Ros1 (ROS proto-oncogene 1 , receptor tyrosine kinase) - Rat Genome Database

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Gene: Ros1 (ROS proto-oncogene 1 , receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Ros1
Name: ROS proto-oncogene 1 , receptor tyrosine kinase
RGD ID: 3591
Description: Predicted to enable protein phosphatase binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including columnar/cuboidal epithelial cell development; positive regulation of kinase activity; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; and regulation of phosphate transport. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase); INTERACTS WITH 1-naphthyl isothiocyanate; 2-acetamidofluorene; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; LOC103694423; proto-oncogene c-Ros; proto-oncogene c-Ros-1; proto-oncogene tyrosine-protein kinase ROS; proto-oncogene tyrosine-protein kinase ROS-like; Rat heart - derived c - ros - 1 proto - oncogene; receptor tyrosine kinase c-ros oncogene 1; Ros1 proto-oncogene; ROS1C; v-ros UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22031,432,636 - 31,583,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2031,432,637 - 31,583,865 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2032,427,520 - 32,581,179 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02031,818,427 - 31,972,078 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02032,559,314 - 32,709,237 (-)NCBIRnor_WKY
Rnor_6.02033,100,190 - 33,323,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2033,100,191 - 33,323,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02034,936,277 - 35,104,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02034,881,357 - 34,926,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42030,755,101 - 30,910,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12030,768,900 - 30,924,404 (-)NCBI
Celera2032,831,324 - 32,982,421 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Tissue-specific expression of rat c-ros-1 gene and partial structural similarity of its predicted products with sev protein of Drosophila melanogaster. Matsushime H and Shibuya M, J Virol 1990 May;64(5):2117-25.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
Additional References at PubMed
PMID:7854358   PMID:7970722   PMID:8675006   PMID:11266449   PMID:12773415   PMID:16885344   PMID:17187413   PMID:28770648  


Genomics

Comparative Map Data
Ros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22031,432,636 - 31,583,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2031,432,637 - 31,583,865 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2032,427,520 - 32,581,179 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02031,818,427 - 31,972,078 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02032,559,314 - 32,709,237 (-)NCBIRnor_WKY
Rnor_6.02033,100,190 - 33,323,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2033,100,191 - 33,323,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02034,936,277 - 35,104,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02034,881,357 - 34,926,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42030,755,101 - 30,910,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12030,768,900 - 30,924,404 (-)NCBI
Celera2032,831,324 - 32,982,421 (-)NCBICelera
Cytogenetic Map20q11NCBI
ROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386117,287,353 - 117,425,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6117,287,353 - 117,425,942 (-)EnsemblGRCh38hg38GRCh38
GRCh376117,608,516 - 117,747,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366117,716,223 - 117,853,711 (-)NCBINCBI36Build 36hg18NCBI36
Build 346117,716,222 - 117,853,711NCBI
Celera6118,352,446 - 118,489,916 (-)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6115,189,890 - 115,327,310 (-)NCBIHuRef
CHM1_16117,873,670 - 118,011,105 (-)NCBICHM1_1
T2T-CHM13v2.06118,471,267 - 118,609,847 (-)NCBIT2T-CHM13v2.0
Ros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391051,920,959 - 52,071,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1051,921,817 - 52,071,340 (-)EnsemblGRCm39 Ensembl
GRCm381052,044,863 - 52,195,398 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1052,045,721 - 52,195,244 (-)EnsemblGRCm38mm10GRCm38
MGSCv371051,765,732 - 51,915,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361051,734,341 - 51,883,659 (-)NCBIMGSCv36mm8
Celera1052,882,450 - 53,031,104 (-)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1026.18NCBI
Ros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955436524,854 - 636,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955436528,038 - 636,194 (-)NCBIChiLan1.0ChiLan1.0
ROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16119,238,419 - 119,376,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6119,238,419 - 119,376,053 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06115,095,753 - 115,234,525 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,555,278 - 57,677,541 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl157,555,989 - 57,677,761 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,350,186 - 58,478,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0157,737,166 - 57,858,909 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,737,370 - 57,859,071 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,631,666 - 57,759,473 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0157,479,365 - 57,601,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,114,541 - 58,232,431 (-)NCBIUU_Cfam_GSD_1.0
Ros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946108,274,580 - 108,400,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936658382,261 - 506,818 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936658382,025 - 506,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,410,351 - 44,534,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,409,877 - 44,535,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,755,363 - 49,864,460 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ROS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11356,412,451 - 56,561,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1356,413,298 - 56,562,503 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604028,749,526 - 28,898,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ros1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479812,339,446 - 12,449,316 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ros1
1287 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:220
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000000459
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

Markers in Region
RH94709  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22031,583,627 - 31,583,826 (+)MAPPERmRatBN7.2
Rnor_6.02033,323,130 - 33,323,328NCBIRnor6.0
Rnor_5.02035,104,143 - 35,104,341UniSTSRnor5.0
RGSC_v3.42030,910,367 - 30,910,565UniSTSRGSC3.4
Celera2032,982,184 - 32,982,382UniSTS
Cytogenetic Map20q11UniSTS
RH94708  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22031,432,757 - 31,432,914 (+)MAPPERmRatBN7.2
Rnor_6.02033,100,312 - 33,100,468NCBIRnor6.0
Rnor_5.02034,881,478 - 34,881,634UniSTSRnor5.0
RGSC_v3.42030,755,222 - 30,755,378UniSTSRGSC3.4
Celera2032,831,445 - 32,831,601UniSTS
Cytogenetic Map20q11UniSTS
RH140879  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02034,963,739 - 34,963,958NCBIRnor5.0
Rnor_5.0840,115,679 - 40,115,898NCBIRnor5.0
Rnor_5.02034,957,843 - 34,958,062NCBIRnor5.0
RGSC_v3.42030,831,872 - 30,832,090UniSTSRGSC3.4
RGSC_v3.4838,890,794 - 38,891,012UniSTSRGSC3.4
Celera2032,905,365 - 32,905,583UniSTS
Celera837,099,823 - 37,100,041UniSTS
RH 3.4 Map8344.3UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map8q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 43 8 8 3 8 8 10 31 9 11 8
Below cutoff 1 35 24 8 24 1 25 4 21

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000459   ⟹   ENSRNOP00000000459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2031,432,637 - 31,583,865 (-)Ensembl
Rnor_6.0 Ensembl2033,100,678 - 33,322,966 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080444   ⟹   ENSRNOP00000068996
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2031,432,637 - 31,583,865 (-)Ensembl
Rnor_6.0 Ensembl2033,100,191 - 33,323,367 (-)Ensembl
RefSeq Acc Id: NM_012874   ⟹   NP_037006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22031,432,637 - 31,583,865 (-)NCBI
Rnor_6.02033,100,191 - 33,323,367 (-)NCBI
Rnor_5.02034,881,357 - 34,926,189 (-)NCBI
Rnor_5.02034,936,277 - 35,104,380 (-)NCBI
RGSC_v3.42030,755,101 - 30,910,604 (-)RGD
Celera2032,831,324 - 32,982,421 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772862   ⟹   XP_008771084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22031,432,637 - 31,583,865 (-)NCBI
Rnor_6.02033,100,190 - 33,323,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098445   ⟹   XP_038954373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22031,432,636 - 31,583,996 (-)NCBI
RefSeq Acc Id: XM_039098447   ⟹   XP_038954375
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22031,433,121 - 31,583,997 (-)NCBI
RefSeq Acc Id: XM_039098448   ⟹   XP_038954376
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22031,433,121 - 31,545,672 (-)NCBI
RefSeq Acc Id: XM_039098449   ⟹   XP_038954377
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22031,433,121 - 31,541,223 (-)NCBI
RefSeq Acc Id: XR_005497176
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22031,438,113 - 31,583,998 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037006   ⟸   NM_012874
- Peptide Label: precursor
- UniProtKB: Q63131 (UniProtKB/Swiss-Prot),   Q63132 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008771084   ⟸   XM_008772862
- Peptide Label: isoform X3
- UniProtKB: Q63132 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068996   ⟸   ENSRNOT00000080444
RefSeq Acc Id: ENSRNOP00000000459   ⟸   ENSRNOT00000000459
RefSeq Acc Id: XP_038954373   ⟸   XM_039098445
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UPK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954375   ⟸   XM_039098447
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954376   ⟸   XM_039098448
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038954377   ⟸   XM_039098449
- Peptide Label: isoform X5
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63132-F1-model_v2 AlphaFold Q63132 1-2338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701627
Promoter ID:EPDNEW_R12146
Type:single initiation site
Name:Ros1_1
Description:ROS proto-oncogene 1 , receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02033,322,965 - 33,323,025EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3591 AgrOrtholog
BioCyc Gene G2FUF-3649 BioCyc
Ensembl Genes ENSRNOG00000000406 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000459 ENTREZGENE
  ENSRNOP00000000459.6 UniProtKB/TrEMBL
  ENSRNOP00000068996 ENTREZGENE
  ENSRNOP00000068996.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000459 ENTREZGENE
  ENSRNOT00000000459.6 UniProtKB/TrEMBL
  ENSRNOT00000080444 ENTREZGENE
  ENSRNOT00000080444.2 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25346 UniProtKB/Swiss-Prot
NCBI Gene 25346 ENTREZGENE
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Ros1 PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UH45_RAT UniProtKB/TrEMBL
  A0A8L2UPK7 ENTREZGENE, UniProtKB/TrEMBL
  Q63131 ENTREZGENE
  Q63132 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q63130 UniProtKB/Swiss-Prot
  Q63131 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ros1  ROS proto-oncogene 1 , receptor tyrosine kinase  LOC103694423  proto-oncogene tyrosine-protein kinase ROS-like  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103694423  proto-oncogene tyrosine-protein kinase ROS-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-07-10 Ros1  ROS proto-oncogene 1 , receptor tyrosine kinase  Ros1  c-ros oncogene 1 , receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-20 Ros1  c-ros oncogene 1 , receptor tyrosine kinase  Ros1  Ros1 proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-13 Ros1  Ros1 proto-oncogene  Ros1  v-ros UR2 sarcoma virus oncogene homolog 1 (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ros1  v-ros UR2 sarcoma virus oncogene homolog 1 (avian)    Rat heart - derived c - ros - 1 proto - oncogene  Name updated 629478 APPROVED
2002-06-10 Ros1  Rat heart - derived c - ros - 1 proto - oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 2,317 amino acids 633804
gene_transcript consists of different size transcripts in lung, kidney and heart which may arise from alternative splicing 633804