Cfap77 (cilia and flagella associated protein 77) - Rat Genome Database

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Gene: Cfap77 (cilia and flagella associated protein 77) Rattus norvegicus
Analyze
Symbol: Cfap77
Name: cilia and flagella associated protein 77
RGD ID: 1564114
Description: Orthologous to human CFAP77 (cilia and flagella associated protein 77); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cilia- and flagella-associated protein 77; hypothetical protein LOC499765; LOC100909960; LOC499765; RGD1564114; similar to FLJ46082 protein; uncharacterized LOC100909960; uncharacterized protein C9orf171 homolog; uncharacterized protein C9orf171-like; uncharacterized protein LOC499765
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2312,258,453 - 12,381,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,258,453 - 12,381,319 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx315,331,516 - 15,454,277 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0323,916,487 - 24,039,252 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0322,170,933 - 22,293,704 (-)NCBIRnor_WKY
Rnor_6.037,508,500 - 7,632,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,508,496 - 7,632,345 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,858,726 - 12,980,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,934,968 - 8,059,535 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera37,037,739 - 7,160,534 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Cfap77
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2312,258,453 - 12,381,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,258,453 - 12,381,319 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx315,331,516 - 15,454,277 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0323,916,487 - 24,039,252 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0322,170,933 - 22,293,704 (-)NCBIRnor_WKY
Rnor_6.037,508,500 - 7,632,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,508,496 - 7,632,345 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,858,726 - 12,980,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,934,968 - 8,059,535 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera37,037,739 - 7,160,534 (-)NCBICelera
Cytogenetic Map3p12NCBI
CFAP77
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389132,410,211 - 132,573,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9132,410,043 - 132,573,319 (+)EnsemblGRCh38hg38GRCh38
GRCh379135,285,598 - 135,448,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,275,432 - 134,438,496 (+)NCBINCBI36Build 36hg18NCBI36
Celera9105,827,436 - 105,990,419 (+)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9104,778,926 - 104,942,484 (+)NCBIHuRef
CHM1_19135,435,625 - 135,599,048 (+)NCBICHM1_1
T2T-CHM13v2.09144,624,655 - 144,784,525 (+)NCBIT2T-CHM13v2.0
Cfap77
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,845,493 - 28,945,078 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,816,961 - 28,945,078 (-)EnsemblGRCm39 Ensembl
GRCm38228,955,481 - 29,055,066 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,926,949 - 29,055,066 (-)EnsemblGRCm38mm10GRCm38
MGSCv37228,811,001 - 28,910,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,777,382 - 28,877,075 (-)NCBIMGSCv36mm8
Celera228,661,281 - 28,761,310 (-)NCBICelera
Cytogenetic Map2A3NCBI
Cfap77
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555131,834,388 - 1,953,638 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555131,834,654 - 1,951,827 (+)NCBIChiLan1.0ChiLan1.0
CFAP77
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19132,162,008 - 132,322,666 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,162,008 - 132,322,666 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09103,528,991 - 103,690,634 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CFAP77
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,721,893 - 51,852,212 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,721,839 - 51,852,453 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha950,986,563 - 51,116,854 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0952,614,914 - 52,745,256 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl952,614,913 - 52,745,594 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1951,394,796 - 51,525,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,719,276 - 51,849,618 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,799,032 - 51,935,926 (-)NCBIUU_Cfam_GSD_1.0
Cfap77
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,218,290 - 199,335,241 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648718,986,966 - 19,103,044 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648718,986,966 - 19,103,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP77
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,217,072 - 272,361,733 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,216,581 - 272,362,321 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,244,364 - 306,394,538 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFAP77
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,566,994 - 5,731,619 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660799,890,199 - 10,071,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap77
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247603,779,492 - 3,890,851 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247603,780,678 - 3,890,265 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfap77
865 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:75
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000049889
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat

Markers in Region
RH133252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2312,258,504 - 12,258,697 (+)MAPPERmRatBN7.2
Rnor_6.037,508,552 - 7,508,744NCBIRnor6.0
Rnor_5.0312,858,778 - 12,858,970UniSTSRnor5.0
RGSC_v3.437,935,020 - 7,935,212UniSTSRGSC3.4
Celera37,037,791 - 7,037,983UniSTS
RH 3.4 Map328.5UniSTS
Cytogenetic Map3p12UniSTS
AU047988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2312,308,175 - 12,308,454 (+)MAPPERmRatBN7.2
Rnor_6.037,558,217 - 7,558,495NCBIRnor6.0
Rnor_6.0310,916,483 - 10,916,761NCBIRnor6.0
Rnor_5.0312,908,443 - 12,908,721UniSTSRnor5.0
Rnor_5.0316,270,713 - 16,270,991UniSTSRnor5.0
RGSC_v3.437,984,684 - 7,984,962UniSTSRGSC3.4
Celera37,087,441 - 7,087,719UniSTS
Cytogenetic Map3p12UniSTS
UniSTS:224561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2312,366,671 - 12,366,891 (+)MAPPERmRatBN7.2
Rnor_6.037,617,019 - 7,617,238NCBIRnor6.0
Rnor_5.0312,966,728 - 12,966,947UniSTSRnor5.0
RGSC_v3.438,044,960 - 8,045,179UniSTSRGSC3.4
Celera37,146,085 - 7,146,304UniSTS
Cytogenetic Map3p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 11
Low 16 14 6 5 6 64 20 29 11
Below cutoff 3 8 39 31 14 31 1 1 8 14 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049889   ⟹   ENSRNOP00000050516
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl312,258,453 - 12,381,319 (-)Ensembl
Rnor_6.0 Ensembl37,508,496 - 7,632,345 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000073625   ⟹   ENSRNOP00000065618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl312,258,453 - 12,381,288 (-)Ensembl
RefSeq Acc Id: NM_001127563   ⟹   NP_001121035
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,258,453 - 12,381,319 (-)NCBI
Rnor_6.037,508,500 - 7,632,311 (-)NCBI
Rnor_5.0312,858,726 - 12,980,874 (-)NCBI
RGSC_v3.437,934,968 - 8,059,535 (-)RGD
Celera37,037,739 - 7,160,534 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001121035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66521 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001121035   ⟸   NM_001127563
- UniProtKB: B2GV45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050516   ⟸   ENSRNOT00000049889
RefSeq Acc Id: ENSRNOP00000065618   ⟸   ENSRNOT00000073625

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV45-F1-model_v2 AlphaFold B2GV45 1-283 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691940
Promoter ID:EPDNEW_R2465
Type:multiple initiation site
Name:Cfap77_1
Description:cilia and flagella associated protein 77
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.037,632,330 - 7,632,390EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564114 AgrOrtholog
BioCyc Gene G2FUF-50265 BioCyc
Ensembl Genes ENSRNOG00000028805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050516 ENTREZGENE
  ENSRNOP00000050516.2 UniProtKB/TrEMBL
  ENSRNOP00000065618.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049889 ENTREZGENE
  ENSRNOT00000049889.4 UniProtKB/TrEMBL
  ENSRNOT00000073625.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133997 IMAGE-MGC_LOAD
InterPro DUF4483 UniProtKB/TrEMBL
KEGG Report rno:499765 UniProtKB/TrEMBL
MGC_CLONE MGC:188104 IMAGE-MGC_LOAD
NCBI Gene 499765 ENTREZGENE
PANTHER PTHR28617 UniProtKB/TrEMBL
Pfam DUF4483 UniProtKB/TrEMBL
PhenoGen Cfap77 PhenoGen
UniProt B2GV45 ENTREZGENE, UniProtKB/TrEMBL
  M0R828_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cfap77  cilia and flagella associated protein 77  LOC100909960  uncharacterized LOC100909960  Data Merged 737654 PROVISIONAL
2015-10-26 Cfap77  cilia and flagella associated protein 77  RGD1564114  similar to FLJ46082 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909960  uncharacterized LOC100909960      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1564114  similar to FLJ46082 protein   RGD1564114_predicted  similar to FLJ46082 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564114_predicted  similar to FLJ46082 protein (predicted)  LOC499765  similar to FLJ46082 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499765  similar to FLJ46082 protein      Symbol and Name status set to provisional 70820 PROVISIONAL