Lep (leptin) - Rat Genome Database

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Gene: Lep (leptin) Rattus norvegicus
Analyze
Symbol: Lep
Name: leptin
RGD ID: 3000
Description: Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; lipid metabolism disorder (multiple); liver disease (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin); PARTICIPATES IN energy homeostasis pathway; leptin system pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: OB; obese; obesity (murine homolog leptin); obesity factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Lepem5Mcwi   Lepm1Kyo   Lepem1Sage   Lepem1  
Genetic Models: SD-Lepem1 SS-Lepem5Mcwi SD-Lepem1Sage-/- SD-Lepem1Sage+/- W.F344-Lepm1Kyo F344-Lepm1Kyo
Is Marker For: Strains:   F344-Lepm1Kyo   SD-Lepem1Narl  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,644,034 - 62,658,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,559,814 - 58,573,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,962,087 - 56,976,240 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBICelera
RH 3.4 Map4309.5RGD
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISS)
abdominal obesity-metabolic syndrome 1  (ISS)
acute pancreatitis  (IEP)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
alcohol dependence  (IDA,IEP)
alcoholic liver cirrhosis  (IDA)
Alzheimer's disease  (IDA,ISO)
asthma  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (ISO)
Body Weight Changes  (IMP)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Hepatitis C  (IEP)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
congenital leptin deficiency  (ISO)
congestive heart failure  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
Dyslipidemias  (IEP)
End Stage Liver Disease  (IEP)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,IMP,ISO)
Experimental Liver Cirrhosis  (IMP,ISO)
Experimental Mammary Neoplasms  (IEP)
familial hyperlipidemia  (IEP)
Female Infertility  (ISO)
Femoral Fractures  (IEP)
Fetal Growth Retardation  (IDA)
gastric ulcer  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (IMP,ISO)
hepatocellular carcinoma  (IAGP,IEP)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
heroin dependence  (ISO)
Huntington's disease  (IEP)
Hypercapnia  (ISO)
Hypercholesterolemia  (IMP,ISO)
hyperglycemia  (ISO)
hyperinsulinism  (IMP,ISO)
Hyperphagia  (ISO)
Hyperplasia  (ISO)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (IMP)
hypogonadism  (IDA,ISO)
Hypoventilation  (ISO)
Inflammation  (ISO)
Insulin Resistance  (IEP,IMP,ISO)
Kidney Reperfusion Injury  (IDA)
Knee Osteoarthritis  (ISO)
lipid metabolism disorder  (IEP)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO,ISS)
Metabolic Syndrome  (IEP,ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (IEP)
Nerve Degeneration  (ISO)
obesity  (IDA,IEP,IMP,ISO,ISS)
obstructive sleep apnea  (ISO)
Oral Ulcer  (ISO)
osteoarthritis  (ISO)
osteoporosis  (IDA,IEP,ISO)
Parkinson's disease  (IDA)
pleomorphic xanthoastrocytoma  (ISO)
Pneumococcal Pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
Polydipsia  (ISO)
Polyuria  (ISO)
pre-eclampsia  (IEP)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA)
rhinitis  (ISO)
Sepsis  (IEP)
short bowel syndrome  (IDA)
Spinal Cord Injuries  (IEP)
steatotic liver disease  (IEP,ISO,ISS)
Tachycardia  (ISO)
type 2 diabetes mellitus  (IMP,ISO,ISS)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (EXP)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,8-cineole  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methyl-4-chlorophenoxybutyric acid  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-aminobenzamide  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxybenzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
AACOCF3  (ISO)
acarbose  (EXP)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
AM-251  (ISO)
Amibegron  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
androst-4-ene-3,17-dione  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP)
Aurothioglucose  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
boron atom  (EXP)
BQ 123  (ISO)
bromodichloromethane  (ISO)
bucladesine  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
carvacrol  (EXP)
CCCP  (ISO)
cerulenin  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chrysin  (ISO)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
corn oil  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cyromazine  (EXP)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
DDE  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazoxide  (EXP)
dibenziodolium  (ISO)
dibutylstannane  (ISO)
diethylstilbestrol  (ISO)
diiodine  (EXP)
dioxygen  (ISO)
dipyridamole  (EXP)
disodium selenite  (ISO)
dobutamine  (ISO)
DPCPX  (EXP)
edelfosine  (ISO)
efavirenz  (ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
Elemicin  (ISO)
enalapril  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
Ethyl icosapentate  (ISO)
ethylparaben  (ISO)
fenofibrate  (EXP,ISO)
fenoterol  (ISO)
fenvalerate  (EXP)
flufenamic acid  (ISO)
flutamide  (EXP)
fonofos  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glycine  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
inulin  (EXP)
iodide salt  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP,ISO)
isoscutellarein  (ISO)
isotretinoin  (EXP)
kaempferol  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lanthanum atom  (ISO)
lead(0)  (ISO)
Licarin A  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (ISO)
lopinavir  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (ISO)
methacholine chloride  (ISO)
methadone  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metronidazole  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
naringin  (EXP,ISO)
nelfinavir  (ISO)
neomycin  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nitric oxide  (ISO)
Nonylphenol  (ISO)
norwogonin  (ISO)
NS-398  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
omaveloxolone  (ISO)
orlistat  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP)
permethrin  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phosphatidylcholine  (ISO)
phosphoramidon  (EXP)
pioglitazone  (EXP)
piperine  (EXP)
pirimicarb  (EXP)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP)
Ptaquiloside  (ISO)
Pyridostigmine bromide  (ISO)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
roxarsone  (ISO)
ruthenium red  (ISO)
rutin  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium perchlorate  (EXP)
Sophocarpine  (EXP)
stavudine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sumatriptan  (EXP)
superoxide  (ISO)
terbufos  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiram  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
U-73122  (ISO)
ursolic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
wogonin  (ISO)
wortmannin  (ISO)
xanthone  (EXP)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adult feeding behavior  (ISO,ISS)
angiogenesis  (ISO)
aorta development  (ISO)
bile acid metabolic process  (ISO)
bone growth  (ISO,ISS)
bone mineralization involved in bone maturation  (IDA)
cAMP-mediated signaling  (TAS)
cardiac muscle hypertrophy  (IDA)
cell surface receptor signaling pathway via JAK-STAT  (TAS)
cellular response to insulin stimulus  (ISO)
cellular response to L-ascorbic acid  (IEP)
cellular response to leptin stimulus  (ISO)
cellular response to retinoic acid  (IEP)
central nervous system neuron development  (ISO)
cholesterol metabolic process  (ISO)
circadian rhythm  (IEP)
determination of adult lifespan  (ISO)
eating behavior  (ISO)
elastin metabolic process  (ISO)
energy reserve metabolic process  (IBA,IDA)
fatty acid beta-oxidation  (ISO)
fatty acid catabolic process  (IDA)
female pregnancy  (IEP)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
glycerol biosynthetic process  (IDA)
hormone metabolic process  (ISO)
insulin secretion  (ISO)
intestinal absorption  (ISO,ISS)
intracellular signal transduction  (IDA,TAS)
leptin-mediated signaling pathway  (IDA,ISO)
leukocyte tethering or rolling  (IDA)
lipid metabolic process  (IBA,ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of appetite  (ISO,ISS)
negative regulation of appetite by leptin-mediated signaling pathway  (IBA,IDA)
negative regulation of autophagy  (ISO,ISS)
negative regulation of cartilage development  (IDA)
negative regulation of glucagon secretion  (ISO)
negative regulation of glucose import  (ISO,ISS)
negative regulation of glutamine transport  (IMP)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid storage  (IDA)
negative regulation of metabolic process  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (IDA)
ovulation from ovarian follicle  (IDA)
phagocytosis  (IDA,ISO,ISS)
placenta development  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytokine production  (IEP)
positive regulation of developmental growth  (ISO)
positive regulation of fat cell apoptotic process  (IDA)
positive regulation of follicle-stimulating hormone secretion  (IEP)
positive regulation of hepatic stellate cell activation  (IDA)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of interleukin-12 production  (ISO,ISS)
positive regulation of interleukin-6 production  (ISO,ISS)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of luteinizing hormone secretion  (IEP)
positive regulation of MAPK cascade  (IDA,ISO)
positive regulation of monoatomic ion transport  (IDA)
positive regulation of myeloid cell differentiation  (ISO)
positive regulation of p38MAPK cascade  (IBA,ISO,ISS)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,ISO,ISS)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species metabolic process  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IMP,ISO,ISS)
positive regulation of T cell proliferation  (ISO,ISS)
positive regulation of TOR signaling  (IBA,ISO,ISS)
positive regulation of tumor necrosis factor production  (ISO,ISS)
positive regulation of tyrosine phosphorylation of STAT protein  (IMP)
prostaglandin secretion  (ISO,ISS)
regulation of angiogenesis  (ISO,ISS)
regulation of blood pressure  (IDA)
regulation of bone remodeling  (ISO,ISS)
regulation of brown fat cell differentiation  (ISO,ISS)
regulation of cell cycle  (ISO,ISS)
regulation of cytokine production involved in inflammatory response  (ISO,ISS)
regulation of endothelial cell proliferation  (ISO,ISS)
regulation of fat cell differentiation  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of insulin secretion  (ISO)
regulation of intestinal cholesterol absorption  (ISO)
regulation of lipid biosynthetic process  (ISO)
regulation of lipoprotein lipid oxidation  (IDA)
regulation of metabolic process  (ISO)
regulation of natural killer cell activation  (ISO,ISS)
regulation of natural killer cell mediated cytotoxicity  (ISO,ISS)
regulation of natural killer cell proliferation  (ISO,ISS)
regulation of protein localization to nucleus  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of steroid biosynthetic process  (ISO)
response to activity  (IEP)
response to dietary excess  (IMP,ISO)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to hypoxia  (IEP)
response to insulin  (IBA,ISO)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to vitamin E  (IEP)
sexual reproduction  (ISO)
T cell differentiation  (ISO,ISS)

Cellular Component
cytoplasm  (ISO)
cytosol  (IDA)
extracellular space  (IBA,IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Basal, endogenous leptin is metabolically active in newborn rat pups. Abdennebi-Najar L, etal., J Matern Fetal Neonatal Med. 2011 Jan 20.
2. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.
3. Leptin induces an inflammatory phenotype in lean Wistar rats. Allman M, etal., Mediators Inflamm. 2009;2009:738620. Epub 2010 Jan 26.
4. Genetic polymorphisms of IL-23R (rs7517847) and LEP (rs7799039) among Egyptian patients with hepatocellular carcinoma. Amer T, etal., Arch Physiol Biochem. 2017 Dec;123(5):279-285. doi: 10.1080/13813455.2017.1320680. Epub 2017 Apr 28.
5. Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. Anderson CM, etal., Am J Obstet Gynecol. 2005 Jul;193(1):267-72.
6. Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Anderwald C, etal., Mol Endocrinol 2002 Jul;16(7):1612-28.
7. Airway inflammation in obstructive sleep apnea: is leptin the missing link? Antonopoulou S, etal., Respir Med. 2008 Oct;102(10):1399-405. Epub 2008 Jul 7.
8. The effect of leptin on the tonic secretion of gonadotropins in the female rats. Arnaoutoglou C, etal., Neuro Endocrinol Lett. 2008 Dec;29(6):999-1006.
9. The relationship between serum adiponectin and steatosis in patients with chronic hepatitis C genotype-4. Ashour E, etal., Clin Lab. 2010;56(3-4):103-10.
10. Leptin Activates Cardiac Fatty Acid Oxidation Independent of Changes in the AMP-activated Protein Kinase-Acetyl-CoA Carboxylase-Malonyl-CoA Axis. Atkinson LL, etal., J Biol Chem 2002 Aug 16;277(33):29424-30.
11. Leptin plays a catabolic role on articular cartilage. Bao JP, etal., Mol Biol Rep. 2010 Oct;37(7):3265-72. Epub 2009 Oct 30.
12. Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: Preliminary study. Bar-El Dadon S, etal., Nutrition. 2011 Feb 23.
13. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
14. Circadian profile of peripheral hormone levels in sprague-dawley rats and in common marmosets (Callithrix jacchus). Bertani S, etal., In Vivo. 2010 Nov-Dec;24(6):827-36.
15. The effect of high fat diet-induced obesity on cardiovascular toxicity in wistar albino rats. Bhandari U, etal., Hum Exp Toxicol. 2010 Nov 12.
16. Increased numbers of motor activity peaks during light cycle are associated with reductions in adrenergic alpha(2)-receptor levels in a transgenic Huntington's disease rat model. Bode FJ, etal., Behav Brain Res. 2009 Dec 14;205(1):175-82. Epub 2009 Jun 30.
17. The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance. Boersma GJ, etal., Physiol Behav. 2009 Jun 22;97(3-4):353-8. Epub 2009 Mar 16.
18. Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): A pivotal role of leptin. Breyer MK, etal., Respir Med. 2011 Feb 28.
19. Effect of high-fat diet on body composition and hormone responses to glucose tolerance tests. Brown JL, etal., Endocrine 2002 Dec;19(3):327-32.
20. Leptin reduces ovariectomy-induced bone loss in rats. Burguera B, etal., Endocrinology. 2001 Aug;142(8):3546-53.
21. Leptin augments cerebral hemodynamic reserve after three-vessel occlusion: distinct effects on cerebrovascular tone and proliferation in a nonlethal model of hypoperfused rat brain. Busch HJ, etal., J Cereb Blood Flow Metab. 2010 Oct 27.
22. Serum leptin and leptin resistance correlations with NAFLD in patients with type 2 diabetes. Cernea S, etal., Diabetes Metab Res Rev. 2018 Nov;34(8):e3050. doi: 10.1002/dmrr.3050. Epub 2018 Sep 13.
23. Central stimulatory effect of leptin on T3 production is mediated by brown adipose tissue type II deiodinase. Cettour-Rose P, etal., Am J Physiol Endocrinol Metab 2002 Nov;283(5):E980-7.
24. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Chen DC, etal., Cancer Lett. 2006 Jun 8;237(1):109-14. Epub 2005 Jul 12.
25. Obesity reduces bone density associated with activation of PPARgamma and suppression of Wnt/beta-catenin in rapidly growing male rats. Chen JR, etal., PLoS One. 2010 Oct 28;5(10):e13704. doi: 10.1371/journal.pone.0013704.
26. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Chen WS, etal., Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.
27. Serum leptin levels depend on allergen exposure in patients with seasonal allergic rhinitis. Ciprandi G, etal., Immunol Invest. 2009;38(8):681-9.
28. Plasma ghrelin and leptin in adult cystic fibrosis patients. Cohen RI, etal., J Cyst Fibros. 2008 Sep;7(5):398-402. Epub 2008 Mar 18.
29. Adipokine Levels Versus Hepatic Histopathology in Bariatric Surgery Patients. D'Incao RB, etal., Obes Surg. 2017 Aug;27(8):2151-2158. doi: 10.1007/s11695-017-2627-4.
30. A Functional Melanocortin System May Be Required For Chronic Cns-Mediated Antidiabetic And Cardiovascular Actions Of Leptin. da Silva AA, etal., Diabetes. 2009 Jun 2.
31. Megalin mediates the transport of leptin across the blood-CSF barrier. Dietrich MO, etal., Neurobiol Aging. 2008 Jun;29(6):902-12. Epub 2007 Feb 26.
32. Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats. Donatto FF, etal., Cytokine. 2013 Feb;61(2):426-32. doi: 10.1016/j.cyto.2012.10.021. Epub 2012 Nov 22.
33. Divergent effects of intracerebroventricular and peripheral leptin administration on feeding and hypothalamic neuropeptide Y in lean and obese (fa/fa) Zucker rats. Dryden S, etal., Clin Sci (Lond). 1999 Mar;96(3):307-12.
34. Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1. Ducroc R, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G179-85. Epub 2010 May 6.
35. Evidence for a key role of leptin in osteoarthritis. Dumond H, etal., Arthritis Rheum. 2003 Nov;48(11):3118-29.
36. Leptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease. Eker S, etal., Scand J Clin Lab Invest. 2010 Feb;70(1):40-4.
37. Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function. Elinav E, etal., Hepatology. 2009 Jan;49(1):278-86.
38. Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects. Ezenwaka CE, etal., Arch Physiol Biochem. 2009 Feb;115(1):22-7.
39. Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. Feigh M, etal., Menopause. 2013 Jul;20(7):785-94. doi: 10.1097/GME.0b013e31827c58ab.
40. [Effects of decreased leptin expression on liver fibrosis]. Feng HJ, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 May;18(5):342-5. doi: 10.3760/cma.j.issn.1007-3418.2010.05.008.
41. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Fortuno A, etal., Endocrinology 2002 Sep;143(9):3555-60.
42. Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes. Garcia-Diaz DF, etal., J Mol Endocrinol. 2010 Jul;45(1):33-43. Epub 2010 Apr 16.
43. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
44. Serum leptin levels following acute experimental spinal cord injury. Gezici AR, etal., J Spinal Cord Med. 2009;32(4):416-21.
45. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
46. Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis. Gultekin FA, etal., World J Gastroenterol. 2007 Jun 7;13(21):2932-8.
47. Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians. Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
48. Effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring. GÃ¥rdebjer EM, etal., Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E694-E704. doi: 10.1152/ajpendo.00251.2017. Epub 2017 Oct 31.
49. Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Hama H, etal., Endocrinology. 2004 Aug;145(8):3935-40. Epub 2004 May 6.
50. Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow. Hamrick MW, etal., Cell Tissue Res. 2007 Jan;327(1):133-41. Epub 2006 Sep 22.
51. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. Han HR, etal., Clin Genet. 2008 Aug;74(2):105-15. Epub 2008 Jun 28.
52. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. Heimburger O, etal., J Am Soc Nephrol. 1997 Sep;8(9):1423-30.
53. Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis. Hoda MR, etal., Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G714-21. Epub 2010 Mar 4.
54. Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor alpha pathway in cultured neonatal rat cardiomyocytes. Hou N, etal., Clin Exp Pharmacol Physiol. 2010 Nov;37(11):1087-95. doi: 10.1111/j.1440-1681.2010.05442.x.
55. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
56. Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Hsu A, etal., Clin Exp Immunol. 2007 Nov;150(2):332-9. Epub 2007 Sep 5.
57. Modulation of circulating leptin levels by its soluble receptor. Huang L, etal., J Biol Chem 2001 Mar 2;276(9):6343-9.
58. Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats. Husum H, etal., Neuropharmacology 2002 May;42(6):798-806.
59. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
60. Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Iversen PO, etal., Blood 2002 Dec 1;100(12):4123-8.
61. Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats. Iwaniec UT, etal., J Bone Miner Res. 2011 Feb 16. doi: 10.1002/jbmr.365.
62. Leptin Promotes Fibroproliferative ARDS by Inhibiting Peroxisome Proliferator-activated Receptor-{gamma} Jain M, etal., Am J Respir Crit Care Med. 2011 Feb 11.
63. Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice. Kojima S, etal., Peptides. 2009 May;30(5):962-6. Epub 2009 Jan 22.
64. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. Kreier F, etal., J Clin Invest 2002 Nov;110(9):1243-50.
65. Hypothalamic CART is a new anorectic peptide regulated by leptin. Kristensen P, etal., Nature. 1998 May 7;393(6680):72-6.
66. Short term 13-cis-retinoic acid treatment at therapeutic doses elevates expression of leptin, GLUT4, PPARgamma and aP2 in rat adipose tissue. Krskova-Tybitanclova K, etal., J Physiol Pharmacol. 2008 Dec;59(4):731-43.
67. Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Kruger AJ, etal., Autoimmunity. 2011 Mar;44(2):137-48. Epub 2010 Aug 9.
68. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
69. Leptin modulates cell morphology and cytokine release in microglia. Lafrance V, etal., Brain Behav Immun. 2010 Mar;24(3):358-65. Epub 2009 Nov 14.
70. Association Between Serum Leptin and Adiponectin Levels with Risk of Insulin Resistance and Impaired Glucose Tolerance in Non-diabetic Women. Lee CY, etal., Kaohsiung J Med Sci. 2009 Mar;25(3):116-25.
71. [Distribution of leptin expression and its effect on the recovery of sepsis-induced internal disorders]. Lin J, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 May;39(3):360-3, 417.
72. Endogenous leptin fluctuates in hepatic ischemia/reperfusion injury and represents a potential therapeutic target. Lin J, etal., World J Gastroenterol. 2010 Nov 21;16(43):5424-34.
73. Leptin regulates proinflammatory immune responses. Loffreda S, etal., FASEB J. 1998 Jan;12(1):57-65.
74. A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat. Lopez M, etal., Diabetologia. 2005 Jan;48(1):140-8. Epub 2004 Dec 23.
75. Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. Lu H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):228-32. Epub 2008 Aug 17.
76. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. Ma D, etal., Hypertension. 2009 Mar;53(3):473-9. Epub 2009 Feb 9.
77. [Association of single nucleotide polymorphisms (SNPs) in leptin receptor gene with knee osteoarthritis in the Ningxia Hui population]. Ma XJ, etal., Yi Chuan. 2013 Mar;35(3):359-64.
78. Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity. Madhavadas S, etal., Indian J Biochem Biophys. 2014 Aug;51(4):257-62.
79. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. Mancuso P, etal., J Immunol. 2002 Apr 15;168(8):4018-24.
80. Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. Mancuso P, etal., J Immunol. 2011 Jan 15;186(2):1081-90. Epub 2010 Dec 10.
81. Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model. Martinez-Garcia C, etal., Dis Model Mech. 2012 Sep;5(5):636-48. doi: 10.1242/dmm.009266. Epub 2012 Jul 5.
82. Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Martins FF, etal., Ann Anat. 2017 Mar;210:44-51. doi: 10.1016/j.aanat.2016.11.013. Epub 2016 Dec 13.
83. Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis. Matheny M, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1254-61. Epub 2009 Sep 2.
84. Regular exercise limits alcohol effects on trabecular, cortical thickness and porosity, and osteocyte apoptosis in the rat. Maurel DB, etal., Joint Bone Spine. 2013 Oct;80(5):492-8. doi: 10.1016/j.jbspin.2012.12.005. Epub 2013 Feb 4.
85. Leptin signalling reduces the severity of cardiac dysfunction and remodelling after chronic ischaemic injury. McGaffin KR, etal., Cardiovasc Res. 2008 Jan;77(1):54-63. Epub 2007 Sep 20.
86. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
87. [Plasma leptin level in patients with bronchial asthma]. Mineev VN, etal., Klin Med (Mosk). 2009;87(7):33-7.
88. A short form of leptin receptor performs signal transduction. Murakami T, etal., Biochem Biophys Res Commun. 1997 Feb 3;231(1):26-9.
89. Leptin induces nitric oxide-mediated inhibition of lipolysis and glyceroneogenesis in rat white adipose tissue. Niang F, etal., J Nutr. 2011 Jan;141(1):4-9. Epub 2010 Nov 10.
90. Intracellular signalling. Key enzyme in leptin-induced anorexia. Niswender KD, etal., Nature. 2001 Oct 25;413(6858):794-5.
91. Leptin, adiponectin, and high-sensitivity C-reactive protein in relation to the metabolic syndrome in urban South African blacks with and without coronary artery disease. Ntyintyane L, etal., Metab Syndr Relat Disord. 2009 Jun;7(3):243-8.
92. Dual relation between leptin and cortisol in humans is disturbed in Alzheimer's disease. Olsson T, etal., Biol Psychiatry. 1998 Sep 1;44(5):374-6.
93. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
94. Effects of the obese gene product on body weight regulation in ob/ob mice. Pelleymounter MA, etal., Science. 1995 Jul 28;269(5223):540-3.
95. Association of serum leptin with hypoventilation in human obesity. Phipps PR, etal., Thorax. 2002 Jan;57(1):75-6.
96. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
97. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
98. Relationship between osteoporosis and adipose tissue leptin and osteoprotegerin in patients with chronic obstructive pulmonary disease. Pobeha P, etal., Bone. 2011 Mar 1.
99. Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis-Normalization After Liver Transplantation and Implications for Future Research. Proskynitopoulos PJ, etal., Alcohol Alcohol. 2018 Sep 1;53(5):511-517. doi: 10.1093/alcalc/agy038.
100. Leptin phase-advances the rat suprachiasmatic circadian clock in vitro. Prosser RA and Bergeron HE, Neurosci Lett 2003 Jan 23;336(3):139-42.
101. Rat heart is a site of leptin production and action. Purdham DM, etal., Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2877-84. Epub 2004 Jul 29.
102. GOA pipeline RGD automated data pipeline
103. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
104. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
105. Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma. Ribatti D, etal., Peptides. 2008 Sep;29(9):1596-602. doi: 10.1016/j.peptides.2008.05.011. Epub 2008 May 22.
106. Inhibitory effect of leptin on the rat ovary during the ovulatory process. Ricci AG, etal., Reproduction. 2006 Nov;132(5):771-780.
107. Serum leptin and insulin in paediatric end-stage liver disease and following successful orthotopic liver transplantation. Roberts GA, etal., Clin Endocrinol (Oxf). 1998 Apr;48(4):401-6. doi: 10.1046/j.1365-2265.1998.00448.x.
108. Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study. Sagiroglu T, etal., Exp Ther Med. 2012 May;3(5):908-914. Epub 2012 Feb 29.
109. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Scarpace PJ, etal., Endocrinology 2002 Aug;143(8):3026-35.
110. Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Seidlova-Wuttke D, etal., Maturitas. 2003 Mar 14;44 Suppl 1:S39-50.
111. Vitamin E regulates adipocytokine expression in a rat model of dietary-induced obesity. Shen XH, etal., Exp Biol Med (Maywood). 2010 Jan;235(1):47-51.
112. 7alpha-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: a preclinical study in the aged male orchidectomized rat model. Sinnesael M, etal., Int J Androl. 2011 Dec;34(6 Pt 2):e601-11. doi: 10.1111/j.1365-2605.2011.01198.x. Epub 2011 Jul 26.
113. Inverse association of leptin levels with renal cell carcinoma: results from a case-control study. Spyridopoulos TN, etal., Hormones (Athens). 2009 Jan-Mar;8(1):39-46.
114. Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. Stefanou N, etal., BMC Cancer. 2010 Aug 19;10:442. doi: 10.1186/1471-2407-10-442.
115. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat. Sukhotnik I, etal., Pediatr Res. 2009 Dec;66(6):648-53.
116. Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis. Szalay F, etal., Eur J Gastroenterol Hepatol. 2005 Sep;17(9):923-8.
117. Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase. Tang Y and Chen A, Br J Pharmacol. 2010 Nov;161(5):1137-49. doi: 10.1111/j.1476-5381.2010.00956.x.
118. Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. Tang Y, etal., Endocrinology. 2009 Jul;150(7):3011-20. Epub 2009 Mar 19.
119. Elevated serum leptin levels: a risk factor for non-small-cell lung cancer? Terzidis A, etal., Oncology. 2009;76(1):19-25. Epub 2008 Nov 24.
120. Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat. Thierry M, etal., PLoS One. 2014 Nov 7;9(11):e112450. doi: 10.1371/journal.pone.0112450. eCollection 2014.
121. Hyperphagia and central mechanisms for leptin resistance during pregnancy. Trujillo ML, etal., Endocrinology. 2011 Apr;152(4):1355-65. Epub 2011 Feb 8.
122. Specific increase in leptin production in obese (falfa) rat adipose cells. Turban S, etal., Biochem J 2002 Feb 15;362(Pt 1):113-8.
123. Creation and preliminary characterization of a leptin knockout rat. Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.
124. Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone. Vandenput L, etal., J Bone Miner Res. 2002 Nov;17(11):2080-6.
125. Effect of leptin on bone metabolism in rat model of traumatic brain injury and femoral fracture. Wang L, etal., Chin J Traumatol. 2011 Feb 1;14(1):7-13.
126. Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis. Wang Q, etal., Sci Rep. 2015 Dec 4;5:17833. doi: 10.1038/srep17833.
127. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. Weng Z, etal., J Biol Chem. 2007 Nov 23;282(47):34479-91. Epub 2007 Sep 25.
128. Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. Widjaja A, etal., Scand J Gastroenterol. 2001 Apr;36(4):426-31. doi: 10.1080/003655201300051333.
129. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Wold LE, etal., Hypertension 2002 Jan;39(1):69-74.
130. [Preliminary investigation of the changes and mechanism of Leptin after myocardial ischemia/reperfusion injury]. Xue H, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Nov;22(11):680-3.
131. Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression. Yamaguchi M and Nakagawa T, Int J Mol Med. 2007 Sep;20(3):323-8.
132. Leptin receptor signal transduction: OBRa and OBRb of fa type. Yamashita T, etal., Biochem Biophys Res Commun. 1998 May 29;246(3):752-9.
133. The polymorphism -2548G/A in leptin and severity of chronic obstructive pulmonary disease. Ye XW, etal., Int J Immunogenet. 2011 Feb;38(1):45-50. doi: 10.1111/j.1744-313X.2010.00968.x. Epub 2010 Sep 20.
134. Treatment of obesity hypoventilation syndrome and serum leptin. Yee BJ, etal., Respiration. 2006;73(2):209-12. Epub 2005 Sep 20.
135. Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. Yilmaz O, etal., J Diabetes Complications. 2009 Mar 6.
136. Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity. Zhang W, etal., J Neuroendocrinol. 2010 Mar;22(3):175-80. Epub 2010 Jan 5.
137. Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats. Zhang X, etal., Iran J Pharm Res. 2013 Summer;12(3):557-62.
138. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Zhao AZ, etal., Nat Neurosci 2002 Aug;5(8):727-8.
139. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. Zhao CQ, etal., Spine (Phila Pa 1976). 2008 Nov 1;33(23):E858-64.
140. The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats. Zhou L, etal., Ecotoxicol Environ Saf. 2019 Apr 15;170:391-398. doi: 10.1016/j.ecoenv.2018.12.009. Epub 2018 Dec 11.
141. Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model. Zhu Z, etal., Cancer Prev Res (Phila). 2012 Mar;5(3):414-22. doi: 10.1158/1940-6207.CAPR-11-0454. Epub 2012 Jan 13.
Additional References at PubMed
PMID:7657834   PMID:7733988   PMID:7794258   PMID:8589726   PMID:8607798   PMID:9732873   PMID:10592285   PMID:10660043   PMID:10742101   PMID:10802666   PMID:11068878   PMID:11387233  
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PMID:12928006   PMID:12933650   PMID:12958061   PMID:12959975   PMID:14576185   PMID:14592417   PMID:14605003   PMID:14688445   PMID:14709837   PMID:14711457   PMID:14715713   PMID:14732484  
PMID:14747284   PMID:14993217   PMID:14993225   PMID:15044184   PMID:15059958   PMID:15081399   PMID:15280541   PMID:15292470   PMID:15304210   PMID:15304373   PMID:15322334   PMID:15331383  
PMID:15381111   PMID:15388782   PMID:15389880   PMID:15449734   PMID:15473134   PMID:15475485   PMID:15498885   PMID:15500001   PMID:15572209   PMID:15572849   PMID:15582724   PMID:15590268  
PMID:15679864   PMID:15687408   PMID:15717845   PMID:15721267   PMID:15727948   PMID:15731403   PMID:15741239   PMID:15742403   PMID:15746250   PMID:15746256   PMID:15798949   PMID:15845621  
PMID:15899045   PMID:15905318   PMID:15955812   PMID:15995171   PMID:16046456   PMID:16092054   PMID:16125533   PMID:16141392   PMID:16144736   PMID:16166199   PMID:16180331   PMID:16195403  
PMID:16203737   PMID:16210420   PMID:16238463   PMID:16321456   PMID:16328017   PMID:16330326   PMID:16339207   PMID:16343770   PMID:16403782   PMID:16413128   PMID:16443671   PMID:16455789  
PMID:16457907   PMID:16513828   PMID:16553787   PMID:16604086   PMID:16627588   PMID:16718624   PMID:16825198   PMID:16914228   PMID:16950545   PMID:16964413   PMID:16965293   PMID:16988073  
PMID:17023527   PMID:17038325   PMID:17038553   PMID:17038557   PMID:17085442   PMID:17093945   PMID:17170237   PMID:17194747   PMID:17220191   PMID:17268854   PMID:17273787   PMID:17280591  
PMID:17303662   PMID:17303663   PMID:17318810   PMID:17321040   PMID:17344214   PMID:17355316   PMID:17356529   PMID:17363621   PMID:17419800   PMID:17433256   PMID:17453686   PMID:17481674  
PMID:17495032   PMID:17562852   PMID:17565119   PMID:17595338   PMID:17610413   PMID:17669377   PMID:17693256   PMID:17957153   PMID:17974623   PMID:17991727   PMID:17992637   PMID:18006472  
PMID:18006626   PMID:18063139   PMID:18063686   PMID:18096657   PMID:18097472   PMID:18155694   PMID:18176912   PMID:18178314   PMID:18179777   PMID:18191822   PMID:18197581   PMID:18210329  
PMID:18296272   PMID:18310448   PMID:18367451   PMID:18401831   PMID:18458326   PMID:18468410   PMID:18516053   PMID:18535786   PMID:18556346   PMID:18568952   PMID:18587446   PMID:18588949  
PMID:18665796   PMID:18669592   PMID:18719678   PMID:18924245   PMID:19000372   PMID:19011998   PMID:19020290   PMID:19084046   PMID:19103999   PMID:19127349   PMID:19139561   PMID:19158409  
PMID:19179437   PMID:19224154   PMID:19276673   PMID:19372589   PMID:19386920   PMID:19390347   PMID:19391127   PMID:19403617   PMID:19539991   PMID:19591986   PMID:19633450   PMID:19671839  
PMID:19688109   PMID:19709655   PMID:19728324   PMID:19876773   PMID:19877509   PMID:19887391   PMID:19888448   PMID:19910644   PMID:19940076   PMID:20036647   PMID:20067107   PMID:20094971  
PMID:20226796   PMID:20307649   PMID:20385158   PMID:20412389   PMID:20541607   PMID:20584107   PMID:20620997   PMID:20668022   PMID:20668029   PMID:20731748   PMID:20838752   PMID:20952387  
PMID:20960110   PMID:21059361   PMID:21141565   PMID:21158112   PMID:21234744   PMID:21239630   PMID:21255014   PMID:21257164   PMID:21270124   PMID:21304902   PMID:21334429   PMID:21340571  
PMID:21378499   PMID:21418127   PMID:21512961   PMID:21544068   PMID:21557150   PMID:21607623   PMID:21771332   PMID:21777028   PMID:22033902   PMID:22115950   PMID:22133515   PMID:22210233  
PMID:22253420   PMID:22372349   PMID:22374757   PMID:22459287   PMID:22610169   PMID:22638834   PMID:22645452   PMID:22653842   PMID:22751689   PMID:22773379   PMID:22927639   PMID:22956308  
PMID:22958918   PMID:22967108   PMID:22982569   PMID:22995391   PMID:23056516   PMID:23064363   PMID:23093703   PMID:23129112   PMID:23172699   PMID:23201827   PMID:23211513   PMID:23264212  
PMID:23413430   PMID:23418591   PMID:23506735   PMID:23506793   PMID:23525184   PMID:23535030   PMID:23544111   PMID:23576026   PMID:23579487   PMID:23669042   PMID:23724144   PMID:23782941  
PMID:23825665   PMID:23936817   PMID:24007473   PMID:24026073   PMID:24039946   PMID:24063596   PMID:24100028   PMID:24184591   PMID:24239717   PMID:24243000   PMID:24243887   PMID:24340098  
PMID:24361011   PMID:24446159   PMID:24467741   PMID:24495350   PMID:24498181   PMID:24499246   PMID:24561183   PMID:24662007   PMID:24787748   PMID:24913911   PMID:24926823   PMID:25001932  
PMID:25060689   PMID:25065280   PMID:25205242   PMID:25260611   PMID:25330951   PMID:25398524   PMID:25561025   PMID:25575055   PMID:25583546   PMID:25645057   PMID:25722014   PMID:25793389  
PMID:25797953   PMID:25833759   PMID:25846408   PMID:25935421   PMID:25979360   PMID:25981175   PMID:26017929   PMID:26122392   PMID:26496899   PMID:26506851   PMID:26529250   PMID:26538454  
PMID:26676252   PMID:26731409   PMID:26751999   PMID:26780438   PMID:26846568   PMID:26907996   PMID:26982498   PMID:27037668   PMID:27222924   PMID:27378381   PMID:27534878   PMID:27623562  
PMID:27629888   PMID:27751931   PMID:27827305   PMID:27923787   PMID:27923809   PMID:28069950   PMID:28097455   PMID:28112679   PMID:28179125   PMID:28276709   PMID:28407241   PMID:28407664  
PMID:28627582   PMID:28677772   PMID:28759941   PMID:28797891   PMID:28877872   PMID:28957383   PMID:29044801   PMID:29241183   PMID:29254298   PMID:29294325   PMID:29519872   PMID:29568885  
PMID:29849871   PMID:30019195   PMID:30206280   PMID:30311938   PMID:30424542   PMID:31077169   PMID:31222048   PMID:31306448   PMID:31708912   PMID:31840160   PMID:32127397   PMID:32149734  
PMID:32840013   PMID:33396616   PMID:33431976   PMID:33799501   PMID:34121590   PMID:34717752   PMID:34830465   PMID:35806240   PMID:37769981  


Genomics

Comparative Map Data
Lep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,644,034 - 62,658,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,559,814 - 58,573,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,962,087 - 56,976,240 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBICelera
RH 3.4 Map4309.5RGD
Cytogenetic Map4q22NCBI
LEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,241,278 - 128,257,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,241,278 - 128,257,629 (+)EnsemblGRCh38hg38GRCh38
GRCh377127,881,331 - 127,897,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,668,567 - 127,684,917 (+)NCBINCBI36Build 36hg18NCBI36
Build 347127,475,281 - 127,491,632NCBI
Celera7122,684,619 - 122,700,967 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,242,298 - 122,258,647 (+)NCBIHuRef
CHM1_17127,814,632 - 127,830,980 (+)NCBICHM1_1
T2T-CHM13v2.07129,552,743 - 129,569,093 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,264,455 - 127,280,803 (+)NCBI
Lep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,060,220 - 29,073,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,060,219 - 29,073,876 (+)EnsemblGRCm39 Ensembl
GRCm38629,060,221 - 29,073,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,010,221 - 29,023,876 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,010,231 - 29,023,886 (+)NCBIMGSCv36mm8
Celera629,063,769 - 29,077,429 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.3NCBI
Lep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,274,516 - 9,279,472 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,266,604 - 9,276,568 (+)NCBIChiLan1.0ChiLan1.0
LEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,095,350 - 165,111,990 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,116,521 - 17,122,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,230,896 - 120,248,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17132,884,994 - 132,901,519 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7132,885,011 - 132,901,519 (+)Ensemblpanpan1.1panPan2
LEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,115,396 - 8,130,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,116,122 - 8,131,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,802,696 - 7,807,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0147,880,580 - 7,897,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,883,040 - 7,897,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,087,574 - 8,091,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,828,397 - 7,832,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,975,126 - 7,979,538 (-)NCBIUU_Cfam_GSD_1.0
Lep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,282,689 - 54,287,494 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,394,966 - 15,411,334 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,394,966 - 15,411,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1820,106,868 - 20,123,323 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11820,106,867 - 20,124,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21821,200,988 - 21,231,275 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,056,913 - 97,071,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,057,529 - 97,071,220 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660426,335,426 - 6,349,076 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,708,588 - 7,721,727 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247837,708,820 - 7,721,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lep
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:471
Count of miRNA genes:263
Interacting mature miRNAs:330
Transcripts:ENSRNOT00000071926
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat

Markers in Region
PMC21729P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,672,228 - 57,672,419 (+)MAPPERmRatBN7.2
Rnor_6.0456,348,785 - 56,348,975NCBIRnor6.0
Rnor_5.0456,096,176 - 56,096,366UniSTSRnor5.0
RGSC_v3.4455,945,637 - 55,945,827UniSTSRGSC3.4
Celera452,781,115 - 52,781,305UniSTS
Cytogenetic Map4q22UniSTS
RH94808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,672,559 - 57,672,658 (+)MAPPERmRatBN7.2
Rnor_6.0456,349,116 - 56,349,214NCBIRnor6.0
Rnor_5.0456,096,507 - 56,096,605UniSTSRnor5.0
RGSC_v3.4455,945,968 - 55,946,066UniSTSRGSC3.4
Celera452,781,446 - 52,781,544UniSTS
RH 3.4 Map4309.5UniSTS
Cytogenetic Map4q22UniSTS
Lep  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,479,601 - 46,480,909 (+)MAPPERmRatBN7.2
Rnor_6.0850,477,430 - 50,478,737NCBIRnor6.0
Rnor_5.0849,103,749 - 49,105,056UniSTSRnor5.0
Celera846,061,659 - 46,062,966UniSTS
Cytogenetic Map4q22UniSTS
LEP-3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,670,569 - 57,672,217 (+)MAPPERmRatBN7.2
Rnor_6.0456,347,126 - 56,348,773NCBIRnor6.0
Rnor_5.0456,094,517 - 56,096,164UniSTSRnor5.0
RGSC_v3.4455,943,978 - 55,945,625UniSTSRGSC3.4
Celera452,779,456 - 52,781,103UniSTS
Cytogenetic Map4q22UniSTS


Related Rat Strains
The following Strains have been annotated to Lep


Genetic Models
This gene Lep is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 3 2
Low 2 6 7 5 8 8 12 7 9 8
Below cutoff 1 13 7 5 8 5 3 8 12 5 2

Sequence


RefSeq Acc Id: ENSRNOT00000071926   ⟹   ENSRNOP00000066184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)Ensembl
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)Ensembl
RefSeq Acc Id: NM_013076   ⟹   NP_037208
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,626,538 - 58,640,661 (+)NCBI
mRatBN7.2457,661,131 - 57,675,262 (+)NCBI
Rnor_6.0456,337,695 - 56,351,818 (+)NCBI
Rnor_5.0456,085,079 - 56,099,209 (+)NCBI
RGSC_v3.4455,943,837 - 55,945,938 (+)RGD
Celera452,770,132 - 52,784,148 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107126   ⟹   XP_038963054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,626,529 - 58,640,663 (+)NCBI
mRatBN7.2457,661,127 - 57,675,262 (+)NCBI
RefSeq Acc Id: NP_037208   ⟸   NM_013076
- Peptide Label: precursor
- UniProtKB: P50596 (UniProtKB/Swiss-Prot),   A6IEB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066184   ⟸   ENSRNOT00000071926
RefSeq Acc Id: XP_038963054   ⟸   XM_039107126
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50596-F1-model_v2 AlphaFold P50596 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3000 AgrOrtholog
BioCyc Gene G2FUF-45408 BioCyc
Ensembl Genes ENSRNOG00000045797 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021484 UniProtKB/Swiss-Prot
  ENSRNOG00060028054 UniProtKB/Swiss-Prot
  ENSRNOG00065025045 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071926 ENTREZGENE
  ENSRNOT00000071926.2 UniProtKB/Swiss-Prot
  ENSRNOT00055036716 UniProtKB/Swiss-Prot
  ENSRNOT00060048713 UniProtKB/Swiss-Prot
  ENSRNOT00065043064 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25608 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25608 ENTREZGENE
PANTHER LEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11724 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Leptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LEP RGD
PhenoGen Lep PhenoGen
PIRSF Leptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045797 RatGTEx
  ENSRNOG00055021484 RatGTEx
  ENSRNOG00060028054 RatGTEx
  ENSRNOG00065025045 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1C9CJH3_RAT UniProtKB/TrEMBL
  A6IEB6 ENTREZGENE, UniProtKB/TrEMBL
  LEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lep  leptin      Symbol and Name status set to approved 70586 APPROVED
2001-07-23 Lep  leptin      Name withdrawn 67952 WITHDRAWN
2001-07-23 Lep  leptin      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-26 Lep  leptin      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-26 Lep  Obesity (murine homolog, leptin)      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs cilostamide, a Pde3b inhibitor blocks inhibitory effect on food intake 625547
gene_expression produced by adipose tissues 625675
gene_expression higher expression in heterozygous (Fa/fa) than homozygous lean rats 625532
gene_expression expressed in the adipose tissues 625675
gene_function adipocyte-derived peptide hormone 625547
gene_function adipocyte-derived peptide hormone 625675
gene_function peptide hormone 625675
gene_mutations_overexpression high dosage increase the arterial pressure and heart rate 625675
gene_other change in levels may be directly linked to fa mutation in Zucker rats 625532
gene_other leptin resistance may involve attenuation of either the anorexic or energy expenditure response to leptin 625675
gene_pathway activates Jak-Stat pathway and phosphatidyl inositol 3-kinase (PI3K)-regulated phosphodiesterase 3B(PDE3B)-cyclic AMP (PI3K-PDE3B-cAMP) pathway 625547
gene_process involved in energy homeostasis 61790
gene_process may have a role in the inhibition of neuropeptideY/agouti-related protein neurons and activation of pro-opiomelanocortin/cocaine- and amphetamine regulated transcript neurons 61790
gene_process causes feeding inhibition through induction of PI3K, Pde3b activity and decreasing cAMP in hypothalamus 625547
gene_process infusion induces nitric oxide-mediated vasodilation in aortic and mesenteric arteries 625675
gene_process inhibits the ANG-II ( angiotensin II)-induced fast contractions in the endothelium-denuded aortic rings in Wistar rats 625675
gene_process acts in the signaling mechanism to control body fat 625675
gene_process leptin-induced leptin resistance was associated with persistent elevation in hypothalamic phosphorylated signal transducer and activator of transcription-3 (STAT3); curator note 625675
gene_process stimulates leukemic cell growth 729241
gene_process high dosage increase the arterial pressure and heart rate, infusion induces nitric oxide-mediated vasodilation in aortic and mesenteric arteries 625675
gene_regulation mRNA expression significantly increased in adipose cells from obese (fa/fa) compared to lean (Fa/fa) rat 625532
gene_regulation expression of mRNA is decreased by a fat pad specific vagotomy 625675
gene_regulation produced by the adipose tissues 625675