H4C8 (H4 clustered histone 8) - Rat Genome Database

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Gene: H4C8 (H4 clustered histone 8) Homo sapiens
Analyze
Symbol: H4C8
Name: H4 clustered histone 8
RGD ID: 1314497
HGNC Page HGNC:4788
Description: A structural constituent of chromatin. Involved in negative regulation of megakaryocyte differentiation and nucleosome assembly. Located in extracellular exosome and nucleoplasm. Part of nucleosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: H4 histone family, member H; H4-16; H4/h; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C9; H4FH; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4; histone 1, H4h; histone cluster 1 H4 family member h; histone cluster 1, H4h; histone H4
RGD Orthologs
Mouse
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,285,126 - 26,285,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl626,277,609 - 26,285,638 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37626,285,354 - 26,285,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,393,333 - 26,393,706 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34626,393,332 - 26,393,706NCBI
Celera627,514,661 - 27,515,034 (-)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef626,228,361 - 26,228,734 (-)NCBIHuRef
CHM1_1626,287,421 - 26,287,794 (-)NCBICHM1_1
T2T-CHM13v2.0626,153,493 - 26,153,901 (-)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aflatoxin M1  (EXP)
all-trans-retinoic acid  (EXP)
aminoglutethimide  (EXP)
amiodarone  (EXP)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
berberine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
CGP 52608  (EXP)
chlordecone  (ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
DDE  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dichloroacetic acid  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
Enterolactone  (EXP)
ethanol  (EXP)
glyphosate  (ISO)
hydroquinone  (EXP)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
menadione  (EXP)
methyl methanesulfonate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
picene  (EXP)
pirinixic acid  (ISO)
propanal  (EXP)
rac-lactic acid  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sotorasib  (EXP)
T-2 toxin  (EXP)
testosterone  (EXP)
thimerosal  (EXP)
titanium dioxide  (ISO)
trametinib  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP)
vancomycin  (ISO)
versicolorin A  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3035717   PMID:9119399   PMID:9439656   PMID:9540062   PMID:9566873   PMID:10220385   PMID:11080476   PMID:11689053   PMID:12408966   PMID:12477932   PMID:14585971   PMID:14657027  
PMID:14718166   PMID:15161933   PMID:15670829   PMID:15933069   PMID:15951514   PMID:16415788   PMID:16917504   PMID:17540172   PMID:17675446   PMID:18404153   PMID:18408754   PMID:18474616  
PMID:18571423   PMID:19135898   PMID:19199708   PMID:19410544   PMID:19494831   PMID:19498464   PMID:19710015   PMID:19738201   PMID:19862764   PMID:19946888   PMID:20000738   PMID:20224553  
PMID:20458337   PMID:20498094   PMID:20618440   PMID:20709061   PMID:20739937   PMID:20951943   PMID:21081503   PMID:21085121   PMID:21145461   PMID:21164480   PMID:21478274   PMID:21596426  
PMID:21630459   PMID:21636898   PMID:21743476   PMID:21800051   PMID:21812398   PMID:21873635   PMID:21888893   PMID:21907836   PMID:21983900   PMID:22145905   PMID:22268729   PMID:22343720  
PMID:22368283   PMID:22373579   PMID:22493515   PMID:22615379   PMID:22623428   PMID:22658674   PMID:22681889   PMID:23071334   PMID:23075851   PMID:23142979   PMID:23160995   PMID:23376485  
PMID:23377543   PMID:23443559   PMID:23533145   PMID:23760478   PMID:23831576   PMID:23979707   PMID:24183680   PMID:24311584   PMID:24360279   PMID:24361270   PMID:24525235   PMID:24596249  
PMID:24699735   PMID:24711643   PMID:24726341   PMID:24981860   PMID:25281266   PMID:25416956   PMID:25556234   PMID:25579814   PMID:25615412   PMID:25619998   PMID:25651062   PMID:25910212  
PMID:25948554   PMID:25963833   PMID:26167883   PMID:26496610   PMID:26694698   PMID:26725010   PMID:26912361   PMID:27153538   PMID:28514442   PMID:28902428   PMID:28977666   PMID:29507755  
PMID:29676528   PMID:29844126   PMID:29859926   PMID:30021884   PMID:30554943   PMID:31142837   PMID:31759698   PMID:31790919   PMID:32296183   PMID:32350470   PMID:32814053   PMID:33618749  
PMID:33857403   PMID:33961781   PMID:34784299   PMID:35013429   PMID:35271311   PMID:35696571   PMID:35819319   PMID:35944360   PMID:36044842   PMID:36180920   PMID:36373674   PMID:36435862  
PMID:37132043   PMID:37223481   PMID:37384673   PMID:37491377   PMID:39353936   PMID:39664081  


Genomics

Comparative Map Data
H4C8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,285,126 - 26,285,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl626,277,609 - 26,285,638 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37626,285,354 - 26,285,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,393,333 - 26,393,706 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34626,393,332 - 26,393,706NCBI
Celera627,514,661 - 27,515,034 (-)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef626,228,361 - 26,228,734 (-)NCBIHuRef
CHM1_1626,287,421 - 26,287,794 (-)NCBICHM1_1
T2T-CHM13v2.0626,153,493 - 26,153,901 (-)NCBIT2T-CHM13v2.0
H4c12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391321,934,315 - 21,934,723 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1321,934,364 - 21,934,675 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381321,750,145 - 21,750,553 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1321,750,194 - 21,750,505 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371321,842,063 - 21,842,374 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361321,757,659 - 21,757,970 (-)NCBIMGSCv36mm8
Celera1322,025,683 - 22,025,994 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map137.95NCBI
H4C8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl720,908,345 - 20,912,379 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1720,910,487 - 20,912,374 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in H4C8
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33		 pathogenic
NM_003543.4(H4C8):c.83A>C (p.Gln28Pro) single nucleotide variant not specified [RCV004287080] Chr6:26285417 [GRCh38]
Chr6:26285645 [GRCh37]
Chr6:6p22.2		 uncertain significance
GRCh38/hg38 6p22.2-22.1(chr6:26280579-28727313)x3 copy number gain See cases [RCV000133692] Chr6:6p22.2-22.1 uncertain significance
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:6p25.2-21.33 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:6p25.3-12.3 pathogenic
GRCh37/hg19 6p22.2(chr6:26104332-26365573)x4 copy number gain Breast ductal adenocarcinoma [RCV000207323] Chr6:26104332..26365573 [GRCh37]
Chr6:6p22.2		 uncertain significance
GRCh37/hg19 6p22.2(chr6:25839165-26536884)x4 copy number gain See cases [RCV000447433] Chr6:25839165..26536884 [GRCh37]
Chr6:6p22.2		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain Intrauterine growth retardation [RCV000512067] Chr6:6p25.3-q27 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain Abnormality of the ear [RCV000510595] Chr6:6p25.3-q27 pathogenic
GRCh37/hg19 6p22.2(chr6:26178542-26670193)x3 copy number gain not provided [RCV000682657] Chr6:6p22.2 uncertain significance
GRCh37/hg19 6p22.2(chr6:25851789-26319486)x3 copy number gain not provided [RCV000682656] Chr6:6p22.2 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.2(chr6:26110314-26338056)x3 copy number gain not provided [RCV000745546] Chr6:26110314..26338056 [GRCh37]
Chr6:6p22.2		 benign
GRCh37/hg19 6p22.2(chr6:26067580-26306202)x3 copy number gain not provided [RCV000849663] Chr6:6p22.2 uncertain significance
GRCh37/hg19 6p22.2(chr6:26256525-26536884)x3 copy number gain not provided [RCV001005789] Chr6:6p22.2 uncertain significance
GRCh37/hg19 6p22.2(chr6:25996066-26303969)x3 copy number gain not provided [RCV000847447] Chr6:6p22.2 uncertain significance
GRCh37/hg19 6p22.2(chr6:25896585-26287389)x4 copy number gain not provided [RCV000845790] Chr6:6p22.2 uncertain significance
GRCh37/hg19 6p22.2(chr6:26238509-26329714)x1 copy number loss not provided [RCV001005788] Chr6:6p22.2 likely benign
GRCh37/hg19 6p22.2(chr6:26046566-26670193)x3 copy number gain not provided [RCV001258882] Chr6:6p22.2 uncertain significance
GRCh37/hg19 6p22.2(chr6:25839165-26536884) copy number gain not specified [RCV002053562] Chr6:6p22.2 uncertain significance
NM_003543.4(H4C8):c.193A>T (p.Asn65Tyr) single nucleotide variant not specified [RCV005576661] Chr6:26285307 [GRCh38]
Chr6:26285535 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.63G>C (p.Lys21Asn) single nucleotide variant not specified [RCV005576660] Chr6:26285437 [GRCh38]
Chr6:26285665 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.106C>T (p.Arg36Trp) single nucleotide variant not specified [RCV006429816] Chr6:26285394 [GRCh38]
Chr6:26285622 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.28G>A (p.Gly10Ser) single nucleotide variant not specified [RCV006429817] Chr6:26285472 [GRCh38]
Chr6:26285700 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.83A>T (p.Gln28Leu) single nucleotide variant not specified [RCV005846200] Chr6:26285417 [GRCh38]
Chr6:26285645 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.29G>A (p.Gly10Asp) single nucleotide variant not specified [RCV005857148] Chr6:26285471 [GRCh38]
Chr6:26285699 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.235C>T (p.Arg79Cys) single nucleotide variant not specified [RCV005576659] Chr6:26285265 [GRCh38]
Chr6:26285493 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.151A>G (p.Ile51Val) single nucleotide variant not specified [RCV006429818] Chr6:26285349 [GRCh38]
Chr6:26285577 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.103A>C (p.Ile35Leu) single nucleotide variant not specified [RCV004396836] Chr6:26285397 [GRCh38]
Chr6:26285625 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.44G>A (p.Gly15Glu) single nucleotide variant not specified [RCV004396839] Chr6:26285456 [GRCh38]
Chr6:26285684 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.83A>G (p.Gln28Arg) single nucleotide variant not specified [RCV004627346] Chr6:26285417 [GRCh38]
Chr6:26285645 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.13G>A (p.Gly5Ser) single nucleotide variant not specified [RCV004917250] Chr6:26285487 [GRCh38]
Chr6:26285715 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.308G>T (p.Gly103Val) single nucleotide variant not specified [RCV004917249] Chr6:26285192 [GRCh38]
Chr6:26285420 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.58C>T (p.Arg20Cys) single nucleotide variant not specified [RCV004627345] Chr6:26285442 [GRCh38]
Chr6:26285670 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.166C>T (p.Arg56Cys) single nucleotide variant not specified [RCV004396837] Chr6:26285334 [GRCh38]
Chr6:26285562 [GRCh37]
Chr6:6p22.2		 uncertain significance
NM_003543.4(H4C8):c.19G>A (p.Gly7Ser) single nucleotide variant not specified [RCV004396838] Chr6:26285481 [GRCh38]
Chr6:26285709 [GRCh37]
Chr6:6p22.2		 uncertain significance

QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358854MULTSCL4_HMultiple sclerosis susceptibility QTL 4 (human)Multiple sclerosis susceptibility6691196032911960Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
1643377BW325_HBody weight QTL 325 (human)2.320.0005Body fat amount6691196032911960Human
1643569GLUCO21_HGlucose level QTL 21 (human)0.021Glucose levelnon-insulin-dependent6691196032911960Human
1298458BW9_HBody weight QTL 9 (human)2.70.0002Body fat amount6691196032911960Human
628728674GWAS2636903_HBMI-adjusted hip circumference QTL GWAS2636903 (human)1e-30BMI-adjusted hip circumferencehip circumference (CMO:0000014)62628545526285456Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
1643399BMD5_HBone mineral density QTL 5 (human)2.320.0005Bone mineral density6691196032911960Human
628635047GWAS2543276_Hhematological measurement QTL GWAS2543276 (human)1e-08hematopoietic system morphology trait (VT:0010250)blood measurement (CMO:0000035)62628520026285201Human

Markers in Region
RH70852  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37626,285,222 - 26,285,342UniSTSGRCh37
Build 36626,393,201 - 26,393,321RGDNCBI36
Celera627,514,529 - 27,514,649RGD
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map6p22.1UniSTS
HuRef626,228,229 - 26,228,349UniSTS
GeneMap99-GB4 RH Map6106.35UniSTS
STS-N32748  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37626,281,367 - 26,281,510UniSTSGRCh37
Build 36626,389,346 - 26,389,489RGDNCBI36
Celera627,510,674 - 27,510,817RGD
Cytogenetic Map6p22.1UniSTS
HuRef626,224,374 - 26,224,517UniSTS
GeneMap99-GB4 RH Map6106.35UniSTS
NCBI RH Map6370.3UniSTS
AL031212  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37626,284,880 - 26,285,021UniSTSGRCh37
Build 36626,392,859 - 26,393,000RGDNCBI36
Celera627,514,187 - 27,514,328RGD
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map6p22.1UniSTS
HuRef626,227,887 - 26,228,028UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENST00000377727   ⟹   ENSP00000366956
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl626,285,126 - 26,285,534 (-)Ensembl
Ensembl Acc Id: ENST00000634560   ⟹   ENSP00000489319
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl626,281,055 - 26,285,534 (-)Ensembl
Ensembl Acc Id: ENST00000634956   ⟹   ENSP00000489567
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl626,277,609 - 26,285,638 (-)Ensembl
Ensembl Acc Id: ENST00000635491   ⟹   ENSP00000489236
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl626,281,055 - 26,285,534 (-)Ensembl
RefSeq Acc Id: NM_003543   ⟹   NP_003534
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38626,285,126 - 26,285,534 (-)NCBI
GRCh37626,285,354 - 26,285,727 (-)RGD
Build 36626,393,333 - 26,393,706 (-)NCBI Archive
Celera627,514,661 - 27,515,034 (-)RGD
HuRef626,228,361 - 26,228,734 (-)RGD
CHM1_1626,287,421 - 26,287,794 (-)NCBI
T2T-CHM13v2.0626,153,493 - 26,153,901 (-)NCBI
Sequence:
RefSeq Acc Id: NP_003534   ⟸   NM_003543
- UniProtKB: Q6FGB8 (UniProtKB/Swiss-Prot),   Q6DRA9 (UniProtKB/Swiss-Prot),   P02305 (UniProtKB/Swiss-Prot),   P02304 (UniProtKB/Swiss-Prot),   A2VCL0 (UniProtKB/Swiss-Prot),   Q6NWP7 (UniProtKB/Swiss-Prot),   P62805 (UniProtKB/Swiss-Prot),   B2R4R0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000489567   ⟸   ENST00000634956
Ensembl Acc Id: ENSP00000489319   ⟸   ENST00000634560
Ensembl Acc Id: ENSP00000489236   ⟸   ENST00000635491
Ensembl Acc Id: ENSP00000366956   ⟸   ENST00000377727

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62805-F1-model_v2 AlphaFold P62805 1-103 view protein structure

Promoters
RGD ID:6872258
Promoter ID:EPDNEW_H9294
Type:initiation region
Name:HIST1H4H_1
Description:histone cluster 1 H4 family member h
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38626,285,534 - 26,285,594EPDNEW
RGD ID:6804316
Promoter ID:HG_KWN:52589
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000289352
Position:
Human AssemblyChrPosition (strand)Source
Build 36626,393,496 - 26,394,742 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4788 AgrOrtholog
COSMIC H4C8 COSMIC
Ensembl Genes ENSG00000158406 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000197061 UniProtKB/Swiss-Prot
  ENSG00000197238 UniProtKB/Swiss-Prot
  ENSG00000197837 UniProtKB/Swiss-Prot
  ENSG00000270276 UniProtKB/Swiss-Prot
  ENSG00000270882 UniProtKB/Swiss-Prot
  ENSG00000273542 UniProtKB/Swiss-Prot
  ENSG00000274618 UniProtKB/Swiss-Prot
  ENSG00000275126 UniProtKB/Swiss-Prot
  ENSG00000276180 UniProtKB/Swiss-Prot
  ENSG00000276966 UniProtKB/Swiss-Prot
  ENSG00000277157 UniProtKB/Swiss-Prot
  ENSG00000278637 UniProtKB/Swiss-Prot
  ENSG00000278705 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000244537.6 UniProtKB/Swiss-Prot
  ENST00000355057.3 UniProtKB/Swiss-Prot
  ENST00000358064.3 UniProtKB/Swiss-Prot
  ENST00000377727 ENTREZGENE
  ENST00000377727.2 UniProtKB/Swiss-Prot
  ENST00000377745.5 UniProtKB/Swiss-Prot
  ENST00000377803.4 UniProtKB/Swiss-Prot
  ENST00000539745.2 UniProtKB/Swiss-Prot
  ENST00000578186.3 UniProtKB/Swiss-Prot
  ENST00000579512.3 UniProtKB/Swiss-Prot
  ENST00000611927.2 UniProtKB/Swiss-Prot
  ENST00000612061.1 UniProtKB/Swiss-Prot
  ENST00000613412.1 UniProtKB/Swiss-Prot
  ENST00000614247.2 UniProtKB/Swiss-Prot
  ENST00000614272.1 UniProtKB/Swiss-Prot
  ENST00000615164.3 UniProtKB/Swiss-Prot
  ENST00000615353.2 UniProtKB/Swiss-Prot
  ENST00000617569.2 UniProtKB/Swiss-Prot
  ENST00000618193.1 UniProtKB/Swiss-Prot
  ENST00000618305.2 UniProtKB/Swiss-Prot
  ENST00000621520.1 UniProtKB/Swiss-Prot
  ENST00000634560.1 UniProtKB/Swiss-Prot
  ENST00000634956.1 UniProtKB/Swiss-Prot
  ENST00000715894.1 UniProtKB/Swiss-Prot
  ENST00000718258.1 UniProtKB/Swiss-Prot
  ENST00000718434.1 UniProtKB/Swiss-Prot
  ENST00000850564.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot
GTEx ENSG00000158406 GTEx
  ENSG00000197061 GTEx
  ENSG00000197238 GTEx
  ENSG00000197837 GTEx
  ENSG00000270276 GTEx
  ENSG00000270882 GTEx
  ENSG00000273542 GTEx
  ENSG00000274618 GTEx
  ENSG00000275126 GTEx
  ENSG00000276180 GTEx
  ENSG00000276966 GTEx
  ENSG00000277157 GTEx
  ENSG00000278637 GTEx
  ENSG00000278705 GTEx
HGNC ID HGNC:4788 ENTREZGENE
Human Proteome Map H4C8 Human Proteome Map
InterPro CENP-T/H4_C UniProtKB/Swiss-Prot
  Histone-fold UniProtKB/Swiss-Prot
  Histone_H4 UniProtKB/Swiss-Prot
  Histone_H4_CS UniProtKB/Swiss-Prot
  TAF_TATA-bd UniProtKB/Swiss-Prot
KEGG Report hsa:121504 UniProtKB/Swiss-Prot
  hsa:554313 UniProtKB/Swiss-Prot
  hsa:8294 UniProtKB/Swiss-Prot
  hsa:8359 UniProtKB/Swiss-Prot
  hsa:8360 UniProtKB/Swiss-Prot
  hsa:8361 UniProtKB/Swiss-Prot
  hsa:8362 UniProtKB/Swiss-Prot
  hsa:8363 UniProtKB/Swiss-Prot
  hsa:8364 UniProtKB/Swiss-Prot
  hsa:8365 UniProtKB/Swiss-Prot
  hsa:8366 UniProtKB/Swiss-Prot
  hsa:8367 UniProtKB/Swiss-Prot
  hsa:8368 UniProtKB/Swiss-Prot
  hsa:8370 UniProtKB/Swiss-Prot
NCBI Gene 8365 ENTREZGENE
OMIM 602828 OMIM
PANTHER HISTONE H4 UniProtKB/Swiss-Prot
Pfam CENP-T_C UniProtKB/Swiss-Prot
PharmGKB PA166351909 PharmGKB
PRINTS HISTONEH4 UniProtKB/Swiss-Prot
PROSITE HISTONE_H4 UniProtKB/Swiss-Prot
SMART SM00417 UniProtKB/Swiss-Prot
  TAF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot
UniProt A2VCL0 ENTREZGENE
  B2R4R0 ENTREZGENE
  H4_HUMAN UniProtKB/Swiss-Prot
  P02304 ENTREZGENE
  P02305 ENTREZGENE
  P62805 ENTREZGENE
  Q6DRA9 ENTREZGENE
  Q6FGB8 ENTREZGENE
  Q6NWP7 ENTREZGENE
UniProt Secondary A2VCL0 UniProtKB/Swiss-Prot
  P02304 UniProtKB/Swiss-Prot
  P02305 UniProtKB/Swiss-Prot
  Q6DRA9 UniProtKB/Swiss-Prot
  Q6FGB8 UniProtKB/Swiss-Prot
  Q6NWP7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-30 H4C8  H4 clustered histone 8  HIST1H4H  histone cluster 1 H4 family member h  Symbol and/or name change 5135510 APPROVED
2016-08-23 HIST1H4H  histone cluster 1 H4 family member h  HIST1H4H  histone cluster 1, H4h  Symbol and/or name change 5135510 APPROVED