Lrp2 (low density lipoprotein receptor-related protein 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Lrp2 (low density lipoprotein receptor-related protein 2) Mus musculus
Symbol: Lrp2
Name: low density lipoprotein receptor-related protein 2
RGD ID: 68600
Description: Predicted to enable several functions, including PDZ domain binding activity; chaperone binding activity; and insulin-like growth factor I binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including animal organ development; circulatory system development; and vitamin metabolic process. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; heart and pericardium; metanephros; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI315343; AW536255; b2b1625.2Clo; D230004K18Rik; glycoprotein 330; Gp33; Gp330; low-density lipoprotein receptor-related protein 2; LRP-2; Meg; Megalin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBImm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B2  (ISO)
all-trans-retinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
aspartame  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbamazepine  (ISO)
chenodeoxycholic acid  (EXP)
chloroprene  (EXP)
cholic acid  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP)
clobetasol  (EXP)
cobalt dichloride  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
fenamidone  (EXP)
folic acid  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
guggulsterone  (EXP)
hydrogen peroxide  (ISO)
lithocholic acid  (EXP)
manganese(II) chloride  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
O-methyleugenol  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phosgene  (EXP)
progesterone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
sulforaphane  (EXP)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vitamin D  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta clearance  (ISO)
animal organ regeneration  (ISO)
aorta development  (IMP)
cell population proliferation  (IMP)
cellular response to growth factor stimulus  (ISO)
chemoattraction of axon  (ISO)
coronary artery morphogenesis  (IMP)
coronary vasculature development  (IMP)
endocytic hemoglobin import into cell  (ISO)
endocytosis  (ISO)
endosomal transport  (ISO)
folate import across plasma membrane  (IMP)
forebrain development  (IMP)
heart development  (IMP)
hormone secretion  (ISO)
kidney development  (IMP)
male gonad development  (IMP)
metal ion transport  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (IMP)
nervous system development  (IEA)
neural tube closure  (IMP)
neuron projection arborization  (IMP)
outflow tract septum morphogenesis  (IMP)
positive regulation of endocytosis  (ISO)
positive regulation of lipoprotein transport  (ISO)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neurogenesis  (IMP)
positive regulation of oligodendrocyte progenitor proliferation  (IMP)
positive regulation of protein kinase B signaling  (ISO)
protein transport  (IDA,ISO)
pulmonary artery morphogenesis  (IMP)
receptor-mediated endocytosis  (IBA,IDA,IMP,ISO)
response to leptin  (IDA,ISO)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
secondary heart field specification  (IMP)
sensory perception of sound  (IMP)
transcytosis  (ISO)
vagina development  (IMP)
ventricular compact myocardium morphogenesis  (IMP)
ventricular septum development  (IMP)
vitamin metabolic process  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aortic arch morphology  (IEA)
abnormal bone mineralization  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal circulating mineral level  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal ear physiology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal intraocular pressure  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal myocardium compact layer morphology  (IEA)
abnormal olfactory bulb morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal placement of pupils  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal reabsorption  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retinal bipolar cell morphology  (IAGP)
abnormal retinal pigment epithelium morphology  (IAGP)
abnormal retinal pigmentation  (IAGP)
abnormal sclera morphology  (IAGP)
abnormal selenium level  (IAGP)
abnormal strial marginal cell morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal testis development  (IAGP)
abnormal testis morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal viscerocranium morphology  (IAGP)
abnormal vitamin D level  (IAGP)
absent corpus callosum  (IAGP)
absent nasal septum  (IAGP)
absent olfactory bulb  (IAGP)
albuminuria  (IAGP)
anophthalmia  (IAGP)
atelectasis  (IAGP)
choroid plexus hyperplasia  (IAGP)
cleft palate  (IAGP)
cryptorchism  (IAGP)
cyanosis  (IAGP)
decreased bone mineral content  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating calcium level  (IAGP)
decreased embryo size  (IAGP)
decreased glutathione peroxidase activity  (IAGP)
decreased retinal ganglion cell number  (IAGP)
decreased total retina thickness  (IAGP)
delayed neural tube closure  (IAGP)
dilated uterus  (IAGP)
emphysema  (IAGP)
exencephaly  (IAGP)
flat forehead  (IAGP)
heart left ventricle hypertrophy  (IEA)
heart right ventricle hypertrophy  (IEA)
high myopia  (IAGP)
holoprosencephaly  (IAGP)
hydronephrosis  (IEA)
impaired coordination  (IAGP)
impaired hearing  (IAGP)
increased apoptosis  (IAGP)
increased bone resorption  (IAGP)
increased circulating dihydrotestosterone level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased circulating testosterone level  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased retinal apoptosis  (IAGP)
increased susceptibility to age-related hearing loss  (IAGP)
increased urine microglobulin level  (IAGP)
increased urine protein level  (IAGP)
increased urine selenium level  (IAGP)
kidney cysts  (IEA)
kinked tail  (IEA)
macrophthalmia  (IAGP)
micrognathia  (IEA)
microphthalmia  (IAGP)
muscular ventricular septal defect  (IEA)
neonatal lethality, incomplete penetrance  (IAGP)
ocular hypotelorism  (IAGP)
omphalocele  (IEA)
osteomalacia  (IAGP)
overexpanded pulmonary alveoli  (IAGP)
perimembraneous ventricular septal defect  (IEA)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosis  (IEA)
persistent truncus arteriosus type i  (IEA)
respiratory failure  (IAGP)
right aortic arch  (IEA)
round forehead  (IAGP)
sclera thinning  (IAGP)
short snout  (IAGP)
small embryonic telencephalon  (IAGP)
small olfactory bulb  (IAGP)
thin retinal inner nuclear layer  (IAGP)
thin retinal inner plexiform layer  (IAGP)
thin retinal outer nuclear layer  (IAGP)
thymus hypoplasia  (IEA)
umbilical hernia  (IEA)
vaginal septum  (IAGP)
vascular ring  (IEA)
ventricular septal defect  (IEA)

Additional References at PubMed
PMID:7656578   PMID:7720568   PMID:8244399   PMID:8710893   PMID:8827514   PMID:9457688   PMID:9546356   PMID:9616220   PMID:9727058   PMID:10052453   PMID:10073957   PMID:10203351  
PMID:10349636   PMID:10438476   PMID:10469351   PMID:10514418   PMID:10535319   PMID:10556425   PMID:10662735   PMID:10665926   PMID:10725249   PMID:10766831   PMID:10772929   PMID:10811843  
PMID:10827173   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11208732   PMID:11217851   PMID:11544199   PMID:11675412   PMID:11832420   PMID:12370429   PMID:12371967   PMID:12413896  
PMID:12475886   PMID:12477932   PMID:12508107   PMID:12520002   PMID:12724130   PMID:12748857   PMID:12815097   PMID:12904583   PMID:14610273   PMID:14657389   PMID:14983511   PMID:15005800  
PMID:15034091   PMID:15082773   PMID:15314648   PMID:15342463   PMID:15616221   PMID:15623804   PMID:15870384   PMID:15878230   PMID:15976002   PMID:16099815   PMID:16141072   PMID:16141073  
PMID:16143106   PMID:16177003   PMID:16196028   PMID:16251603   PMID:16263760   PMID:16306401   PMID:16319116   PMID:16380466   PMID:16602821   PMID:16787536   PMID:17063000   PMID:17077144  
PMID:17283184   PMID:17324488   PMID:17339320   PMID:17369355   PMID:17389516   PMID:17460141   PMID:17462596   PMID:17846082   PMID:18005667   PMID:18083160   PMID:18174160   PMID:18287559  
PMID:18322545   PMID:18388738   PMID:18400109   PMID:18769366   PMID:19047013   PMID:19177150   PMID:19279259   PMID:19367412   PMID:19416849   PMID:19521566   PMID:20048263   PMID:20357188  
PMID:20460439   PMID:20531455   PMID:20637285   PMID:20653565   PMID:20798259   PMID:20966072   PMID:21170526   PMID:21267068   PMID:21311715   PMID:21337463   PMID:21444625   PMID:21818577  
PMID:21873635   PMID:21926402   PMID:21938401   PMID:21939757   PMID:22340494   PMID:22354480   PMID:22496890   PMID:22555591   PMID:22999937   PMID:23048173   PMID:23362348   PMID:23382219  
PMID:23430977   PMID:23554936   PMID:23592779   PMID:23651543   PMID:23673647   PMID:23825075   PMID:23826131   PMID:23836931   PMID:23968836   PMID:24140060   PMID:24434121   PMID:24586199  
PMID:24639464   PMID:24740791   PMID:24760755   PMID:24825475   PMID:24950692   PMID:24980834   PMID:25270072   PMID:25807483   PMID:26107939   PMID:26206087   PMID:26439398   PMID:26534923  
PMID:26786190   PMID:26822476   PMID:27002738   PMID:27213360   PMID:27382987   PMID:27518433   PMID:27591083   PMID:27773703   PMID:27796299   PMID:27820600   PMID:28087629   PMID:28167773  
PMID:28190767   PMID:28226240   PMID:28289043   PMID:28331063   PMID:28351841   PMID:28366874   PMID:28527294   PMID:28575050   PMID:28659595   PMID:28678521   PMID:29032953   PMID:29186471  
PMID:29449453   PMID:29916093   PMID:30025861   PMID:30046000   PMID:30401801   PMID:30485812   PMID:30567480   PMID:30665232   PMID:30940800   PMID:31308417   PMID:31548351   PMID:31740596  
PMID:31923383   PMID:31937343   PMID:32179912   PMID:32200668   PMID:32290105   PMID:32325033   PMID:32504627   PMID:32736701   PMID:32876567   PMID:32901292   PMID:33069809   PMID:33103447  
PMID:33500317   PMID:34066779  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBImm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh382169,127,109 - 169,362,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)Ensembl
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBI
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBI
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBI
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBI
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBI
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1575,565,301 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11054,672,876 - 54,889,374 (-)NCBI
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)Ensembl
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,424,755 - 69,424,873UniSTSGRCm38
MGSCv37269,262,812 - 69,262,930UniSTSGRCm37
Celera271,090,269 - 71,090,387UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,501,875 - 69,502,026UniSTSGRCm38
MGSCv37269,339,932 - 69,340,083UniSTSGRCm37
Celera271,167,623 - 71,167,774UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Whitehead_YAC2 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,465,036 - 69,465,161UniSTSGRCm38
MGSCv37269,303,093 - 69,303,218UniSTSGRCm37
Celera271,130,458 - 71,130,585UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.4UniSTS
Whitehead Genetic240.4UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,570,569 - 69,570,665UniSTSGRCm38
MGSCv37269,408,626 - 69,408,722UniSTSGRCm37
Cytogenetic Map2C2UniSTS
cM Map240.4UniSTS
Whitehead Genetic240.4UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,424,485 - 69,424,646UniSTSGRCm38
MGSCv37269,262,542 - 69,262,703UniSTSGRCm37
Celera271,089,999 - 71,090,160UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,424,710 - 69,424,974UniSTSGRCm38
MGSCv37269,262,767 - 69,263,031UniSTSGRCm37
Celera271,090,224 - 71,090,488UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,425,638 - 69,425,786UniSTSGRCm38
MGSCv37269,263,695 - 69,263,843UniSTSGRCm37
Celera271,091,152 - 71,091,300UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,519,228 - 69,519,428UniSTSGRCm38
MGSCv37269,357,285 - 69,357,485UniSTSGRCm37
Celera271,184,947 - 71,185,147UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C2UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3590731269907394Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3590731269907394Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3590731269907394Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23610166771779068Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)24008165374081799Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240995481115079684Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24193070775930831Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24369026877690412Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4369026877690412Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24369026877690412Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24369026877690412Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24369026877690412Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24436867378368673Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
4141809Pbwg1.1_mpostnatal body weight growth 1.1 (mouse)Not determined4830206882302151Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24830206882302151Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24843940282439590Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24843940282439590Mouse
1302085Mobe1_mmodifier of obesity 1 (mouse)Not determined24843940282439590Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24843940282439590Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174843940282439590Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25098897084988970Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25109283185092934Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25187293285873081Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25261767586617792Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25261767586617792Mouse
4142299Pbwg1.4_mpostnatal body weight growth 1.4 (mouse)Not determined5562407289624172Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25769377391693944Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25808964792089647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26317561097175769Mouse
1301405Etohr_methanol response acute (mouse)Not determined26317561097175769Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26317561097175769Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26317561097175769Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26317561097175769Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26317561097175769Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26373981097739957Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
1301059Hrtfm1_mheart failure modifier 1 (mouse)Not determined26776159675134589Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267817543101817798Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267817543101817798Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268893925102894063Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268893925102894063Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:861
Count of miRNA genes:501
Interacting mature miRNAs:604
Transcripts:ENSMUST00000080953, ENSMUST00000092551, ENSMUST00000100051, ENSMUST00000128742
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000080953   ⟹   ENSMUSP00000079752
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,254,684 - 69,416,409 (-)Ensembl
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)Ensembl
RefSeq Acc Id: ENSMUST00000092551   ⟹   ENSMUSP00000090212
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,356,710 - 69,416,373 (-)Ensembl
GRCm38.p6 Ensembl269,526,366 - 69,586,029 (-)Ensembl
RefSeq Acc Id: ENSMUST00000100051   ⟹   ENSMUSP00000097628
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,336,548 - 69,416,373 (-)Ensembl
GRCm38.p6 Ensembl269,506,204 - 69,586,029 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128742
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,337,967 - 69,339,489 (-)Ensembl
GRCm38.p6 Ensembl269,507,623 - 69,509,145 (-)Ensembl
RefSeq Acc Id: NM_001081088   ⟹   NP_001074557
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39269,254,679 - 69,416,373 (-)NCBI
GRCm38269,424,335 - 69,586,029 (-)NCBI
MGSCv37269,262,392 - 69,424,124 (-)RGD
Celera271,089,849 - 71,251,632 (-)RGD
Protein Sequences
Protein RefSeqs NP_001074557 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2ARV4 (Get FASTA)   NCBI Sequence Viewer  
  AAF61488 (Get FASTA)   NCBI Sequence Viewer  
  BAE38957 (Get FASTA)   NCBI Sequence Viewer  
  BAE43341 (Get FASTA)   NCBI Sequence Viewer  
  CAA69877 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001074557   ⟸   NM_001081088
- Peptide Label: precursor
- UniProtKB: A2ARV4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000090212   ⟸   ENSMUST00000092551
RefSeq Acc Id: ENSMUSP00000097628   ⟸   ENSMUST00000100051
RefSeq Acc Id: ENSMUSP00000079752   ⟸   ENSMUST00000080953
Protein Domains
EGF-like   EGF_CA   LDL-receptor class A

RGD ID:6831731
Promoter ID:MM_KWN:29540
SO ACC ID:SO:0000170
Tissues & Cell Lines:Kidney,   Lung
Mouse AssemblyChrPosition (strand)Source
MGSCv36269,346,871 - 69,347,371 (-)MPROMDB
RGD ID:6831730
Promoter ID:MM_KWN:29541
SO ACC ID:SO:0000170
Tissues & Cell Lines:ES_Cell,   Kidney,   Lung
Transcripts:NM_001081088,   OTTMUST00000031295,   UC008JYD.1,   UC008JYE.1
Mouse AssemblyChrPosition (strand)Source
MGSCv36269,423,726 - 69,424,226 (-)MPROMDB
RGD ID:6877498
Promoter ID:EPDNEW_M2199
Type:initiation region
Description:Mus musculus low density lipoprotein receptor-related protein2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38269,586,029 - 69,586,089EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95794 AgrOrtholog
Ensembl Genes ENSMUSG00000027070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000079752 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000090212 UniProtKB/TrEMBL
  ENSMUSP00000097628 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000080953 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000092551 UniProtKB/TrEMBL
  ENSMUST00000100051 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14725 UniProtKB/Swiss-Prot
Pfam cEGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrp2 PhenoGen
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRP2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70215 UniProtKB/Swiss-Prot
  Q3TL35 UniProtKB/Swiss-Prot
  Q9JLB3 UniProtKB/Swiss-Prot