Hnf1b (HNF1 homeobox B) - Rat Genome Database

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Gene: Hnf1b (HNF1 homeobox B) Rattus norvegicus
Analyze
Symbol: Hnf1b
Name: HNF1 homeobox B
RGD ID: 3830
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; protein-DNA complex assembly; and regulation of gene expression. Located in nucleus. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; LF-B3; MGC93549; TCF-2; Tcf2; transcription factor 2; transcription factor 2 hepatic; transcription factor 2, hepatic; variant hepatic nuclear factor; variant hepatic nuclear factor 1; VHNF1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau9
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21068,735,894 - 68,789,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,735,894 - 68,789,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1073,355,884 - 73,409,885 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01072,860,897 - 72,914,896 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01068,325,325 - 68,379,318 (+)NCBIRnor_WKY
Rnor_6.01071,159,863 - 71,218,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1071,159,869 - 71,218,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,778,492 - 70,829,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41072,081,091 - 72,187,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11072,095,460 - 72,201,382 (+)NCBI
Celera1067,668,848 - 67,719,403 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
apoptotic process  (ISO)
branching morphogenesis of an epithelial tube  (IEA,ISO)
circadian regulation of gene expression  (IDA)
DNA-templated transcription  (ISO)
DNA-templated transcription elongation  (ISO)
embryonic digestive tract morphogenesis  (IEA,ISO)
embryonic morphogenesis  (IDA)
endocrine pancreas development  (ISO,ISS)
endoderm development  (ISO)
endodermal cell fate specification  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelium development  (ISO)
genitalia development  (ISO,ISS)
hepatoblast differentiation  (IEA,ISO)
hepatocyte differentiation  (IEP)
hindbrain development  (IEA,ISO)
inner cell mass cell differentiation  (IEA,ISO)
insulin secretion  (IEA,ISO)
kidney development  (ISO,ISS)
kidney morphogenesis  (ISO)
liver development  (ISO)
mesenchymal cell apoptotic process involved in metanephros development  (IEA,ISO)
mesonephric duct development  (ISO)
mesonephric duct formation  (IEA,ISO)
mesonephric tubule development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis  (IEA,ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nephric duct development  (ISO)
nephric duct formation  (ISO)
Notch signaling pathway  (IEA,ISO)
pancreas development  (IEA)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gene expression  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO)
pronephric nephron tubule development  (IEA,ISO)
pronephros development  (ISO)
protein-DNA complex assembly  (IMP)
regulation of branch elongation involved in ureteric bud branching  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of pronephros size  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of Wnt signaling pathway  (IEA,ISO)
response to carbohydrate  (IEP)
response to glucose  (IEA,ISO)
response to organic cyclic compound  (IEP)
response to xenobiotic stimulus  (IEP)
ureteric bud elongation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Two members of an HNF1 homeoprotein family are expressed in human liver. Bach I, etal., Nucleic Acids Res. 1991 Jul 11;19(13):3553-9.
2. Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations. Bellanne-Chantelot C, etal., Ann Intern Med. 2004 Apr 6;140(7):510-7.
3. Aroclor 1254 modulates gene expression of nuclear transcription factors: implications for albumin gene transcription and protein synthesis in rat hepatocyte cultures. Borlak J, etal., Toxicol Appl Pharmacol. 2002 Jun 1;181(2):79-88.
4. A set of polyclonal and monoclonal antibodies reveals major differences in post-translational modification of the rat HNF1 and vHNF1 homeoproteins. Chouard T, etal., Biochimie. 1997 Dec;79(12):707-15.
5. Isolation and characterization of a putative liver progenitor population after treatment of fetal rat hepatocytes with TGF-beta. del Castillo G, etal., J Cell Physiol. 2008 Jun;215(3):846-55.
6. Mutations in MODY genes are not common cause of early-onset type 2 diabetes in Mexican families. Dominguez-Lopez A, etal., JOP. 2005 May 10;6(3):238-45.
7. Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease. Edghill EL, etal., Nephrol Dial Transplant. 2008 Feb;23(2):627-35. Epub 2007 Oct 30.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage. Haumaitre C, etal., J Biol Chem. 2003 Oct 17;278(42):40933-42. Epub 2003 Jul 14.
10. Splice site mutation in the hepatocyte nuclear factor-1 beta gene, IVS2nt + 1G > A, associated with maturity-onset diabetes of the young, renal dysplasia and bicornuate uterus. Iwasaki N, etal., Diabetologia. 2001 Mar;44(3):387-8.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Effects of growth and differentiation factors on the epithelial-mesenchymal transition in cultured neonatal rat hepatocytes. Pagan R, etal., J Hepatol. 1999 Nov;31(5):895-904.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young. Raile K, etal., J Clin Endocrinol Metab. 2009 Jul;94(7):2658-64. Epub 2009 May 5.
18. vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. Rey-Campos J, etal., EMBO J 1991 Jun;10(6):1445-57.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Circadian periodicity of intestinal Na+/glucose cotransporter 1 mRNA levels is transcriptionally regulated. Rhoads DB, etal., J Biol Chem. 1998 Apr 17;273(16):9510-6.
22. Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture. Sanchez A, etal., J Hepatol. 2000 Feb;32(2):242-50.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. Weber S, etal., J Am Soc Nephrol. 2006 Oct;17(10):2864-70. Epub 2006 Sep 13.
27. Integrated pathway analysis of rat urine metabolic profiles and kidney transcriptomic profiles to elucidate the systems toxicology of model nephrotoxicants. Xu EY, etal., Chem Res Toxicol. 2008 Aug;21(8):1548-61. Epub 2008 Jul 26.
Additional References at PubMed
PMID:1363228   PMID:1673925   PMID:1685988   PMID:2044952   PMID:8598044   PMID:10518495   PMID:10518496   PMID:10720943   PMID:12367519   PMID:14570708   PMID:14656222   PMID:15067314  
PMID:15142986   PMID:15280201   PMID:15355349   PMID:15489334   PMID:15509593   PMID:15550389   PMID:15647252   PMID:15872003   PMID:16274963   PMID:16297991   PMID:16801329   PMID:16880268  
PMID:16912278   PMID:17218081   PMID:17928287   PMID:18635606   PMID:19913010   PMID:19924231   PMID:20040500   PMID:21281489   PMID:22759397   PMID:23362348   PMID:25446530  


Genomics

Comparative Map Data
Hnf1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21068,735,894 - 68,789,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,735,894 - 68,789,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1073,355,884 - 73,409,885 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01072,860,897 - 72,914,896 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01068,325,325 - 68,379,318 (+)NCBIRnor_WKY
Rnor_6.01071,159,863 - 71,218,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1071,159,869 - 71,218,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,778,492 - 70,829,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41072,081,091 - 72,187,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11072,095,460 - 72,201,382 (+)NCBI
Celera1067,668,848 - 67,719,403 (+)NCBICelera
Cytogenetic Map10q26NCBI
HNF1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381737,686,431 - 37,745,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1737,686,431 - 37,745,059 (-)EnsemblGRCh38hg38GRCh38
GRCh371736,046,434 - 36,105,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361733,120,547 - 33,179,209 (-)NCBINCBI36Build 36hg18NCBI36
Build 341733,162,728 - 33,179,182NCBI
Celera1732,869,487 - 32,928,989 (-)NCBICelera
Cytogenetic Map17q12ENTREZGENE
HuRef1731,984,120 - 32,042,660 (-)NCBIHuRef
CHM1_11736,077,994 - 36,136,668 (-)NCBICHM1_1
T2T-CHM13v2.01738,673,401 - 38,732,032 (-)NCBIT2T-CHM13v2.0
Hnf1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,741,035 - 83,796,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,740,889 - 83,796,645 (+)EnsemblGRCm39 Ensembl
GRCm381183,850,209 - 83,905,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,850,063 - 83,905,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371183,664,371 - 83,719,317 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,667,244 - 83,721,542 (+)NCBIMGSCv36mm8
Celera1193,455,173 - 93,510,691 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.23NCBI
Hnf1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955451320,283 - 371,420 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955451320,283 - 371,420 (+)NCBIChiLan1.0ChiLan1.0
HNF1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11719,633,424 - 19,691,863 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1719,633,424 - 19,691,863 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01719,333,485 - 19,392,147 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HNF1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,437,992 - 37,493,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,438,583 - 37,492,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha936,661,511 - 36,717,034 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,248,175 - 38,303,484 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,248,763 - 38,303,129 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,029,129 - 37,084,643 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,316,583 - 37,372,144 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,403,808 - 37,459,176 (-)NCBIUU_Cfam_GSD_1.0
Hnf1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,371,915 - 36,425,499 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490649,546 - 702,672 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936490649,551 - 702,448 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNF1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,143,121 - 39,201,631 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,143,119 - 39,201,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21240,788,316 - 40,846,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNF1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11630,033,486 - 30,097,106 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1630,036,766 - 30,097,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666077760,378 - 820,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnf1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248714,661,669 - 4,712,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248714,662,104 - 4,713,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnf1b
314 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:78
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000047427
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642290Bp299Blood pressure QTL 299arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106823013469282520Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat

Markers in Region
D10Chm186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,672,291 - 67,672,471 (+)MAPPERmRatBN7.2
Rnor_6.01070,089,235 - 70,089,416NCBIRnor6.0
Rnor_5.01069,720,421 - 69,720,602UniSTSRnor5.0
RGSC_v3.41072,126,820 - 72,127,001UniSTSRGSC3.4
Celera1066,618,862 - 66,619,043UniSTS
Cytogenetic Map10q26UniSTS
Tcf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,735,481 - 68,735,953 (+)MAPPERmRatBN7.2
Rnor_6.01071,159,451 - 71,159,922NCBIRnor6.0
Rnor_5.01070,777,959 - 70,778,430UniSTSRnor5.0
RGSC_v3.41072,080,558 - 72,081,029UniSTSRGSC3.4
Celera1067,668,436 - 67,668,907UniSTS
Cytogenetic Map10q26UniSTS
D11Pas33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,648,493 - 67,648,735 (+)MAPPERmRatBN7.2
Rnor_6.01070,065,438 - 70,065,679NCBIRnor6.0
Rnor_5.01069,696,624 - 69,696,865UniSTSRnor5.0
RGSC_v3.41072,103,024 - 72,103,265UniSTSRGSC3.4
Celera1066,595,017 - 66,595,258UniSTS
Cytogenetic Map10q26UniSTS
AI987804  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,789,735 - 68,789,870 (+)MAPPERmRatBN7.2
Rnor_6.01071,218,750 - 71,218,884NCBIRnor6.0
Rnor_5.01070,829,888 - 70,830,022UniSTSRnor5.0
RGSC_v3.41072,187,157 - 72,187,291UniSTSRGSC3.4
Celera1067,719,251 - 67,719,385UniSTS
Cytogenetic Map10q26UniSTS
RH141230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,789,188 - 68,789,388 (+)MAPPERmRatBN7.2
Rnor_6.01071,218,203 - 71,218,402NCBIRnor6.0
Rnor_5.01070,829,341 - 70,829,540UniSTSRnor5.0
RGSC_v3.41072,186,610 - 72,186,809UniSTSRGSC3.4
Celera1067,718,704 - 67,718,903UniSTS
Cytogenetic Map10q26UniSTS
UniSTS:465411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,740,928 - 68,741,027 (+)MAPPERmRatBN7.2
Rnor_6.01071,164,850 - 71,164,948NCBIRnor6.0
Rnor_5.01070,783,268 - 70,783,366UniSTSRnor5.0
RGSC_v3.41072,086,182 - 72,086,280UniSTSRGSC3.4
Celera1067,673,883 - 67,673,981UniSTS
Cytogenetic Map10q26UniSTS
RH71331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,652,663 - 67,653,261 (+)MAPPERmRatBN7.2
Rnor_6.01070,069,609 - 70,070,206NCBIRnor6.0
Rnor_5.01069,700,795 - 69,701,392UniSTSRnor5.0
RGSC_v3.41072,107,194 - 72,107,791UniSTSRGSC3.4
Celera1066,599,187 - 66,599,784UniSTS
Cytogenetic Map10q26UniSTS
Tcf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,746,552 - 68,746,745 (+)MAPPERmRatBN7.2
Rnor_6.01071,170,499 - 71,170,691NCBIRnor6.0
Rnor_5.01070,788,692 - 70,788,884UniSTSRnor5.0
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 11 11 11 35 11 3
Low 30 30 30 28 8
Below cutoff 10 6 15 2 2 45 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047427   ⟹   ENSRNOP00000046025
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1068,735,894 - 68,789,888 (+)Ensembl
Rnor_6.0 Ensembl1071,159,984 - 71,218,605 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075977   ⟹   ENSRNOP00000068016
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1071,159,869 - 71,172,898 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076192   ⟹   ENSRNOP00000068024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1071,217,966 - 71,218,902 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076893   ⟹   ENSRNOP00000068123
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1071,202,456 - 71,209,285 (+)Ensembl
RefSeq Acc Id: NM_001308148   ⟹   NP_001295077
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21068,735,894 - 68,789,888 (+)NCBI
Rnor_6.01071,159,863 - 71,218,902 (+)NCBI
Celera1067,668,848 - 67,719,403 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001308149   ⟹   NP_001295078
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21068,735,894 - 68,789,888 (+)NCBI
Rnor_6.01071,159,863 - 71,218,902 (+)NCBI
Celera1067,668,848 - 67,719,403 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013103   ⟹   NP_037235
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21068,735,894 - 68,789,888 (+)NCBI
Rnor_6.01071,159,863 - 71,218,902 (+)NCBI
Rnor_5.01070,778,492 - 70,829,745 (+)NCBI
RGSC_v3.41072,081,091 - 72,187,014 (+)RGD
Celera1067,668,848 - 67,719,403 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037235   ⟸   NM_013103
- Peptide Label: isoform 2
- UniProtKB: P23899 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001295077   ⟸   NM_001308148
- Peptide Label: isoform 1
- UniProtKB: A1EC66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295078   ⟸   NM_001308149
- Peptide Label: isoform 3
- UniProtKB: A1EC67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000046025   ⟸   ENSRNOT00000047427
RefSeq Acc Id: ENSRNOP00000068016   ⟸   ENSRNOT00000075977
RefSeq Acc Id: ENSRNOP00000068123   ⟸   ENSRNOT00000076893
RefSeq Acc Id: ENSRNOP00000068024   ⟸   ENSRNOT00000076192
Protein Domains
HNF-p1   Homeobox   POU-specific atypical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23899-F1-model_v2 AlphaFold P23899 1-557 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697548
Promoter ID:EPDNEW_R8067
Type:multiple initiation site
Name:Hnf1b_1
Description:HNF1 homeobox B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01071,159,840 - 71,159,900EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3830 AgrOrtholog
BioCyc Gene G2FUF-23852 BioCyc
Ensembl Genes ENSRNOG00000002598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000046025 ENTREZGENE
  ENSRNOP00000046025.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047427 ENTREZGENE
  ENSRNOT00000047427.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109422 IMAGE-MGC_LOAD
InterPro HNF-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF-1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF-1_POU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF1_dimer_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF1b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF_P1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lambda_DNA-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25640 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93549 IMAGE-MGC_LOAD
NCBI Gene 25640 ENTREZGENE
PANTHER PTHR11568 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HNF-1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNF-1B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HNF1B RGD
PhenoGen Hnf1b PhenoGen
PROSITE HNF_P1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POU_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100957 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47413 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209180
UniProt A1EC66 ENTREZGENE, UniProtKB/TrEMBL
  A1EC67 ENTREZGENE, UniProtKB/TrEMBL
  HNF1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Hnf1b  HNF1 homeobox B  Tcf2  transcription factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tcf2  transcription factor 2    Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor  Name updated 629478 APPROVED
2002-06-10 Tcf2  Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA found in kidney, liver and intestine 729944
gene_function probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' 729944
gene_physical_interaction forms a heterodimer with Tcf1 729944