LRP2 (LDL receptor related protein 2) - Rat Genome Database

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Gene: LRP2 (LDL receptor related protein 2) Pan paniscus
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Symbol: LRP2
Name: LDL receptor related protein 2
RGD ID: 11767467
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); hemoglobin binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); animal organ regeneration (ortholog); aorta development (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH 46, XY Disorders of Sex Development (ortholog); acute kidney failure (ortholog); Albuminuria (ortholog); FOUND IN apical plasma membrane (ortholog); axonal growth cone (ortholog); brush border (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low-density lipoprotein receptor-related protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,791,193 - 72,028,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,806,164 - 72,043,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
animal organ regeneration  (ISO)
aorta development  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to growth factor stimulus  (ISO)
chemoattraction of axon  (ISO)
coronary artery morphogenesis  (IEA)
coronary vasculature development  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
diol metabolic process  (IEA,ISO)
endocytic hemoglobin import into cell  (ISO)
endocytosis  (IEA,ISO)
endosomal transport  (ISO)
folate import across plasma membrane  (IEA)
forebrain development  (IEA,ISO)
gene expression  (IEA,ISO)
heart development  (IEA,ISO)
kidney development  (IEA,ISO)
male gonad development  (IEA)
metal ion transport  (IEA)
metanephric proximal tubule development  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA)
neural tube closure  (IEA)
neuron projection arborization  (IEA)
outflow tract morphogenesis  (IEA,ISO)
outflow tract septum morphogenesis  (IEA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of endocytosis  (ISO)
positive regulation of lipoprotein transport  (ISO)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neurogenesis  (IEA)
positive regulation of oligodendrocyte progenitor proliferation  (IEA)
protein import  (ISO)
protein transport  (IEA)
pulmonary artery morphogenesis  (IEA)
receptor-mediated endocytosis  (IEA,ISO)
response to leptin  (IEA)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
secondary heart field specification  (IEA)
sensory perception of sound  (IEA)
transcytosis  (ISO)
vagina development  (IEA)
ventricular compact myocardium morphogenesis  (IEA)
ventricular septum development  (IEA,ISO)
vitamin D metabolic process  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,791,193 - 72,028,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,806,164 - 72,043,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382169,127,109 - 169,362,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
T2T-CHM13v2.02169,602,803 - 169,838,534 (-)NCBIT2T-CHM13v2.0
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)EnsemblGRCm39 Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBIMGSCv36mm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,597,148 - 74,754,535 (-)NCBIGRCr8
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,588,938 - 57,746,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,172,509 - 66,330,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,935,221 - 64,092,679 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3614,025,608 - 14,223,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBIUU_Cfam_GSD_1.0
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,244,881 - 10,438,935 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,303 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,798,938 - 6,998,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000061429   ⟹   ENSPPAP00000038526
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B173,873,767 - 174,069,162 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000061439   ⟹   ENSPPAP00000038536
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B173,985,844 - 174,103,697 (-)Ensembl
RefSeq Acc Id: XM_003824300   ⟹   XP_003824348
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21371,791,193 - 72,028,996 (-)NCBI
NHGRI_mPanPan12B71,806,164 - 72,043,965 (-)NCBI
Mhudiblu_PPA_v02B56,407,871 - 56,640,469 (-)NCBI
PanPan1.12B173,873,454 - 174,103,911 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003824348 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000038526.1
  ENSPPAP00000038536.1
RefSeq Acc Id: XP_003824348   ⟸   XM_003824300
- UniProtKB: A0A2R9C9A4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000038536   ⟸   ENSPPAT00000061439
Ensembl Acc Id: ENSPPAP00000038526   ⟸   ENSPPAT00000061429
Protein Domains
EGF-like   EGF-like calcium-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041907 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061429.1 UniProtKB/TrEMBL
  ENSPPAT00000061439.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  2.40.128.620 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  cEGF UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR-related UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  Lectin_legB_Mn/Ca_BS UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
NCBI Gene LRP2 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam cEGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
  LECTIN_LEGUME_BETA UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0A2R9C9A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C9B4_PANPA UniProtKB/TrEMBL