Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus
Symbol: Ace
Name: angiotensin I converting enzyme
Description: ENCODES a protein that exhibits drug binding; metallopeptidase activity; peptidyl-dipeptidase activity; INVOLVED IN aging; angiogenesis involved in coronary vascular morphogenesis; animal organ regeneration; PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; angiotensin II signaling pathway; ASSOCIATED WITH decreased angiotensin I-converting enzyme activity; increased angiotensin I-converting enzyme activity; ASSOCIATED WITH abdominal aortic aneurysm; acute kidney failure; Albuminuria; FOUND IN basal plasma membrane; brush border membrane; extracellular space; INTERACTS WITH (R)-lipoic acid; (S)-colchicine; 14,15-EET
Type: protein-coding
Also known as: angiotensin 1 converting enzyme; angiotensin 1 converting enzyme 1; angiotensin converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme; CD143; Dcp1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; kininase II; StsRR92
Allele / Splice: Aceem1Mcwi   Aceem2Mcwi  
Genetic Models: SS-Aceem1Mcwi SS-Aceem2Mcwi
Is Marker For: Strains:   SD-Tg(Ren2)27   SS.MNS-(D10M11Mit119-D10Mit11)/Jr   LOU.BN-(D10Mgh1-D10Mgh14)/Ins  
QTLs:   Bp9   Bw57   Bp342   Bw102  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models


Nucleotide Sequences
Protein Sequences
Protein Structures

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ace
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2493
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE