Lep Rat (+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23365609 Lep Rat (+)-catechin decreases expression ISO Lep (Mus musculus) 6480464 Catechin results in decreased expression of LEP protein CTD PMID:30445784 Lep Rat (+)-catechin multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 Lep Rat (+)-epicatechin-3-O-gallate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 Lep Rat (-)-epigallocatechin 3-gallate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 Lep Rat (R)-lipoic acid decreases secretion ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 Lep Rat (R)-lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA and Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 Lep Rat (R)-lipoic acid decreases expression ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 Lep Rat (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 and PMID:29155039 Lep Rat (S)-nicotine decreases response to substance EXP 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 Lep Rat 1,4-bis(2-ethylhexyl) sulfosuccinate increases expression ISO Lep (Mus musculus) 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of LEP mRNA CTD PMID:30728429 Lep Rat 1,4-bis(2-ethylhexyl) sulfosuccinate multiple interactions ISO Lep (Mus musculus) 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of and results in increased secretion of LEP protein CTD PMID:30728429 Lep Rat 1,8-cineole multiple interactions ISO Lep (Mus musculus) 6480464 Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein] more ... CTD PMID:31483951 Lep Rat 1-(3-chlorophenyl)piperazine multiple interactions ISO Lep (Mus musculus) 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 Lep Rat 1-naphthyl isothiocyanate affects expression EXP 6480464 1-Naphthylisothiocyanate affects the expression of LEP protein CTD PMID:25051504 Lep Rat 15-deoxy-Delta(12,14)-prostaglandin J2 increases secretion ISO LEP (Homo sapiens) 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased secretion of LEP protein CTD PMID:11092516 Lep Rat 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO LEP (Homo sapiens) 6480464 [Dexamethasone co-treated with 15-deoxy-delta(12 and 14)-prostaglandin J2] results in decreased secretion of LEP protein CTD PMID:11092516 Lep Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat 17beta-estradiol increases expression ISO Lep (Mus musculus) 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:18359623 Lep Rat 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:26164745 Lep Rat 17beta-estradiol multiple interactions ISO LEP (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 Lep Rat 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO LEP (Homo sapiens) 6480464 Dihydrotestosterone results in decreased expression of LEP mRNA CTD PMID:18801408 Lep Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:23618531 more ... Lep Rat 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:24978599 Lep Rat 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:24559133 Lep Rat 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 Lep Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LEP protein more ... CTD PMID:19063610 more ... Lep Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Lep (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of LEP mRNA CTD PMID:21570461 and PMID:26377647 Lep Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA more ... CTD PMID:15977195 Lep Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Lep (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA CTD PMID:19063610 Lep Rat 2,4-dinitrophenol multiple interactions ISO Lep (Mus musculus) 6480464 [2 and 4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA CTD PMID:24872412 Lep Rat 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO Lep (Mus musculus) 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 Lep Rat 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of LEP protein CTD PMID:25051504 Lep Rat 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Lep (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA more ... CTD PMID:19913045 Lep Rat 2-amino-2-deoxy-D-galactopyranose increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Galactosamine CTD PMID:19913045 Lep Rat 2-amino-2-deoxy-D-glucopyranose 6-phosphate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 Lep Rat 2-amino-6-diazo-5-oxohexanoic acid multiple interactions ISO Lep (Mus musculus) 6480464 Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA] and Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein] CTD PMID:10753628 Lep Rat 2-aminopurine multiple interactions ISO Lep (Mus musculus) 6480464 2-Aminopurine affects the reaction [LEP protein affects the expression of ADGRE1 mRNA] more ... CTD PMID:24150608 Lep Rat 2-arachidonoylglycerol multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with LEP protein] results in increased chemical synthesis of glyceryl 2-arachidonate CTD PMID:27071101 Lep Rat 2-deoxy-D-glucose multiple interactions EXP 6480464 [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 Lep Rat 2-deoxy-D-glucose decreases secretion EXP 6480464 Deoxyglucose results in decreased secretion of LEP protein CTD PMID:10780946 Lep Rat 2-hydroxypropanoic acid affects expression ISO LEP (Homo sapiens) 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 Lep Rat 2-methyl-4-chlorophenoxybutyric acid multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 Lep Rat 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO Lep (Mus musculus) 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] and geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 Lep Rat 24,25-Dihydroxyvitamin D decreases expression ISO LEP (Homo sapiens) 6480464 24 and 25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein CTD PMID:18379402 Lep Rat 3',5'-cyclic AMP increases abundance ISO LEP (Homo sapiens) 6480464 LEP protein results in increased abundance of Cyclic AMP CTD PMID:11342529 Lep Rat 3',5'-cyclic AMP multiple interactions ISO Lep (Mus musculus) 6480464 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA] CTD PMID:27381457 Lep Rat 3',5'-cyclic AMP increases expression ISO Lep (Mus musculus) 6480464 Cyclic AMP analog results in increased expression of LEP mRNA CTD PMID:27381457 Lep Rat 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:28973532 Lep Rat 3,3',5,5'-tetrabromobisphenol A increases expression ISO Lep (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of LEP mRNA CTD PMID:30496566 Lep Rat 3,4-methylenedioxymethamphetamine affects expression EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine affects the expression of LEP protein CTD PMID:17910739 Lep Rat 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases expression ISO Lep (Mus musculus) 6480464 3 more ... CTD PMID:20512997 Lep Rat 3-aminobenzamide increases expression EXP 6480464 3-aminobenzamide results in increased expression of LEP mRNA CTD PMID:18815186 Lep Rat 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of LEP mRNA CTD PMID:20409345 Lep Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO LEP (Homo sapiens) 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:19186324 more ... Lep Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Lep (Mus musculus) 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... Lep Rat 4,4'-sulfonyldiphenol increases secretion ISO Lep (Mus musculus) 6480464 bisphenol S results in increased secretion of LEP protein CTD PMID:25111128 and PMID:31820560 Lep Rat 4,4'-sulfonyldiphenol decreases methylation ISO Lep (Mus musculus) 6480464 bisphenol S results in decreased methylation of LEP promoter CTD PMID:33297965 Lep Rat 4,4'-sulfonyldiphenol multiple interactions ISO Lep (Mus musculus) 6480464 bisphenol S affects the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27241191 Lep Rat 4,4'-sulfonyldiphenol decreases expression ISO LEP (Homo sapiens) 6480464 bisphenol S results in decreased expression of LEP mRNA CTD PMID:27685785 Lep Rat 4-hydroxy-17beta-estradiol increases abundance ISO LEP (Homo sapiens) 6480464 LEP protein results in increased abundance of 4-hydroxyestradiol CTD PMID:24631339 Lep Rat 4-hydroxy-TEMPO multiple interactions EXP 6480464 tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 Lep Rat 4-hydroxybenzoic acid decreases expression ISO LEP (Homo sapiens) 6480464 4-hydroxybenzoic acid results in decreased expression of LEP mRNA CTD PMID:22956630 Lep Rat 4-hydroxyphenyl retinamide decreases expression ISO Lep (Mus musculus) 6480464 Fenretinide results in decreased expression of LEP mRNA CTD PMID:28973697 Lep Rat 4-nonylphenol increases expression EXP 6480464 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 Lep Rat 5-aza-2'-deoxycytidine increases expression ISO LEP (Homo sapiens) 6480464 [Decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA and Decitabine results in increased expression of LEP mRNA CTD PMID:17502362 Lep Rat 5-aza-2'-deoxycytidine multiple interactions ISO LEP (Homo sapiens) 6480464 trichostatin A promotes the reaction [Decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 Lep Rat 5-aza-2'-deoxycytidine decreases methylation ISO LEP (Homo sapiens) 6480464 Decitabine results in decreased methylation of LEP promoter CTD PMID:17502362 Lep Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of LEP mRNA CTD PMID:24534949 Lep Rat 8-Br-cAMP multiple interactions ISO LEP (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] more ... CTD PMID:19849856 Lep Rat 8-Br-cAMP decreases response to substance ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased susceptibility to 8-Bromo Cyclic Adenosine Monophosphate CTD PMID:19849856 Lep Rat 9-cis-retinoic acid multiple interactions EXP 6480464 [Alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 Lep Rat AACOCF3 multiple interactions ISO Lep (Mus musculus) 6480464 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 Lep Rat acarbose decreases expression EXP 6480464 Acarbose results in decreased expression of LEP protein CTD PMID:18290871 Lep Rat acetaldehyde multiple interactions ISO Lep (Mus musculus) 6480464 Acetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein] more ... CTD PMID:15130784 and PMID:17949463 Lep Rat acetylsalicylic acid multiple interactions EXP 6480464 [lipopolysaccharide and Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein CTD PMID:15024038 Lep Rat actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 Lep Rat Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] decreases response to substance ISO LEP (Homo sapiens) 6480464 adenosine-3' and 5'-cyclic phosphorothioate results in decreased susceptibility to LEP protein CTD PMID:11342529 Lep Rat Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] multiple interactions ISO LEP (Homo sapiens) 6480464 adenosine-3' more ... CTD PMID:11342529 Lep Rat aflatoxin B1 increases methylation ISO LEP (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of LEP gene CTD PMID:27153756 Lep Rat AH23848 multiple interactions ISO LEP (Homo sapiens) 6480464 AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 Lep Rat aldehydo-D-glucosamine 6-phosphate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 Lep Rat aldehydo-D-glucose multiple interactions ISO LEP (Homo sapiens) 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 Lep Rat aldehydo-D-glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 Lep Rat aldehydo-D-glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 Lep Rat aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... Lep Rat aldehydo-D-glucose increases response to substance ISO LEP (Homo sapiens) 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 Lep Rat aldehydo-D-glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... Lep Rat all-trans-retinoic acid multiple interactions ISO LEP (Homo sapiens) 6480464 Tretinoin results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:32929351 Lep Rat all-trans-retinol multiple interactions EXP 6480464 LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 Lep Rat allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 Lep Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of LEP mRNA CTD PMID:35163327 Lep Rat AM-251 multiple interactions ISO Lep (Mus musculus) 6480464 AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA] more ... CTD PMID:27071101 Lep Rat Amibegron decreases expression EXP 6480464 amibegron results in decreased expression of LEP mRNA CTD PMID:9718277 Lep Rat Amibegron multiple interactions EXP 6480464 3-(2-ethylphenoxy)-1-(1 more ... CTD PMID:9718277 Lep Rat amlodipine decreases expression ISO LEP (Homo sapiens) 6480464 Amlodipine results in decreased expression of LEP and Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 and PMID:19059660 Lep Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of LEP mRNA CTD PMID:16483693 Lep Rat anandamide decreases abundance ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:16154199 Lep Rat anandamide multiple interactions ISO Lep (Mus musculus) 6480464 Dietary Fats inhibits the reaction [LEP protein results in decreased abundance of anandamide] CTD PMID:29967158 Lep Rat anandamide decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:29967158 Lep Rat anandamide decreases activity ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased activity of anandamide CTD PMID:16154199 Lep Rat anandamide decreases transport ISO LEP (Homo sapiens) 6480464 LEP protein results in decreased transport of anandamide CTD PMID:16154199 Lep Rat androst-4-ene-3,17-dione multiple interactions EXP 6480464 LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione] CTD PMID:14657608 Lep Rat anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO LEP (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 Lep Rat apigenin increases expression ISO Lep (Mus musculus) 6480464 Apigenin results in increased expression of LEP mRNA and Apigenin results in increased expression of LEP protein CTD PMID:18359623 Lep Rat apocynin multiple interactions ISO Lep (Mus musculus) 6480464 acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 Lep Rat arachidonic acid multiple interactions ISO Lep (Mus musculus) 6480464 Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 Lep Rat arsane affects expression ISO LEP (Homo sapiens) 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 Lep Rat arsane multiple interactions ISO LEP (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA more ... CTD PMID:32525701 and PMID:36989998 Lep Rat arsenic atom affects expression ISO LEP (Homo sapiens) 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 Lep Rat arsenic atom multiple interactions ISO LEP (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA more ... CTD PMID:32525701 and PMID:36989998 Lep Rat arsenite(3-) decreases methylation ISO LEP (Homo sapiens) 6480464 arsenite results in decreased methylation of LEP promoter CTD PMID:23974009 Lep Rat arsenous acid multiple interactions ISO LEP (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein and Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 Lep Rat aspartame decreases expression EXP 6480464 Aspartame results in decreased expression of LEP protein CTD PMID:11890951 Lep Rat aspartame multiple interactions ISO Lep (Mus musculus) 6480464 [Fats more ... CTD PMID:23783067 Lep Rat atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein] CTD PMID:21122807 Lep Rat ATP multiple interactions EXP 6480464 [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein and [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 Lep Rat Aurothioglucose multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP mRNA and [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP protein CTD PMID:9794456 Lep Rat Aurothioglucose increases expression ISO Lep (Mus musculus) 6480464 Aurothioglucose results in increased expression of LEP mRNA and Aurothioglucose results in increased expression of LEP protein CTD PMID:15809509 more ... Lep Rat Azoxymethane increases expression ISO Lep (Mus musculus) 6480464 Azoxymethane results in increased expression of LEP protein CTD PMID:19914226 Lep Rat Azoxymethane multiple interactions ISO Lep (Mus musculus) 6480464 [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA more ... CTD PMID:19914226 and PMID:19931517 Lep Rat azoxystrobin multiple interactions ISO Lep (Mus musculus) 6480464 [azoxystrobin co-treated with Dietary Fats] affects the expression of LEP protein CTD PMID:24726979 Lep Rat Bardoxolone methyl multiple interactions ISO Lep (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein] and bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27417254 Lep Rat benzene multiple interactions ISO Lep (Mus musculus) 6480464 Benzene inhibits the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:37084897 Lep Rat benzo[a]pyrene affects methylation ISO LEP (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of LEP intron CTD PMID:30157460 Lep Rat Benzyl parahydroxybenzoate increases expression ISO Lep (Mus musculus) 6480464 benzylparaben results in increased expression of LEP mRNA CTD PMID:22956630 Lep Rat Benzyl parahydroxybenzoate decreases expression ISO LEP (Homo sapiens) 6480464 benzylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 Lep Rat beta-D-glucosamine 6-sulfate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-O-sulfate results in decreased expression of LEP mRNA CTD PMID:19520133 Lep Rat beta-naphthoflavone decreases expression ISO LEP (Homo sapiens) 6480464 beta-Naphthoflavone results in decreased expression of LEP mRNA CTD PMID:32858204 Lep Rat bezafibrate decreases expression ISO LEP (Homo sapiens) 6480464 Bezafibrate results in decreased expression of LEP CTD PMID:10726910 Lep Rat bezafibrate multiple interactions ISO Lep (Mus musculus) 6480464 Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein] CTD PMID:21549692 Lep Rat bezafibrate decreases expression EXP 6480464 Bezafibrate results in decreased expression of LEP mRNA CTD PMID:11216866 and PMID:11473052 Lep Rat bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] CTD PMID:17379010 Lep Rat bis(2-ethylhexyl) phthalate increases expression ISO Lep (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of LEP mRNA and Diethylhexyl Phthalate results in increased expression of LEP protein CTD PMID:22588786 and PMID:35550907 Lep Rat bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of LEP protein CTD PMID:33309551 Lep Rat bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP mRNA and [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP protein CTD PMID:33166671 Lep Rat bis(2-ethylhexyl) phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein more ... CTD PMID:29175711 more ... Lep Rat bis(2-ethylhexyl) phthalate increases expression EXP 25330351 bis(2-ethylhexyl) phthalate increased expression of LEP in adipose tissue (rat) RGD Lep Rat bisphenol A increases expression ISO Lep (Mus musculus) 6480464 bisphenol A results in increased expression of LEP more ... CTD PMID:18359623 more ... Lep Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of LEP mRNA and bisphenol A results in increased expression of LEP protein CTD PMID:34947998 more ... Lep Rat bisphenol A decreases secretion ISO LEP (Homo sapiens) 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:29223775 Lep Rat bisphenol A multiple interactions EXP 6480464 bisphenol A results in increased expression of and results in increased secretion of LEP protein and Resveratrol inhibits the reaction [bisphenol A results in decreased expression of LEP protein] CTD PMID:32339907 and PMID:37570835 Lep Rat bisphenol A decreases secretion EXP 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:31697385 Lep Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LEP mRNA CTD PMID:30816183 and PMID:32528016 Lep Rat bisphenol A increases secretion ISO Lep (Mus musculus) 6480464 bisphenol A results in increased secretion of LEP protein CTD PMID:31820560 Lep Rat bisphenol A decreases expression ISO LEP (Homo sapiens) 6480464 bisphenol A results in decreased expression of LEP mRNA and bisphenol A results in decreased expression of LEP protein CTD PMID:24349194 more ... Lep Rat bisphenol A increases expression ISO LEP (Homo sapiens) 6480464 bisphenol A results in increased expression of LEP mRNA and bisphenol A results in increased expression of LEP protein CTD PMID:25878060 more ... Lep Rat bisphenol A multiple interactions ISO LEP (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 Lep Rat bisphenol A multiple interactions ISO Lep (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23493373 more ... Lep Rat Bisphenol A diglycidyl ether increases expression ISO Lep (Mus musculus) 6480464 bisphenol A diglycidyl ether results in increased expression of LEP mRNA CTD PMID:22763116 Lep Rat Bisphenol A diglycidyl ether multiple interactions ISO Lep (Mus musculus) 6480464 [bisphenol A diglycidyl ether co-treated with cobaltous chloride] affects the expression of LEP mRNA more ... CTD PMID:32408695 Lep Rat bisphenol AF multiple interactions ISO LEP (Homo sapiens) 6480464 bisphenol AF inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in increased expression of LEP mRNA] CTD PMID:31596606 Lep Rat Bisphenol B increases secretion ISO Lep (Mus musculus) 6480464 bisphenol B results in increased secretion of LEP protein CTD PMID:31820560 Lep Rat bisphenol F increases secretion ISO Lep (Mus musculus) 6480464 bisphenol F results in increased secretion of LEP protein CTD PMID:31820560 Lep Rat bleomycin A2 increases expression ISO Lep (Mus musculus) 6480464 Bleomycin results in increased expression of LEP protein CTD PMID:29175452 Lep Rat boric acid multiple interactions ISO Lep (Mus musculus) 6480464 boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA] and boric acid results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:28285642 Lep Rat boron atom multiple interactions EXP 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 Lep Rat BQ 123 multiple interactions ISO Lep (Mus musculus) 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 Lep Rat bromodichloromethane increases expression ISO Lep (Mus musculus) 6480464 bromodichloromethane results in increased expression of LEP mRNA CTD PMID:23640861 Lep Rat bromodichloromethane multiple interactions ISO Lep (Mus musculus) 6480464 bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA] more ... CTD PMID:23438451 and PMID:24211274 Lep Rat bromodichloromethane decreases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in decreased susceptibility to bromodichloromethane CTD PMID:23640861 Lep Rat bucladesine decreases expression ISO Lep (Mus musculus) 6480464 Bucladesine results in decreased expression of LEP mRNA CTD PMID:9002984 Lep Rat Butylbenzyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 Lep Rat Butylparaben decreases expression ISO LEP (Homo sapiens) 6480464 butylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 Lep Rat Butylparaben increases expression ISO Lep (Mus musculus) 6480464 butylparaben results in increased expression of LEP mRNA CTD PMID:22956630 Lep Rat butyric acid multiple interactions ISO Lep (Mus musculus) 6480464 Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 Lep Rat cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of LEP mRNA CTD PMID:36278208 Lep Rat cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP protein CTD PMID:38712533 Lep Rat cadmium atom multiple interactions ISO LEP (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 Lep Rat cadmium dichloride decreases expression ISO Lep (Mus musculus) 6480464 Cadmium Chloride results in decreased expression of LEP mRNA and Cadmium Chloride results in decreased expression of LEP protein CTD PMID:23921151 Lep Rat cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP protein CTD PMID:38712533 Lep Rat cadmium dichloride multiple interactions ISO LEP (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 Lep Rat cadmium dichloride decreases expression ISO LEP (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of LEP mRNA CTD PMID:19847775 Lep Rat cadmium dichloride increases expression ISO Lep (Mus musculus) 6480464 Cadmium Chloride results in increased expression of LEP protein CTD PMID:27634282 Lep Rat cadmium dichloride multiple interactions ISO Lep (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:23921151 and PMID:27814245 Lep Rat caffeine decreases expression ISO Lep (Mus musculus) 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:23727198 Lep Rat caffeine decreases expression ISO LEP (Homo sapiens) 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:26367767 Lep Rat caffeine multiple interactions ISO LEP (Homo sapiens) 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] and Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 Lep Rat caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of LEP mRNA and Caffeine results in decreased expression of LEP protein CTD PMID:23727198 and PMID:26367767 Lep Rat calcitriol decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcitriol CTD PMID:14657008 Lep Rat calcium atom multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 and PMID:20107083 Lep Rat calcium atom multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 Lep Rat calcium atom affects secretion EXP 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 Lep Rat calcium atom affects expression EXP 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 Lep Rat calcium atom decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 Lep Rat calcium atom affects abundance ISO Lep (Mus musculus) 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 Lep Rat calcium atom increases transport ISO Lep (Mus musculus) 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 Lep Rat calcium(0) multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 and PMID:20107083 Lep Rat calcium(0) multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 Lep Rat calcium(0) affects secretion EXP 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 Lep Rat calcium(0) affects expression EXP 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 Lep Rat calcium(0) decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 Lep Rat calcium(0) affects abundance ISO Lep (Mus musculus) 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 Lep Rat calcium(0) increases transport ISO Lep (Mus musculus) 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 Lep Rat candesartan multiple interactions ISO LEP (Homo sapiens) 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP] and Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 Lep Rat candesartan increases response to substance EXP 6480464 LEP protein results in increased susceptibility to candesartan CTD PMID:21287150 Lep Rat candesartan decreases expression ISO LEP (Homo sapiens) 6480464 candesartan results in decreased expression of LEP CTD PMID:19059660 Lep Rat cannabidiol multiple interactions ISO Lep (Mus musculus) 6480464 Cannabidiol analog inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:30382123 Lep Rat capsaicin decreases expression ISO Lep (Mus musculus) 6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:17295509 and PMID:19798065 Lep Rat capsaicin multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] more ... CTD PMID:20359164 and PMID:22150557 Lep Rat capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of LEP mRNA and Capsaicin results in increased expression of LEP protein CTD PMID:16278290 and PMID:22150557 Lep Rat capsazepine multiple interactions ISO Lep (Mus musculus) 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 Lep Rat carbon nanotube increases expression ISO Lep (Mus musculus) 6480464 Nanotubes and Carbon results in increased expression of LEP protein CTD PMID:20381574 Lep Rat carvacrol multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 Lep Rat CCCP multiple interactions ISO LEP (Homo sapiens) 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 Lep Rat CCCP decreases response to substance ISO LEP (Homo sapiens) 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein CTD PMID:11342529 Lep Rat cerulenin affects response to substance ISO Lep (Mus musculus) 6480464 LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 Lep Rat CGP 52608 multiple interactions ISO LEP (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to LEP gene] CTD PMID:28238834 Lep Rat CGS-21680 multiple interactions ISO LEP (Homo sapiens) 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 Lep Rat chlorohydrocarbon multiple interactions ISO Lep (Mus musculus) 6480464 [LEP protein co-treated with Hydrocarbons more ... CTD PMID:31313498 Lep Rat chloroquine multiple interactions ISO Lep (Mus musculus) 6480464 Chloroquine inhibits the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 Lep Rat chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 Lep Rat chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of LEP protein CTD PMID:33994353 Lep Rat chlorpyrifos increases expression ISO LEP (Homo sapiens) 6480464 Chlorpyrifos results in increased expression of LEP mRNA CTD PMID:30879083 Lep Rat choline multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:24384915 more ... Lep Rat chromium atom decreases expression EXP 6480464 Chromium results in decreased expression of LEP protein CTD PMID:17114815 Lep Rat chromium atom increases expression EXP 6480464 Chromium deficiency results in increased expression of LEP mRNA and Chromium deficiency results in increased expression of LEP protein CTD PMID:19846803 Lep Rat chromium atom multiple interactions ISO Lep (Mus musculus) 6480464 [Linoleic Acids and Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 Lep Rat chrysin decreases expression ISO Lep (Mus musculus) 6480464 chrysin results in decreased expression of LEP protein CTD PMID:30445784 Lep Rat cisplatin affects expression EXP 6480464 Cisplatin affects the expression of LEP protein CTD PMID:25051504 Lep Rat clofibrate multiple interactions ISO Lep (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 Lep Rat clofibrate multiple interactions EXP 6480464 [alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 Lep Rat clozapine affects response to substance ISO LEP (Homo sapiens) 6480464 LEP protein affects the susceptibility to Clozapine CTD PMID:17502770 Lep Rat clozapine increases expression EXP 6480464 Clozapine results in increased expression of LEP protein CTD PMID:16402076 Lep Rat cobalt dichloride increases expression ISO LEP (Homo sapiens) 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 Lep Rat cobalt dichloride multiple interactions ISO Lep (Mus musculus) 6480464 [bisphenol A diglycidyl ether co-treated with cobaltous chloride] affects the expression of LEP mRNA more ... CTD PMID:32408695 Lep Rat cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 Lep Rat cobalt dichloride increases secretion EXP 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 Lep Rat cobalt dichloride increases secretion ISO LEP (Homo sapiens) 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 Lep Rat cobalt dichloride increases secretion ISO Lep (Mus musculus) 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:22019852 Lep Rat colforsin daropate hydrochloride decreases secretion ISO Lep (Mus musculus) 6480464 Colforsin results in decreased secretion of LEP protein CTD PMID:27381457 Lep Rat colforsin daropate hydrochloride multiple interactions ISO LEP (Homo sapiens) 6480464 Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 Lep Rat colforsin daropate hydrochloride decreases expression ISO Lep (Mus musculus) 6480464 Colforsin results in decreased expression of LEP mRNA CTD PMID:27381457 and PMID:9002984 Lep Rat conjugated linoleic acid multiple interactions ISO Lep (Mus musculus) 6480464 [Linoleic Acids and Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 Lep Rat conjugated linoleic acid decreases expression ISO Lep (Mus musculus) 6480464 Linoleic Acids and Conjugated results in decreased expression of LEP protein CTD PMID:16933788 Lep Rat conjugated linoleic acid increases expression ISO Lep (Mus musculus) 6480464 Linoleic Acids and Conjugated results in increased expression of LEP protein CTD PMID:17322064 Lep Rat corn oil multiple interactions EXP 6480464 Corn Oil inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:29165388 Lep Rat corticosterone multiple interactions ISO Lep (Mus musculus) 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 and PMID:29751049 Lep Rat corticosterone decreases expression ISO Lep (Mus musculus) 6480464 Corticosterone results in decreased expression of LEP protein CTD PMID:28186389 Lep Rat crocidolite asbestos decreases expression ISO Lep (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of LEP mRNA CTD PMID:23917077 Lep Rat cycloheximide multiple interactions ISO Lep (Mus musculus) 6480464 LEP protein inhibits the reaction [Cycloheximide results in decreased expression of LEPR protein] CTD PMID:31199479 Lep Rat cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of LEP protein CTD PMID:27348886 Lep Rat cyromazine multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 Lep Rat D-glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... Lep Rat D-glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 Lep Rat D-glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... Lep Rat D-glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 Lep Rat D-glucose increases response to substance ISO LEP (Homo sapiens) 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 Lep Rat D-glucose multiple interactions ISO LEP (Homo sapiens) 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 Lep Rat dantrolene decreases expression EXP 6480464 Dantrolene results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat DDE increases secretion ISO Lep (Mus musculus) 6480464 Dichlorodiphenyl Dichloroethylene results in increased secretion of LEP protein CTD PMID:21044676 Lep Rat DDE multiple interactions ISO LEP (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:26200599 Lep Rat DDT increases expression ISO LEP (Homo sapiens) 6480464 DDT results in increased expression of LEP mRNA CTD PMID:25014179 Lep Rat dehydroepiandrosterone decreases expression EXP 6480464 Dehydroepiandrosterone results in decreased expression of LEP protein CTD PMID:12659879 Lep Rat deoxycholic acid decreases expression ISO Lep (Mus musculus) 6480464 Deoxycholic Acid results in decreased expression of LEP mRNA CTD PMID:23911798 Lep Rat desferrioxamine B increases expression ISO LEP (Homo sapiens) 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 Lep Rat desferrioxamine B increases secretion EXP 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 Lep Rat desferrioxamine B increases secretion ISO LEP (Homo sapiens) 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 Lep Rat desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 Lep Rat dexamethasone multiple interactions ISO LEP (Homo sapiens) 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:10946865 more ... Lep Rat dexamethasone multiple interactions ISO Lep (Mus musculus) 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... Lep Rat dexamethasone increases secretion ISO LEP (Homo sapiens) 6480464 Dexamethasone results in increased secretion of LEP protein CTD PMID:10946865 Lep Rat dexamethasone increases expression ISO LEP (Homo sapiens) 6480464 Dexamethasone results in increased expression of LEP mRNA CTD PMID:10946865 and PMID:32976960 Lep Rat dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of LEP mRNA and Dexamethasone results in increased expression of LEP protein CTD PMID:15824971 and PMID:23166830 Lep Rat dextran sulfate multiple interactions ISO Lep (Mus musculus) 6480464 [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA and [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein CTD PMID:19931517 Lep Rat diallyl trisulfide decreases expression EXP 6480464 diallyl trisulfide results in decreased expression of LEP mRNA CTD PMID:34014027 Lep Rat diarsenic trioxide multiple interactions ISO LEP (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein and Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 Lep Rat diazoxide multiple interactions EXP 6480464 Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 Lep Rat diazoxide decreases secretion EXP 6480464 Diazoxide results in decreased secretion of LEP protein CTD PMID:10780946 Lep Rat dibenziodolium multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] more ... CTD PMID:17668557 Lep Rat dibutyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 Lep Rat dibutylstannane multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with di-n-butyltin] results in increased expression of LEP protein CTD PMID:29787037 Lep Rat diethyl hydrogen phosphate decreases secretion EXP 6480464 diethyl phosphate results in decreased secretion of LEP protein CTD PMID:34038317 Lep Rat diethyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 Lep Rat diethylstilbestrol decreases secretion ISO Lep (Mus musculus) 6480464 Diethylstilbestrol results in decreased secretion of LEP protein CTD PMID:25111128 Lep Rat diethylstilbestrol multiple interactions ISO Lep (Mus musculus) 6480464 Diethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23493373 Lep Rat diiodine multiple interactions EXP 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 Lep Rat diisobutyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 Lep Rat diisononyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 Lep Rat dioxygen increases secretion ISO LEP (Homo sapiens) 6480464 Oxygen deficiency results in increased secretion of LEP protein CTD PMID:12032628 Lep Rat dioxygen increases expression ISO LEP (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of LEP mRNA CTD PMID:12032628 and PMID:23466666 Lep Rat dioxygen decreases expression ISO Lep (Mus musculus) 6480464 Oxygen deficiency results in decreased expression of LEP mRNA and Oxygen deficiency results in decreased expression of LEP protein CTD PMID:21531777 and PMID:23539316 Lep Rat dipyridamole multiple interactions EXP 6480464 1 and 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 Lep Rat dipyridamole increases expression EXP 6480464 Dipyridamole results in increased expression of LEP protein CTD PMID:10746648 Lep Rat disodium selenite decreases expression ISO Lep (Mus musculus) 6480464 Sodium Selenite results in decreased expression of LEP mRNA CTD PMID:23274088 Lep Rat dobutamine decreases secretion ISO LEP (Homo sapiens) 6480464 Dobutamine results in decreased secretion of LEP protein CTD PMID:11022189 Lep Rat dobutamine decreases expression ISO Lep (Mus musculus) 6480464 Dobutamine results in decreased expression of LEP mRNA and Dobutamine results in decreased expression of LEP protein CTD PMID:9002984 Lep Rat DPCPX multiple interactions EXP 6480464 1 and 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 Lep Rat edelfosine multiple interactions ISO Lep (Mus musculus) 6480464 edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 Lep Rat efavirenz decreases expression ISO LEP (Homo sapiens) 6480464 efavirenz results in decreased expression of LEP mRNA CTD PMID:21619898 Lep Rat elemental boron multiple interactions EXP 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 Lep Rat elemental selenium decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 Lep Rat Elemicin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 Lep Rat enalapril increases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 Lep Rat ethambutol decreases expression EXP 6480464 Ethambutol results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat ethanol multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:18227024 Lep Rat ethanol multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 Lep Rat ethionamide decreases expression EXP 6480464 Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat Ethyl icosapentate multiple interactions ISO Lep (Mus musculus) 6480464 Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA] and Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein] CTD PMID:10753628 Lep Rat Ethyl icosapentate increases secretion ISO Lep (Mus musculus) 6480464 eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein CTD PMID:10753628 Lep Rat Ethyl icosapentate increases expression ISO Lep (Mus musculus) 6480464 eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA CTD PMID:10753628 Lep Rat ethylparaben decreases expression ISO LEP (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA CTD PMID:22956630 Lep Rat fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] and Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA] CTD PMID:26973390 Lep Rat fenofibrate multiple interactions ISO LEP (Homo sapiens) 6480464 Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 Lep Rat fenoterol decreases secretion ISO LEP (Homo sapiens) 6480464 Fenoterol results in decreased secretion of LEP protein CTD PMID:11022189 Lep Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of LEP mRNA CTD PMID:30307764 Lep Rat flufenamic acid multiple interactions ISO Lep (Mus musculus) 6480464 Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 Lep Rat flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat fonofos increases methylation ISO LEP (Homo sapiens) 6480464 Fonofos results in increased methylation of LEP promoter CTD PMID:22847954 Lep Rat fructose multiple interactions EXP 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:21122807 more ... Lep Rat fructose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of LEP mRNA CTD PMID:37567420 Lep Rat fructose increases secretion EXP 6480464 Fructose results in increased secretion of LEP protein CTD PMID:10780946 more ... Lep Rat fructose increases expression EXP 6480464 Fructose results in increased expression of LEP mRNA and Fructose results in increased expression of LEP protein CTD PMID:11741341 more ... Lep Rat furan decreases expression EXP 6480464 furan results in decreased expression of LEP mRNA CTD PMID:25539665 Lep Rat gallocatechin multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 Lep Rat gamma-hexachlorocyclohexane affects expression EXP 6480464 Hexachlorocyclohexane affects the expression of LEP mRNA CTD PMID:17785943 Lep Rat Ganoderic acid A multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of LEP mRNA CTD PMID:29852127 Lep Rat gemcitabine decreases expression ISO LEP (Homo sapiens) 6480464 Gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 Lep Rat gemfibrozil decreases expression EXP 6480464 Gemfibrozil results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat gemfibrozil increases expression EXP 6480464 Gemfibrozil results in increased expression of LEP protein CTD PMID:25051504 Lep Rat genistein decreases expression ISO Lep (Mus musculus) 6480464 Genistein results in decreased expression of LEP mRNA and Genistein results in decreased expression of LEP protein CTD PMID:18359623 Lep Rat genistein decreases response to substance ISO LEP (Homo sapiens) 6480464 Genistein results in decreased susceptibility to LEP protein CTD PMID:11342529 Lep Rat genistein multiple interactions ISO LEP (Homo sapiens) 6480464 Genistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and Genistein inhibits the reaction [LEP protein results in increased expression of CCL2] CTD PMID:11342529 Lep Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of LEP mRNA CTD PMID:33387578 Lep Rat gingerol multiple interactions ISO Lep (Mus musculus) 6480464 gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] and gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 Lep Rat glucagon multiple interactions ISO Lep (Mus musculus) 6480464 Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein] and Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein] CTD PMID:29988851 Lep Rat glucose multiple interactions EXP 6480464 1 more ... CTD PMID:10780946 more ... Lep Rat glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 Lep Rat glucose increases expression EXP 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... Lep Rat glucose increases secretion EXP 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 Lep Rat glucose increases response to substance ISO LEP (Homo sapiens) 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 Lep Rat glucose multiple interactions ISO LEP (Homo sapiens) 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 Lep Rat glycine multiple interactions ISO Lep (Mus musculus) 6480464 Glycine affects the reaction [Sodium Glutamate affects the expression of LEP protein] CTD PMID:18930730 Lep Rat hesperidin decreases expression EXP 6480464 Hesperidin results in decreased expression of LEP protein CTD PMID:21820093 Lep Rat hesperidin multiple interactions EXP 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein CTD PMID:21820093 Lep Rat hexadecanoic acid decreases expression ISO Lep (Mus musculus) 6480464 Palmitic Acid results in decreased expression of LEP mRNA and Palmitic Acid results in decreased expression of LEP protein CTD PMID:34968464 Lep Rat hexadecanoic acid multiple interactions ISO Lep (Mus musculus) 6480464 [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of LEP mRNA more ... CTD PMID:34968464 Lep Rat hydrogen peroxide affects expression ISO LEP (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of LEP mRNA CTD PMID:21179406 Lep Rat hydrogen peroxide decreases expression ISO LEP (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of LEP mRNA CTD PMID:26339600 Lep Rat imidacloprid multiple interactions ISO Lep (Mus musculus) 6480464 Dietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein] and imidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein] CTD PMID:27960282 Lep Rat imidacloprid increases secretion ISO Lep (Mus musculus) 6480464 imidacloprid results in increased secretion of LEP protein CTD PMID:27960282 Lep Rat indinavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] CTD PMID:17668557 Lep Rat indinavir multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 Lep Rat indinavir decreases expression ISO LEP (Homo sapiens) 6480464 Indinavir results in decreased expression of LEP protein CTD PMID:17668557 Lep Rat indometacin increases expression EXP 6480464 Indomethacin results in increased expression of LEP protein CTD PMID:16280098 and PMID:25051504 Lep Rat indometacin multiple interactions ISO LEP (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA more ... CTD PMID:23086663 and PMID:28628672 Lep Rat indometacin multiple interactions EXP 6480464 BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein] more ... CTD PMID:16280098 and PMID:18181030 Lep Rat inulin decreases expression EXP 6480464 Inulin results in decreased expression of LEP protein CTD PMID:27760213 Lep Rat iodide salt increases expression EXP 6480464 Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 Lep Rat iron(2+) sulfate (anhydrous) increases expression ISO LEP (Homo sapiens) 6480464 ferrous sulfate results in increased expression of LEP mRNA CTD PMID:21540303 Lep Rat isoflavones increases expression EXP 6480464 Isoflavones results in increased expression of LEP protein CTD PMID:22155228 Lep Rat isoprenaline increases secretion ISO Lep (Mus musculus) 6480464 Isoproterenol results in increased secretion of LEP protein CTD PMID:25111128 Lep Rat isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of LEP protein CTD PMID:20307649 Lep Rat isoprenaline multiple interactions EXP 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] CTD PMID:20307649 Lep Rat isoprenaline multiple interactions ISO LEP (Homo sapiens) 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 Lep Rat isoprenaline decreases secretion ISO LEP (Homo sapiens) 6480464 Isoproterenol results in decreased secretion of LEP protein CTD PMID:11022189 Lep Rat isoscutellarein decreases expression ISO Lep (Mus musculus) 6480464 isoscutellarein results in decreased expression of LEP protein CTD PMID:30445784 Lep Rat isotretinoin increases expression EXP 6480464 Isotretinoin results in increased expression of LEP mRNA CTD PMID:19212007 Lep Rat kaempferol decreases expression ISO Lep (Mus musculus) 6480464 kaempferol results in decreased expression of LEP protein CTD PMID:30445784 Lep Rat kainic acid decreases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 Lep Rat ketamine decreases expression ISO LEP (Homo sapiens) 6480464 Ketamine results in decreased expression of LEP protein CTD PMID:36907275 Lep Rat ketamine multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of BCL2 protein]] more ... CTD PMID:36907275 Lep Rat L-ascorbic acid decreases secretion EXP 6480464 Ascorbic Acid results in decreased secretion of LEP protein CTD PMID:20400526 Lep Rat L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [INS1 protein results in increased secretion of LEP protein] CTD PMID:20400526 Lep Rat L-methionine multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:24384915 more ... Lep Rat lamivudine multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA and [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 Lep Rat lanthanum atom multiple interactions ISO Lep (Mus musculus) 6480464 Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 Lep Rat lead(0) multiple interactions ISO LEP (Homo sapiens) 6480464 Lead results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24709140 Lep Rat Licarin A multiple interactions ISO Lep (Mus musculus) 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA CTD PMID:29288687 Lep Rat lipoic acid decreases secretion ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 Lep Rat lipoic acid decreases expression EXP 6480464 Thioctic Acid results in decreased expression of LEP mRNA and Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 Lep Rat lipoic acid decreases expression ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 Lep Rat lipopolysaccharide multiple interactions ISO LEP (Homo sapiens) 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 Lep Rat lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of LEP protein CTD PMID:17379010 Lep Rat lipopolysaccharide multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] and Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17379010 and PMID:17621560 Lep Rat lipopolysaccharide multiple interactions ISO Lep (Mus musculus) 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein and TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 Lep Rat lipopolysaccharide increases expression ISO Lep (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of LEP mRNA CTD PMID:12057914 Lep Rat lipopolysaccharide decreases expression ISO Lep (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of LEP mRNA CTD PMID:12057914 Lep Rat loganin affects expression ISO Lep (Mus musculus) 6480464 loganin affects the expression of LEP protein CTD PMID:21864639 Lep Rat lopinavir decreases expression ISO LEP (Homo sapiens) 6480464 Lopinavir results in decreased expression of LEP protein CTD PMID:17668557 Lep Rat lopinavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein] CTD PMID:17668557 Lep Rat LY294002 decreases expression ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA CTD PMID:19254925 and PMID:21351249 Lep Rat LY294002 multiple interactions ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein] CTD PMID:29248466 Lep Rat LY294002 multiple interactions ISO LEP (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 Lep Rat LY294002 decreases secretion ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein CTD PMID:19254925 and PMID:21351249 Lep Rat manganese atom decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 Lep Rat manganese(0) decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 Lep Rat melatonin decreases expression ISO LEP (Homo sapiens) 6480464 Melatonin results in decreased expression of LEP mRNA CTD PMID:20738756 Lep Rat melatonin decreases expression EXP 6480464 Melatonin results in decreased expression of LEP protein CTD PMID:19028472 Lep Rat menadione multiple interactions ISO LEP (Homo sapiens) 6480464 1 more ... CTD PMID:16996477 Lep Rat menadione increases expression ISO LEP (Homo sapiens) 6480464 Vitamin K 3 results in increased expression of LEP mRNA CTD PMID:16996477 Lep Rat mercury dichloride decreases expression ISO Lep (Mus musculus) 6480464 Mercuric Chloride results in decreased expression of LEP mRNA CTD PMID:22019852 Lep Rat mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of LEP mRNA CTD PMID:30807803 Lep Rat mercury dichloride decreases secretion ISO Lep (Mus musculus) 6480464 Mercuric Chloride results in decreased secretion of LEP protein CTD PMID:22019852 Lep Rat metformin increases expression ISO Lep (Mus musculus) 6480464 Metformin results in increased expression of LEP protein CTD PMID:20869956 Lep Rat metformin multiple interactions ISO Lep (Mus musculus) 6480464 Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 Lep Rat methacholine chloride increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 Lep Rat methadone increases expression ISO LEP (Homo sapiens) 6480464 Methadone results in increased expression of LEP protein CTD PMID:15717844 Lep Rat methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of LEP protein CTD PMID:25051504 Lep Rat methotrexate affects expression ISO Lep (Mus musculus) 6480464 Methotrexate affects the expression of LEP mRNA CTD PMID:18502557 Lep Rat methylmercury chloride multiple interactions ISO Lep (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:27814245 and PMID:33338554 Lep Rat methylmercury chloride decreases expression ISO Lep (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of LEP mRNA CTD PMID:29850906 Lep Rat methylparaben decreases expression ISO LEP (Homo sapiens) 6480464 methylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 Lep Rat metronidazole multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 Lep Rat metyrapone multiple interactions EXP 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA CTD PMID:37088303 Lep Rat mevalonic acid multiple interactions ISO Lep (Mus musculus) 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] and Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 Lep Rat MK-2206 multiple interactions ISO Lep (Mus musculus) 6480464 MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3' and 5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein] CTD PMID:27381457 Lep Rat mono(2-ethylhexyl) phthalate decreases secretion ISO LEP (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in decreased secretion of LEP protein CTD PMID:29223775 Lep Rat Monobutylphthalate decreases secretion ISO LEP (Homo sapiens) 6480464 monobutyl phthalate results in decreased secretion of LEP protein CTD PMID:29223775 Lep Rat monocrotaline affects expression EXP 6480464 Monocrotaline affects the expression of LEP protein CTD PMID:25051504 Lep Rat monocrotaline multiple interactions ISO Lep (Mus musculus) 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein and TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 Lep Rat monocrotophos increases expression EXP 6480464 Monocrotophos results in increased expression of LEP protein CTD PMID:32207356 Lep Rat monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of LEP protein CTD PMID:14657608 Lep Rat monosodium L-glutamate increases expression ISO Lep (Mus musculus) 6480464 Sodium Glutamate results in increased expression of LEP mRNA and Sodium Glutamate results in increased expression of LEP protein CTD PMID:15809509 more ... Lep Rat monosodium L-glutamate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats more ... CTD PMID:18930730 more ... Lep Rat monosodium L-glutamate affects expression ISO Lep (Mus musculus) 6480464 Sodium Glutamate affects the expression of LEP protein CTD PMID:18930730 Lep Rat morin multiple interactions EXP 6480464 morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 Lep Rat N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO LEP (Homo sapiens) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] more ... CTD PMID:11342529 and PMID:28571770 Lep Rat N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases response to substance ISO LEP (Homo sapiens) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased susceptibility to LEP protein CTD PMID:11342529 Lep Rat N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO Lep (Mus musculus) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] CTD PMID:19254925 Lep Rat N-methyl-4-phenylpyridinium multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA] CTD PMID:19763737 Lep Rat N-methyl-N-nitrosourea multiple interactions ISO Lep (Mus musculus) 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] more ... CTD PMID:16822543 Lep Rat N-methyl-N-nitrosourea increases expression ISO Lep (Mus musculus) 6480464 Methylnitrosourea results in increased expression of LEP protein CTD PMID:16822543 Lep Rat N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of LEP protein CTD PMID:25051504 Lep Rat N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of LEP mRNA and Dimethylnitrosamine results in increased expression of LEP protein CTD PMID:15798949 Lep Rat naproxen multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] and Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 Lep Rat naringin multiple interactions EXP 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein and naringin inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:21820093 and PMID:24399619 Lep Rat naringin multiple interactions ISO Lep (Mus musculus) 6480464 naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:22198281 Lep Rat nelfinavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein] CTD PMID:17668557 Lep Rat nelfinavir decreases secretion ISO Lep (Mus musculus) 6480464 Nelfinavir results in decreased secretion of LEP protein CTD PMID:19033543 Lep Rat nelfinavir decreases expression ISO LEP (Homo sapiens) 6480464 Nelfinavir results in decreased expression of LEP protein CTD PMID:17668557 Lep Rat neomycin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 Lep Rat nevirapine increases expression ISO LEP (Homo sapiens) 6480464 Nevirapine results in increased expression of LEP mRNA CTD PMID:21619898 Lep Rat nickel atom decreases expression ISO LEP (Homo sapiens) 6480464 Nickel results in decreased expression of LEP mRNA CTD PMID:25583101 Lep Rat nickel dichloride multiple interactions ISO LEP (Homo sapiens) 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 Lep Rat nickel dichloride multiple interactions EXP 6480464 nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 Lep Rat nickel sulfate multiple interactions ISO LEP (Homo sapiens) 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA CTD PMID:18832182 Lep Rat nickel sulfate increases expression ISO LEP (Homo sapiens) 6480464 nickel sulfate results in increased expression of LEP mRNA CTD PMID:18832182 Lep Rat nicotine increases expression EXP 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 and PMID:29155039 Lep Rat nicotine decreases response to substance EXP 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 Lep Rat nicotinic acid increases expression ISO LEP (Homo sapiens) 6480464 Niacin results in increased expression of LEP protein CTD PMID:16887123 Lep Rat nicotinic acid increases expression ISO Lep (Mus musculus) 6480464 Niacin results in increased expression of LEP mRNA CTD PMID:21236357 Lep Rat nitric oxide multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:9312173 Lep Rat Nonylphenol increases expression ISO Lep (Mus musculus) 6480464 nonylphenol results in increased expression of LEP mRNA CTD PMID:18417718 Lep Rat norwogonin decreases expression ISO Lep (Mus musculus) 6480464 norwogonin analog results in decreased expression of LEP protein and norwogonin results in decreased expression of LEP protein CTD PMID:30445784 Lep Rat NS-398 multiple interactions ISO LEP (Homo sapiens) 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 Lep Rat olanzapine increases expression ISO LEP (Homo sapiens) 6480464 olanzapine results in increased expression of LEP protein CTD PMID:11927762 and PMID:19512971 Lep Rat olanzapine increases expression ISO Lep (Mus musculus) 6480464 Olanzapine results in increased expression of LEP protein CTD PMID:32652086 Lep Rat olanzapine multiple interactions ISO Lep (Mus musculus) 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] more ... CTD PMID:32652086 Lep Rat oleanolic acid increases expression ISO Lep (Mus musculus) 6480464 Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 Lep Rat oleic acid decreases expression ISO Lep (Mus musculus) 6480464 Oleic Acid results in decreased expression of LEP mRNA CTD PMID:9002984 Lep Rat oleic acid increases expression EXP 6480464 Oleic Acid results in increased expression of LEP mRNA CTD PMID:23395669 Lep Rat oleic acid multiple interactions EXP 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 Lep Rat omaveloxolone multiple interactions ISO Lep (Mus musculus) 6480464 omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein] CTD PMID:32410268 Lep Rat orlistat multiple interactions ISO Lep (Mus musculus) 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 Lep Rat orlistat multiple interactions EXP 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 Lep Rat ozone multiple interactions ISO Lep (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL11 protein more ... CTD PMID:12794034 and PMID:27472835 Lep Rat ozone multiple interactions EXP 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA more ... CTD PMID:23968387 more ... Lep Rat ozone decreases secretion ISO Lep (Mus musculus) 6480464 Ozone results in decreased secretion of LEP protein CTD PMID:27240593 Lep Rat ozone increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Ozone and LEP protein results in increased susceptibility to Ozone CTD PMID:12794034 more ... Lep Rat ozone increases expression EXP 6480464 Ozone results in increased expression of LEP and Ozone results in increased expression of LEP protein CTD PMID:24103449 more ... Lep Rat paracetamol multiple interactions ISO Lep (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 Lep Rat paracetamol decreases expression ISO LEP (Homo sapiens) 6480464 Acetaminophen results in decreased expression of LEP mRNA CTD PMID:26690555 Lep Rat paracetamol affects expression ISO Lep (Mus musculus) 6480464 Acetaminophen affects the expression of LEP mRNA CTD PMID:17562736 Lep Rat paraquat affects expression EXP 6480464 Paraquat affects the expression of LEP mRNA CTD PMID:18198484 Lep Rat parathion increases methylation ISO LEP (Homo sapiens) 6480464 Parathion results in increased methylation of LEP promoter CTD PMID:22847954 Lep Rat perfluorohexanesulfonic acid multiple interactions EXP 6480464 [perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 Lep Rat perfluorooctane-1-sulfonic acid increases expression ISO LEP (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in increased expression of LEP mRNA CTD PMID:28011154 Lep Rat perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 Lep Rat perfluorooctane-1-sulfonic acid affects expression ISO LEP (Homo sapiens) 6480464 perfluorooctane sulfonic acid affects the expression of LEP mRNA CTD PMID:30738844 Lep Rat perfluorooctanoic acid multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with perfluorooctanoic acid co-treated with perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 and PMID:35163327 Lep Rat perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of LEP protein CTD PMID:18083506 Lep Rat permethrin multiple interactions ISO Lep (Mus musculus) 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein and Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 Lep Rat phencyclidine increases expression ISO Lep (Mus musculus) 6480464 Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 Lep Rat phenethyl caffeate decreases expression ISO Lep (Mus musculus) 6480464 caffeic acid phenethyl ester results in decreased expression of LEP mRNA and caffeic acid phenethyl ester results in decreased expression of LEP protein CTD PMID:21467634 Lep Rat phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of LEP protein CTD PMID:25051504 Lep Rat phenobarbital multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA and [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein CTD PMID:14758566 Lep Rat phloretin multiple interactions ISO Lep (Mus musculus) 6480464 [cobaltous chloride co-treated with lipopolysaccharide more ... CTD PMID:32408695 Lep Rat phlorizin multiple interactions ISO Lep (Mus musculus) 6480464 [bisphenol A diglycidyl ether co-treated with lipopolysaccharide more ... CTD PMID:32408695 Lep Rat phosphatidylcholine decreases expression ISO Lep (Mus musculus) 6480464 Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 Lep Rat phosphoramidon decreases expression EXP 6480464 phosphoramidon results in decreased expression of LEP protein CTD PMID:16391412 Lep Rat pioglitazone increases expression EXP 6480464 pioglitazone results in increased expression of LEP protein CTD PMID:15655531 Lep Rat piperine multiple interactions EXP 6480464 piperine inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 Lep Rat pirimicarb multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 Lep Rat pirinixic acid multiple interactions ISO Lep (Mus musculus) 6480464 pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein] CTD PMID:16306350 Lep Rat pitavastatin multiple interactions ISO Lep (Mus musculus) 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 Lep Rat pitavastatin(1-) multiple interactions ISO Lep (Mus musculus) 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 Lep Rat pluronic P-123 multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] and Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 Lep Rat pluronic P-123 increases secretion EXP 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Lep Rat Poloxamer increases secretion EXP 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 Lep Rat Poloxamer multiple interactions EXP 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] and Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 Lep Rat potassium dichromate increases expression ISO LEP (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of LEP mRNA CTD PMID:11678601 Lep Rat pravastatin multiple interactions ISO Lep (Mus musculus) 6480464 Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 Lep Rat prochloraz decreases expression ISO LEP (Homo sapiens) 6480464 prochloraz results in decreased expression of LEP mRNA CTD PMID:30879083 Lep Rat progesterone decreases secretion ISO LEP (Homo sapiens) 6480464 Progesterone results in decreased secretion of LEP protein CTD PMID:16048798 Lep Rat progesterone multiple interactions ISO LEP (Homo sapiens) 6480464 LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone] and LEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]] CTD PMID:19849856 Lep Rat progesterone increases expression ISO Lep (Mus musculus) 6480464 Progesterone results in increased expression of LEP mRNA CTD PMID:15713686 Lep Rat propranolol multiple interactions ISO LEP (Homo sapiens) 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 Lep Rat propranolol increases expression EXP 6480464 Propranolol results in increased expression of LEP protein CTD PMID:24250662 Lep Rat propylparaben increases expression ISO Lep (Mus musculus) 6480464 propylparaben results in increased expression of LEP mRNA CTD PMID:22956630 Lep Rat propylparaben decreases expression ISO LEP (Homo sapiens) 6480464 propylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 Lep Rat prostaglandin E2 increases expression EXP 6480464 Dinoprostone results in increased expression of LEP protein CTD PMID:11060898 Lep Rat prostaglandin E2 increases abundance EXP 6480464 LEP protein results in increased abundance of Dinoprostone CTD PMID:16015682 Lep Rat prostaglandin E2 increases secretion EXP 6480464 Dinoprostone results in increased secretion of LEP protein CTD PMID:11060898 Lep Rat Ptaquiloside decreases expression ISO Lep (Mus musculus) 6480464 ptaquiloside results in decreased expression of LEP mRNA CTD PMID:23274088 Lep Rat Pyridostigmine bromide multiple interactions ISO Lep (Mus musculus) 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein and Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 Lep Rat pyruvic acid increases secretion EXP 6480464 Pyruvic Acid results in increased secretion of LEP protein CTD PMID:10780946 Lep Rat pyruvic acid multiple interactions EXP 6480464 INS1 protein promotes the reaction [Pyruvic Acid results in increased secretion of LEP protein] CTD PMID:10780946 Lep Rat quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] more ... CTD PMID:22426011 more ... Lep Rat quercetin increases expression ISO LEP (Homo sapiens) 6480464 Quercetin results in increased expression of LEP mRNA and Quercetin results in increased expression of LEP protein CTD PMID:22230496 Lep Rat quercetin decreases expression ISO Lep (Mus musculus) 6480464 Quercetin results in decreased expression of LEP mRNA and Quercetin results in decreased expression of LEP protein CTD PMID:19914226 and PMID:30445784 Lep Rat quercetin decreases secretion ISO Lep (Mus musculus) 6480464 Quercetin results in decreased secretion of LEP protein CTD PMID:19914226 Lep Rat quercetin multiple interactions ISO Lep (Mus musculus) 6480464 Quercetin affects the reaction [LEP protein affects the expression of NOS2 mRNA] more ... CTD PMID:19914226 more ... Lep Rat rac-lactic acid affects expression ISO LEP (Homo sapiens) 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 Lep Rat ramipril multiple interactions ISO LEP (Homo sapiens) 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP] and Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 Lep Rat ramipril decreases expression ISO LEP (Homo sapiens) 6480464 Ramipril results in decreased expression of LEP CTD PMID:19059660 Lep Rat reactive oxygen species multiple interactions ISO LEP (Homo sapiens) 6480464 adenosine-3' more ... CTD PMID:11342529 Lep Rat reactive oxygen species increases chemical synthesis ISO LEP (Homo sapiens) 6480464 LEP protein results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:11342529 Lep Rat rebaudioside A multiple interactions ISO Lep (Mus musculus) 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 Lep Rat reserpine increases expression ISO Lep (Mus musculus) 6480464 Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 Lep Rat resveratrol decreases secretion ISO Lep (Mus musculus) 6480464 resveratrol metabolite results in decreased secretion of LEP protein and resveratrol results in decreased secretion of LEP protein CTD PMID:23717508 Lep Rat resveratrol multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with Resveratrol] results in increased expression of LEP mRNA more ... CTD PMID:29197120 and PMID:31881177 Lep Rat resveratrol multiple interactions EXP 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:26973390 and PMID:37570835 Lep Rat resveratrol decreases expression ISO LEP (Homo sapiens) 6480464 resveratrol results in decreased expression of LEP mRNA and resveratrol results in decreased expression of LEP protein CTD PMID:21713995 and PMID:23536519 Lep Rat resveratrol decreases expression ISO Lep (Mus musculus) 6480464 resveratrol metabolite results in decreased expression of LEP mRNA more ... CTD PMID:23717508 more ... Lep Rat rifampicin increases expression EXP 6480464 Rifampin results in increased expression of LEP protein CTD PMID:25051504 Lep Rat rimonabant multiple interactions ISO Lep (Mus musculus) 6480464 Rimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein] more ... CTD PMID:19030233 and PMID:26967640 Lep Rat ritonavir multiple interactions ISO LEP (Homo sapiens) 6480464 diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 Lep Rat ritonavir decreases expression ISO LEP (Homo sapiens) 6480464 Ritonavir results in decreased expression of LEP protein CTD PMID:17668557 Lep Rat rotenone decreases response to substance ISO LEP (Homo sapiens) 6480464 Rotenone results in decreased susceptibility to LEP protein CTD PMID:11342529 Lep Rat rotenone multiple interactions ISO LEP (Homo sapiens) 6480464 Rotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 Lep Rat roxarsone decreases expression ISO LEP (Homo sapiens) 6480464 Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 Lep Rat ruthenium red multiple interactions ISO Lep (Mus musculus) 6480464 Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 Lep Rat rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 Lep Rat S-adenosyl-L-methioninate multiple interactions ISO LEP (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] and S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 Lep Rat S-adenosyl-L-methionine multiple interactions ISO LEP (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] and S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 Lep Rat saquinavir multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 Lep Rat SB 203580 multiple interactions ISO LEP (Homo sapiens) 6480464 SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] and SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 and PMID:19849856 Lep Rat SB 203580 decreases response to substance ISO LEP (Homo sapiens) 6480464 SB 203580 results in decreased susceptibility to LEP protein CTD PMID:19849856 Lep Rat selenium atom decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 Lep Rat serpentine asbestos decreases expression ISO Lep (Mus musculus) 6480464 Asbestos and Serpentine results in decreased expression of LEP mRNA CTD PMID:23917077 Lep Rat silicon dioxide decreases expression ISO LEP (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of LEP mRNA CTD PMID:23806026 Lep Rat silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of LEP mRNA CTD PMID:32721576 Lep Rat simvastatin multiple interactions ISO Lep (Mus musculus) 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] more ... CTD PMID:19254925 Lep Rat simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 Lep Rat simvastatin decreases secretion ISO Lep (Mus musculus) 6480464 Simvastatin results in decreased secretion of LEP protein CTD PMID:19254925 Lep Rat simvastatin decreases expression ISO Lep (Mus musculus) 6480464 Simvastatin results in decreased expression of LEP mRNA and Simvastatin results in decreased expression of LEP mRNA alternative form CTD PMID:19254925 Lep Rat SKF-96365 hydrochloride multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 Lep Rat sodium arsenate multiple interactions ISO LEP (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 Lep Rat sodium arsenite increases expression ISO LEP (Homo sapiens) 6480464 sodium arsenite results in increased expression of LEP mRNA CTD PMID:25879800 Lep Rat sodium arsenite decreases expression ISO LEP (Homo sapiens) 6480464 sodium arsenite results in decreased expression of LEP mRNA CTD PMID:37956786 Lep Rat sodium arsenite decreases expression ISO Lep (Mus musculus) 6480464 sodium arsenite results in decreased expression of LEP mRNA CTD PMID:34968464 and PMID:36209798 Lep Rat sodium arsenite multiple interactions ISO LEP (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LEP mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LEP protein CTD PMID:36989998 Lep Rat sodium arsenite multiple interactions ISO Lep (Mus musculus) 6480464 [Palmitic Acid co-treated with sodium arsenite] results in decreased expression of LEP mRNA more ... CTD PMID:28593471 more ... Lep Rat sodium arsenite increases expression ISO Lep (Mus musculus) 6480464 sodium arsenite results in increased expression of LEP protein CTD PMID:28593471 and PMID:29755549 Lep Rat sodium arsenite affects expression ISO Lep (Mus musculus) 6480464 sodium arsenite affects the expression of LEP mRNA and sodium arsenite affects the expression of LEP protein CTD PMID:25367288 and PMID:28206643 Lep Rat sodium perchlorate multiple interactions EXP 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 Lep Rat Sophocarpine multiple interactions EXP 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 Lep Rat stavudine decreases expression ISO LEP (Homo sapiens) 6480464 Stavudine results in decreased expression of LEP protein CTD PMID:17668557 Lep Rat steviol multiple interactions ISO Lep (Mus musculus) 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA] more ... CTD PMID:25554529 Lep Rat stevioside multiple interactions ISO Lep (Mus musculus) 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 Lep Rat streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:24854284 Lep Rat streptozocin multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein more ... CTD PMID:29988851 and PMID:32410268 Lep Rat sumatriptan multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] and Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 Lep Rat superoxide multiple interactions ISO Lep (Mus musculus) 6480464 acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides] more ... CTD PMID:16380530 Lep Rat superoxide multiple interactions ISO LEP (Homo sapiens) 6480464 [LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides CTD PMID:11342529 Lep Rat superoxide increases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in increased abundance of Superoxides CTD PMID:16380530 Lep Rat tauroursodeoxycholic acid multiple interactions ISO Lep (Mus musculus) 6480464 ursodoxicoltaurine inhibits the reaction [LEP protein mutant form results in decreased expression of ATP2A2 protein] more ... CTD PMID:38906502 Lep Rat terbufos increases methylation ISO LEP (Homo sapiens) 6480464 terbufos results in increased methylation of LEP promoter CTD PMID:22847954 Lep Rat terbutaline decreases expression ISO Lep (Mus musculus) 6480464 Terbutaline results in decreased expression of LEP mRNA and Terbutaline results in decreased expression of LEP protein CTD PMID:9002984 Lep Rat testosterone affects secretion ISO Lep (Mus musculus) 6480464 LEP protein affects the secretion of Testosterone CTD PMID:24502529 Lep Rat testosterone multiple interactions ISO Lep (Mus musculus) 6480464 alpha-cyano-(3 more ... CTD PMID:24502529 Lep Rat tetrachloromethane multiple interactions ISO Lep (Mus musculus) 6480464 LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein] more ... CTD PMID:11481614 more ... Lep Rat tetrachloromethane increases expression ISO Lep (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:29987408 Lep Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:27623180 Lep Rat tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:14758566 and PMID:18227024 Lep Rat Theaflavin 3,3'-digallate multiple interactions ISO Lep (Mus musculus) 6480464 theaflavin-3 more ... CTD PMID:36105184 Lep Rat thioacetamide decreases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in decreased susceptibility to Thioacetamide CTD PMID:12085344 Lep Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of LEP protein CTD PMID:17621560 Lep Rat thioacetamide multiple interactions EXP 6480464 Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17621560 Lep Rat thioacetamide increases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in increased susceptibility to Thioacetamide CTD PMID:12085344 Lep Rat thioacetamide multiple interactions ISO Lep (Mus musculus) 6480464 [Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNA more ... CTD PMID:11481614 more ... Lep Rat thiram multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 Lep Rat titanium dioxide decreases expression ISO Lep (Mus musculus) 6480464 titanium dioxide results in decreased expression of LEP mRNA CTD PMID:23131501 and PMID:35295148 Lep Rat titanium dioxide increases expression ISO Lep (Mus musculus) 6480464 titanium dioxide results in increased expression of LEP mRNA CTD PMID:29264374 Lep Rat triazophos decreases secretion EXP 6480464 triazophos results in decreased secretion of LEP protein CTD PMID:34038317 Lep Rat tributylstannane increases expression ISO LEP (Homo sapiens) 6480464 tributyltin results in increased expression of LEP mRNA CTD PMID:28011154 Lep Rat tributylstannane decreases expression ISO Lep (Mus musculus) 6480464 tributyltin results in decreased expression of LEP protein CTD PMID:27310180 Lep Rat tributylstannane multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein CTD PMID:29787037 Lep Rat tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 Lep Rat tributylstannane increases expression ISO Lep (Mus musculus) 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 Lep Rat tributylstannane increases secretion EXP 6480464 tributyltin results in increased secretion of LEP protein CTD PMID:28161095 Lep Rat trichloroethene multiple interactions ISO Lep (Mus musculus) 6480464 Trichloroethylene inhibits the reaction [Dietary Fats affects the expression of LEP mRNA] CTD PMID:29669109 Lep Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of LEP mRNA CTD PMID:33387578 Lep Rat trichostatin A increases expression ISO LEP (Homo sapiens) 6480464 trichostatin A results in increased expression of LEP mRNA CTD PMID:17502362 Lep Rat trichostatin A multiple interactions ISO LEP (Homo sapiens) 6480464 trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 Lep Rat triclosan increases expression ISO LEP (Homo sapiens) 6480464 Triclosan results in increased expression of LEP mRNA CTD PMID:38048832 Lep Rat triflumizole multiple interactions ISO LEP (Homo sapiens) 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA and T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:23086663 Lep Rat triflumizole multiple interactions ISO Lep (Mus musculus) 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA and T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA] CTD PMID:23086663 Lep Rat triphenyl phosphate multiple interactions ISO Lep (Mus musculus) 6480464 [tris(1 more ... CTD PMID:29112739 Lep Rat triptonide increases expression ISO Lep (Mus musculus) 6480464 triptonide results in increased expression of LEP mRNA CTD PMID:33045310 Lep Rat troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of LEP mRNA and troglitazone results in decreased expression of LEP protein CTD PMID:11909685 more ... Lep Rat troglitazone decreases expression ISO LEP (Homo sapiens) 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:10946865 and PMID:9727893 Lep Rat troglitazone decreases expression ISO Lep (Mus musculus) 6480464 troglitazone results in decreased expression of LEP mRNA CTD PMID:10753628 Lep Rat troglitazone increases secretion ISO LEP (Homo sapiens) 6480464 troglitazone results in increased secretion of LEP protein CTD PMID:11092516 Lep Rat troglitazone multiple interactions ISO LEP (Homo sapiens) 6480464 [Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein more ... CTD PMID:10946865 and PMID:11092516 Lep Rat U-73122 multiple interactions ISO Lep (Mus musculus) 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:20107083 Lep Rat ursolic acid increases expression ISO Lep (Mus musculus) 6480464 Ursolic Acid results in increased expression of LEP protein CTD PMID:20869956 Lep Rat vanadium atom multiple interactions EXP 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein] and Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 Lep Rat vanadium(0) multiple interactions EXP 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein] and Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 Lep Rat vancomycin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 Lep Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of LEP mRNA CTD PMID:23160963 Lep Rat vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA] and Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein] CTD PMID:20404018 Lep Rat wogonin decreases expression ISO Lep (Mus musculus) 6480464 wogonin analog results in decreased expression of LEP protein and wogonin results in decreased expression of LEP protein CTD PMID:30445784 Lep Rat wortmannin decreases expression ISO Lep (Mus musculus) 6480464 wortmannin results in decreased expression of LEP mRNA CTD PMID:19254925 Lep Rat wortmannin multiple interactions ISO Lep (Mus musculus) 6480464 wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 Lep Rat wortmannin decreases secretion ISO Lep (Mus musculus) 6480464 wortmannin results in decreased secretion of LEP protein CTD PMID:19254925 Lep Rat xanthone multiple interactions EXP 6480464 xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein] and xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 Lep Rat zidovudine decreases expression ISO LEP (Homo sapiens) 6480464 Zidovudine results in decreased expression of LEP protein CTD PMID:17668557 Lep Rat zidovudine multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA and [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 Lep Rat zinc atom decreases expression ISO Lep (Mus musculus) 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 Lep Rat zinc atom multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 Lep Rat zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 Lep Rat zinc atom decreases expression ISO LEP (Homo sapiens) 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 Lep Rat zinc atom multiple interactions ISO LEP (Homo sapiens) 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] and MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 Lep Rat zinc atom decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 Lep Rat zinc dichloride increases expression ISO LEP (Homo sapiens) 6480464 zinc chloride results in increased expression of LEP mRNA CTD PMID:21540303 Lep Rat zinc molecular entity multiple interactions EXP 6480464 Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 Lep Rat zinc sulfate decreases expression EXP 6480464 Zinc Sulfate deficiency results in decreased expression of LEP mRNA CTD PMID:11568307 Lep Rat zinc sulfate multiple interactions EXP 6480464 Zinc Sulfate deficiency results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:11568307 Lep Rat zinc(0) decreases expression ISO Lep (Mus musculus) 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 Lep Rat zinc(0) decreases abundance ISO LEP (Homo sapiens) 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 Lep Rat zinc(0) multiple interactions ISO LEP (Homo sapiens) 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] and MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 Lep Rat zinc(0) decreases expression ISO LEP (Homo sapiens) 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 Lep Rat zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 Lep Rat zinc(0) multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 Lep Rat ziram multiple interactions EXP 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614