Gh1 (growth hormone 1) - Rat Genome Database

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Gene: Gh1 (growth hormone 1) Rattus norvegicus
Analyze
Symbol: Gh1
Name: growth hormone 1
RGD ID: 2686
Description: Enables hormone activity. Involved in several processes, including cellular response to alkaline pH; cellular response to thyroid hormone stimulus; and positive regulation of steroid hormone biosynthetic process. Located in several cellular components, including collagen-containing extracellular matrix; mitochondrion; and secretory granule. Used to study isolated growth hormone deficiency and type 1 diabetes mellitus. Biomarker of congenital hypothyroidism; osteoporosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gh; Ghb1; growth hormone b1; RNGHGP; somatotropin
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Alliance Genes
More Info more info ...
Allele / Splice: Gh1sdr  
Genetic Models: SDR/Slc
Is Marker For: QTLs:   Bp1   Cia5   Bp134  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21091,228,102 - 91,230,079 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1091,228,103 - 91,230,078 (-)Ensembl
Rnor_6.01094,486,204 - 94,488,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,486,205 - 94,488,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,237,414 - 94,239,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,692,240 - 95,694,117 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11095,708,476 - 95,710,261 (-)NCBI
Celera1089,903,834 - 89,905,811 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-trifluoroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxybutyric acid  (ISO)
4-nonylphenol  (EXP)
4-octylphenol  (EXP)
4-tert-Octylphenol  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (EXP)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apomorphine  (ISO)
arsenous acid  (EXP,ISO)
ATP  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bromocriptine  (ISO)
butan-1-ol  (ISO)
butan-2-ol  (ISO)
butyric acid  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
CGP 12177  (EXP)
chlormequat chloride  (EXP)
chromium(6+)  (EXP)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
corticotropin  (ISO)
cortisol  (ISO)
cypermethrin  (EXP)
cyproheptadine  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
disulfiram  (EXP)
dobutamine  (EXP)
doxorubicin  (EXP)
enalapril  (ISO)
endosulfan  (EXP)
estriol  (EXP)
ethanol  (ISO)
ethylbenzene  (EXP)
ethylene glycol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
fenvalerate  (EXP)
formaldehyde  (EXP)
fulvestrant  (EXP)
glucose  (ISO)
Guanfacine  (ISO)
homocysteine  (ISO)
hydrogen sulfide  (ISO)
idazoxan  (EXP)
ionomycin  (ISO)
L-ascorbic acid  (EXP)
lead nitrate  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP)
maneb  (ISO)
mephenytoin  (ISO)
monosodium L-glutamate  (EXP)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-N-nitrosourea  (EXP)
naproxen  (EXP)
nicotinic acid  (ISO)
Nivalenol  (EXP)
octreotide  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paraquat  (ISO)
PCB138  (EXP)
pentetic acid  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
phenylarsine oxide  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
propan-1-ol  (ISO)
propan-2-ol  (ISO)
propane-1,2-diol  (ISO)
pyridoxal 5'-phosphate  (EXP)
raloxifene  (ISO)
resveratrol  (EXP)
SB 203580  (EXP)
sirtinol  (EXP)
sodium atom  (EXP,ISO)
sulpiride  (EXP)
sumatriptan  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tert-butanol  (ISO)
testosterone  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Recombinant human growth hormone treatment in children with thalassemia major. Arcasoy A, etal., Pediatr Int. 1999 Dec;41(6):655-61.
2. Cortistatin and pituitary hormone secretion in rat. Baranowska B, etal., J Physiol Pharmacol. 2009 Mar;60(1):151-6.
3. Evaluation of anterior pituitary function in patients with posttraumatic diabetes insipidus. Barreca T, etal., J Clin Endocrinol Metab. 1980 Dec;51(6):1279-82.
4. Macrophage epoxygenase determines a profibrotic transcriptome signature. Behmoaras J, etal., J Immunol. 2015 May 15;194(10):4705-16. doi: 10.4049/jimmunol.1402979. Epub 2015 Apr 3.
5. Growth hormone-dependent changes in the rat lung proteome during alveorization. Beyea JA, etal., Mol Cell Biochem. 2009 Jan;321(1-2):197-204. Epub 2008 Nov 5.
6. Identification of novel GHRHR and GH1 mutations in patients with isolated growth hormone deficiency. Birla S, etal., Growth Horm IGF Res. 2016 Aug;29:50-6. doi: 10.1016/j.ghir.2016.04.001. Epub 2016 Apr 16.
7. Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. Bouillon R Verh K Acad Geneeskd Belg. 1992;54(4):365-91; discussion 391-2.
8. Effect of high-fat diet on body composition and hormone responses to glucose tolerance tests. Brown JL, etal., Endocrine 2002 Dec;19(3):327-32.
9. Effects of growth hormone secretagogues on prolactin release in anesthetized dwarf (dw/dw) rats. Carmignac DF, etal., Endocrinology. 1998 Aug;139(8):3590-6.
10. Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining. Castagnino HE, etal., Neuro Endocrinol Lett. 2002 Oct-Dec;23(5-6):391-5.
11. Growth hormone receptor immunoreactivity is increased in the subventricular zone of juvenile rat brain after focal ischemia: a potential role for growth hormone in injury-induced neurogenesis. Christophidis LJ, etal., Growth Horm IGF Res. 2009 Dec;19(6):497-506. Epub 2009 Jun 12.
12. Novel neuronal and endocrine autoantibody targets in Autoimmune Polyendocrine Syndrome type 1. Cocco C, etal., Autoimmunity. 2012 Sep;45(6):485-94. doi: 10.3109/08916934.2012.680632. Epub 2012 May 18.
13. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Colon E, etal., Endocrinology. 2007 Jan;148(1):128-39. Epub 2006 Oct 5.
14. Hormones in the nucleus of mast cells: confocal microscopic immunocytochemical observations. Csaba G and Kovacs P, Horm Metab Res. 2009 Aug;41(8):621-5. Epub 2009 Apr 15.
15. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
16. Effects of physical training on serum and pituitary growth hormone contents in diabetic rats. de Almeida Leme JA, etal., Pituitary. 2009;12(4):304-8. Epub 2009 Apr 16.
17. Dynamics of growth hormone secretion in patients with osteoporosis and in patients with osteoarthrosis. Dequeker J, etal., Horm Res. 1982;16(6):353-6.
18. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Ekenstedt KJ, etal., Arthritis Rheum. 2006 Dec;54(12):3850-8.
19. The pregnancy-induced increase in baseline circulating growth hormone in rats is not induced by ghrelin. El-Kasti MM, etal., J Neuroendocrinol. 2008 Mar;20(3):309-22. Epub 2008 Jan 16.
20. Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. Flavell DM, etal., EMBO J. 1996 Aug 1;15(15):3871-9.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Growth factors and glucose homeostasis in diabetic rats: effects of exercise training. Gomes RJ, etal., Cell Biochem Funct. 2009 Apr 20.
24. [Experimental and clinical studies of recombinant human growth hormone treatement of hypoproteinemia of liver cirrhosis patients]. Guo X, etal., Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2001 Dec;15(4):339-41.
25. Effects of recombinant human growth hormone (r-hGH) on experimental osteoporotic fracture healing. Hao Y, etal., Chin J Traumatol. 2001 May;4(2):102-5.
26. Growth hormone and somatomedin in insulin-dependent diabetes mellitus. Horner JM, etal., J Clin Endocrinol Metab. 1981 Dec;53(6):1148-53.
27. Growth hormone improves short stature in children with Diamond-Blackfan anemia. Howell JC, etal., Pediatr Blood Cancer. 2015 Mar;62(3):402-8. doi: 10.1002/pbc.25341. Epub 2014 Dec 9.
28. Modulation of rat pituitary growth hormone by 670 nm light. Hymer WC, etal., Growth Horm IGF Res. 2009 Jun;19(3):274-9. Epub 2008 Dec 16.
29. Age-related changes in the dorsal skin histology in Mini and Wistar rats. Ikawa A, etal., Histol Histopathol 2002 Apr;17(2):419-26.
30. Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-kappaB and phosphatidylinositol 3-kinase. Jeay S, etal., Endocrinology 2001 Jan;142(1):147-56.
31. Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylation. Ji S, etal., J Biol Chem 2002 Aug 9;277(32):28384-93.
32. Functional expression of CXCR4 in somatotrophs: CXCL12 activates GH gene, GH production and secretion, and cellular proliferation. Lee Y, etal., J Endocrinol. 2008 Nov;199(2):191-9. Epub 2008 Aug 27.
33. Growth hormone response following growth hormone releasing hormone injection in thalassemia major: influence of pubertal development. Leheup BP, etal., J Endocrinol Invest. 1991 Jan;14(1):37-40.
34. [Effect of recombinant human growth hormone on hypoalbuminemia in peritoneal sepsis: experimental and clinical research]. Li W, etal., Zhonghua Yi Xue Za Zhi. 1998 Jun;78(6):413-5.
35. Effect of growth hormone-releasing stimuli in streptozotocin diabetic rats. Locatelli V, etal., Brain Res. 1985 Aug 19;341(1):35-40.
36. High levels of growth hormone and human placental lactogen in pregnancy complicated by diabetes. Lopez-Espinoza I, etal., Diabetes Res. 1986 Mar;3(3):119-25.
37. A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD). Madeira JL, etal., Eur J Endocrinol. 2016 Aug;175(2):K7-K15. doi: 10.1530/EJE-15-0149. Epub 2016 Jun 1.
38. Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Marino G, etal., Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16268-73. doi: 10.1073/pnas.1002696107. Epub 2010 Aug 30.
39. Regulation of rat growth hormone receptor gene expression. Mathews LS, etal., J Biol Chem 1989 Jun 15;264(17):9905-10.
40. Growth retardation in rats whose growth hormone gene expression was suppressed by antisense RNA transgene. Matsumoto K, etal., Mol Reprod Dev. 1993 Sep;36(1):53-8.
41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
42. Distinct neuronal growth hormone receptor ligand specificity in the rat brain. Moderscheim TA, etal., Brain Res. 2007 Mar 16;1137(1):29-34. Epub 2006 Dec 20.
43. Suppressed spontaneous secretion of growth hormone in girls after treatment for acute lymphoblastic leukaemia. Moell C, etal., Arch Dis Child. 1989 Feb;64(2):252-8.
44. Isolated growth hormone deficiency in Chilean patients: clinical and molecular analysis. Molina G, etal., J Pediatr Endocrinol Metab. 2003 Oct-Nov;16(8):1143-55.
45. Growth hormone kinetics in diabetic patients. Navalesi R, etal., Diabetes. 1975 Apr;24(4):317-27.
46. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. Studies on prolactin and growth hormone gene expression in the pituitary gland of spontaneous dwarf rats. Nogami H, etal., Endocrinology. 1989 Aug;125(2):964-70.
48. Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor. Okazaki K, etal., Endocrinology. 1999 Oct;140(10):4821-30.
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
51. Growth hormone activity in mitochondria depends on GH receptor Box 1 and involves caveolar pathway targeting. Perret-Vivancos C, etal., Exp Cell Res. 2006 Feb 1;312(3):215-32.
52. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
53. Retinal laser photocoagulation in diabetic patients causes prolactin, growth hormone and cortisol release. Pontiroli AE, etal., J Endocrinol Invest. 1988 May;11(5):389-91.
54. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
55. GOA pipeline RGD automated data pipeline
56. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
57. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
58. Comprehensive gene review and curation RGD comprehensive gene curation
59. Discrimination between signaling pathways in regulation of specific gene expression by insulin and growth hormone in hepatocytes. Ribaux P, etal., Endocrinology 2002 Oct;143(10):3766-72.
60. Rat mammary carcinoma regressions during suppression of serum growth hormone and prolactin. Rose DP, etal., Anticancer Res. 1983 Sep-Oct;3(5):323-5.
61. Effect of recombinant human growth hormone on peripheral nerve regeneration: experimental work on the ulnar nerve of the rat. Saceda J, etal., Neurosci Lett. 2011 Oct 24;504(2):146-50. doi: 10.1016/j.neulet.2011.09.020. Epub 2011 Sep 17.
62. Growth hormone attenuates skeletal muscle changes in experimental chronic heart failure. Santos DP, etal., Growth Horm IGF Res. 2010 Apr;20(2):149-55. doi: 10.1016/j.ghir.2009.11.007. Epub 2010 Jan 8.
63. Growth hormone responsiveness in vivo and in vitro to growth hormone releasing factor in the spontaneously diabetic BB Wistar rat. Serri O and Brazeau P, Neuroendocrinology. 1987 Aug;46(2):162-6.
64. Advanced rat mammary cancers are growth hormone dependent. Shen Q, etal., Endocrinology. 2007 Oct;148(10):4536-44. Epub 2007 Jun 21.
65. Pituitary growth hormone secretory granules in streptozotocin-induced diabetic rats. Shiino M and Ishibashi T, Histol Histopathol. 1988 Jul;3(3):263-8.
66. Thyroid hormone and apotransferrin regulation of growth hormone secretion by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium. Sirbasku DA, etal., In Vitro Cell Dev Biol. 1992 Jan;28A(1):67-71.
67. Effect of long-term administration of recombinant human growth hormone (rhGH) on plasma erythropoietin (EPO) and haemoglobin levels in anaemic patients with adult GH deficiency. Sohmiya M and Kato Y, Clin Endocrinol (Oxf). 2001 Dec;55(6):749-54.
68. Effects of sericin on the testicular growth hormone/insulin-like growth factor-1 axis in a rat model of type 2 diabetes. Song CJ, etal., Int J Clin Exp Med. 2015 Jul 15;8(7):10411-9. eCollection 2015.
69. Biologically inactive growth hormone caused by an amino acid substitution. Takahashi Y, etal., J Clin Invest. 1997 Sep 1;100(5):1159-65.
70. Molecular mechanism of growth hormone (GH) deficiency in the spontaneous dwarf rat: detection of abnormal splicing of GH messenger ribonucleic acid by the polymerase chain reaction. Takeuchi T, etal., Endocrinology. 1990 Jan;126(1):31-8.
71. Changes in growth hormone (GH), GH receptor, and GH signal transduction in hippocampus of congenital hypothyroid rats. Tang H, etal., J Neurosci Res. 2011 Feb;89(2):248-55. doi: 10.1002/jnr.22540. Epub 2010 Dec 8.
72. Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: effect of a growth hormone receptor antagonist. Thirone AC, etal., Diabetes 2002 Jul;51(7):2270-81.
73. Effects of intravenous TRH on growth hormone and cortisol serum levels in children and adolescents with insulin dependent diabetes mellitus. Vanelli M, etal., J Endocrinol Invest. 1986 Aug;9(4):293-7.
74. Growth hormone gene expression and secretion in aging rats is age dependent and not age-associated weight increase related. Velasco B, etal., Endocrinology. 1998 Mar;139(3):1314-20. doi: 10.1210/endo.139.3.5779.
75. The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly. Wassenaar MJ, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4671-8. doi: 10.1210/jc.2009-1172. Epub 2009 Oct 28.
76. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
77. Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes. Weigent DA Cell Immunol. 2013 Mar;282(1):9-16. doi: 10.1016/j.cellimm.2013.03.007. Epub 2013 Apr 11.
78. Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Wolf N, etal., Exp Eye Res. 2005 Sep;81(3):276-85.
79. Growth hormone reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. Yigiter M, etal., Eur J Obstet Gynecol Reprod Biol. 2011 Jul;157(1):94-100. doi: 10.1016/j.ejogrb.2011.02.012. Epub 2011 Mar 25.
80. Evidence for a local action of growth hormone in embryonic tooth development in the rat. Zhang CZ, etal., Growth Factors. 1997;14(2-3):131-43.
81. Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles. Zhao J, etal., Zygote 2002 Feb;10(1):85-94.
82. Vitreous growth hormone and visual dysfunction. Ziaei M, etal., Neurosci Lett. 2009 Aug 21;460(1):87-91. Epub 2009 May 20.
Additional References at PubMed
PMID:339105   PMID:1329576   PMID:1549776   PMID:2825030   PMID:6272224   PMID:6303755   PMID:6946433   PMID:7565946   PMID:7664670   PMID:7782332   PMID:7984244   PMID:8063815  
PMID:8496314   PMID:8521139   PMID:8889548   PMID:8923468   PMID:8943276   PMID:9144201   PMID:9360546   PMID:9571026   PMID:10556780   PMID:10890569   PMID:11549663   PMID:12477932  
PMID:12552091   PMID:14530511   PMID:14532269   PMID:15223841   PMID:15456855   PMID:15480745   PMID:15545705   PMID:15582725   PMID:15790724   PMID:15985453   PMID:16083987   PMID:16139950  
PMID:16272159   PMID:16340176   PMID:16467156   PMID:16513828   PMID:16574776   PMID:16867182   PMID:17363453   PMID:17485162   PMID:17706597   PMID:17993760   PMID:18079205   PMID:18363807  
PMID:18372242   PMID:18483176   PMID:18628614   PMID:19016354   PMID:19106217   PMID:19115393   PMID:19297186   PMID:19553459   PMID:19589870   PMID:19797429   PMID:19815586   PMID:20015464  
PMID:20016135   PMID:20110402   PMID:20378540   PMID:20814072   PMID:21195069   PMID:21291903   PMID:21592969   PMID:22026435   PMID:22080499   PMID:22217849   PMID:22370764   PMID:22583947  
PMID:22645024   PMID:22865430   PMID:22922167   PMID:23185594   PMID:23715123   PMID:23770714   PMID:23774069   PMID:23792323   PMID:24029240   PMID:24338415   PMID:24606125   PMID:24617825  
PMID:25716693   PMID:25874614   PMID:26697363   PMID:26862561   PMID:27150070   PMID:28223314   PMID:28513740   PMID:28864499   PMID:29080043   PMID:31059193   PMID:32084499   PMID:33799501  


Genomics

Comparative Map Data
Gh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21091,228,102 - 91,230,079 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1091,228,103 - 91,230,078 (-)Ensembl
Rnor_6.01094,486,204 - 94,488,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,486,205 - 94,488,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,237,414 - 94,239,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,692,240 - 95,694,117 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11095,708,476 - 95,710,261 (-)NCBI
Celera1089,903,834 - 89,905,811 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
GH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,917,203 - 63,918,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1763,917,200 - 63,918,839 (-)EnsemblGRCh38hg38GRCh38
GRCh371761,994,563 - 61,996,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,348,295 - 59,349,930 (-)NCBINCBI36hg18NCBI36
Build 341759,348,294 - 59,349,930NCBI
Celera1756,382,602 - 56,384,237 (-)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1757,362,255 - 57,363,890 (-)NCBIHuRef
CHM1_11762,058,482 - 62,060,117 (-)NCBICHM1_1
T2T-CHM13v2.01764,787,962 - 64,789,598 (-)NCBI
Gh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,191,087 - 106,194,529 (-)NCBIGRCm39mm39
GRCm39 Ensembl11106,191,097 - 106,192,691 (-)Ensembl
GRCm3811106,300,261 - 106,303,703 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,300,271 - 106,301,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,161,582 - 106,163,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611106,116,358 - 106,117,900 (-)NCBImm8
Celera11118,030,755 - 118,032,297 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
LOC100971425
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11763,103,339 - 63,105,719 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01758,010,848 - 58,013,421 (-)NCBIMhudiblu_PPA_v0panPan3
LOC101969021
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,668,568 - 14,670,240 (+)NCBI
SpeTri2.0NW_0049365414,524,397 - 4,528,234 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Position Markers
BGH  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,228,384 - 91,228,661 (+)MAPPERmRatBN7.2
Rnor_6.01094,486,487 - 94,486,763NCBIRnor6.0
Rnor_5.01094,237,697 - 94,237,973UniSTSRnor5.0
RGSC_v3.41095,692,424 - 95,692,700UniSTSRGSC3.4
Celera1089,904,117 - 89,904,393UniSTS
Cytogenetic Map10q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat


Genetic Models
This gene Gh1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:29
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000015818
Prediction methods:Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 1
Low 1 4
Below cutoff 1 1 1 4 1 1 2 24 24 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015818   ⟹   ENSRNOP00000015818
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,228,103 - 91,230,078 (-)Ensembl
Rnor_6.0 Ensembl1094,486,205 - 94,488,180 (-)Ensembl
RefSeq Acc Id: NM_001034848   ⟹   NP_001030020
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21091,228,102 - 91,230,079 (-)NCBI
Rnor_6.01094,486,204 - 94,488,181 (-)NCBI
Rnor_5.01094,237,414 - 94,239,391 (-)NCBI
RGSC_v3.41095,692,240 - 95,694,117 (-)RGD
Celera1089,903,834 - 89,905,811 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001030020   ⟸   NM_001034848
- Peptide Label: precursor
- UniProtKB: P01244 (UniProtKB/Swiss-Prot),   B2RYR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015818   ⟸   ENSRNOT00000015818

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01244-F1-model_v2 AlphaFold P01244 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697842
Promoter ID:EPDNEW_R8367
Type:single initiation site
Name:Gh1_1
Description:growth hormone 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,488,179 - 94,488,239EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2686 AgrOrtholog
BioCyc Gene G2FUF-22953 BioCyc
Ensembl Genes ENSRNOG00000011207 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000015818 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015818 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922077 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24391 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:188794 IMAGE-MGC_LOAD
NCBI Gene 24391 ENTREZGENE
PANTHER PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11417:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gh1 PhenoGen
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOTROPIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RYR2 ENTREZGENE, UniProtKB/TrEMBL
  P01244 ENTREZGENE
  Q63543_RAT UniProtKB/TrEMBL
  SOMA_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gh1  growth hormone 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hemopoietic cells 61524
gene_expression expressed in hemopoietic cells 625493
gene_function hormone and a ligand for growth hormone receptor 625703
gene_process plays an important role in growth regulation 625703
gene_process causes a dose and time dependent increase in tyrosine phosphorylation of Stat 5 protein; induces cytokine inducible SH2-containing protein 2 (Cish2) 625703
gene_regulation insulin blocks growth hormone functions in hepatocytes 625703