 Monobutylphthalate decreases secretion ISO LEP (Homo sapiens) 6480464 monobutyl phthalate results in decreased secretion of LEP protein CTD PMID:29223775 monocrotaline affects expression EXP 6480464 Monocrotaline affects the expression of LEP protein CTD PMID:25051504 monocrotaline multiple interactions ISO Lep (Mus musculus) 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein and TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of LEP protein CTD PMID:14657608 monosodium L-glutamate increases expression ISO Lep (Mus musculus) 6480464 Sodium Glutamate results in increased expression of LEP mRNA and Sodium Glutamate results in increased expression of LEP protein CTD PMID:15809509 more ... monosodium L-glutamate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats more ... CTD PMID:18930730 more ... monosodium L-glutamate affects expression ISO Lep (Mus musculus) 6480464 Sodium Glutamate affects the expression of LEP protein CTD PMID:18930730 morin multiple interactions EXP 6480464 morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO LEP (Homo sapiens) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] more ... CTD PMID:11342529 and PMID:28571770 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases response to substance ISO LEP (Homo sapiens) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased susceptibility to LEP protein CTD PMID:11342529 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO Lep (Mus musculus) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] CTD PMID:19254925 N-methyl-4-phenylpyridinium multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA] CTD PMID:19763737 N-methyl-N-nitrosourea multiple interactions ISO Lep (Mus musculus) 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] more ... CTD PMID:16822543 N-methyl-N-nitrosourea increases expression ISO Lep (Mus musculus) 6480464 Methylnitrosourea results in increased expression of LEP protein CTD PMID:16822543 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of LEP protein CTD PMID:25051504 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of LEP mRNA and Dimethylnitrosamine results in increased expression of LEP protein CTD PMID:15798949 naproxen multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] and Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 naringin multiple interactions EXP 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein and naringin inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:21820093 and PMID:24399619 naringin multiple interactions ISO Lep (Mus musculus) 6480464 naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:22198281 nelfinavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein] CTD PMID:17668557 nelfinavir decreases secretion ISO Lep (Mus musculus) 6480464 Nelfinavir results in decreased secretion of LEP protein CTD PMID:19033543 nelfinavir decreases expression ISO LEP (Homo sapiens) 6480464 Nelfinavir results in decreased expression of LEP protein CTD PMID:17668557 neomycin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 nevirapine increases expression ISO LEP (Homo sapiens) 6480464 Nevirapine results in increased expression of LEP mRNA CTD PMID:21619898 nickel atom decreases expression ISO LEP (Homo sapiens) 6480464 Nickel results in decreased expression of LEP mRNA CTD PMID:25583101 nickel dichloride multiple interactions ISO LEP (Homo sapiens) 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 nickel dichloride multiple interactions EXP 6480464 nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 nickel sulfate multiple interactions ISO LEP (Homo sapiens) 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA CTD PMID:18832182 nickel sulfate increases expression ISO LEP (Homo sapiens) 6480464 nickel sulfate results in increased expression of LEP mRNA CTD PMID:18832182 nicotine increases expression EXP 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 and PMID:29155039 nicotine decreases response to substance EXP 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 nicotinic acid increases expression ISO LEP (Homo sapiens) 6480464 Niacin results in increased expression of LEP protein CTD PMID:16887123 nicotinic acid increases expression ISO Lep (Mus musculus) 6480464 Niacin results in increased expression of LEP mRNA CTD PMID:21236357 nitric oxide multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:9312173 Nonylphenol increases expression ISO Lep (Mus musculus) 6480464 nonylphenol results in increased expression of LEP mRNA CTD PMID:18417718 norwogonin decreases expression ISO Lep (Mus musculus) 6480464 norwogonin analog results in decreased expression of LEP protein and norwogonin results in decreased expression of LEP protein CTD PMID:30445784 NS-398 multiple interactions ISO LEP (Homo sapiens) 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 olanzapine increases expression ISO LEP (Homo sapiens) 6480464 olanzapine results in increased expression of LEP protein CTD PMID:11927762 and PMID:19512971 olanzapine increases expression ISO Lep (Mus musculus) 6480464 Olanzapine results in increased expression of LEP protein CTD PMID:32652086 olanzapine multiple interactions ISO Lep (Mus musculus) 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] more ... CTD PMID:32652086 oleanolic acid increases expression ISO Lep (Mus musculus) 6480464 Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 oleic acid decreases expression ISO Lep (Mus musculus) 6480464 Oleic Acid results in decreased expression of LEP mRNA CTD PMID:9002984 oleic acid increases expression EXP 6480464 Oleic Acid results in increased expression of LEP mRNA CTD PMID:23395669 oleic acid multiple interactions EXP 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 omaveloxolone multiple interactions ISO Lep (Mus musculus) 6480464 omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein] CTD PMID:32410268 orlistat multiple interactions ISO Lep (Mus musculus) 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 orlistat multiple interactions EXP 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 ozone multiple interactions ISO Lep (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL11 protein more ... CTD PMID:12794034 and PMID:27472835 ozone multiple interactions EXP 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA more ... CTD PMID:23968387 more ... ozone decreases secretion ISO Lep (Mus musculus) 6480464 Ozone results in decreased secretion of LEP protein CTD PMID:27240593 ozone increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Ozone and LEP protein results in increased susceptibility to Ozone CTD PMID:12794034 more ... ozone increases expression EXP 6480464 Ozone results in increased expression of LEP and Ozone results in increased expression of LEP protein CTD PMID:24103449 more ... paracetamol multiple interactions ISO Lep (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 paracetamol decreases expression ISO LEP (Homo sapiens) 6480464 Acetaminophen results in decreased expression of LEP mRNA CTD PMID:26690555 paracetamol affects expression ISO Lep (Mus musculus) 6480464 Acetaminophen affects the expression of LEP mRNA CTD PMID:17562736 paraquat affects expression EXP 6480464 Paraquat affects the expression of LEP mRNA CTD PMID:18198484 parathion increases methylation ISO LEP (Homo sapiens) 6480464 Parathion results in increased methylation of LEP promoter CTD PMID:22847954 perfluorohexanesulfonic acid multiple interactions EXP 6480464 [perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 perfluorooctane-1-sulfonic acid increases expression ISO LEP (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in increased expression of LEP mRNA CTD PMID:28011154 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 perfluorooctane-1-sulfonic acid affects expression ISO LEP (Homo sapiens) 6480464 perfluorooctane sulfonic acid affects the expression of LEP mRNA CTD PMID:30738844 perfluorooctanoic acid multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with perfluorooctanoic acid co-treated with perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of LEP protein CTD PMID:18083506 permethrin multiple interactions ISO Lep (Mus musculus) 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein and Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 phencyclidine increases expression ISO Lep (Mus musculus) 6480464 Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 phenethyl caffeate decreases expression ISO Lep (Mus musculus) 6480464 caffeic acid phenethyl ester results in decreased expression of LEP mRNA and caffeic acid phenethyl ester results in decreased expression of LEP protein CTD PMID:21467634 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of LEP protein CTD PMID:25051504 phenobarbital multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA and [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein CTD PMID:14758566 phloretin multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 phlorizin multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 phosphatidylcholine decreases expression ISO Lep (Mus musculus) 6480464 Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 phosphoramidon decreases expression EXP 6480464 phosphoramidon results in decreased expression of LEP protein CTD PMID:16391412 pioglitazone increases expression EXP 6480464 pioglitazone results in increased expression of LEP protein CTD PMID:15655531 piperine multiple interactions EXP 6480464 piperine inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 pirimicarb multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 pirinixic acid multiple interactions ISO Lep (Mus musculus) 6480464 pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein] CTD PMID:16306350 pitavastatin multiple interactions ISO Lep (Mus musculus) 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 pitavastatin(1-) multiple interactions ISO Lep (Mus musculus) 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 pluronic P-123 multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] and Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 pluronic P-123 increases secretion EXP 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Poloxamer increases secretion EXP 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Poloxamer multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] and Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 potassium dichromate increases expression ISO LEP (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of LEP mRNA CTD PMID:11678601 pravastatin multiple interactions ISO Lep (Mus musculus) 6480464 Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 prochloraz decreases expression ISO LEP (Homo sapiens) 6480464 prochloraz results in decreased expression of LEP mRNA CTD PMID:30879083 progesterone decreases secretion ISO LEP (Homo sapiens) 6480464 Progesterone results in decreased secretion of LEP protein CTD PMID:16048798 progesterone multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone] and LEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]] CTD PMID:19849856 progesterone increases expression ISO Lep (Mus musculus) 6480464 Progesterone results in increased expression of LEP mRNA CTD PMID:15713686 propranolol multiple interactions ISO LEP (Homo sapiens) 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 propranolol increases expression EXP 6480464 Propranolol results in increased expression of LEP protein CTD PMID:24250662 propylparaben increases expression ISO Lep (Mus musculus) 6480464 propylparaben results in increased expression of LEP mRNA CTD PMID:22956630 propylparaben decreases expression ISO LEP (Homo sapiens) 6480464 propylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 prostaglandin E2 increases expression EXP 6480464 Dinoprostone results in increased expression of LEP protein CTD PMID:11060898 prostaglandin E2 increases abundance EXP 6480464 LEP protein results in increased abundance of Dinoprostone CTD PMID:16015682 prostaglandin E2 increases secretion EXP 6480464 Dinoprostone results in increased secretion of LEP protein CTD PMID:11060898 Ptaquiloside decreases expression ISO Lep (Mus musculus) 6480464 ptaquiloside results in decreased expression of LEP mRNA CTD PMID:23274088 Pyridostigmine bromide multiple interactions ISO Lep (Mus musculus) 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein and Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 pyruvic acid increases secretion EXP 6480464 Pyruvic Acid results in increased secretion of LEP protein CTD PMID:10780946 pyruvic acid multiple interactions EXP 6480464 INS1 protein promotes the reaction [Pyruvic Acid results in increased secretion of LEP protein] CTD PMID:10780946 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] more ... CTD PMID:22426011 more ... quercetin increases expression ISO LEP (Homo sapiens) 6480464 Quercetin results in increased expression of LEP mRNA and Quercetin results in increased expression of LEP protein CTD PMID:22230496 quercetin decreases expression ISO Lep (Mus musculus) 6480464 Quercetin results in decreased expression of LEP mRNA and Quercetin results in decreased expression of LEP protein CTD PMID:19914226 and PMID:30445784 quercetin decreases secretion ISO Lep (Mus musculus) 6480464 Quercetin results in decreased secretion of LEP protein CTD PMID:19914226 quercetin multiple interactions ISO Lep (Mus musculus) 6480464 Quercetin affects the reaction [LEP protein affects the expression of NOS2 mRNA] more ... CTD PMID:19914226 more ... rac-lactic acid affects expression ISO LEP (Homo sapiens) 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 ramipril multiple interactions ISO LEP (Homo sapiens) 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP] and Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 ramipril decreases expression ISO LEP (Homo sapiens) 6480464 Ramipril results in decreased expression of LEP CTD PMID:19059660 reactive oxygen species multiple interactions ISO LEP (Homo sapiens) 6480464 adenosine-3' more ... CTD PMID:11342529 reactive oxygen species increases chemical synthesis ISO LEP (Homo sapiens) 6480464 LEP protein results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:11342529 rebaudioside A multiple interactions ISO Lep (Mus musculus) 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 reserpine increases expression ISO Lep (Mus musculus) 6480464 Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 resveratrol decreases secretion ISO Lep (Mus musculus) 6480464 resveratrol metabolite results in decreased secretion of LEP protein and resveratrol results in decreased secretion of LEP protein CTD PMID:23717508 resveratrol multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with Resveratrol] results in increased expression of LEP mRNA more ... CTD PMID:29197120 and PMID:31881177 resveratrol multiple interactions EXP 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:26973390 and PMID:37570835 resveratrol decreases expression ISO LEP (Homo sapiens) 6480464 resveratrol results in decreased expression of LEP mRNA and resveratrol results in decreased expression of LEP protein CTD PMID:21713995 and PMID:23536519 resveratrol decreases expression ISO Lep (Mus musculus) 6480464 resveratrol metabolite results in decreased expression of LEP mRNA more ... CTD PMID:23717508 more ... rifampicin increases expression EXP 6480464 Rifampin results in increased expression of LEP protein CTD PMID:25051504 rimonabant multiple interactions ISO Lep (Mus musculus) 6480464 Rimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein] more ... CTD PMID:19030233 and PMID:26967640 ritonavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 ritonavir decreases expression ISO LEP (Homo sapiens) 6480464 Ritonavir results in decreased expression of LEP protein CTD PMID:17668557 rotenone decreases response to substance ISO LEP (Homo sapiens) 6480464 Rotenone results in decreased susceptibility to LEP protein CTD PMID:11342529 rotenone multiple interactions ISO LEP (Homo sapiens) 6480464 Rotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 roxarsone decreases expression ISO LEP (Homo sapiens) 6480464 Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 ruthenium red multiple interactions ISO Lep (Mus musculus) 6480464 Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 S-adenosyl-L-methioninate multiple interactions ISO LEP (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] and S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 S-adenosyl-L-methionine multiple interactions ISO LEP (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] and S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 saquinavir multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 SB 203580 multiple interactions ISO LEP (Homo sapiens) 6480464 SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] and SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 and PMID:19849856 SB 203580 decreases response to substance ISO LEP (Homo sapiens) 6480464 SB 203580 results in decreased susceptibility to LEP protein CTD PMID:19849856 selenium atom decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 serpentine asbestos decreases expression ISO Lep (Mus musculus) 6480464 Asbestos and Serpentine results in decreased expression of LEP mRNA CTD PMID:23917077 silicon dioxide decreases expression ISO LEP (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of LEP mRNA CTD PMID:23806026 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of LEP mRNA CTD PMID:32721576 simvastatin multiple interactions ISO Lep (Mus musculus) 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] more ... CTD PMID:19254925 simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 simvastatin decreases secretion ISO Lep (Mus musculus) 6480464 Simvastatin results in decreased secretion of LEP protein CTD PMID:19254925 simvastatin decreases expression ISO Lep (Mus musculus) 6480464 Simvastatin results in decreased expression of LEP mRNA and Simvastatin results in decreased expression of LEP mRNA alternative form CTD PMID:19254925 SKF-96365 hydrochloride multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 sodium arsenate multiple interactions ISO LEP (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 sodium arsenite increases expression ISO LEP (Homo sapiens) 6480464 sodium arsenite results in increased expression of LEP mRNA CTD PMID:25879800 sodium arsenite decreases expression ISO LEP (Homo sapiens) 6480464 sodium arsenite results in decreased expression of LEP mRNA CTD PMID:37956786 sodium arsenite decreases expression ISO Lep (Mus musculus) 6480464 sodium arsenite results in decreased expression of LEP mRNA CTD PMID:34968464 and PMID:36209798 sodium arsenite multiple interactions ISO Lep (Mus musculus) 6480464 [Palmitic Acid co-treated with sodium arsenite] results in decreased expression of LEP mRNA more ... CTD PMID:28593471 more ... sodium arsenite increases expression ISO Lep (Mus musculus) 6480464 sodium arsenite results in increased expression of LEP protein CTD PMID:28593471 and PMID:29755549 sodium arsenite affects expression ISO Lep (Mus musculus) 6480464 sodium arsenite affects the expression of LEP mRNA and sodium arsenite affects the expression of LEP protein CTD PMID:25367288 and PMID:28206643 sodium perchlorate multiple interactions EXP 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 Sophocarpine multiple interactions EXP 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 stavudine decreases expression ISO LEP (Homo sapiens) 6480464 Stavudine results in decreased expression of LEP protein CTD PMID:17668557 steviol multiple interactions ISO Lep (Mus musculus) 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA] more ... CTD PMID:25554529 stevioside multiple interactions ISO Lep (Mus musculus) 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:24854284 streptozocin multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein more ... CTD PMID:29988851 and PMID:32410268 sumatriptan multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] and Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 superoxide multiple interactions ISO Lep (Mus musculus) 6480464 acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides] more ... CTD PMID:16380530 superoxide multiple interactions ISO LEP (Homo sapiens) 6480464 [LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides CTD PMID:11342529 superoxide increases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in increased abundance of Superoxides CTD PMID:16380530 terbufos increases methylation ISO LEP (Homo sapiens) 6480464 terbufos results in increased methylation of LEP promoter CTD PMID:22847954 terbutaline decreases expression ISO Lep (Mus musculus) 6480464 Terbutaline results in decreased expression of LEP mRNA and Terbutaline results in decreased expression of LEP protein CTD PMID:9002984 testosterone affects secretion ISO Lep (Mus musculus) 6480464 LEP protein affects the secretion of Testosterone CTD PMID:24502529 testosterone multiple interactions ISO Lep (Mus musculus) 6480464 alpha-cyano-(3 more ... CTD PMID:24502529 tetrachloromethane multiple interactions ISO Lep (Mus musculus) 6480464 LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein] more ... CTD PMID:11481614 more ... tetrachloromethane increases expression ISO Lep (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:29987408 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:27623180 tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:14758566 and PMID:18227024 thioacetamide decreases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in decreased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of LEP protein CTD PMID:17621560 thioacetamide multiple interactions EXP 6480464 Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17621560 thioacetamide increases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in increased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide multiple interactions ISO Lep (Mus musculus) 6480464 [Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNA more ... CTD PMID:11481614 more ... thiram multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 titanium dioxide decreases expression ISO Lep (Mus musculus) 6480464 titanium dioxide results in decreased expression of LEP mRNA CTD PMID:23131501 titanium dioxide increases expression ISO Lep (Mus musculus) 6480464 titanium dioxide results in increased expression of LEP mRNA CTD PMID:29264374 tributylstannane increases expression ISO LEP (Homo sapiens) 6480464 tributyltin results in increased expression of LEP mRNA CTD PMID:28011154 tributylstannane decreases expression ISO Lep (Mus musculus) 6480464 tributyltin results in decreased expression of LEP protein CTD PMID:27310180 tributylstannane multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein CTD PMID:29787037 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 tributylstannane increases expression ISO Lep (Mus musculus) 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 tributylstannane increases secretion EXP 6480464 tributyltin results in increased secretion of LEP protein CTD PMID:28161095 trichloroethene multiple interactions ISO Lep (Mus musculus) 6480464 Trichloroethylene inhibits the reaction [Dietary Fats affects the expression of LEP mRNA] CTD PMID:29669109 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of LEP mRNA CTD PMID:33387578 trichostatin A increases expression ISO LEP (Homo sapiens) 6480464 trichostatin A results in increased expression of LEP mRNA CTD PMID:17502362 trichostatin A multiple interactions ISO LEP (Homo sapiens) 6480464 trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 triclosan increases expression ISO LEP (Homo sapiens) 6480464 Triclosan results in increased expression of LEP mRNA CTD PMID:38048832 triflumizole multiple interactions ISO LEP (Homo sapiens) 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA and T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:23086663 triflumizole multiple interactions ISO Lep (Mus musculus) 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA and T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA] CTD PMID:23086663 triphenyl phosphate multiple interactions ISO Lep (Mus musculus) 6480464 [tris(1 more ... CTD PMID:29112739 triptonide increases expression ISO Lep (Mus musculus) 6480464 triptonide results in increased expression of LEP mRNA CTD PMID:33045310 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of LEP mRNA and troglitazone results in decreased expression of LEP protein CTD PMID:11909685 more ... troglitazone decreases expression ISO LEP (Homo sapiens) 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:10946865 and PMID:9727893 troglitazone decreases expression ISO Lep (Mus musculus) 6480464 troglitazone results in decreased expression of LEP mRNA CTD PMID:10753628 troglitazone increases secretion ISO LEP (Homo sapiens) 6480464 troglitazone results in increased secretion of LEP protein CTD PMID:11092516 troglitazone multiple interactions ISO LEP (Homo sapiens) 6480464 [Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein more ... CTD PMID:10946865 and PMID:11092516 U-73122 multiple interactions ISO Lep (Mus musculus) 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:20107083 ursolic acid increases expression ISO Lep (Mus musculus) 6480464 Ursolic Acid results in increased expression of LEP protein CTD PMID:20869956 vanadium atom multiple interactions EXP 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein] and Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 vanadium(0) multiple interactions EXP 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein] and Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 vancomycin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of LEP mRNA CTD PMID:23160963 vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA] and Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein] CTD PMID:20404018 wogonin decreases expression ISO Lep (Mus musculus) 6480464 wogonin analog results in decreased expression of LEP protein and wogonin results in decreased expression of LEP protein CTD PMID:30445784 wortmannin decreases expression ISO Lep (Mus musculus) 6480464 wortmannin results in decreased expression of LEP mRNA CTD PMID:19254925 wortmannin multiple interactions ISO Lep (Mus musculus) 6480464 wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 wortmannin decreases secretion ISO Lep (Mus musculus) 6480464 wortmannin results in decreased secretion of LEP protein CTD PMID:19254925 xanthone multiple interactions EXP 6480464 xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein] and xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 zidovudine decreases expression ISO LEP (Homo sapiens) 6480464 Zidovudine results in decreased expression of LEP protein CTD PMID:17668557 zidovudine multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA and [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 zinc atom decreases expression ISO Lep (Mus musculus) 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 zinc atom multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 zinc atom decreases expression ISO LEP (Homo sapiens) 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc atom multiple interactions ISO LEP (Homo sapiens) 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] and MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 zinc atom decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc dichloride increases expression ISO LEP (Homo sapiens) 6480464 zinc chloride results in increased expression of LEP mRNA CTD PMID:21540303 zinc molecular entity multiple interactions EXP 6480464 Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 zinc sulfate decreases expression EXP 6480464 Zinc Sulfate deficiency results in decreased expression of LEP mRNA CTD PMID:11568307 zinc sulfate multiple interactions EXP 6480464 Zinc Sulfate deficiency results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:11568307 zinc(0) decreases expression ISO Lep (Mus musculus) 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 zinc(0) decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc(0) multiple interactions ISO LEP (Homo sapiens) 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] and MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 zinc(0) decreases expression ISO LEP (Homo sapiens) 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 zinc(0) multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 ziram multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614