RGD Reference Report - Proximal tubule Na transporter responses are the same during acute and chronic hypertension. - Rat Genome Database

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Proximal tubule Na transporter responses are the same during acute and chronic hypertension.

Authors: Magyar, CE  Zhang, Y  Holstein-Rathlou, NH  McDonough, AA 
Citation: Magyar CE, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F358-69.
RGD ID: 1641827
Pubmed: PMID:10919857   (View Abstract at PubMed)

Acute hypertension in Sprague-Dawley rats (SD) provokes a decrease in renal proximal tubule (PT) salt and fluid reabsorption, redistribution of apical Na/H exchanger isoform 3 (NHE3) and Na-P(i) cotransporter type 2 (NaPi2) out of the brush border into higher density membranes, and inhibition of renal cortical Na-K-ATPase (NKA) activity (41). The aims of this study were to determine 1) whether an increase in arterial pressure affects distribution or activity of Na transporters in the spontaneously hypertensive rat (SHR) and 2) whether development of chronic hypertension in SHR leads to persistent adaptive changes in NHE3 and NaPi2 distribution and/or NKA activity. Renal cortex Na transporter protein density distributions and activities were compared by subcellular fractionation in 1) adult SHR with an acute increase or decrease in arterial pressure and 2) young SD (YSD) and young SHR (YSHR) vs. adult SD and SHR. In adult hypertensive SHR NHE3 was shifted to membranes of higher densities, analogous to SD with acute hypertension, and there were no further changes with a further increase or decrease in arterial pressure. There was no change in total pool size of NHE3 in cortex in YSHR vs. SHR. NHE3, NaPi2, megalin, NKA alpha-/beta-subunit, dipeptidyl peptidase IV (DPPIV), and villin distributions were the same in YSHR vs. YSD. NHE3, NaPi2, and megalin shifted to higher densities in adult SHR, but not SD, with age. Basolateral NKA and apical alkaline phosphatase activities were 40% greater in YSHR than YSD and decreased to SD levels in adults. We conclude that there are persistent changes in Na(+) transporter distributions and activity in response to chronic hypertension in SHR that mimic the responses to acute hypertension seen in SD rats and that elevated sodium pump activity per transporter in YSHR may contribute to the generation of hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LRP2Humanhypertension  ISOLrp2 (Rattus norvegicus)protein:altered localization:apical plasma membraneRGD 
Lrp2Rathypertension  IDA protein:altered localization:apical plasma membraneRGD 
Lrp2Mousehypertension  ISOLrp2 (Rattus norvegicus)protein:altered localization:apical plasma membraneRGD 
LRP2Humanmembranous glomerulonephritis  ISOLrp2 (Rattus norvegicus)mRNA:decreased expression:glomerulusRGD 
Lrp2Ratmembranous glomerulonephritis  IEP mRNA:decreased expression:glomerulusRGD 
Lrp2Mousemembranous glomerulonephritis  ISOLrp2 (Rattus norvegicus)mRNA:decreased expression:glomerulusRGD 
LRP2Humannephrosis  ISOLrp2 (Rattus norvegicus)mRNA:decreased expression:glomerulusRGD 
Lrp2Ratnephrosis  IEP mRNA:decreased expression:glomerulusRGD 
Lrp2Mousenephrosis  ISOLrp2 (Rattus norvegicus)mRNA:decreased expression:glomerulusRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Lrp2Ratapical plasma membrane  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lrp2  (LDL receptor related protein 2)

Genes (Mus musculus)
Lrp2  (low density lipoprotein receptor-related protein 2)

Genes (Homo sapiens)
LRP2  (LDL receptor related protein 2)


Additional Information