Myo1c (myosin 1C) - Rat Genome Database

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Gene: Myo1c (myosin 1C) Rattus norvegicus
Analyze
Symbol: Myo1c
Name: myosin 1C
RGD ID: 620443
Description: Enables actin filament binding activity; calmodulin binding activity; and microfilament motor activity. Involved in positive regulation of actin filament polymerization and positive regulation of cellular response to insulin stimulus. Located in several cellular components, including membrane raft; ruffle membrane; and stereocilium bundle. Orthologous to human MYO1C (myosin IC); PARTICIPATES IN auditory mechanotransduction pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100365624; LOC686250; MMI-beta; MMIb; myosin heavy chain myr 2; myosin I beta; myosin IC; myosin IC-like; myosin-Ic; Myr2; similar to unconventional myosin Myr2 I heavy chain; unconventional myosin Myr2 I heavy chain; unconventional myosin-Ic
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,498,374 - 60,520,752 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,498,280 - 60,520,752 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,150,370 - 65,167,442 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01064,655,787 - 64,672,859 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01060,118,363 - 60,135,435 (+)NCBIRnor_WKY
Rnor_6.01063,803,311 - 63,819,614 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,803,309 - 63,819,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,185,628 - 64,201,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,990,673 - 63,006,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11063,004,293 - 63,020,597 (+)NCBI
Celera1059,530,993 - 59,546,121 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Adamek N, etal., Biochemistry. 2010 Feb 9;49(5):958-71. doi: 10.1021/bi901803j.
2. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Arif E, etal., Mol Cell Biol. 2011 May;31(10):2134-50. doi: 10.1128/MCB.05051-11. Epub 2011 Mar 14.
3. A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Batters C, etal., Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1895-905.
4. Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles. Boguslavsky S, etal., Mol Biol Cell. 2012 Oct;23(20):4065-78. doi: 10.1091/mbc.E12-04-0263. Epub 2012 Aug 23.
5. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. Chinthalapudi K, etal., J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16.
6. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, etal., J Assoc Res Otolaryngol 2002 Dec;3(4):375-89. Epub 2002 Feb 27.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Mechanotransduction by hair cells: models, molecules, and mechanisms. Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Calcium, nucleotide, and actin affect the interaction of mammalian Myo1c with its light chain calmodulin. Lieto-Trivedi A and Coluccio LM, Biochemistry. 2008 Sep 23;47(38):10218-26. doi: 10.1021/bi8011059. Epub 2008 Aug 26.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Information Derived from GenBank Report RGD, Sept. 2003
17. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
18. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
Additional References at PubMed
PMID:8719884   PMID:9858156   PMID:11208135   PMID:12490950   PMID:15758024   PMID:15976448   PMID:16957816   PMID:17050716   PMID:17994197   PMID:19046570   PMID:19056867   PMID:19144319  
PMID:19199708   PMID:19946888   PMID:20089841   PMID:20458337   PMID:21362503   PMID:22114352   PMID:23262137   PMID:23376485   PMID:23533145   PMID:24056301   PMID:24625528   PMID:26940917  


Genomics

Comparative Map Data
Myo1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,498,374 - 60,520,752 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,498,280 - 60,520,752 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,150,370 - 65,167,442 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01064,655,787 - 64,672,859 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01060,118,363 - 60,135,435 (+)NCBIRnor_WKY
Rnor_6.01063,803,311 - 63,819,614 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,803,309 - 63,819,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,185,628 - 64,201,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,990,673 - 63,006,974 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11063,004,293 - 63,020,597 (+)NCBI
Celera1059,530,993 - 59,546,121 (+)NCBICelera
Cytogenetic Map10q24NCBI
MYO1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,464,186 - 1,492,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl171,464,186 - 1,492,686 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,367,480 - 1,395,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,314,230 - 1,342,751 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,314,874 - 1,342,745NCBI
Celera171,382,666 - 1,411,498 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,267,587 - 1,296,167 (-)NCBIHuRef
CHM1_1171,376,234 - 1,404,693 (-)NCBICHM1_1
T2T-CHM13v2.0171,352,909 - 1,381,443 (-)NCBIT2T-CHM13v2.0
Myo1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,541,345 - 75,565,469 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,541,330 - 75,564,736 (+)EnsemblGRCm39 Ensembl
GRCm381175,650,519 - 75,674,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,650,504 - 75,673,910 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,465,011 - 75,488,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,467,773 - 75,490,838 (+)NCBIMGSCv36mm8
Celera1183,160,567 - 83,183,742 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Myo1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,676,728 - 1,703,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,676,788 - 1,701,421 (+)NCBIChiLan1.0ChiLan1.0
MYO1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,345,143 - 1,375,540 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,345,143 - 1,375,540 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0171,446,506 - 1,475,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MYO1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,635,295 - 45,658,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,636,208 - 45,658,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,787,550 - 44,810,320 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,463,244 - 46,486,023 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,463,244 - 46,485,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,233,730 - 45,256,432 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,528,186 - 45,550,881 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,581,598 - 45,604,345 (-)NCBIUU_Cfam_GSD_1.0
Myo1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,733,124 - 44,761,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,611,008 - 7,639,581 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365387,614,985 - 7,639,603 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,691,256 - 47,718,337 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,691,252 - 47,715,670 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,785,597 - 49,802,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYO1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,137,469 - 1,167,497 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605920,819,456 - 20,849,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,188,143 - 4,211,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,188,143 - 4,211,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo1c
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:149
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000036666
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 51 35 19 35 8 11 74 35 34 11 8
Low 6 6 6 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036666   ⟹   ENSRNOP00000028929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,503,411 - 60,520,752 (+)Ensembl
Rnor_6.0 Ensembl1063,803,309 - 63,819,614 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101210   ⟹   ENSRNOP00000097261
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,498,280 - 60,520,752 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108756   ⟹   ENSRNOP00000080420
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,503,692 - 60,520,752 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117022   ⟹   ENSRNOP00000096158
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,501,879 - 60,520,752 (+)Ensembl
RefSeq Acc Id: NM_023092   ⟹   NP_075580
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21060,503,661 - 60,520,752 (+)NCBI
Rnor_6.01063,803,311 - 63,819,614 (+)NCBI
Rnor_5.01064,185,628 - 64,201,931 (-)NCBI
RGSC_v3.41062,990,673 - 63,006,974 (+)RGD
Celera1059,530,993 - 59,546,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086808   ⟹   XP_038942736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21060,498,374 - 60,520,750 (+)NCBI
RefSeq Acc Id: XM_039086809   ⟹   XP_038942737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21060,499,330 - 60,520,750 (+)NCBI
RefSeq Acc Id: XM_039086810   ⟹   XP_038942738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21060,502,673 - 60,520,750 (+)NCBI
RefSeq Acc Id: XM_039086811   ⟹   XP_038942739
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21060,505,094 - 60,520,750 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_075580   ⟸   NM_023092
- UniProtKB: Q63355 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028929   ⟸   ENSRNOT00000036666
RefSeq Acc Id: XP_038942736   ⟸   XM_039086808
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942737   ⟸   XM_039086809
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942738   ⟸   XM_039086810
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942739   ⟸   XM_039086811
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QFL2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096158   ⟸   ENSRNOT00000117022
RefSeq Acc Id: ENSRNOP00000080420   ⟸   ENSRNOT00000108756
RefSeq Acc Id: ENSRNOP00000097261   ⟸   ENSRNOT00000101210
Protein Domains
IQ   Myosin motor   TH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63355-F1-model_v2 AlphaFold Q63355 1-1044 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697443
Promoter ID:EPDNEW_R7967
Type:initiation region
Name:Myo1c_1
Description:myosin 1C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01063,803,333 - 63,803,393EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620443 AgrOrtholog
BioCyc Gene G2FUF-24191 BioCyc
Ensembl Genes ENSRNOG00000004072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028929 ENTREZGENE
  ENSRNOP00000028929.6 UniProtKB/TrEMBL
  ENSRNOP00000080420.1 UniProtKB/TrEMBL
  ENSRNOP00000096158 ENTREZGENE
  ENSRNOP00000096158.1 UniProtKB/TrEMBL
  ENSRNOP00000097261 ENTREZGENE
  ENSRNOP00000097261.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036666 ENTREZGENE
  ENSRNOT00000036666.6 UniProtKB/TrEMBL
  ENSRNOT00000101210 ENTREZGENE
  ENSRNOT00000101210.1 UniProtKB/TrEMBL
  ENSRNOT00000108756.1 UniProtKB/TrEMBL
  ENSRNOT00000117022 ENTREZGENE
  ENSRNOT00000117022.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYSc_Myo1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65261 UniProtKB/Swiss-Prot
NCBI Gene 65261 ENTREZGENE
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myo1c PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQN4_RAT UniProtKB/TrEMBL
  A0A8I6AQB5_RAT UniProtKB/TrEMBL
  A0A8I6ASB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QFL2 ENTREZGENE, UniProtKB/TrEMBL
  MYO1C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Myo1c  myosin 1C  Myo1c  myosin IC  Name changed 629549 APPROVED
2013-04-17 Myo1c  myosin IC  LOC100365624  myosin IC-like  Data Merged 737654 PROVISIONAL
2013-04-17 Myo1c  myosin IC  LOC686250  similar to unconventional myosin Myr2 I heavy chain  Data Merged 737654 PROVISIONAL
2010-05-05 LOC100365624  myosin IC-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686250  similar to unconventional myosin Myr2 I heavy chain      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-02 Myo1c  myosin IC  Myr2  unconventional myosin Myr2 I heavy chain  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-08-07 Myr2  unconventional myosin Myr2 I heavy chain      Symbol and Name status set to provisional 70820 PROVISIONAL