Gene: Lep (leptin) Rattus norvegicus
Symbol: Lep
Name: leptin
Description: ENCODES a protein that exhibits hormone activity; peptide hormone receptor binding; signaling receptor binding; INVOLVED IN bone mineralization involved in bone maturation; cardiac muscle hypertrophy; cellular response to L-ascorbic acid; PARTICIPATES IN energy homeostasis pathway; leptin system pathway; hypoxia inducible factor pathway; ASSOCIATED WITH increased circulating cholesterol level; increased circulating triglyceride level; increased liver triglyceride level; ASSOCIATED WITH Alzheimer's disease; Body Weight Changes; Brain Injuries; FOUND IN extracellular space; cytoplasm (ortholog); INTERACTS WITH (+)-catechin; (R)-lipoic acid; (S)-nicotine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: OB; obese; obesity (murine homolog leptin); obesity factor
Homo sapiens (human) : LEP (leptin)  HGNC  Alliance
Mus musculus (house mouse) : Lep (leptin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lep (leptin)
Pan paniscus (bonobo/pygmy chimpanzee) : LEP (leptin)
Canis lupus familiaris (dog) : LEP (leptin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lep (leptin)
more info ...
Allele / Splice: Lepem5Mcwi   Lepm1Kyo   Lepem1Sage   Lepem1  
Genetic Models: SD-Lepem1 SD-Lepem1Sage F344-Lepm1Kyo SS-Lepem5Mcwi
Is Marker For: Strains:   F344-Lepm1Kyo   SD-Lepem1Narl  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBICelera
Cytogenetic Map4q22NCBI
RH 3.4 Map4309.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lep
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3000
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-06-19
Status: ACTIVE