ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) - Rat Genome Database

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Gene: ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) Chlorocebus sabaeus
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Symbol: ROS1
Name: ROS proto-oncogene 1, receptor tyrosine kinase
RGD ID: 18341286
Description: ENCODES a protein that exhibits ATP binding (inferred); boss receptor activity (inferred); brain-derived neurotrophic factor receptor activity (inferred); INVOLVED IN gene expression (ortholog); negative regulation of gene expression (ortholog); peptidyl-tyrosine autophosphorylation (ortholog); ASSOCIATED WITH body dysmorphic disorder (ortholog); congenital disorder of glycosylation Iaa (ortholog); Dwarfism (ortholog); FOUND IN cell surface (inferred); membrane (inferred); perinuclear region of cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene tyrosine-protein kinase ROS
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11356,412,451 - 56,561,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1356,413,298 - 56,562,503 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604028,749,526 - 28,898,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ROS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11356,412,451 - 56,561,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1356,413,298 - 56,562,503 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604028,749,526 - 28,898,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386117,287,353 - 117,425,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6117,287,353 - 117,425,942 (-)EnsemblGRCh38hg38GRCh38
GRCh376117,608,516 - 117,747,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366117,716,223 - 117,853,711 (-)NCBINCBI36Build 36hg18NCBI36
Build 346117,716,222 - 117,853,711NCBI
Celera6118,352,446 - 118,489,916 (-)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6115,189,890 - 115,327,310 (-)NCBIHuRef
CHM1_16117,873,670 - 118,011,105 (-)NCBICHM1_1
T2T-CHM13v2.06118,471,267 - 118,609,847 (-)NCBIT2T-CHM13v2.0
Ros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391051,920,959 - 52,071,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1051,921,817 - 52,071,340 (-)EnsemblGRCm39 Ensembl
GRCm381052,044,863 - 52,195,398 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1052,045,721 - 52,195,244 (-)EnsemblGRCm38mm10GRCm38
MGSCv371051,765,732 - 51,915,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361051,734,341 - 51,883,659 (-)NCBIMGSCv36mm8
Celera1052,882,450 - 53,031,104 (-)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1026.18NCBI
Ros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82031,975,328 - 32,126,675 (-)NCBIGRCr8
mRatBN7.22031,432,636 - 31,583,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2031,432,637 - 31,583,865 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2032,427,520 - 32,581,179 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02031,818,427 - 31,972,078 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02032,559,314 - 32,709,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02033,100,190 - 33,323,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2033,100,191 - 33,323,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02034,936,277 - 35,104,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02034,881,357 - 34,926,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42030,755,101 - 30,910,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12030,768,900 - 30,924,404 (-)NCBI
Celera2032,831,324 - 32,982,421 (-)NCBICelera
Cytogenetic Map20q11NCBI
Ros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955436524,854 - 636,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955436528,038 - 636,194 (-)NCBIChiLan1.0ChiLan1.0
ROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25137,301,307 - 137,440,050 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16135,194,174 - 135,333,045 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06115,095,753 - 115,234,525 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16119,238,419 - 119,376,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6119,238,419 - 119,376,053 (-)Ensemblpanpan1.1panPan2
ROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,555,278 - 57,677,541 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl157,555,989 - 57,677,761 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,350,186 - 58,478,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0157,737,166 - 57,858,909 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,737,370 - 57,859,071 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,631,666 - 57,759,473 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0157,479,365 - 57,601,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,114,541 - 58,232,431 (-)NCBIUU_Cfam_GSD_1.0
Ros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946108,274,580 - 108,400,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936658382,261 - 506,818 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936658382,025 - 506,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,410,351 - 44,534,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,409,877 - 44,535,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,755,363 - 49,864,460 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ros1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479812,339,446 - 12,449,316 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
21 4 17 17 17 21 4

Sequence


Ensembl Acc Id: ENSCSAT00000013974   ⟹   ENSCSAP00000011955
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1356,413,298 - 56,562,503 (+)Ensembl
RefSeq Acc Id: XM_038000980   ⟹   XP_037856908
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604028,749,526 - 28,898,180 (+)NCBI
RefSeq Acc Id: XM_038000981   ⟹   XP_037856909
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604028,749,526 - 28,898,180 (+)NCBI
RefSeq Acc Id: XM_038000982   ⟹   XP_037856910
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604028,749,526 - 28,898,180 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037856908 (Get FASTA)   NCBI Sequence Viewer  
  XP_037856909 (Get FASTA)   NCBI Sequence Viewer  
  XP_037856910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011955.1
Ensembl Acc Id: ENSCSAP00000011955   ⟸   ENSCSAT00000013974
RefSeq Acc Id: XP_037856909   ⟸   XM_038000981
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RTL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037856910   ⟸   XM_038000982
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RTL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037856908   ⟸   XM_038000980
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RTL6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015976 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013974.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/TrEMBL
NCBI Gene ROS1 ENTREZGENE
PANTHER PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0A0D9RTL6 ENTREZGENE, UniProtKB/TrEMBL