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Gene: Slc9a3r2 (SLC9A3 regulator 2) Rattus norvegicus
Symbol: Slc9a3r2
Name: SLC9A3 regulator 2
Description: Exhibits low-density lipoprotein particle receptor binding activity; molecular adaptor activity; and protein N-terminus binding activity. Involved in inner ear development and positive regulation of ion transmembrane transport. Localizes to apical plasma membrane; nucleus; and protein-containing complex. Biomarker of hypertension. Orthologous to human SLC9A3R2 (SLC9A3 regulator 2); PARTICIPATES IN parathyroid hormone signaling pathway; platelet-derived growth factor signaling pathway; aldosterone signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3karp; na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein; NHE3 kinase A regulatory protein E3KARP; NHERF-2; SIP-1; sodium-hydrogen exchanger regulatory factor 2; sodium/hydrogen exchanger; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; solute carrier family 9 isoform 3 regulator 2; solute carrier family 9 isoform A3 regulatory factor 2; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; SRY-interacting protein 1; TKA-1; tyrosine kinase activator protein 1
Homo sapiens (human) : SLC9A3R2 (SLC9A3 regulator 2)  HGNC  Alliance
Mus musculus (house mouse) : Slc9a3r2 (solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc9a3r2 (SLC9A3 regulator 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC9A3R2 (SLC9A3 regulator 2)
Canis lupus familiaris (dog) : SLC9A3R2 (SLC9A3 regulator 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc9a3r2 (SLC9A3 regulator 2)
Sus scrofa (pig) : SLC9A3R2 (SLC9A3 regulator 2)
Chlorocebus sabaeus (African green monkey) : SLC9A3R2 (SLC9A3 regulator 2)
Heterocephalus glaber (naked mole-rat) : Slc9a3r2 (SLC9A3 regulator 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01014,003,330 - 14,015,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,003,320 - 14,013,870 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,820,310 - 13,830,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,890,293 - 13,900,807 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11013,891,061 - 13,900,879 (-)NCBI
Celera1013,342,543 - 13,353,058 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc9a3r2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620380
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.