(+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23365609 (+)-catechin multiple interactions ISO RGD:69124 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (+)-epicatechin-3-O-gallate multiple interactions ISO RGD:69124 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:69124 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 (R)-lipoic acid decreases secretion ISO RGD:69124 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 (R)-lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA, Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 (R)-lipoic acid decreases expression ISO RGD:69124 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 (R)-mevalonic acid multiple interactions ISO RGD:69124 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA], Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 , PMID:29155039 (S)-nicotine decreases response to substance EXP 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 1-(3-chlorophenyl)piperazine multiple interactions ISO RGD:69124 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 1-naphthyl isothiocyanate affects expression EXP 6480464 1-Naphthylisothiocyanate affects the expression of LEP protein CTD PMID:25051504 15-deoxy-Delta(12,14)-prostaglandin J2 increases secretion ISO RGD:69123 6480464 15-deoxy-delta(12, 14)-prostaglandin J2 results in increased secretion of LEP protein CTD PMID:11092516 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with 15-deoxy-delta(12, 14)-prostaglandin J2] results in decreased secretion of LEP protein CTD PMID:11092516 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of LEP protein CTD PMID:25051504 17beta-estradiol increases expression ISO RGD:69124 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:18359623 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:26164745 17beta-estradiol multiple interactions ISO RGD:69123 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:69123 6480464 Dihydrotestosterone results in decreased expression of LEP mRNA CTD PMID:18801408 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:69124 6480464 2 more ... CTD PMID:23618531 more ... 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO RGD:69124 6480464 2 more ... CTD PMID:24978599 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:69124 6480464 2 more ... CTD PMID:24559133 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:69124 6480464 [Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LEP protein more ... CTD PMID:19063610 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:69124 6480464 Tetrachlorodibenzodioxin affects the expression of LEP mRNA CTD PMID:21570461 , PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA more ... CTD PMID:15977195 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:69124 6480464 Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA CTD PMID:19063610 2,4-dinitrophenol multiple interactions ISO RGD:69124 6480464 [2, 4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA CTD PMID:24872412 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO RGD:69124 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of LEP protein CTD PMID:25051504 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:69124 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA more ... CTD PMID:19913045 2-amino-2-deoxy-D-galactopyranose increases response to substance ISO RGD:69124 6480464 LEP gene mutant form results in increased susceptibility to Galactosamine CTD PMID:19913045 2-amino-2-deoxy-D-glucopyranose 6-phosphate decreases expression ISO RGD:69124 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 2-aminopurine multiple interactions ISO RGD:69124 6480464 2-Aminopurine affects the reaction [LEP protein affects the expression of ADGRE1 mRNA] more ... CTD PMID:24150608 2-deoxy-D-glucose multiple interactions EXP 6480464 [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 2-deoxy-D-glucose decreases secretion EXP 6480464 Deoxyglucose results in decreased secretion of LEP protein CTD PMID:10780946 2-hydroxypropanoic acid affects expression ISO RGD:69123 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 2-methyl-4-chlorophenoxybutyric acid multiple interactions EXP 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:69124 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA], geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 24,25-Dihydroxyvitamin D decreases expression ISO RGD:69123 6480464 24, 25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein CTD PMID:18379402 3',5'-cyclic AMP increases abundance ISO RGD:69123 6480464 LEP protein results in increased abundance of Cyclic AMP CTD PMID:11342529 3',5'-cyclic AMP multiple interactions ISO RGD:69124 6480464 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA] CTD PMID:27381457 3',5'-cyclic AMP increases expression ISO RGD:69124 6480464 Cyclic AMP analog results in increased expression of LEP mRNA CTD PMID:27381457 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:69124 6480464 [3 more ... CTD PMID:28973532 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:69124 6480464 tetrabromobisphenol A results in increased expression of LEP mRNA CTD PMID:30496566 3,4-methylenedioxymethamphetamine affects expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine affects the expression of LEP protein CTD PMID:17910739 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases expression ISO RGD:69124 6480464 3 more ... CTD PMID:20512997 3-aminobenzamide increases expression EXP 6480464 3-aminobenzamide results in increased expression of LEP mRNA CTD PMID:18815186 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of LEP mRNA CTD PMID:20409345 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:69123 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:19186324 more ... 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:69124 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... 4,4'-sulfonyldiphenol increases secretion ISO RGD:69124 6480464 bis(4-hydroxyphenyl)sulfone results in increased secretion of LEP protein CTD PMID:25111128 4,4'-sulfonyldiphenol multiple interactions ISO RGD:69124 6480464 bis(4-hydroxyphenyl)sulfone affects the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27241191 4,4'-sulfonyldiphenol decreases expression ISO RGD:69123 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of LEP mRNA CTD PMID:27685785 4-hydroxy-17beta-estradiol increases abundance ISO RGD:69123 6480464 LEP protein results in increased abundance of 4-hydroxyestradiol CTD PMID:24631339 4-hydroxybenzoic acid decreases expression ISO RGD:69123 6480464 4-hydroxybenzoic acid results in decreased expression of LEP mRNA CTD PMID:22956630 4-hydroxyphenyl retinamide decreases expression ISO RGD:69124 6480464 Fenretinide results in decreased expression of LEP mRNA CTD PMID:28973697 4-nonylphenol increases expression EXP 6480464 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 5-aza-2'-deoxycytidine increases expression ISO RGD:69123 6480464 [Decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA, Decitabine results in increased expression of LEP mRNA CTD PMID:17502362 5-aza-2'-deoxycytidine multiple interactions ISO RGD:69123 6480464 trichostatin A promotes the reaction [Decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 5-aza-2'-deoxycytidine decreases methylation ISO RGD:69123 6480464 Decitabine results in decreased methylation of LEP promoter CTD PMID:17502362 8-Br-cAMP multiple interactions ISO RGD:69123 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] more ... CTD PMID:19849856 8-Br-cAMP decreases response to substance ISO RGD:69123 6480464 LEP protein results in decreased susceptibility to 8-Bromo Cyclic Adenosine Monophosphate CTD PMID:19849856 9-cis-retinoic acid multiple interactions EXP 6480464 [Alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 AACOCF3 multiple interactions ISO RGD:69124 6480464 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 acarbose decreases expression EXP 6480464 Acarbose results in decreased expression of LEP protein CTD PMID:18290871 acetaldehyde multiple interactions ISO RGD:69124 6480464 Acetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein] more ... CTD PMID:15130784 , PMID:17949463 acetylsalicylic acid multiple interactions EXP 6480464 [lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein CTD PMID:15024038 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 aflatoxin B1 increases methylation ISO RGD:69123 6480464 Aflatoxin B1 results in increased methylation of LEP gene CTD PMID:27153756 AH23848 multiple interactions ISO RGD:69123 6480464 AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 aldehydo-D-glucosamine 6-phosphate decreases expression ISO RGD:69124 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 aldehydo-D-glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 aldehydo-D-glucose multiple interactions ISO RGD:69124 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose CTD PMID:27712037 aldehydo-D-glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA, Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... aldehydo-D-glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 aldehydo-D-glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... all-trans-retinol multiple interactions EXP 6480464 LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 amlodipine decreases expression ISO RGD:69123 6480464 Amlodipine results in decreased expression of LEP, Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 , PMID:19059660 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of LEP mRNA CTD PMID:16483693 anandamide decreases abundance ISO RGD:69123 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:16154199 anandamide decreases activity ISO RGD:69123 6480464 LEP protein results in decreased activity of anandamide CTD PMID:16154199 anandamide decreases transport ISO RGD:69123 6480464 LEP protein results in decreased transport of anandamide CTD PMID:16154199 androst-4-ene-3,17-dione multiple interactions EXP 6480464 LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione] CTD PMID:14657608 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:69123 6480464 pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 apigenin increases expression ISO RGD:69124 6480464 Apigenin results in increased expression of LEP mRNA, Apigenin results in increased expression of LEP protein CTD PMID:18359623 apocynin multiple interactions ISO RGD:69124 6480464 acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 arachidonic acid multiple interactions ISO RGD:69124 6480464 Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 arsane affects expression ISO RGD:69123 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 arsenic atom affects expression ISO RGD:69123 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 arsenite(3-) decreases methylation ISO RGD:69123 6480464 arsenite results in decreased methylation of LEP promoter CTD PMID:23974009 aspartame decreases expression EXP 6480464 Aspartame results in decreased expression of LEP protein CTD PMID:11890951 aspartame multiple interactions ISO RGD:69124 6480464 [Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein, [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein] CTD PMID:23783067 atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein] CTD PMID:21122807 ATP multiple interactions EXP 6480464 [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein, [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 Aurothioglucose multiple interactions ISO RGD:69124 6480464 [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP mRNA, [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP protein CTD PMID:9794456 Aurothioglucose increases expression ISO RGD:69124 6480464 Aurothioglucose results in increased expression of LEP mRNA, Aurothioglucose results in increased expression of LEP protein CTD PMID:15809509 more ... azoxystrobin multiple interactions ISO RGD:69124 6480464 [azoxystrobin co-treated with Dietary Fats] affects the expression of LEP protein CTD PMID:24726979 benzo[a]pyrene affects methylation ISO RGD:69123 6480464 Benzo(a)pyrene affects the methylation of LEP intron CTD PMID:30157460 Benzyl parahydroxybenzoate increases expression ISO RGD:69124 6480464 benzylparaben results in increased expression of LEP mRNA CTD PMID:22956630 Benzyl parahydroxybenzoate decreases expression ISO RGD:69123 6480464 benzylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 beta-D-glucosamine 6-sulfate decreases expression ISO RGD:69124 6480464 glucosamine 6-O-sulfate results in decreased expression of LEP mRNA CTD PMID:19520133 bezafibrate decreases expression ISO RGD:69123 6480464 Bezafibrate results in decreased expression of LEP CTD PMID:10726910 bezafibrate multiple interactions ISO RGD:69124 6480464 Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein] CTD PMID:21549692 bezafibrate decreases expression EXP 6480464 Bezafibrate results in decreased expression of LEP mRNA CTD PMID:11216866 , PMID:11473052 bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] CTD PMID:17379010 bis(2-ethylhexyl) phthalate increases expression ISO RGD:69124 6480464 Diethylhexyl Phthalate results in increased expression of LEP mRNA, Diethylhexyl Phthalate results in increased expression of LEP protein CTD PMID:22588786 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:69124 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:29175711 , PMID:30660623 bis(2-ethylhexyl) phthalate increases expression EXP RGD:69123 25330351 bis(2-ethylhexyl) phthalate increased expression of LEP in adipose tissue (rat) RGD bisphenol A increases expression ISO RGD:69124 6480464 bisphenol A results in increased expression of LEP more ... CTD PMID:18359623 more ... bisphenol A decreases secretion EXP 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:31697385 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LEP mRNA CTD PMID:30816183 bisphenol A decreases expression ISO RGD:69123 6480464 bisphenol A results in decreased expression of LEP mRNA, bisphenol A results in decreased expression of LEP protein CTD PMID:24349194 more ... bisphenol A increases expression ISO RGD:69123 6480464 bisphenol A results in increased expression of LEP mRNA, bisphenol A results in increased expression of LEP protein CTD PMID:25878060 , PMID:27145005 bisphenol A multiple interactions ISO RGD:69123 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 bisphenol A multiple interactions ISO RGD:69124 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23493373 , PMID:29175711 Bisphenol A diglycidyl ether increases expression ISO RGD:69124 6480464 2, 2-bis(4-glycidyloxyphenyl)propane results in increased expression of LEP mRNA CTD PMID:22763116 bleomycin A2 increases expression ISO RGD:69124 6480464 Bleomycin results in increased expression of LEP protein CTD PMID:29175452 boric acid multiple interactions ISO RGD:69124 6480464 boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA], boric acid results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:28285642 BQ 123 multiple interactions ISO RGD:69124 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 bromodichloromethane increases expression ISO RGD:69124 6480464 bromodichloromethane results in increased expression of LEP mRNA CTD PMID:23640861 bromodichloromethane multiple interactions ISO RGD:69124 6480464 bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA] more ... CTD PMID:23438451 , PMID:24211274 bromodichloromethane decreases response to substance ISO RGD:69124 6480464 LEP gene mutant form results in decreased susceptibility to bromodichloromethane CTD PMID:23640861 bucladesine decreases expression ISO RGD:69124 6480464 Bucladesine results in decreased expression of LEP mRNA CTD PMID:9002984 Butylparaben decreases expression ISO RGD:69123 6480464 butylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 Butylparaben increases expression ISO RGD:69124 6480464 butylparaben results in increased expression of LEP mRNA CTD PMID:22956630 butyric acid multiple interactions ISO RGD:69124 6480464 Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 cadmium dichloride decreases expression ISO RGD:69124 6480464 Cadmium Chloride results in decreased expression of LEP mRNA, Cadmium Chloride results in decreased expression of LEP protein CTD PMID:23921151 cadmium dichloride decreases expression ISO RGD:69123 6480464 Cadmium Chloride results in decreased expression of LEP mRNA CTD PMID:19847775 cadmium dichloride increases expression ISO RGD:69124 6480464 Cadmium Chloride results in increased expression of LEP protein CTD PMID:27634282 cadmium dichloride multiple interactions ISO RGD:69124 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:23921151 , PMID:27814245 caffeine decreases expression ISO RGD:69124 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:23727198 caffeine decreases expression ISO RGD:69123 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:26367767 caffeine multiple interactions ISO RGD:69123 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA], Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of LEP mRNA, Caffeine results in decreased expression of LEP protein CTD PMID:23727198 , PMID:26367767 calcitriol decreases abundance ISO RGD:69124 6480464 LEP protein results in decreased abundance of Calcitriol CTD PMID:14657008 calcium atom multiple interactions ISO RGD:69124 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 , PMID:20107083 calcium atom multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium atom affects secretion EXP 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium atom affects expression EXP 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium atom decreases abundance ISO RGD:69124 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium atom affects abundance ISO RGD:69124 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium atom increases transport ISO RGD:69124 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 calcium(0) multiple interactions ISO RGD:69124 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 , PMID:20107083 calcium(0) multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium(0) affects secretion EXP 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium(0) affects expression EXP 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium(0) decreases abundance ISO RGD:69124 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium(0) affects abundance ISO RGD:69124 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium(0) increases transport ISO RGD:69124 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 candesartan multiple interactions ISO RGD:69123 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP], Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 candesartan increases response to substance EXP 6480464 LEP protein results in increased susceptibility to candesartan CTD PMID:21287150 candesartan decreases expression ISO RGD:69123 6480464 candesartan results in decreased expression of LEP CTD PMID:19059660 capsaicin decreases expression ISO RGD:69124 6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:17295509 , PMID:19798065 capsaicin multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] more ... CTD PMID:20359164 , PMID:22150557 capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of LEP mRNA, Capsaicin results in increased expression of LEP protein CTD PMID:16278290 , PMID:22150557 carbon nanotube increases expression ISO RGD:69124 6480464 Nanotubes, Carbon results in increased expression of LEP protein CTD PMID:20381574 carvacrol multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 CCCP multiple interactions ISO RGD:69123 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 CCCP decreases response to substance ISO RGD:69123 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein CTD PMID:11342529 cerulenin affects response to substance ISO RGD:69124 6480464 LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 CGS-21680 multiple interactions ISO RGD:69123 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 chlorohydrocarbon multiple interactions ISO RGD:69124 6480464 [LEP protein co-treated with Hydrocarbons, Chlorinated co-treated with Polychlorinated Biphenyls] affects the phosphorylation of RELA protein more ... CTD PMID:31313498 chloroquine multiple interactions ISO RGD:69124 6480464 Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 chlorpyrifos increases expression ISO RGD:69123 6480464 Chlorpyrifos results in increased expression of LEP mRNA CTD PMID:30879083 choline multiple interactions ISO RGD:69124 6480464 [3 more ... CTD PMID:24384915 more ... chromium atom decreases expression EXP 6480464 Chromium results in decreased expression of LEP protein CTD PMID:17114815 chromium atom increases expression EXP 6480464 Chromium deficiency results in increased expression of LEP mRNA, Chromium deficiency results in increased expression of LEP protein CTD PMID:19846803 chromium atom multiple interactions ISO RGD:69124 6480464 [Linoleic Acids, Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 cisplatin affects expression EXP 6480464 Cisplatin affects the expression of LEP protein CTD PMID:25051504 clofibrate multiple interactions ISO RGD:69124 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 clofibrate multiple interactions EXP 6480464 [alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 clozapine affects response to substance ISO RGD:69123 6480464 LEP protein affects the susceptibility to Clozapine CTD PMID:17502770 clozapine increases expression EXP 6480464 Clozapine results in increased expression of LEP protein CTD PMID:16402076 cobalt dichloride increases expression ISO RGD:69123 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride increases secretion EXP 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion ISO RGD:69123 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion ISO RGD:69124 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:22019852 Colforsin dapropate hydrochloride decreases secretion ISO RGD:69124 6480464 Colforsin results in decreased secretion of LEP protein CTD PMID:27381457 Colforsin dapropate hydrochloride multiple interactions ISO RGD:69123 6480464 Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 Colforsin dapropate hydrochloride decreases expression ISO RGD:69124 6480464 Colforsin results in decreased expression of LEP mRNA CTD PMID:27381457 , PMID:9002984 conjugated linoleic acid multiple interactions ISO RGD:69124 6480464 [Linoleic Acids, Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 conjugated linoleic acid decreases expression ISO RGD:69124 6480464 Linoleic Acids, Conjugated results in decreased expression of LEP protein CTD PMID:16933788 conjugated linoleic acid increases expression ISO RGD:69124 6480464 Linoleic Acids, Conjugated results in increased expression of LEP protein CTD PMID:17322064 corticosterone multiple interactions ISO RGD:69124 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 , PMID:29751049 corticosterone decreases expression ISO RGD:69124 6480464 Corticosterone results in decreased expression of LEP protein CTD PMID:28186389 crocidolite asbestos decreases expression ISO RGD:69124 6480464 Asbestos, Crocidolite results in decreased expression of LEP mRNA CTD PMID:23917077 cycloheximide multiple interactions ISO RGD:69124 6480464 LEP protein inhibits the reaction [Cycloheximide results in decreased expression of LEPR protein] CTD PMID:31199479 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of LEP protein CTD PMID:25051504 cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of LEP protein CTD PMID:27348886 cyromazine multiple interactions EXP 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 D-glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... D-glucose multiple interactions ISO RGD:69124 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose CTD PMID:27712037 D-glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA, Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... D-glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 D-glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 D-glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 dantrolene decreases expression EXP 6480464 Dantrolene results in decreased expression of LEP protein CTD PMID:25051504 DDE increases secretion ISO RGD:69124 6480464 Dichlorodiphenyl Dichloroethylene results in increased secretion of LEP protein CTD PMID:21044676 DDE multiple interactions ISO RGD:69123 6480464 Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:26200599 DDT increases expression ISO RGD:69123 6480464 DDT results in increased expression of LEP mRNA CTD PMID:25014179 dehydroepiandrosterone decreases expression EXP 6480464 Dehydroepiandrosterone results in decreased expression of LEP protein CTD PMID:12659879 deoxycholic acid decreases expression ISO RGD:69124 6480464 Deoxycholic Acid results in decreased expression of LEP mRNA CTD PMID:23911798 desferrioxamine B increases expression ISO RGD:69123 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 desferrioxamine B increases secretion EXP 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases secretion ISO RGD:69123 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 dexamethasone multiple interactions ISO RGD:69123 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:10946865 more ... dexamethasone multiple interactions ISO RGD:69124 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... dexamethasone increases secretion ISO RGD:69123 6480464 Dexamethasone results in increased secretion of LEP protein CTD PMID:10946865 dexamethasone increases expression ISO RGD:69123 6480464 Dexamethasone results in increased expression of LEP mRNA CTD PMID:10946865 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of LEP mRNA, Dexamethasone results in increased expression of LEP protein CTD PMID:15824971 , PMID:23166830 dextran sulfate multiple interactions ISO RGD:69124 6480464 [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA, [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein CTD PMID:19931517 diazoxide multiple interactions EXP 6480464 Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 diazoxide decreases secretion EXP 6480464 Diazoxide results in decreased secretion of LEP protein CTD PMID:10780946 dibenziodolium multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] more ... CTD PMID:17668557 dibutylstannane multiple interactions ISO RGD:69124 6480464 [Dietary Fats co-treated with di-n-butyltin] results in increased expression of LEP protein CTD PMID:29787037 diethylstilbestrol decreases secretion ISO RGD:69124 6480464 Diethylstilbestrol results in decreased secretion of LEP protein CTD PMID:25111128 diethylstilbestrol multiple interactions ISO RGD:69124 6480464 Diethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23493373 diiodine multiple interactions EXP 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 dioxygen increases secretion ISO RGD:69123 6480464 Oxygen deficiency results in increased secretion of LEP protein CTD PMID:12032628 dioxygen increases expression ISO RGD:69123 6480464 Oxygen deficiency results in increased expression of LEP mRNA CTD PMID:12032628 , PMID:23466666 dioxygen decreases expression ISO RGD:69124 6480464 Oxygen deficiency results in decreased expression of LEP mRNA, Oxygen deficiency results in decreased expression of LEP protein CTD PMID:21531777 , PMID:23539316 dipyridamole multiple interactions EXP 6480464 1, 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 dipyridamole increases expression EXP 6480464 Dipyridamole results in increased expression of LEP protein CTD PMID:10746648 disodium selenite decreases expression ISO RGD:69124 6480464 Sodium Selenite results in decreased expression of LEP mRNA CTD PMID:23274088 dobutamine decreases secretion ISO RGD:69123 6480464 Dobutamine results in decreased secretion of LEP protein CTD PMID:11022189 dobutamine decreases expression ISO RGD:69124 6480464 Dobutamine results in decreased expression of LEP mRNA, Dobutamine results in decreased expression of LEP protein CTD PMID:9002984 DPCPX multiple interactions EXP 6480464 1, 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 edelfosine multiple interactions ISO RGD:69124 6480464 edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 efavirenz decreases expression ISO RGD:69123 6480464 efavirenz results in decreased expression of LEP mRNA CTD PMID:21619898 elemental selenium decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 enalapril increases response to substance ISO RGD:69124 6480464 LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 ethambutol decreases expression EXP 6480464 Ethambutol results in decreased expression of LEP protein CTD PMID:25051504 ethanol multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein, Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein] CTD PMID:18227024 ethanol multiple interactions ISO RGD:69124 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 ethionamide decreases expression EXP 6480464 Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 Ethyl icosapentate multiple interactions ISO RGD:69124 6480464 Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA], Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein] CTD PMID:10753628 Ethyl icosapentate increases secretion ISO RGD:69124 6480464 eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein CTD PMID:10753628 Ethyl icosapentate increases expression ISO RGD:69124 6480464 eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA CTD PMID:10753628 ethylparaben decreases expression ISO RGD:69123 6480464 ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA CTD PMID:22956630 fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA], Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA] CTD PMID:26973390 fenoterol decreases secretion ISO RGD:69123 6480464 Fenoterol results in decreased secretion of LEP protein CTD PMID:11022189 ferroheme b multiple interactions ISO RGD:69124 6480464 cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme], tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 ferroheme b increases abundance ISO RGD:69124 6480464 LEP gene mutant form results in increased abundance of Heme CTD PMID:23839791 flufenamic acid multiple interactions ISO RGD:69124 6480464 Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of LEP protein CTD PMID:25051504 fonofos increases methylation ISO RGD:69123 6480464 Fonofos results in increased methylation of LEP promoter CTD PMID:22847954 fructose multiple interactions EXP 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:21122807 more ... fructose increases secretion EXP 6480464 Fructose results in increased secretion of LEP protein CTD PMID:10780946 more ... fructose increases expression EXP 6480464 Fructose results in increased expression of LEP mRNA, Fructose results in increased expression of LEP protein CTD PMID:11741341 more ... furan decreases expression EXP 6480464 furan results in decreased expression of LEP mRNA CTD PMID:25539665 gallocatechin multiple interactions ISO RGD:69124 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 gamma-hexachlorocyclohexane affects expression EXP 6480464 Hexachlorocyclohexane affects the expression of LEP mRNA CTD PMID:17785943 gemcitabine decreases expression ISO RGD:69123 6480464 gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 gemfibrozil decreases expression EXP 6480464 Gemfibrozil results in decreased expression of LEP protein CTD PMID:25051504 gemfibrozil increases expression EXP 6480464 Gemfibrozil results in increased expression of LEP protein CTD PMID:25051504 genistein decreases expression ISO RGD:69124 6480464 Genistein results in decreased expression of LEP mRNA, Genistein results in decreased expression of LEP protein CTD PMID:18359623 genistein decreases response to substance ISO RGD:69123 6480464 Genistein results in decreased susceptibility to LEP protein CTD PMID:11342529 genistein multiple interactions ISO RGD:69123 6480464 Genistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], Genistein inhibits the reaction [LEP protein results in increased expression of CCL2] CTD PMID:11342529 gingerol multiple interactions ISO RGD:69124 6480464 gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA], gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 glucagon multiple interactions ISO RGD:69124 6480464 Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein], Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein] CTD PMID:29988851 glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... glucose multiple interactions ISO RGD:69124 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose CTD PMID:27712037 glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA, Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species], LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 glycine multiple interactions ISO RGD:69124 6480464 Glycine affects the reaction [Sodium Glutamate affects the expression of LEP protein] CTD PMID:18930730 heme b multiple interactions ISO RGD:69124 6480464 cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme], tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 heme b increases abundance ISO RGD:69124 6480464 LEP gene mutant form results in increased abundance of Heme CTD PMID:23839791 hesperidin decreases expression EXP 6480464 Hesperidin results in decreased expression of LEP protein CTD PMID:21820093 hesperidin multiple interactions EXP 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein CTD PMID:21820093 hydrogen peroxide affects expression ISO RGD:69123 6480464 Hydrogen Peroxide affects the expression of LEP mRNA CTD PMID:21179406 hydrogen peroxide decreases expression ISO RGD:69123 6480464 Hydrogen Peroxide results in decreased expression of LEP mRNA CTD PMID:26339600 imidacloprid multiple interactions ISO RGD:69124 6480464 Dietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein], imidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein] CTD PMID:27960282 imidacloprid increases secretion ISO RGD:69124 6480464 imidacloprid results in increased secretion of LEP protein CTD PMID:27960282 indinavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] CTD PMID:17668557 indinavir multiple interactions ISO RGD:69124 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 indinavir decreases expression ISO RGD:69123 6480464 Indinavir results in decreased expression of LEP protein CTD PMID:17668557 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of LEP protein CTD PMID:16280098 , PMID:25051504 indometacin multiple interactions ISO RGD:69123 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA more ... CTD PMID:23086663 , PMID:28628672 indometacin multiple interactions EXP 6480464 BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein] more ... CTD PMID:16280098 , PMID:18181030 iodide salt increases expression EXP 6480464 Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 iron(2+) sulfate (anhydrous) increases expression ISO RGD:69123 6480464 ferrous sulfate results in increased expression of LEP mRNA CTD PMID:21540303 isoflavones increases expression EXP 6480464 Isoflavones results in increased expression of LEP protein CTD PMID:22155228 isoprenaline increases secretion ISO RGD:69124 6480464 Isoproterenol results in increased secretion of LEP protein CTD PMID:25111128 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of LEP protein CTD PMID:20307649 isoprenaline multiple interactions EXP 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] CTD PMID:20307649 isoprenaline multiple interactions ISO RGD:69123 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 isoprenaline decreases secretion ISO RGD:69123 6480464 Isoproterenol results in decreased secretion of LEP protein CTD PMID:11022189 isotretinoin increases expression EXP 6480464 Isotretinoin results in increased expression of LEP mRNA CTD PMID:19212007 kainic acid decreases response to substance ISO RGD:69124 6480464 LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 L-ascorbic acid decreases secretion EXP 6480464 Ascorbic Acid results in decreased secretion of LEP protein CTD PMID:20400526 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [INS1 protein results in increased secretion of LEP protein] CTD PMID:20400526 L-methionine multiple interactions ISO RGD:69124 6480464 [3 more ... CTD PMID:24384915 more ... lamivudine multiple interactions ISO RGD:69124 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA, [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 lanthanum atom multiple interactions ISO RGD:69124 6480464 Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 lead(0) multiple interactions ISO RGD:69123 6480464 Lead results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24709140 lead(2+) multiple interactions ISO RGD:69123 6480464 Lead results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24709140 Licarin A multiple interactions ISO RGD:69124 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA CTD PMID:29288687 lipoic acid decreases secretion ISO RGD:69124 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA, Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 lipoic acid decreases expression ISO RGD:69124 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 lipopolysaccharide multiple interactions ISO RGD:69123 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of LEP protein CTD PMID:17379010 lipopolysaccharide multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein], Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17379010 , PMID:17621560 lipopolysaccharide multiple interactions ISO RGD:69124 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein, TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 lipopolysaccharide increases expression ISO RGD:69124 6480464 Lipopolysaccharides results in increased expression of LEP mRNA CTD PMID:12057914 lipopolysaccharide decreases expression ISO RGD:69124 6480464 Lipopolysaccharides results in decreased expression of LEP mRNA CTD PMID:12057914 loganin affects expression ISO RGD:69124 6480464 loganin affects the expression of LEP protein CTD PMID:21864639 lopinavir decreases expression ISO RGD:69123 6480464 Lopinavir results in decreased expression of LEP protein CTD PMID:17668557 lopinavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein] CTD PMID:17668557 LY294002 decreases expression ISO RGD:69124 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA CTD PMID:19254925 , PMID:21351249 LY294002 multiple interactions ISO RGD:69124 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein] CTD PMID:29248466 LY294002 multiple interactions ISO RGD:69123 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 LY294002 decreases secretion ISO RGD:69124 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein CTD PMID:19254925 , PMID:21351249 manganese atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 manganese(0) decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 melatonin decreases expression ISO RGD:69123 6480464 Melatonin results in decreased expression of LEP mRNA CTD PMID:20738756 melatonin decreases expression EXP 6480464 Melatonin results in decreased expression of LEP protein CTD PMID:19028472 menadione multiple interactions ISO RGD:69123 6480464 1 more ... CTD PMID:16996477 menadione increases expression ISO RGD:69123 6480464 Vitamin K 3 results in increased expression of LEP mRNA CTD PMID:16996477 mercury dichloride decreases expression ISO RGD:69124 6480464 Mercuric Chloride results in decreased expression of LEP mRNA CTD PMID:22019852 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of LEP mRNA CTD PMID:30807803 mercury dichloride decreases secretion ISO RGD:69124 6480464 Mercuric Chloride results in decreased secretion of LEP protein CTD PMID:22019852 metformin increases expression ISO RGD:69124 6480464 Metformin results in increased expression of LEP protein CTD PMID:20869956 methacholine chloride increases response to substance ISO RGD:69124 6480464 LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 methadone increases expression ISO RGD:69123 6480464 Methadone results in increased expression of LEP protein CTD PMID:15717844 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of LEP protein CTD PMID:25051504 methotrexate affects expression ISO RGD:69124 6480464 Methotrexate affects the expression of LEP mRNA CTD PMID:18502557 methylmercury chloride multiple interactions ISO RGD:69124 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein CTD PMID:27814245 methylmercury chloride decreases expression ISO RGD:69124 6480464 methylmercuric chloride results in decreased expression of LEP mRNA CTD PMID:29850906 methylparaben decreases expression ISO RGD:69123 6480464 methylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 MK-2206 multiple interactions ISO RGD:69124 6480464 MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3', 5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein] CTD PMID:27381457 monocrotaline affects expression EXP 6480464 Monocrotaline affects the expression of LEP protein CTD PMID:25051504 monocrotaline multiple interactions ISO RGD:69124 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein, TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of LEP protein CTD PMID:14657608 monosodium L-glutamate increases expression ISO RGD:69124 6480464 Sodium Glutamate results in increased expression of LEP mRNA, Sodium Glutamate results in increased expression of LEP protein CTD PMID:15809509 more ... monosodium L-glutamate multiple interactions ISO RGD:69124 6480464 [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein] more ... CTD PMID:18930730 more ... monosodium L-glutamate affects expression ISO RGD:69124 6480464 Sodium Glutamate affects the expression of LEP protein CTD PMID:18930730 morin multiple interactions EXP 6480464 morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:69123 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] more ... CTD PMID:11342529 , PMID:28571770 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases response to substance ISO RGD:69123 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased susceptibility to LEP protein CTD PMID:11342529 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:69124 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] CTD PMID:19254925 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:69123 6480464 LEP protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA] CTD PMID:19763737 N-methyl-N-nitrosourea multiple interactions ISO RGD:69124 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] more ... CTD PMID:16822543 N-methyl-N-nitrosourea increases expression ISO RGD:69124 6480464 Methylnitrosourea results in increased expression of LEP protein CTD PMID:16822543 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of LEP protein CTD PMID:25051504 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of LEP mRNA, Dimethylnitrosamine results in increased expression of LEP protein CTD PMID:15798949 naproxen multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 naringin multiple interactions EXP 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein, naringin inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:21820093 , PMID:24399619 naringin multiple interactions ISO RGD:69124 6480464 naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:22198281 nelfinavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein] CTD PMID:17668557 nelfinavir decreases secretion ISO RGD:69124 6480464 Nelfinavir results in decreased secretion of LEP protein CTD PMID:19033543 nelfinavir decreases expression ISO RGD:69123 6480464 Nelfinavir results in decreased expression of LEP protein CTD PMID:17668557 nevirapine increases expression ISO RGD:69123 6480464 Nevirapine results in increased expression of LEP mRNA CTD PMID:21619898 nickel atom decreases expression ISO RGD:69123 6480464 Nickel results in decreased expression of LEP mRNA CTD PMID:25583101 nickel dichloride multiple interactions ISO RGD:69123 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 nickel dichloride multiple interactions EXP 6480464 nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 nickel sulfate multiple interactions ISO RGD:69123 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA CTD PMID:18832182 nickel sulfate increases expression ISO RGD:69123 6480464 nickel sulfate results in increased expression of LEP mRNA CTD PMID:18832182 nicotine increases expression EXP 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 , PMID:29155039 nicotine decreases response to substance EXP 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 nicotinic acid increases expression ISO RGD:69123 6480464 Niacin results in increased expression of LEP protein CTD PMID:16887123 nicotinic acid increases expression ISO RGD:69124 6480464 Niacin results in increased expression of LEP mRNA CTD PMID:21236357 nitric oxide multiple interactions ISO RGD:69123 6480464 LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:9312173 Nonylphenol increases expression ISO RGD:69124 6480464 nonylphenol results in increased expression of LEP mRNA CTD PMID:18417718 NS-398 multiple interactions ISO RGD:69123 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA], N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 olanzapine increases expression ISO RGD:69123 6480464 olanzapine results in increased expression of LEP protein CTD PMID:11927762 , PMID:19512971 oleanolic acid increases expression ISO RGD:69124 6480464 Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 oleic acid decreases expression ISO RGD:69124 6480464 Oleic Acid results in decreased expression of LEP mRNA CTD PMID:9002984 oleic acid increases expression EXP 6480464 Oleic Acid results in increased expression of LEP mRNA CTD PMID:23395669 oleic acid multiple interactions EXP 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 orlistat multiple interactions ISO RGD:69124 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 orlistat multiple interactions EXP 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 ozone multiple interactions ISO RGD:69124 6480464 [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL11 protein more ... CTD PMID:12794034 , PMID:27472835 ozone decreases secretion ISO RGD:69124 6480464 Ozone results in decreased secretion of LEP protein CTD PMID:27240593 ozone increases response to substance ISO RGD:69124 6480464 LEP gene mutant form results in increased susceptibility to Ozone, LEP protein results in increased susceptibility to Ozone CTD PMID:12794034 more ... ozone increases expression EXP 6480464 Ozone results in increased expression of LEP, Ozone results in increased expression of LEP protein CTD PMID:24103449 , PMID:25838073 paracetamol multiple interactions ISO RGD:69124 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 paracetamol decreases expression ISO RGD:69123 6480464 Acetaminophen results in decreased expression of LEP mRNA CTD PMID:26690555 paracetamol affects expression ISO RGD:69124 6480464 Acetaminophen affects the expression of LEP mRNA CTD PMID:17562736 paraquat affects expression EXP 6480464 Paraquat affects the expression of LEP mRNA CTD PMID:18198484 parathion increases methylation ISO RGD:69123 6480464 Parathion results in increased methylation of LEP promoter CTD PMID:22847954 perfluorooctane-1-sulfonic acid increases expression ISO RGD:69123 6480464 perfluorooctane sulfonic acid results in increased expression of LEP mRNA CTD PMID:28011154 perfluorooctane-1-sulfonic acid affects expression ISO RGD:69123 6480464 perfluorooctane sulfonic acid affects the expression of LEP mRNA CTD PMID:30738844 perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of LEP protein CTD PMID:18083506 permethrin multiple interactions ISO RGD:69124 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein, Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 phencyclidine increases expression ISO RGD:69124 6480464 Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 phenethyl caffeate decreases expression ISO RGD:69124 6480464 caffeic acid phenethyl ester results in decreased expression of LEP mRNA, caffeic acid phenethyl ester results in decreased expression of LEP protein CTD PMID:21467634 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of LEP protein CTD PMID:25051504 phenobarbital multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA, [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein CTD PMID:14758566 phosphatidylcholine decreases expression ISO RGD:69124 6480464 Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 phosphoramidon decreases expression EXP 6480464 phosphoramidon results in decreased expression of LEP protein CTD PMID:16391412 pioglitazone increases expression EXP 6480464 pioglitazone results in increased expression of LEP protein CTD PMID:15655531 piperine multiple interactions EXP 6480464 piperine inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 pirimicarb multiple interactions EXP 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 pirinixic acid multiple interactions ISO RGD:69124 6480464 pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein] CTD PMID:16306350 pitavastatin multiple interactions ISO RGD:69124 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 pitavastatin(1-) multiple interactions ISO RGD:69124 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 pluronic P-123 multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein], Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 pluronic P-123 increases secretion EXP 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Poloxamer increases secretion EXP 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Poloxamer multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein], Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 potassium dichromate increases expression ISO RGD:69123 6480464 Potassium Dichromate results in increased expression of LEP mRNA CTD PMID:11678601 pravastatin multiple interactions ISO RGD:69124 6480464 Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 prochloraz decreases expression ISO RGD:69123 6480464 prochloraz results in decreased expression of LEP mRNA CTD PMID:30879083 progesterone decreases secretion ISO RGD:69123 6480464 Progesterone results in decreased secretion of LEP protein CTD PMID:16048798 progesterone multiple interactions ISO RGD:69123 6480464 LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone], LEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]] CTD PMID:19849856 progesterone increases expression ISO RGD:69124 6480464 Progesterone results in increased expression of LEP mRNA CTD PMID:15713686 propranolol multiple interactions ISO RGD:69123 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 propranolol increases expression EXP 6480464 Propranolol results in increased expression of LEP protein CTD PMID:24250662 propylparaben increases expression ISO RGD:69124 6480464 propylparaben results in increased expression of LEP mRNA CTD PMID:22956630 propylparaben decreases expression ISO RGD:69123 6480464 propylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 prostaglandin E2 increases expression EXP 6480464 Dinoprostone results in increased expression of LEP protein CTD PMID:11060898 prostaglandin E2 increases abundance EXP 6480464 LEP protein results in increased abundance of Dinoprostone CTD PMID:16015682 prostaglandin E2 increases secretion EXP 6480464 Dinoprostone results in increased secretion of LEP protein CTD PMID:11060898 Ptaquiloside decreases expression ISO RGD:69124 6480464 ptaquiloside results in decreased expression of LEP mRNA CTD PMID:23274088 Pyridostigmine bromide multiple interactions ISO RGD:69124 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein, Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 pyruvic acid increases secretion EXP 6480464 Pyruvic Acid results in increased secretion of LEP protein CTD PMID:10780946 pyruvic acid multiple interactions EXP 6480464 INS1 protein promotes the reaction [Pyruvic Acid results in increased secretion of LEP protein] CTD PMID:10780946 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] more ... CTD PMID:22426011 more ... quercetin increases expression ISO RGD:69123 6480464 Quercetin results in increased expression of LEP mRNA, Quercetin results in increased expression of LEP protein CTD PMID:22230496 quercetin decreases expression ISO RGD:69124 6480464 Quercetin results in decreased expression of LEP mRNA CTD PMID:19914226 quercetin decreases secretion ISO RGD:69124 6480464 Quercetin results in decreased secretion of LEP protein CTD PMID:19914226 quercetin multiple interactions ISO RGD:69124 6480464 Quercetin affects the reaction [LEP protein affects the expression of NOS2 mRNA] more ... CTD PMID:19914226 more ... rac-lactic acid affects expression ISO RGD:69123 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 ramipril multiple interactions ISO RGD:69123 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP], Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 ramipril decreases expression ISO RGD:69123 6480464 Ramipril results in decreased expression of LEP CTD PMID:19059660 reactive oxygen species multiple interactions ISO RGD:69123 6480464 adenosine-3' more ... CTD PMID:11342529 reactive oxygen species increases chemical synthesis ISO RGD:69123 6480464 LEP protein results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:11342529 rebaudioside A multiple interactions ISO RGD:69124 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 reserpine increases expression ISO RGD:69124 6480464 Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 resveratrol decreases secretion ISO RGD:69124 6480464 resveratrol metabolite results in decreased secretion of LEP protein, resveratrol results in decreased secretion of LEP protein CTD PMID:23717508 resveratrol multiple interactions ISO RGD:69124 6480464 [Dietary Fats co-treated with Resveratrol] results in increased expression of LEP mRNA more ... CTD PMID:29197120 , PMID:31881177 resveratrol multiple interactions EXP 6480464 [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA], resveratrol inhibits the reaction [Fructose results in increased expression of LEP mRNA] CTD PMID:26973390 resveratrol decreases expression ISO RGD:69123 6480464 resveratrol results in decreased expression of LEP mRNA, resveratrol results in decreased expression of LEP protein CTD PMID:21713995 , PMID:23536519 resveratrol decreases expression ISO RGD:69124 6480464 resveratrol metabolite results in decreased expression of LEP mRNA more ... CTD PMID:23717508 more ... rifampicin increases expression EXP 6480464 Rifampin results in increased expression of LEP protein CTD PMID:25051504 ritonavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 ritonavir decreases expression ISO RGD:69123 6480464 Ritonavir results in decreased expression of LEP protein CTD PMID:17668557 rotenone decreases response to substance ISO RGD:69123 6480464 Rotenone results in decreased susceptibility to LEP protein CTD PMID:11342529 rotenone multiple interactions ISO RGD:69123 6480464 Rotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 roxarsone decreases expression ISO RGD:69123 6480464 Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 S-adenosyl-L-methioninate multiple interactions ISO RGD:69123 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA], S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 S-adenosyl-L-methionine multiple interactions ISO RGD:69123 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA], S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 saquinavir multiple interactions ISO RGD:69124 6480464 [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 SB 203580 multiple interactions ISO RGD:69123 6480464 SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]], SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 , PMID:19849856 SB 203580 decreases response to substance ISO RGD:69123 6480464 SB 203580 results in decreased susceptibility to LEP protein CTD PMID:19849856 selenium atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 serpentine asbestos decreases expression ISO RGD:69124 6480464 Asbestos, Serpentine results in decreased expression of LEP mRNA CTD PMID:23917077 silicon dioxide decreases expression ISO RGD:69123 6480464 Silicon Dioxide analog results in decreased expression of LEP mRNA CTD PMID:23806026 simvastatin multiple interactions ISO RGD:69124 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] more ... CTD PMID:19254925 simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 simvastatin decreases secretion ISO RGD:69124 6480464 Simvastatin results in decreased secretion of LEP protein CTD PMID:19254925 simvastatin decreases expression ISO RGD:69124 6480464 Simvastatin results in decreased expression of LEP mRNA, Simvastatin results in decreased expression of LEP mRNA alternative form CTD PMID:19254925 SKF-96365 hydrochloride multiple interactions ISO RGD:69124 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 sodium arsenite increases expression ISO RGD:69123 6480464 sodium arsenite results in increased expression of LEP mRNA CTD PMID:25879800 sodium arsenite multiple interactions ISO RGD:69124 6480464 sodium arsenite promotes the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:28593471 , PMID:29755549 sodium arsenite increases expression ISO RGD:69124 6480464 sodium arsenite results in increased expression of LEP protein CTD PMID:28593471 , PMID:29755549 sodium arsenite affects expression ISO RGD:69124 6480464 sodium arsenite affects the expression of LEP mRNA, sodium arsenite affects the expression of LEP protein CTD PMID:25367288 , PMID:28206643 sodium perchlorate multiple interactions EXP 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 stavudine decreases expression ISO RGD:69123 6480464 Stavudine results in decreased expression of LEP protein CTD PMID:17668557 steviol multiple interactions ISO RGD:69124 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA] more ... CTD PMID:25554529 stevioside multiple interactions ISO RGD:69124 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:24854284 streptozocin multiple interactions ISO RGD:69124 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein, Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein] CTD PMID:29988851 sumatriptan multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 superoxide multiple interactions ISO RGD:69124 6480464 acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides] more ... CTD PMID:16380530 superoxide multiple interactions ISO RGD:69123 6480464 [LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides CTD PMID:11342529 superoxide increases abundance ISO RGD:69124 6480464 LEP protein results in increased abundance of Superoxides CTD PMID:16380530 terbufos increases methylation ISO RGD:69123 6480464 terbufos results in increased methylation of LEP promoter CTD PMID:22847954 terbutaline decreases expression ISO RGD:69124 6480464 Terbutaline results in decreased expression of LEP mRNA, Terbutaline results in decreased expression of LEP protein CTD PMID:9002984 testosterone affects secretion ISO RGD:69124 6480464 LEP protein affects the secretion of Testosterone CTD PMID:24502529 testosterone multiple interactions ISO RGD:69124 6480464 alpha-cyano-(3 more ... CTD PMID:24502529 tetrachloromethane multiple interactions ISO RGD:69124 6480464 LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein] more ... CTD PMID:11481614 more ... tetrachloromethane increases expression ISO RGD:69124 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:29987408 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:27623180 tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:14758566 , PMID:18227024 thioacetamide decreases response to substance ISO RGD:69124 6480464 LEP gene mutant form results in decreased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of LEP protein CTD PMID:17621560 thioacetamide multiple interactions EXP 6480464 Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17621560 thioacetamide increases response to substance ISO RGD:69124 6480464 LEP protein results in increased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide multiple interactions ISO RGD:69124 6480464 [Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNA more ... CTD PMID:11481614 more ... thiram multiple interactions EXP 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 titanium dioxide decreases expression ISO RGD:69124 6480464 titanium dioxide results in decreased expression of LEP mRNA CTD PMID:23131501 titanium dioxide increases expression ISO RGD:69124 6480464 titanium dioxide results in increased expression of LEP mRNA CTD PMID:29264374 tributylstannane increases expression ISO RGD:69123 6480464 tributyltin results in increased expression of LEP mRNA CTD PMID:28011154 tributylstannane decreases expression ISO RGD:69124 6480464 tributyltin results in decreased expression of LEP protein CTD PMID:27310180 tributylstannane multiple interactions ISO RGD:69124 6480464 [Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein CTD PMID:29787037 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 tributylstannane increases expression ISO RGD:69124 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 tributylstannane increases secretion EXP 6480464 tributyltin results in increased secretion of LEP protein CTD PMID:28161095 trichloroethene multiple interactions ISO RGD:69124 6480464 Trichloroethylene inhibits the reaction [Dietary Fats affects the expression of LEP mRNA] CTD PMID:29669109 trichostatin A increases expression ISO RGD:69123 6480464 trichostatin A results in increased expression of LEP mRNA CTD PMID:17502362 trichostatin A multiple interactions ISO RGD:69123 6480464 trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 triflumizole multiple interactions ISO RGD:69123 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA, T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:23086663 triflumizole multiple interactions ISO RGD:69124 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA, T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA] CTD PMID:23086663 triphenyl phosphate multiple interactions ISO RGD:69124 6480464 [tris(1 more ... CTD PMID:29112739 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of LEP mRNA, troglitazone results in decreased expression of LEP protein CTD PMID:11909685 more ... troglitazone decreases expression ISO RGD:69123 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:10946865 , PMID:9727893 troglitazone decreases expression ISO RGD:69124 6480464 troglitazone results in decreased expression of LEP mRNA CTD PMID:10753628 troglitazone increases secretion ISO RGD:69123 6480464 troglitazone results in increased secretion of LEP protein CTD PMID:11092516 troglitazone multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein more ... CTD PMID:10946865 , PMID:11092516 U-73122 multiple interactions ISO RGD:69124 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:20107083 ursolic acid increases expression ISO RGD:69124 6480464 ursolic acid results in increased expression of LEP protein CTD PMID:20869956 vanadium atom multiple interactions EXP 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein], Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 vanadium(0) multiple interactions EXP 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein], Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of LEP mRNA CTD PMID:23160963 vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA], Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein] CTD PMID:20404018 wortmannin decreases expression ISO RGD:69124 6480464 wortmannin results in decreased expression of LEP mRNA CTD PMID:19254925 wortmannin multiple interactions ISO RGD:69124 6480464 wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 wortmannin decreases secretion ISO RGD:69124 6480464 wortmannin results in decreased secretion of LEP protein CTD PMID:19254925 xanthone multiple interactions EXP 6480464 xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein], xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 zidovudine decreases expression ISO RGD:69123 6480464 Zidovudine results in decreased expression of LEP protein CTD PMID:17668557 zidovudine multiple interactions ISO RGD:69124 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA, [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 zinc atom decreases expression ISO RGD:69124 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 zinc atom multiple interactions ISO RGD:69124 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 zinc atom decreases expression ISO RGD:69123 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc atom multiple interactions ISO RGD:69123 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA], MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 zinc atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc dichloride increases expression ISO RGD:69123 6480464 zinc chloride results in increased expression of LEP mRNA CTD PMID:21540303 zinc molecular entity multiple interactions EXP 6480464 Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 zinc sulfate decreases expression EXP 6480464 Zinc Sulfate deficiency results in decreased expression of LEP mRNA CTD PMID:11568307 zinc sulfate multiple interactions EXP 6480464 Zinc Sulfate deficiency results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:11568307 zinc(0) decreases expression ISO RGD:69124 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 zinc(0) decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc(0) multiple interactions ISO RGD:69123 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA], MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 zinc(0) decreases expression ISO RGD:69123 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 zinc(0) multiple interactions ISO RGD:69124 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 ziram multiple interactions EXP 6480464 [2-amino-3-chloro-1, 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614
Gene-Chemical Interaction Annotations
