Nherf2 (NHERF family PDZ scaffold protein 2) - Rat Genome Database

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Gene: Nherf2 (NHERF family PDZ scaffold protein 2) Rattus norvegicus
Analyze
Symbol: Nherf2
Name: NHERF family PDZ scaffold protein 2
RGD ID: 620380
Description: Enables low-density lipoprotein particle receptor binding activity and molecular adaptor activity. Involved in inner ear development and positive regulation of monoatomic ion transmembrane transport. Located in apical plasma membrane. Part of protein-containing complex. Biomarker of hypertension. Orthologous to human NHERF2 (NHERF family PDZ scaffold protein 2); PARTICIPATES IN parathyroid hormone signaling pathway; platelet-derived growth factor signaling pathway; aldosterone signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3karp; na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein; NHE3 kinase A regulatory protein E3KARP; NHERF-2; SIP-1; SLC9A3 regulator 2; Slc9a3r2; sodium-hydrogen exchanger regulatory factor 2; sodium/hydrogen exchanger; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; solute carrier family 9 isoform 3 regulator 2; solute carrier family 9 isoform A3 regulatory factor 2; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; SRY-interacting protein 1; TKA-1; tyrosine kinase activator protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,167,005 - 14,177,519 (-)NCBIGRCr8
mRatBN7.21013,662,461 - 13,672,975 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,662,461 - 13,673,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,409,255 - 18,419,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,898,101 - 17,908,626 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,397,300 - 13,407,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,003,330 - 14,015,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,003,320 - 14,013,870 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,820,310 - 13,830,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,890,293 - 13,900,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,891,061 - 13,900,879 (-)NCBI
Celera1013,342,543 - 13,353,058 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP)
Deoxycorticosterone acetate  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenthion  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chloride  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. Deval E, etal., J Biol Chem. 2006 Jan 20;281(3):1796-807. Epub 2005 Oct 17.
2. Ezrin-radixin-moesin-binding phosphoprotein 50 is expressed at the apical membrane of rat liver epithelia. Fouassier L, etal., Hepatology 2001 Jan;33(1):166-76.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The interaction between megalin and ClC-5 is scaffolded by the Na(+)-H(+) exchanger regulatory factor 2 (NHERF2) in proximal tubule cells. Hryciw DH, etal., Int J Biochem Cell Biol. 2012 May;44(5):815-23. doi: 10.1016/j.biocel.2012.02.007. Epub 2012 Feb 13.
6. Postnatal developmental expression of the PDZ scaffolds Na+ -H+ exchanger regulatory factors 1 and 2 in the rat cochlea. Kanjhan R, etal., Cell Tissue Res. 2006 Jan;323(1):53-70. Epub 2005 Sep 14.
7. Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats. Kobayashi K, etal., J Hypertens. 2004 Sep;22(9):1723-30.
8. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.
Additional References at PubMed
PMID:8889548   PMID:10410901   PMID:11786550   PMID:12169661   PMID:15115658   PMID:15143197   PMID:16456542   PMID:17048262   PMID:17242191   PMID:19056867   PMID:20720114   PMID:21423176  
PMID:23376485   PMID:23482569   PMID:23533145   PMID:23612977   PMID:24920589   PMID:25468996   PMID:26173747   PMID:28669731  


Genomics

Comparative Map Data
Nherf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,167,005 - 14,177,519 (-)NCBIGRCr8
mRatBN7.21013,662,461 - 13,672,975 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,662,461 - 13,673,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,409,255 - 18,419,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,898,101 - 17,908,626 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,397,300 - 13,407,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,003,330 - 14,015,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,003,320 - 14,013,870 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,820,310 - 13,830,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,890,293 - 13,900,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,891,061 - 13,900,879 (-)NCBI
Celera1013,342,543 - 13,353,058 (-)NCBICelera
Cytogenetic Map10q12NCBI
NHERF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,026,902 - 2,039,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,025,356 - 2,039,026 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,076,903 - 2,089,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,016,930 - 2,028,484 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,016,911 - 2,028,481NCBI
Celera162,289,067 - 2,301,134 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,001,109 - 2,013,254 (+)NCBIHuRef
CHM1_1162,076,850 - 2,089,007 (+)NCBICHM1_1
T2T-CHM13v2.0162,046,859 - 2,058,835 (+)NCBIT2T-CHM13v2.0
Nherf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,858,255 - 24,869,279 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,858,260 - 24,869,301 (-)EnsemblGRCm39 Ensembl
GRCm381724,639,281 - 24,650,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,639,286 - 24,650,327 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,776,227 - 24,787,250 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,366,888 - 24,377,878 (-)NCBIMGSCv36mm8
Celera1725,161,671 - 25,172,581 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.43NCBI
Nherf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,224,214 - 15,235,379 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,224,214 - 15,235,372 (-)NCBIChiLan1.0ChiLan1.0
NHERF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,307,556 - 2,319,737 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,089,244 - 6,101,377 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016664,310 - 676,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,121,215 - 2,127,069 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,115,583 - 2,127,069 (+)Ensemblpanpan1.1panPan2
NHERF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,905,070 - 38,915,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,905,635 - 38,942,774 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,144,686 - 40,155,043 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,214,038 - 39,216,647 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,213,735 - 39,216,642 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,898,838 - 38,909,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,871,153 - 38,881,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,349,958 - 39,360,323 (-)NCBIUU_Cfam_GSD_1.0
Nherf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,703,346 - 104,707,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,000,854 - 2,006,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,000,977 - 2,006,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHERF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,942,367 - 39,952,825 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,942,366 - 39,952,824 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,205,136 - 42,239,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NHERF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,923,773 - 1,935,641 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,924,131 - 1,939,062 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,129,026 - 29,140,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nherf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913210,315 - 221,538 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913210,315 - 220,936 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nherf2
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:117
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000004172
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat

Markers in Region
AA957994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,662,550 - 13,662,736 (+)MAPPERmRatBN7.2
Rnor_6.01014,003,420 - 14,003,605NCBIRnor6.0
Rnor_5.01013,820,400 - 13,820,585UniSTSRnor5.0
RGSC_v3.41013,890,383 - 13,890,568UniSTSRGSC3.4
Celera1013,342,633 - 13,342,818UniSTS
RH 3.4 Map10189.9UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004172   ⟹   ENSRNOP00000004172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,662,461 - 13,672,975 (-)Ensembl
Rnor_6.0 Ensembl1014,003,320 - 14,013,870 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094821   ⟹   ENSRNOP00000095231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,663,482 - 13,673,049 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097124   ⟹   ENSRNOP00000085544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,662,967 - 13,667,875 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098088   ⟹   ENSRNOP00000080200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,662,461 - 13,672,975 (-)Ensembl
RefSeq Acc Id: NM_053811   ⟹   NP_446263
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,167,005 - 14,177,519 (-)NCBI
mRatBN7.21013,662,461 - 13,672,975 (-)NCBI
Rnor_6.01014,003,330 - 14,013,844 (-)NCBI
Rnor_5.01013,820,310 - 13,830,824 (-)NCBI
RGSC_v3.41013,890,293 - 13,900,807 (-)RGD
Celera1013,342,543 - 13,353,058 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245893   ⟹   XP_006245955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,167,005 - 14,172,489 (-)NCBI
mRatBN7.21013,662,461 - 13,667,932 (-)NCBI
Rnor_6.01014,003,333 - 14,011,109 (-)NCBI
Rnor_5.01013,820,310 - 13,830,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085043   ⟹   XP_038940971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,167,005 - 14,172,973 (-)NCBI
mRatBN7.21013,662,461 - 13,668,446 (-)NCBI
RefSeq Acc Id: XM_039085044   ⟹   XP_038940972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,167,005 - 14,172,483 (-)NCBI
mRatBN7.21013,662,461 - 13,667,639 (-)NCBI
RefSeq Acc Id: NP_446263   ⟸   NM_053811
- UniProtKB: Q91Y70 (UniProtKB/Swiss-Prot),   Q920G2 (UniProtKB/Swiss-Prot),   G3V6D9 (UniProtKB/TrEMBL),   A6HCU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245955   ⟸   XM_006245893
- Peptide Label: isoform X1
- UniProtKB: A6HCU7 (UniProtKB/TrEMBL),   A0A8I6A0E3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004172   ⟸   ENSRNOT00000004172
RefSeq Acc Id: XP_038940971   ⟸   XM_039085043
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A0E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940972   ⟸   XM_039085044
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A0E3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095231   ⟸   ENSRNOT00000094821
Ensembl Acc Id: ENSRNOP00000080200   ⟸   ENSRNOT00000098088
Ensembl Acc Id: ENSRNOP00000085544   ⟸   ENSRNOT00000097124
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920G2-F1-model_v2 AlphaFold Q920G2 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697018
Promoter ID:EPDNEW_R7543
Type:multiple initiation site
Name:Slc9a3r2_1
Description:SLC9A3 regulator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,013,924 - 14,013,984EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620380 AgrOrtholog
BioCyc Gene G2FUF-25843 BioCyc
Ensembl Genes ENSRNOG00000002997 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004172.5 UniProtKB/TrEMBL
  ENSRNOT00000094821.1 UniProtKB/TrEMBL
  ENSRNOT00000097124.1 UniProtKB/TrEMBL
  ENSRNOT00000098088.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EBP50_C-term UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHERF-1/NHERF-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116501 ENTREZGENE
PANTHER PDZ DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14191:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EBP50_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nherf2 PhenoGen
PIRSF EBP50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002997 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPM4_RAT UniProtKB/TrEMBL
  A0A8I6A0E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANC3_RAT UniProtKB/TrEMBL
  A6HCU6 ENTREZGENE, UniProtKB/TrEMBL
  A6HCU7 ENTREZGENE, UniProtKB/TrEMBL
  G3V6D9 ENTREZGENE, UniProtKB/TrEMBL
  NHRF2_RAT UniProtKB/Swiss-Prot
  Q91Y70 ENTREZGENE
  Q920G2 ENTREZGENE
UniProt Secondary Q91Y70 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-11-28 Nherf2  NHERF family PDZ scaffold protein 2  Slc9a3r2  SLC9A3 regulator 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-24 Slc9a3r2  SLC9A3 regulator 2  Slc9a3r2  solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc9a3r2  solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2  Slc9a3r2  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Slc9a3r2  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2  Slc9a3r2  solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc9a3r2  solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc9a3r2  solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the hepatocytes and cholangiocytes; distributed distinctly in the cytoplasm and nucleus 634170
gene_physical_interaction binds Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 (EBP50) by utilizing 2 PSD-95/DIg/ZO-1 (PDZ) domains and an ERM binding site 634170
gene_process regulates ion-transport in the liver epithelia 634170
gene_product member of the ERM family 634170