Exhibits hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Localizes to the extracellular space. Used to study several diseases, including glucose metabolism disease (multiple); neurodegenerative disease (multiple); obesity; osteoporosis; and short bowel syndrome. Biomarker of Huntington's disease; familial hyperlipidemia; obesity; osteoporosis; and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including fatty liver disease; lung disease (multiple); obesity; osteoporosis; and rhinitis. Orthologous to human LEP (leptin); PARTICIPATES IN energy homeostasis pathway; leptin system pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; (S)-nicotine.
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA], Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein] more ...
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA], geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]
3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] more ...
AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]
Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]
pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]
[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein, [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein] more ...
boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA], boric acid results in decreased expression of and results in decreased secretion of LEP protein
Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA], Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ...
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ...
candesartan promotes the reaction [Ramipril results in increased expression of LEP], Ramipril promotes the reaction [candesartan results in increased expression of LEP]
[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA]
[2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein
Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]
Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA]
[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA, [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein
[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein, Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]
Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA], Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein]
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA], Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]
cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme], tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]]
Genistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], Genistein inhibits the reaction [LEP protein results in increased expression of CCL2]
gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA], gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein], Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein]
Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]
cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme], tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]]
Dietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein], imidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA more ...
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA, [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA
[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA
Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein], Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein]
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein, TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]
MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3', 5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein]
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein, TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] more ...
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein]
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein, naringin inhibits the reaction [Glucose results in increased expression of LEP protein]
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]
[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA]
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein, Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein]
[Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA, [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein
[2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein
carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein], Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein]
carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein], Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein]
LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone], LEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]]
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein, Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein]
candesartan promotes the reaction [Ramipril results in increased expression of LEP], Ramipril promotes the reaction [candesartan results in increased expression of LEP]
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA], resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA]
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA], S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA], S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]
SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]], SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]
[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein, Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein]
[2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein
[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA, T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]
[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA, T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA]
Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein], Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein]
Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein], Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein]
Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein], Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein]
Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA], Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein]
xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein], xanthone inhibits the reaction [LEP protein results in increased expression of ACE2]
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA, [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA
IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA], MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]
IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA], MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]
[2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
may have a role in the inhibition of neuropeptideY/agouti-related protein neurons and activation of pro-opiomelanocortin/cocaine- and amphetamine regulated transcript neurons
leptin-induced leptin resistance was associated with persistent elevation in hypothalamic phosphorylated signal transducer and activator of transcription-3 (STAT3); curator note
Gene-Chemical Interaction Annotations
