LRP2 (LDL receptor related protein 2) - Rat Genome Database

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Gene: LRP2 (LDL receptor related protein 2) Sus scrofa
Analyze
Symbol: LRP2
Name: LDL receptor related protein 2
RGD ID: 14280699
Description: ENCODES a protein that exhibits amyloid-beta binding; protein-folding chaperone binding; calcium ion binding (ortholog); INVOLVED IN positive regulation of lysosomal protein catabolic process; receptor-mediated endocytosis; amyloid-beta clearance (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH 46, XY Disorders of Sex Development (ortholog); acute kidney failure (ortholog); Albuminuria (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); axonal growth cone (ortholog); INTERACTS WITH cadmium dichloride; chenodeoxycholic acid; cholic acid
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low-density lipoprotein receptor-related protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,303 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
animal organ regeneration  (ISO)
aorta development  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to growth factor stimulus  (ISO)
chemoattraction of axon  (ISO)
coronary artery morphogenesis  (IEA,ISS)
coronary vasculature development  (IEA,ISO)
diol metabolic process  (IEA,ISO)
endocytic hemoglobin import into cell  (ISO)
endocytosis  (IEA,ISO)
endosomal transport  (ISO)
folate import across plasma membrane  (IEA,ISS)
forebrain development  (IEA,ISO)
heart development  (IEA,ISO)
kidney development  (IEA,ISO)
male gonad development  (IEA,ISS)
metal ion transport  (IEA,ISS)
metanephric proximal tubule development  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISS)
nervous system development  (IEA)
neural tube closure  (IEA,ISS)
neuron projection arborization  (IEA,ISS)
outflow tract septum morphogenesis  (IEA,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of endocytosis  (ISO)
positive regulation of lipoprotein transport  (ISO)
positive regulation of lysosomal protein catabolic process  (IDA)
positive regulation of neurogenesis  (IEA,ISS)
positive regulation of oligodendrocyte progenitor proliferation  (IEA,ISS)
protein import  (ISO)
protein transport  (IEA)
pulmonary artery morphogenesis  (IEA,ISS)
receptor-mediated endocytosis  (IEA,IGI,ISO,ISS)
response to leptin  (IEA)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
secondary heart field specification  (IEA,ISS)
sensory perception of sound  (IEA,ISS)
transcytosis  (ISO)
vagina development  (IEA,ISS)
ventricular compact myocardium morphogenesis  (IEA,ISS)
ventricular septum development  (IEA,ISO)
vitamin D metabolic process  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9228033   PMID:11964399   PMID:14681463   PMID:17121993   PMID:17145712   PMID:22301074   PMID:29871929  


Genomics

Comparative Map Data
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,303 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382169,127,109 - 169,362,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
T2T-CHM13v2.02169,602,803 - 169,838,534 (-)NCBIT2T-CHM13v2.0
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)EnsemblGRCm39 Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBIMGSCv36mm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,597,148 - 74,754,535 (-)NCBIGRCr8
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,588,938 - 57,746,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,172,509 - 66,330,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,935,221 - 64,092,679 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,791,193 - 72,028,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,806,164 - 72,043,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3614,025,608 - 14,223,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBIUU_Cfam_GSD_1.0
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,244,881 - 10,438,935 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,798,938 - 6,998,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LRP2
3123 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 2 3 3 5 13 1
Below cutoff 8 1 2 10 1

Sequence


RefSeq Acc Id: ENSSSCT00000061421   ⟹   ENSSSCP00000049411
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1575,565,303 - 75,716,694 (-)Ensembl
RefSeq Acc Id: XM_021076311   ⟹   XP_020931970
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020931970 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein C0HL13 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000049411
  ENSSSCP00000049411.2
  ENSSSCP00030008711.1
  ENSSSCP00030008722.1
  ENSSSCP00035026366.1
  ENSSSCP00035026395.1
  ENSSSCP00035026419.1
RefSeq Acc Id: XP_020931970   ⟸   XM_021076311
- UniProtKB: C0HL13 (UniProtKB/Swiss-Prot),   A0A480QS49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000049411   ⟸   ENSSSCT00000061421
Protein Domains
EGF-like   LDL-receptor class A


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030014082 UniProtKB/TrEMBL
  ENSSSCG00035048818 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061421 ENTREZGENE
  ENSSSCT00000061421.3 UniProtKB/TrEMBL
  ENSSSCT00030019588.1 UniProtKB/TrEMBL
  ENSSSCT00030019613.1 UniProtKB/TrEMBL
  ENSSSCT00035065143.1 UniProtKB/TrEMBL
  ENSSSCT00035065192.1 UniProtKB/TrEMBL
  ENSSSCT00035065239.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type module UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene LRP2 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AZ36_PIG UniProtKB/TrEMBL
  A0A480QS49 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0VPV4_PIG UniProtKB/TrEMBL
  A0A8D1ABE9_PIG UniProtKB/TrEMBL
  A0A8D1ABH8_PIG UniProtKB/TrEMBL
  A0A8D1C0I7_PIG UniProtKB/TrEMBL
  A0A8D1CWI3_PIG UniProtKB/TrEMBL
  C0HL13 ENTREZGENE, UniProtKB/Swiss-Prot