H4c14 (H4 clustered histone 14) - Rat Genome Database

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Gene: H4c14 (H4 clustered histone 14) Mus musculus
Analyze
Symbol: H4c14
Name: H4 clustered histone 14
RGD ID: 1316646
MGI Page MGI
Description: Predicted to enable DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in nucleosome assembly. Located in nucleus. Is expressed in several structures, including bone; gut; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including H4C3 (H4 clustered histone 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: H4; H4c1; H4c11; H4c12; H4c16; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4f16; Hist1h4a; Hist1h4b; Hist1h4c; Hist1h4d; Hist1h4f; Hist1h4h; Hist1h4i; Hist1h4j; Hist1h4k; Hist1h4m; Hist2; Hist2h4; Hist2h4a; Hist4h4; histone 2, H4; histone cluster 2, H4; histone H4; X04652
RGD Orthologs
Human
Squirrel
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,170,250 - 96,170,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,168,998 - 96,170,627 (-)EnsemblGRCm39 Ensembl
GRCm38396,262,934 - 96,263,317 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,261,682 - 96,263,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv37396,066,893 - 96,067,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,348,341 - 96,348,738 (-)NCBIMGSCv36mm8
Celera397,692,545 - 97,692,892 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antimony(0)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
chlorambucil  (ISO)
chloropicrin  (ISO)
chromium atom  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dinophysistoxin 1  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (EXP)
gemcitabine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
okadaic acid  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP,ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetraphene  (EXP)
thalidomide  (EXP)
titanium dioxide  (EXP)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
versicolorin A  (ISO)
vincristine  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3396543   PMID:3816761   PMID:6276563   PMID:12408966   PMID:12477932   PMID:15601857   PMID:17767906   PMID:17923681   PMID:18487609   PMID:19590016   PMID:21605641   PMID:21873635  
PMID:22354994   PMID:23086144   PMID:24797072   PMID:30550785   PMID:30562941  


Genomics

Comparative Map Data
H4c14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,170,250 - 96,170,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,168,998 - 96,170,627 (-)EnsemblGRCm39 Ensembl
GRCm38396,262,934 - 96,263,317 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,261,682 - 96,263,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv37396,066,893 - 96,067,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,348,341 - 96,348,738 (-)NCBIMGSCv36mm8
Celera397,692,545 - 97,692,892 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.7NCBI
H4C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,103,933 - 26,104,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl626,103,933 - 26,104,337 (+)EnsemblGRCh38hg38GRCh38
GRCh37626,104,161 - 26,104,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,212,140 - 26,212,544 (+)NCBINCBI36Build 36hg18NCBI36
Build 34626,212,154 - 26,212,544NCBI
Celera627,333,446 - 27,333,850 (+)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef626,047,237 - 26,047,626 (+)NCBIHuRef
CHM1_1626,106,435 - 26,106,824 (+)NCBICHM1_1
T2T-CHM13v2.0625,972,081 - 25,972,485 (+)NCBIT2T-CHM13v2.0
LOC101972801
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049461,667,931 - 1,668,479 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366711,953,045 - 1,953,612 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in H4c14
4 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse

Markers in Region
Hist2h4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1-F2UniSTS
cM Map341.7UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000171473   ⟹   ENSMUSP00000129930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,168,998 - 96,170,627 (-)Ensembl
GRCm38.p6 Ensembl396,261,682 - 96,263,311 (-)Ensembl
RefSeq Acc Id: NM_033596   ⟹   NP_291074
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,170,250 - 96,170,633 (-)NCBI
GRCm38396,262,934 - 96,263,317 (-)NCBI
MGSCv37396,066,893 - 96,067,240 (-)RGD
Celera397,692,509 - 97,692,892 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_291074   ⟸   NM_033596
- UniProtKB: Q9D0C9 (UniProtKB/Swiss-Prot),   Q811M0 (UniProtKB/Swiss-Prot),   Q6PDS7 (UniProtKB/Swiss-Prot),   Q5T006 (UniProtKB/Swiss-Prot),   Q2M2Q5 (UniProtKB/Swiss-Prot),   Q0VDL9 (UniProtKB/Swiss-Prot),   A4QMY0 (UniProtKB/Swiss-Prot),   A4FUP8 (UniProtKB/Swiss-Prot),   A0AUM5 (UniProtKB/Swiss-Prot),   Q9D6Q8 (UniProtKB/Swiss-Prot),   P62806 (UniProtKB/Swiss-Prot),   B2RTM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000129930   ⟸   ENSMUST00000171473
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62806-F1-model_v2 AlphaFold P62806 1-103 view protein structure

Promoters
RGD ID:6833955
Promoter ID:MM_KWN:35366
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_033596
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36396,067,071 - 96,068,177 (-)MPROMDB
RGD ID:6849400
Promoter ID:EP07052
Type:single initiation site
Name:MM_H4_A
Description:Histone H4
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:[S]
Experiment Methods:Nuclease protection with homologous sequence ladder
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37396,067,256 - 96,067,316EPD
MGSCv36396,067,256 - 96,067,316EPD
RGD ID:6881660
Promoter ID:EPDNEW_M4281
Type:initiation region
Name:Hist2h4_1
Description:Mus musculus histone cluster 2, H4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38396,263,333 - 96,263,393EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2140113 AgrOrtholog
Ensembl Genes ENSMUSG00000060093 UniProtKB/Swiss-Prot
  ENSMUSG00000060639 UniProtKB/Swiss-Prot
  ENSMUSG00000060678 UniProtKB/Swiss-Prot
  ENSMUSG00000060981 UniProtKB/Swiss-Prot
  ENSMUSG00000061482 UniProtKB/Swiss-Prot
  ENSMUSG00000064288 UniProtKB/Swiss-Prot
  ENSMUSG00000067455 UniProtKB/Swiss-Prot
  ENSMUSG00000069266 UniProtKB/Swiss-Prot
  ENSMUSG00000069274 UniProtKB/Swiss-Prot
  ENSMUSG00000069305 UniProtKB/Swiss-Prot
  ENSMUSG00000069306 UniProtKB/Swiss-Prot
  ENSMUSG00000091405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000096010 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087714.6 UniProtKB/Swiss-Prot
  ENSMUST00000102964.4 UniProtKB/Swiss-Prot
  ENSMUST00000102965.4 UniProtKB/Swiss-Prot
  ENSMUST00000102967.3 UniProtKB/Swiss-Prot
  ENSMUST00000102968.3 UniProtKB/Swiss-Prot
  ENSMUST00000102971.2 UniProtKB/Swiss-Prot
  ENSMUST00000102972.6 UniProtKB/Swiss-Prot
  ENSMUST00000102977.4 UniProtKB/Swiss-Prot
  ENSMUST00000102979.2 UniProtKB/Swiss-Prot
  ENSMUST00000102983.2 UniProtKB/Swiss-Prot
  ENSMUST00000104941.4 UniProtKB/Swiss-Prot
  ENSMUST00000171473 ENTREZGENE
  ENSMUST00000171473.3 UniProtKB/Swiss-Prot
  ENSMUST00000179285.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CENP-T/H4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H4_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAF_TATA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319155 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319157 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319158 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319161 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:320332 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:326619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:326620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:69386 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:97122 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2140113 ENTREZGENE
NCBI Gene 97122 ENTREZGENE
PANTHER HISTONE H4 UniProtKB/Swiss-Prot
  HISTONE H4 UniProtKB/Swiss-Prot
  HISTONE H4 UniProtKB/TrEMBL
  HISTONE H4 UniProtKB/TrEMBL
Pfam CENP-T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen H4c14 PhenoGen
PRINTS HISTONEH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HISTONE_H4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AUM5 ENTREZGENE
  A4FUP8 ENTREZGENE
  A4QMY0 ENTREZGENE
  B2RTM0 ENTREZGENE, UniProtKB/TrEMBL
  H4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VDL9 ENTREZGENE
  Q2M2Q5 ENTREZGENE
  Q5T006 ENTREZGENE
  Q6PDS7 ENTREZGENE
  Q811M0 ENTREZGENE
  Q9D0C9 ENTREZGENE
  Q9D6Q8 ENTREZGENE
UniProt Secondary A0AUM5 UniProtKB/Swiss-Prot
  A4FUP8 UniProtKB/Swiss-Prot
  A4QMY0 UniProtKB/Swiss-Prot
  P02304 UniProtKB/Swiss-Prot
  P02305 UniProtKB/Swiss-Prot
  Q0VDL9 UniProtKB/Swiss-Prot
  Q2M2Q5 UniProtKB/Swiss-Prot
  Q5T006 UniProtKB/Swiss-Prot
  Q6PDS7 UniProtKB/Swiss-Prot
  Q811M0 UniProtKB/Swiss-Prot
  Q9D0C9 UniProtKB/Swiss-Prot
  Q9D6Q8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-13 H4c14  H4 clustered histone 14  Hist2h4  histone cluster 2, H4  Symbol and/or name change 5135510 APPROVED