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Gene: Hnf1b (HNF1 homeobox B) Rattus norvegicus
Symbol: Hnf1b
Name: HNF1 homeobox B
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; protein-DNA complex assembly; and regulation of gene expression. Localizes to nucleus. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; LF-B3; MGC93549; TCF-2; Tcf2; transcription factor 2; transcription factor 2 hepatic; transcription factor 2, hepatic; variant hepatic nuclear factor; variant hepatic nuclear factor 1; VHNF1
Homo sapiens (human) : HNF1B (HNF1 homeobox B)  HGNC  Alliance
Mus musculus (house mouse) : Hnf1b (HNF1 homeobox B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf1b (HNF1 homeobox B)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF1B (HNF1 homeobox B)
Canis lupus familiaris (dog) : HNF1B (HNF1 homeobox B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf1b (HNF1 homeobox B)
Sus scrofa (pig) : HNF1B (HNF1 homeobox B)
Chlorocebus sabaeus (African green monkey) : HNF1B (HNF1 homeobox B)
Heterocephalus glaber (naked mole-rat) : Hnf1b (HNF1 homeobox B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01071,159,863 - 71,218,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1071,159,869 - 71,218,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,778,492 - 70,829,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41072,081,091 - 72,187,014 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11072,095,460 - 72,201,382 (+)NCBI
Celera1067,668,848 - 67,719,403 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hnf1b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3830
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.