Ros1 (ROS proto-oncogene 1, receptor tyrosine kinase) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ros1 (ROS proto-oncogene 1, receptor tyrosine kinase) Heterocephalus glaber
Analyze
Symbol: Ros1
Name: ROS proto-oncogene 1, receptor tyrosine kinase
RGD ID: 18905504
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cell differentiation (ortholog); columnar/cuboidal epithelial cell development (ortholog); gene expression (ortholog); ASSOCIATED WITH disease of cellular proliferation (ortholog); Dwarfism (ortholog); esophageal cancer (ortholog); FOUND IN cell surface (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: c-ros oncogene 1 , receptor tyrosine kinase; Proto-oncogene tyrosine-protein kinase ROS
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479812,339,446 - 12,449,316 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ros1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479812,339,446 - 12,449,316 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
ROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386117,287,353 - 117,425,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6117,287,353 - 117,425,946 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh376117,608,516 - 117,747,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366117,716,223 - 117,853,711 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346117,716,222 - 117,853,711NCBI
Celera6118,352,446 - 118,489,916 (-)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6115,189,890 - 115,327,310 (-)NCBIHuRef
CHM1_16117,873,670 - 118,011,105 (-)NCBICHM1_1
T2T-CHM13v2.06118,471,267 - 118,609,847 (-)NCBIT2T-CHM13v2.0
Ros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391051,920,959 - 52,071,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1051,921,817 - 52,071,340 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381052,044,863 - 52,195,398 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1052,045,721 - 52,195,244 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371051,765,732 - 51,915,050 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361051,734,341 - 51,883,659 (-)NCBIMGSCv36mm8
Celera1052,882,450 - 53,031,104 (-)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1026.18NCBI
Ros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82031,975,328 - 32,126,675 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2031,975,329 - 32,126,547 (-)EnsemblGRCr8
mRatBN7.22031,432,636 - 31,583,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2031,432,637 - 31,583,865 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2032,427,520 - 32,581,179 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02031,818,427 - 31,972,078 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02032,559,314 - 32,709,237 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2031,995,513 - 32,146,729 (-)NCBI
Lyon_Normotensive2033,042,289 - 33,193,504 (-)NCBI
Lyon_Hypertensive2033,080,090 - 33,231,296 (-)NCBI
F344_StmMcwi2031,940,073 - 32,091,297 (-)NCBI
Rnor_6.02033,100,190 - 33,323,544 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2033,100,191 - 33,323,367 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.02034,936,277 - 35,104,380 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02034,881,357 - 34,926,189 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42030,755,101 - 30,910,604 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2032,831,324 - 32,982,421 (-)NCBICelera
RGSC_v3.12030,768,900 - 30,924,404 (-)NCBI
Cytogenetic Map20q11NCBI
Ros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955436524,854 - 636,338 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_004955436528,038 - 636,194 (-)NCBIChiLan1.0ChiLan1.0
ROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25137,301,307 - 137,440,050 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16135,194,174 - 135,333,045 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06115,095,753 - 115,234,525 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16119,238,419 - 119,376,053 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6119,238,419 - 119,376,053 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,555,278 - 57,677,541 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl157,555,989 - 57,677,761 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha158,350,186 - 58,478,059 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0157,737,166 - 57,858,909 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,737,370 - 57,859,071 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,631,666 - 57,759,473 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0157,479,365 - 57,601,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,114,541 - 58,232,431 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1844,967,789 - 45,093,085 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024404946108,274,580 - 108,400,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936658382,261 - 506,818 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936658382,025 - 506,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,410,351 - 44,534,874 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1144,409,877 - 44,535,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,755,363 - 49,864,460 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ROS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11341,447,864 - 41,596,493 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604028,749,526 - 28,898,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11356,412,451 - 56,561,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1356,413,298 - 56,562,503 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Ros1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11829,334,962 - 29,413,371 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_013077919   ⟹   XP_012933373
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479812,339,446 - 12,449,316 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012933373 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB06662 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012933373   ⟸   XM_013077919
- UniProtKB: A0AAX6R518 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Gene3D-CATH Immunoglobulins UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  TolB, C-terminal domain UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/TrEMBL
KEGG Report hgl:101715520 UniProtKB/TrEMBL
NCBI Gene Ros1 ENTREZGENE
PANTHER PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Fn3_ROS1 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Fibronectin type III UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0AAX6R518 ENTREZGENE, UniProtKB/TrEMBL