LRP2 (LDL receptor related protein 2) - Rat Genome Database
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Gene: LRP2 (LDL receptor related protein 2) Sus scrofa
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Symbol: LRP2
Name: LDL receptor related protein 2
RGD ID: 14280699
Description: ENCODES a protein that exhibits chaperone binding; calcium ion binding (ortholog); hemoglobin binding (ortholog); INVOLVED IN positive regulation of lysosomal protein catabolic process; receptor-mediated endocytosis; aging (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); autoimmune thyroiditis (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon (ortholog); INTERACTS WITH cadmium dichloride; chenodeoxycholic acid; cholic acid
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 2; low-density lipoprotein receptor-related protein 2
Orthologs:
Homo sapiens (human) : LRP2 (LDL receptor related protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Lrp2 (low density lipoprotein receptor-related protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrp2 (LDL receptor related protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp2 (LDL receptor related protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP2 (LDL receptor related protein 2)
Canis lupus familiaris (dog) : LRP2 (LDL receptor related protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp2 (LDL receptor related protein 2)
Chlorocebus sabaeus (African green monkey) : LRP2 (LDL receptor related protein 2)
Heterocephalus glaber (naked mole-rat) : Lrp2 (LDL receptor related protein 2)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,301 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta clearance  (ISO)
animal organ regeneration  (ISO)
aorta development  (IEA)
cell population proliferation  (IEA)
cellular response to growth factor stimulus  (ISO)
chemoattraction of axon  (ISO)
coronary artery morphogenesis  (IEA,ISS)
coronary vasculature development  (ISO)
endocytic hemoglobin import into cell  (ISO)
endocytosis  (ISO)
endosomal transport  (ISO)
folate import across plasma membrane  (IEA,ISS)
forebrain development  (IEA)
heart development  (ISO)
hormone secretion  (ISO)
kidney development  (IEA)
male gonad development  (IEA,ISS)
metal ion transport  (IEA,ISS)
negative regulation of apoptotic process  (IEA)
negative regulation of BMP signaling pathway  (IEA,ISS)
neural tube closure  (IEA,ISS)
neuron projection arborization  (IEA,ISS)
outflow tract septum morphogenesis  (IEA,ISS)
positive regulation of endocytosis  (ISO)
positive regulation of lipoprotein transport  (ISO)
positive regulation of lysosomal protein catabolic process  (IDA)
positive regulation of neurogenesis  (ISS)
positive regulation of oligodendrocyte progenitor proliferation  (IEA,ISS)
positive regulation of protein kinase B signaling  (IEA)
protein transport  (IEA)
pulmonary artery morphogenesis  (IEA,ISS)
receptor-mediated endocytosis  (IEA,IGI,ISS)
response to drug  (ISO)
response to leptin  (IEA)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to X-ray  (ISO)
secondary heart field specification  (IEA,ISS)
sensory perception of sound  (IEA,ISS)
transcytosis  (ISO)
vagina development  (IEA,ISS)
ventricular compact myocardium morphogenesis  (IEA,ISS)
ventricular septum development  (IEA)
vitamin metabolic process  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9228033   PMID:11964399   PMID:14681463   PMID:17121993   PMID:17145712   PMID:29871929  


Genomics

Comparative Map Data
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,301 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh382169,127,109 - 169,362,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBI
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBImm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0panPan3
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)Ensembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBI
Lrp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 2 3 3 5 13 1
Below cutoff 8 1 2 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000061421   ⟹   ENSSSCP00000049411
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1575,565,301 - 75,716,694 (-)Ensembl
RefSeq Acc Id: XM_021076311   ⟹   XP_020931970
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020931970 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein C0HL13 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020931970   ⟸   XM_021076311
- Sequence:
RefSeq Acc Id: ENSSSCP00000049411   ⟸   ENSSSCT00000061421
Protein Domains
EGF-like   LDL-receptor class A


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000049411 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061421 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene LRP2 ENTREZGENE
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.4289 ENTREZGENE
UniProt A0A287AZ36_PIG UniProtKB/TrEMBL
  C0HL13 ENTREZGENE, UniProtKB/Swiss-Prot