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Gene: Dab2 (DAB adaptor protein 2) Rattus norvegicus
Symbol: Dab2
Name: DAB adaptor protein 2
RGD ID: 621007
Description: Exhibits low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to growth factor stimulus; regulation of cell development; and regulation of protein phosphorylation. Localizes to clathrin-coated vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Used to study myocardial infarction. Biomarker of metabolic acidosis and myocardial infarction. Orthologous to human DAB2 (DAB adaptor protein 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: adaptor molecule disabled-2; C9; DAB2, clathrin adaptor protein; differentially expressed in ovarian carcinoma 2; disabled 2, mitogen-responsive phosphoprotein; disabled homolog 2; disabled homolog 2 (Drosophila); disabled homolog 2 mitogen-responsive phosphoprotein; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); Doc-2; DOC-2 p82 isoform; Doc2; mitogen-responsive phosphoprotein
Homo sapiens (human) : DAB2 (DAB adaptor protein 2)  Alliance
Mus musculus (house mouse) : Dab2 (disabled 2, mitogen-responsive phosphoprotein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dab2 (DAB adaptor protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DAB2 (DAB adaptor protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dab2 (DAB adaptor protein 2)
Sus scrofa (pig) : DAB2 (DAB adaptor protein 2)
Chlorocebus sabaeus (African green monkey) : DAB2 (DAB adaptor protein 2)
Heterocephalus glaber (naked mole-rat) : Dab2 (DAB adaptor protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0255,747,353 - 55,768,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl255,747,318 - 55,768,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,489,435 - 75,510,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,714,874 - 55,736,370 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1255,643,109 - 55,664,600 (+)NCBI
Celera251,166,390 - 51,187,877 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dab2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621007
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.