Myh9 (myosin, heavy chain 9) - Rat Genome Database

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Gene: Myh9 (myosin, heavy chain 9) Rattus norvegicus
Analyze
Symbol: Myh9
Name: myosin, heavy chain 9
RGD ID: 3140
Description: Enables several functions, including G-protein alpha-subunit binding activity; follicle-stimulating hormone receptor binding activity; and scaffold protein binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; actin cytoskeleton organization; and positive regulation of cell communication. Located in several cellular components, including actin filament; brush border; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with endosome and phagocytic vesicle. Biomarker of metabolic acidosis. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9); PARTICIPATES IN follicle-stimulating hormone signaling pathway; myocarditis pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cellular myosin heavy chain, type A; Myh9l1; myosin heavy chain 9; myosin heavy chain 9-like 1; myosin heavy chain, non-muscle IIa; Myosin heavy polypeptide 9 non-muscle; myosin, heavy chain 9, non-muscle; myosin, heavy chain 9, non-muscle-like 1; myosin, heavy polypeptide 9; Myosin, heavy polypeptide 9, non-muscle; myosin-9; NMIIA; NMMHC II-a; NMMHC-A; NMMHC-IIA; non-muscle myosin heavy chain A; non-muscle myosin heavy chain IIa; nonmuscle myosin heavy chain-A; nonmuscle myosin IIA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Gene ID:100911597 and GeneID:25745 on Rnor_6.0 are nearly identical to each other, and are both annotated on chromosome 7. This duplication is likely the result of a genome assembly error, and GeneID:100911597 is thought to better represent the Myh9 locus. [06 Apr 2015]; Note: Gene ID:100911597 and GeneID:25745 on Rnor_6.0 are nearly identical to each other, and are both annotated on chromosome 7. This duplication is likely the result of a genome assembly error, and GeneID:100911597 is thought to better represent the Myh9 locus. [08 Apr 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,343,718 - 109,424,457 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7109,343,706 - 109,424,457 (-)Ensembl
Rnor_6.07118,740,005 - 118,792,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,741,110 - 118,792,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,992,356 - 119,071,712 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07118,737,555 - 118,797,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,681,459 - 115,732,774 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,715,686 - 115,767,004 (-)NCBI
Celera7105,684,430 - 105,736,878 (-)NCBICelera
RH 3.4 Map7811.2RGD
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
blebbistatin  (ISO)
Brodifacoum  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
genistein  (ISO)
glafenine  (EXP)
hypochlorous acid  (ISO)
isobutanol  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
medroxyprogesterone acetate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
Monobutylphthalate  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
paracetamol  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thiophenes  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (IMP,ISO,ISS)
actin filament bundle assembly  (IMP)
actin filament bundle distribution  (IMP)
actin filament capping  (ISO)
actin filament polymerization  (ISO)
actin filament-based movement  (ISO,ISS)
actomyosin structure organization  (ISO)
angiogenesis  (ISO,ISS)
blood vessel endothelial cell migration  (ISO,ISS)
cell adhesion  (ISO)
cell morphogenesis involved in differentiation  (ISO)
cell-cell adhesion  (IMP,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cortical granule exocytosis  (ISO,ISS)
cytokinetic process  (ISO,ISS)
establishment of meiotic spindle localization  (ISO)
establishment of T cell polarity  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (IEA)
follicle-stimulating hormone signaling pathway  (IMP)
in utero embryonic development  (ISO)
lysosome localization  (ISO)
meiotic spindle organization  (ISO)
membrane protein ectodomain proteolysis  (ISO,ISS)
monocyte differentiation  (ISO,ISS)
myoblast fusion  (ISO)
negative regulation of actin filament severing  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (IMP)
phagocytosis, engulfment  (ISO)
plasma membrane repair  (ISO)
platelet aggregation  (ISO)
platelet formation  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IMP)
positive regulation of endocytosis  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of focal adhesion assembly  (IMP)
positive regulation of G protein-coupled receptor signaling pathway  (IMP)
positive regulation of inositol trisphosphate biosynthetic process  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of phagocytosis  (IMP)
positive regulation of protein processing in phagocytic vesicle  (ISO)
protein transport  (ISO,ISS)
regulated exocytosis  (ISO)
regulation of cell shape  (ISO,ISS)
regulation of plasma membrane repair  (ISO)
uropod organization  (ISO)
vesicle targeting  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Arous C, etal., Diabetologia. 2013 Apr;56(4):792-802. doi: 10.1007/s00125-012-2800-1. Epub 2013 Jan 26.
2. Arrondel C, etal., J Am Soc Nephrol. 2002 Jan;13(1):65-74.
3. Ashley-Koch AE, etal., Br J Haematol. 2011 Nov;155(3):386-94. doi: 10.1111/j.1365-2141.2011.08832.x. Epub 2011 Sep 13.
4. Baeyens N, etal., J Cell Biochem. 2011 Sep;112(9):2574-84. doi: 10.1002/jcb.23183.
5. Behar DM, etal., Hum Mol Genet. 2010 May 1;19(9):1816-27. Epub 2010 Feb 9.
6. Birnbaum S, etal., Eur J Oral Sci. 2009 Apr;117(2):200-3. doi: 10.1111/j.1600-0722.2008.00604.x.
7. Chiquet BT, etal., Eur J Hum Genet. 2009 Feb;17(2):195-204. doi: 10.1038/ejhg.2008.149. Epub 2008 Aug 20.
8. Choi OH, etal., J Muscle Res Cell Motil 1996 Feb;17(1):69-77.
9. Cooke JN, etal., Nephrol Dial Transplant. 2012 Apr;27(4):1505-11. Epub 2011 Oct 3.
10. Freedman BI, etal., Am J Nephrol. 2009;29(6):626-32. Epub 2009 Jan 20.
11. Freedman BI, etal., Kidney Int. 2009 Apr;75(7):736-45. Epub 2009 Jan 28.
12. Freedman BI, etal., Nephrol Dial Transplant. 2009 Nov;24(11):3366-71. Epub 2009 Jun 30.
13. Gallagher PJ, etal., Am J Physiol Cell Physiol. 2000 Oct;279(4):C1078-87.
14. Ghiggeri GM, etal., Am J Kidney Dis. 2003 Jan;41(1):95-104.
15. Hays T, etal., AIDS. 2012 Apr 24;26(7):797-803.
16. Hosaka K, etal., Kidney Int. 2009 Jun;75(12):1308-15. Epub 2009 Apr 1.
17. Huda S, etal., J Cell Sci. 2012 Dec 1;125(Pt 23):5790-9. doi: 10.1242/jcs.110494. Epub 2012 Sep 19.
18. Jia ZL, etal., DNA Cell Biol. 2010 Jan;29(1):25-32. doi: 10.1089/dna.2009.0935.
19. Johnstone DB, etal., Mol Cell Biol. 2011 May;31(10):2162-70. Epub 2011 Mar 14.
20. Kao WH, etal., Nat Genet. 2008 Oct;40(10):1185-92. Epub 2008 Sep 14.
21. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
22. Lalwani AK, etal., Am J Hum Genet. 2000 Nov;67(5):1121-8. Epub 2000 Oct 9.
23. Lin YF, etal., Endocrinology. 2010 Mar;151(3):876-85. Epub 2010 Jan 12.
24. Martinelli M, etal., J Med Genet. 2007 Jun;44(6):387-92. Epub 2007 Mar 2.
25. MGD data from the GO Consortium
26. Miura K, etal., Nephrol Dial Transplant. 2013 Dec;28(12):2993-3003. doi: 10.1093/ndt/gft350. Epub 2013 Sep 15.
27. NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
29. OMIM Disease Annotation Pipeline
30. Ozaslan D, etal., J Biol Chem. 2003 Nov 7;278(45):43991-4000. Epub 2003 Aug 27.
31. Pipeline to import KEGG annotations from KEGG into RGD
32. Reusch P, etal., Circ Res. 1996 Nov;79(5):1046-53.
33. Reyes A, etal., Nucleic Acids Res. 2011 Jul;39(12):5098-108. doi: 10.1093/nar/gkr052. Epub 2011 Mar 11.
34. RGD automated data pipeline
35. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. RGD automated import pipeline for gene-chemical interactions
37. RGD comprehensive gene curation
38. Sekine T, etal., Kidney Int. 2010 Jul;78(2):207-14. Epub 2010 Mar 3.
39. Seri M, etal., Hum Genet. 2002 Feb;110(2):182-6. Epub 2001 Dec 14.
40. Seri M, etal., Nat Genet. 2000 Sep;26(1):103-5.
41. Shull MM, etal., J Biol Chem. 1989 Oct 15;264(29):17532-43.
42. Shutova MS, etal., Curr Biol. 2014 Sep 8;24(17):1958-68. doi: 10.1016/j.cub.2014.07.070. Epub 2014 Aug 14.
43. Strick DJ, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2427-35. Epub 2008 Dec 30.
44. Suzuki N, etal., PLoS One. 2013 Aug 20;8(8):e71187. doi: 10.1371/journal.pone.0071187. eCollection 2013.
45. Tayo BO, etal., Int Urol Nephrol. 2013 Apr;45(2):485-94. doi: 10.1007/s11255-012-0263-4. Epub 2012 Sep 7.
46. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
47. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
48. Verver EJ, etal., Ear Hear. 2016 Jan-Feb;37(1):112-20. doi: 10.1097/AUD.0000000000000198.
49. Walmsley SJ, etal., Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1465-77. doi: 10.1152/ajprenal.00390.2011. Epub 2012 Feb 22.
50. Yi Y, etal., Clin Chim Acta. 2006 Nov;373(1-2):49-54. Epub 2006 May 16.
Additional References at PubMed
PMID:1912569   PMID:2732579   PMID:7699007   PMID:8482409   PMID:9356462   PMID:9725909   PMID:10822899   PMID:11029059   PMID:12237319   PMID:12421915   PMID:12477932   PMID:12893741  
PMID:14508515   PMID:14706930   PMID:15064761   PMID:15065866   PMID:15177565   PMID:15292239   PMID:15555549   PMID:15774463   PMID:15845534   PMID:15856021   PMID:15869600   PMID:16012337  
PMID:16025302   PMID:16186248   PMID:16403913   PMID:16407977   PMID:16630581   PMID:16641100   PMID:16862555   PMID:16895968   PMID:18504258   PMID:18850735   PMID:19056867   PMID:19199708  
PMID:19946888   PMID:20131911   PMID:20458337   PMID:21126233   PMID:21362503   PMID:21700703   PMID:22082260   PMID:22114352   PMID:22206666   PMID:22681889   PMID:23325791   PMID:23376485  
PMID:23382103   PMID:23533145   PMID:23979707   PMID:24072716   PMID:24625528   PMID:25468996   PMID:27325790   PMID:29093437   PMID:29476059   PMID:29956586   PMID:31118506   PMID:32513915  


Genomics

Comparative Map Data
Myh9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,343,718 - 109,424,457 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7109,343,706 - 109,424,457 (-)Ensembl
Rnor_6.07118,740,005 - 118,792,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,741,110 - 118,792,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,992,356 - 119,071,712 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07118,737,555 - 118,797,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,681,459 - 115,732,774 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,715,686 - 115,767,004 (-)NCBI
Celera7105,684,430 - 105,736,878 (-)NCBICelera
RH 3.4 Map7811.2RGD
Cytogenetic Map7q34NCBI
MYH9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2236,281,280 - 36,387,967 (-)EnsemblGRCh38hg38GRCh38
GRCh382236,281,280 - 36,387,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372236,677,326 - 36,784,012 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,007,272 - 35,113,927 (-)NCBINCBI36hg18NCBI36
Build 342235,001,826 - 35,108,481NCBI
Celera2220,479,895 - 20,586,681 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2219,645,404 - 19,752,216 (-)NCBIHuRef
CHM1_12236,636,447 - 36,743,196 (-)NCBICHM1_1
Myh9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,644,785 - 77,726,375 (-)NCBIGRCm39mm39
GRCm39 Ensembl1577,644,787 - 77,726,375 (-)Ensembl
GRCm381577,760,585 - 77,842,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,760,587 - 77,842,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,591,019 - 77,672,545 (-)NCBIGRCm37mm9NCBIm37
MGSCv361577,587,843 - 77,669,360 (-)NCBImm8
Celera1579,227,040 - 79,308,545 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1536.81NCBI
Myh9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541322,881,045 - 22,972,450 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541322,881,759 - 22,972,182 (-)NCBIChiLan1.0ChiLan1.0
MYH9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12235,039,461 - 35,121,618 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,039,101 - 35,121,618 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02217,200,623 - 17,305,826 (-)NCBIMhudiblu_PPA_v0panPan3
MYH9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,063,626 - 28,122,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,063,624 - 28,122,953 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,985,072 - 28,076,495 (+)NCBI
ROS_Cfam_1.01028,817,559 - 28,909,010 (+)NCBI
UMICH_Zoey_3.11028,544,285 - 28,635,641 (+)NCBI
UNSW_CanFamBas_1.01028,853,021 - 28,944,583 (+)NCBI
UU_Cfam_GSD_1.01029,031,010 - 29,122,482 (+)NCBI
Myh9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,373,869 - 11,455,815 (+)NCBI
SpeTri2.0NW_0049364924,384,215 - 4,466,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1511,365,603 - 11,456,475 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.259,076,302 - 9,165,918 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYH9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,985,709 - 19,093,304 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,986,598 - 19,052,671 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045106,805,704 - 106,913,198 (+)NCBIVero_WHO_p1.0
Myh9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475211,327,881 - 11,414,037 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH94614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,344,893 - 109,345,018 (+)MAPPERmRatBN7.2
Rnor_6.07118,992,427 - 118,992,551NCBIRnor6.0
Rnor_6.07118,741,181 - 118,741,305NCBIRnor6.0
Rnor_5.07118,988,103 - 118,988,227UniSTSRnor5.0
Rnor_5.07118,738,730 - 118,738,854UniSTSRnor5.0
RGSC_v3.47115,681,472 - 115,681,596UniSTSRGSC3.4
Celera7105,685,604 - 105,685,728UniSTS
RH 3.4 Map7811.2UniSTS
Cytogenetic Map7q34UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low
Below cutoff 1 19 3 17 3 1 6 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007398   ⟹   ENSRNOP00000007398
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,343,718 - 109,424,457 (-)Ensembl
Rnor_6.0 Ensembl7118,741,110 - 118,792,625 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000037611   ⟹   ENSRNOP00000035440
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,343,718 - 109,424,457 (-)Ensembl
Rnor_6.0 Ensembl7118,992,356 - 119,071,712 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111963   ⟹   ENSRNOP00000088365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,377,955 - 109,424,457 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116925   ⟹   ENSRNOP00000089403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,343,706 - 109,424,457 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119854   ⟹   ENSRNOP00000092547
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,343,718 - 109,376,509 (-)Ensembl
RefSeq Acc Id: NM_013194   ⟹   NP_037326
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,343,718 - 109,396,360 (-)NCBI
Rnor_6.07118,740,005 - 118,792,507 (-)NCBI
Rnor_5.07118,737,555 - 118,797,086 (-)NCBI
RGSC_v3.47115,681,459 - 115,732,774 (-)RGD
Celera7105,684,430 - 105,736,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078500   ⟹   XP_038934428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,343,719 - 109,424,457 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001292806 (Get FASTA)   NCBI Sequence Viewer  
  NP_037326 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA74950 (Get FASTA)   NCBI Sequence Viewer  
  EDM15905 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037326   ⟸   NM_013194
- UniProtKB: G3V6P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038934428   ⟸   XM_039078500
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000035440   ⟸   ENSRNOT00000037611
RefSeq Acc Id: ENSRNOP00000007398   ⟸   ENSRNOT00000007398
RefSeq Acc Id: ENSRNOP00000089403   ⟸   ENSRNOT00000116925
RefSeq Acc Id: ENSRNOP00000092547   ⟸   ENSRNOT00000119854
RefSeq Acc Id: ENSRNOP00000088365   ⟸   ENSRNOT00000111963
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3140 AgrOrtholog
  RGD:6492022 AgrOrtholog
Ensembl Genes ENSRNOG00000004860 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000049236 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007398 UniProtKB/TrEMBL
  ENSRNOP00000035440 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007398 UniProtKB/TrEMBL
  ENSRNOT00000037611 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_IQ_contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25745 UniProtKB/TrEMBL
NCBI Gene 25745 ENTREZGENE
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myh9 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220174
UniProt G3V6P7 ENTREZGENE, UniProtKB/TrEMBL
  MYH9_RAT UniProtKB/Swiss-Prot
UniProt Secondary E9PTI3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-06-01 Myh9  myosin, heavy chain 9  Myh9l1  myosin heavy chain 9-like 1  Data Merged 737654 PROVISIONAL
2016-09-07 Myh9  myosin, heavy chain 9  Myh9temp  myosin, heavy chain 9temp  Name and Symbol changed 629549 APPROVED
2016-09-07 Myh9l1  myosin heavy chain 9-like 1  Myh9  myosin heavy chain 9  Name and Symbol changed 629549 APPROVED
2016-09-07 Myh9temp  myosin, heavy chain 9temp  Myh9l1  myosin, heavy chain 9, non-muscle-like 1  Name and Symbol changed 629549 APPROVED
2016-08-29 Myh9  myosin heavy chain 9  Myh9  myosin, heavy chain 9, non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-04-07 Myh9  myosin, heavy chain 9, non-muscle  Myh9  myosin, heavy polypeptide 9, non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-04-06 Myh9  myosin, heavy polypeptide 9, non-muscle  LOC100911597  myosin-9-like  Name and Symbol changed 629549 APPROVED
2015-04-06 Myh9l1  myosin, heavy chain 9, non-muscle-like 1  Myh9  myosin, heavy chain 9, non-muscle  Name and Symbol changed 629549 APPROVED
2012-07-05 LOC100911597  myosin-9-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-23 Myh9  myosin, heavy chain 9, non-muscle  Myh9  myosin, heavy polypeptide 9, non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Myh9  myosin, heavy polypeptide 9, non-muscle    myosin, heavy polypeptide 9  Name updated 1299863 APPROVED
2003-04-09 Myh9  myosin, heavy polypeptide 9    Myosin, heavy polypeptide 9, non-muscle  Name updated 629478 APPROVED
2002-06-10 Myh9  Myosin, heavy polypeptide 9, non-muscle      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in secretory rat mast cell line, RBL-2H3 cells 729058
gene_protein 1961 amino acids 729058