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Gene: Lrp2 (low density lipoprotein receptor-related protein 2) Mus musculus
Symbol: Lrp2
Name: low density lipoprotein receptor-related protein 2
Description: Predicted to have several functions, including PDZ domain binding activity; chaperone binding activity; and signaling receptor binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Localizes to several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; metanephros; neural plate; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI315343; AW536255; b2b1625.2Clo; D230004K18Rik; glycoprotein 330; Gp330; low-density lipoprotein receptor-related protein 2; LRP-2; Megalin
Homo sapiens (human) : LRP2 (LDL receptor related protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrp2 (LDL receptor related protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp2 (LDL receptor related protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP2 (LDL receptor related protein 2)
Canis lupus familiaris (dog) : LRP2 (LDL receptor related protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp2 (LDL receptor related protein 2)
Sus scrofa (pig) : LRP2 (LDL receptor related protein 2)
Chlorocebus sabaeus (African green monkey) : LRP2 (LDL receptor related protein 2)
Heterocephalus glaber (naked mole-rat) : Lrp2 (LDL receptor related protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBImm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lrp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68600
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.