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Gene: H4C4 (H4 clustered histone 4) Homo sapiens
Symbol: H4C4
Name: H4 clustered histone 4
Description: Exhibits protein domain specific binding activity. Involved in negative regulation of megakaryocyte differentiation; nucleosome assembly; and protein heterotetramerization. Localizes to the nuclear nucleosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dJ221C16.9; H4 histone family, member B; H4-16; H4/b; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C2; H4C3; H4C5; H4C6; H4C8; H4C9; H4FB; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4; histone 1, H4d; histone cluster 1 H4 family member d; histone cluster 1, H4d; histone H4
Rattus norvegicus (Norway rat) : Hist2h4a (histone cluster 2 H4 family member A)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC112440134 (histone H4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101972420 (histone H4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38626,188,710 - 26,189,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37626,188,938 - 26,189,304 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,296,917 - 26,297,283 (-)NCBINCBI36hg18NCBI36
Build 34626,296,916 - 26,297,283NCBI
Celera627,418,239 - 27,418,605 (-)NCBI
Cytogenetic Map6p22.2NCBI
HuRef626,131,943 - 26,132,309 (-)NCBIHuRef
CHM1_1626,191,140 - 26,191,506 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on H4C4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347367
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.