Lep (leptin) - Rat Genome Database

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Gene: Lep (leptin) Rattus norvegicus
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Symbol: Lep
Name: leptin
RGD ID: 3000
Description: Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of metabolic process; and regulation of apoptotic process. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; lipid metabolism disorder (multiple); liver disease (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin); PARTICIPATES IN energy homeostasis pathway; leptin system pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: OB; obese; obesity (murine homolog leptin); obesity factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lepem5Mcwi   Lepm1Kyo   Lepem1Sage   Lepem1  
Genetic Models: SD-Lepem1 SS-Lepem5Mcwi SD-Lepem1Sage-/- SD-Lepem1Sage+/- W.F344-Lepm1Kyo F344-Lepm1Kyo
Is Marker For: Strains:   F344-Lepm1Kyo   SD-Lepem1Narl  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,644,034 - 62,658,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,559,814 - 58,573,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,962,087 - 56,976,240 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBICelera
RH 3.4 Map4309.5RGD
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISS)
abdominal obesity-metabolic syndrome 1  (ISS)
acute pancreatitis  (IEP)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
alcohol dependence  (IDA,IEP,ISO)
alcoholic liver cirrhosis  (IDA)
Alzheimer's disease  (IDA,ISO)
asthma  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (ISO)
Body Weight Changes  (IMP)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Hepatitis C  (IEP)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
congenital leptin deficiency  (ISO)
congestive heart failure  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
Dyslipidemias  (IEP)
End Stage Liver Disease  (IEP)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,IMP,ISO)
Experimental Liver Cirrhosis  (IMP,ISO)
Experimental Mammary Neoplasms  (IEP)
familial hyperlipidemia  (IEP)
Female Infertility  (ISO)
Femoral Fractures  (IEP)
Fetal Growth Retardation  (IDA)
gastric ulcer  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (IMP,ISO)
hepatocellular carcinoma  (IAGP,IEP)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
heroin dependence  (ISO)
Huntington's disease  (IEP)
Hypercapnia  (ISO)
Hypercholesterolemia  (IMP,ISO)
hyperglycemia  (ISO)
hyperinsulinism  (IMP,ISO)
Hyperphagia  (ISO)
Hyperplasia  (ISO)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (IMP)
hypogonadism  (IDA,ISO)
Hypoventilation  (ISO)
Inflammation  (ISO)
Insulin Resistance  (IEP,IMP,ISO)
Kidney Reperfusion Injury  (IDA)
Knee Osteoarthritis  (ISO)
lipid metabolism disorder  (IEP)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO,ISS)
Metabolic Syndrome  (IEP,ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (IEP)
Nerve Degeneration  (ISO)
obesity  (IDA,IEP,IMP,ISO,ISS)
obstructive sleep apnea  (ISO)
Oral Ulcer  (ISO)
osteoarthritis  (ISO)
osteoporosis  (IDA,IEP,ISO)
Parkinson's disease  (IDA)
pleomorphic xanthoastrocytoma  (ISO)
Pneumococcal Pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
Polydipsia  (ISO)
Polyuria  (ISO)
pre-eclampsia  (IEP)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA)
rhinitis  (ISO)
Sepsis  (IEP)
short bowel syndrome  (IDA)
Spinal Cord Injuries  (IEP)
steatotic liver disease  (IEP,ISO,ISS)
Tachycardia  (ISO)
type 2 diabetes mellitus  (IMP,ISO,ISS)
Ventricular Remodeling  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (EXP)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,8-cineole  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-amino-6-diazo-5-oxohexanoic acid  (ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methyl-4-chlorophenoxybutyric acid  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-aminobenzamide  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxybenzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
AACOCF3  (ISO)
acarbose  (EXP)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
Amibegron  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
androst-4-ene-3,17-dione  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP)
Aurothioglucose  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
boron atom  (EXP)
BQ 123  (ISO)
bromodichloromethane  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
carvacrol  (EXP)
CCCP  (ISO)
cerulenin  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chrysin  (ISO)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
corn oil  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cyromazine  (EXP)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
DDE  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazoxide  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
diethyl hydrogen phosphate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dipyridamole  (EXP)
disodium selenite  (ISO)
dobutamine  (ISO)
DPCPX  (EXP)
edelfosine  (ISO)
efavirenz  (ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
Elemicin  (ISO)
enalapril  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
Ethyl icosapentate  (ISO)
ethylparaben  (ISO)
fenofibrate  (EXP,ISO)
fenoterol  (ISO)
fenvalerate  (EXP)
flufenamic acid  (ISO)
flutamide  (EXP)
fonofos  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glycine  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
inulin  (EXP)
iodide salt  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP,ISO)
isoscutellarein  (ISO)
isotretinoin  (EXP)
kaempferol  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lanthanum atom  (ISO)
lead(0)  (ISO)
Licarin A  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (ISO)
lopinavir  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (ISO)
methacholine chloride  (ISO)
methadone  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metronidazole  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
naringin  (EXP,ISO)
nelfinavir  (ISO)
neomycin  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nitric oxide  (ISO)
Nonylphenol  (ISO)
norwogonin  (ISO)
NS-398  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
omaveloxolone  (ISO)
orlistat  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP)
permethrin  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phosphatidylcholine  (ISO)
phosphoramidon  (EXP)
pioglitazone  (EXP)
piperine  (EXP)
pirimicarb  (EXP)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP)
Ptaquiloside  (ISO)
Pyridostigmine bromide  (ISO)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
roxarsone  (ISO)
ruthenium red  (ISO)
rutin  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium perchlorate  (EXP)
Sophocarpine  (EXP)
stavudine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sumatriptan  (EXP)
superoxide  (ISO)
tauroursodeoxycholic acid  (ISO)
terbufos  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP,ISO)
thiram  (EXP)
titanium dioxide  (ISO)
triazophos  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
U-73122  (ISO)
ursolic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
wogonin  (ISO)
wortmannin  (ISO)
xanthone  (EXP)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase C activity  (ISO,ISS)
adipose tissue development  (ISO)
adult feeding behavior  (ISO,ISS)
angiogenesis  (ISO)
aorta development  (ISO)
bile acid metabolic process  (ISO)
bone growth  (ISO,ISS)
bone mineralization involved in bone maturation  (IDA)
cAMP-mediated signaling  (TAS)
cardiac muscle hypertrophy  (IDA)
cell surface receptor signaling pathway via JAK-STAT  (ISO,TAS)
cell surface receptor signaling pathway via STAT  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to L-ascorbic acid  (IEP)
cellular response to leptin stimulus  (ISO)
cellular response to retinoic acid  (IEP)
central nervous system neuron development  (ISO)
cholesterol metabolic process  (ISO)
circadian rhythm  (IEP)
determination of adult lifespan  (ISO)
eating behavior  (ISO)
elastin metabolic process  (ISO)
energy homeostasis  (ISO)
energy reserve metabolic process  (IBA,IDA)
fatty acid beta-oxidation  (ISO)
fatty acid catabolic process  (IDA)
female pregnancy  (IEP)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
glycerol biosynthetic process  (IDA)
hormone metabolic process  (ISO)
insulin secretion  (ISO)
intestinal absorption  (ISO,ISS)
intracellular signal transduction  (IDA,TAS)
leptin-mediated signaling pathway  (IDA,ISO)
leukocyte tethering or rolling  (IDA)
lipid metabolic process  (IBA,ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of appetite  (ISO,ISS)
negative regulation of appetite by leptin-mediated signaling pathway  (IBA,IDA)
negative regulation of autophagy  (ISO,ISS)
negative regulation of cartilage development  (IDA)
negative regulation of D-glucose import  (ISO,ISS)
negative regulation of glucagon secretion  (ISO)
negative regulation of glutamine transport  (IMP)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid storage  (IDA)
negative regulation of metabolic process  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (IDA)
ovulation from ovarian follicle  (IDA)
phagocytosis  (IDA,ISO,ISS)
placenta development  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytokine production  (IEP)
positive regulation of developmental growth  (ISO)
positive regulation of fat cell apoptotic process  (IDA)
positive regulation of follicle-stimulating hormone secretion  (IEP)
positive regulation of hepatic stellate cell activation  (IDA)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of interleukin-12 production  (ISO,ISS)
positive regulation of interleukin-6 production  (ISO,ISS)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of luteinizing hormone secretion  (IEP)
positive regulation of MAPK cascade  (IDA,ISO)
positive regulation of monoatomic ion transport  (IDA)
positive regulation of p38MAPK cascade  (IBA,ISO,ISS)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IDA,ISO,ISS)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein modification process  (IMP)
positive regulation of reactive oxygen species metabolic process  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IMP,ISO,ISS)
positive regulation of T cell proliferation  (ISO,ISS)
positive regulation of TOR signaling  (IBA,ISO,ISS)
positive regulation of tumor necrosis factor production  (ISO,ISS)
prostaglandin secretion  (ISO,ISS)
regulation of angiogenesis  (ISO,ISS)
regulation of blood pressure  (IDA)
regulation of bone remodeling  (ISO,ISS)
regulation of brown fat cell differentiation  (ISO,ISS)
regulation of catalytic activity  (ISO)
regulation of cell cycle  (ISO,ISS)
regulation of cytokine production involved in inflammatory response  (ISO,ISS)
regulation of endothelial cell proliferation  (ISO,ISS)
regulation of fat cell differentiation  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of insulin secretion  (ISO)
regulation of intestinal cholesterol absorption  (ISO)
regulation of lipid biosynthetic process  (ISO)
regulation of lipoprotein lipid oxidation  (IDA)
regulation of metabolic process  (ISO)
regulation of natural killer cell activation  (ISO,ISS)
regulation of natural killer cell mediated cytotoxicity  (ISO,ISS)
regulation of natural killer cell proliferation  (ISO,ISS)
regulation of nitric-oxide synthase activity  (ISO,ISS)
regulation of protein localization to nucleus  (ISO)
regulation of steroid biosynthetic process  (ISO)
response to activity  (IEP)
response to dietary excess  (IMP,ISO)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to hypoxia  (IEP)
response to insulin  (IBA,ISO)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to vitamin E  (IEP)
sexual reproduction  (ISO)
T cell differentiation  (ISO,ISS)

Cellular Component
cytoplasm  (ISO)
cytosol  (IDA)
extracellular space  (IBA,IDA,ISO)

Molecular Function

References

References - curated
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Additional References at PubMed
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Genomics

Comparative Map Data
Lep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2