Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus
Analyze
Symbol:
Ace
Name:
angiotensin I converting enzyme
Description:
Exhibits drug binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Localizes to several cellular components, including the basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; lung disease (multiple); and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); lung disease (multiple); and nephritis (multiple). Orthologous to human ACE (angiotensin I converting enzyme); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; angiotensin II signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-colchicine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
angiotensin 1 converting enzyme; angiotensin 1 converting enzyme 1; angiotensin converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme; CD143; Dcp1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; kininase II; StsRR92
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ACE (angiotensin I converting enzyme) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Canis lupus familiaris (dog):
ACE (angiotensin I converting enzyme) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
LOC101968921 (angiotensin-converting enzyme) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ACE (angiotensin I converting enzyme)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Acer
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Ance
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Ance-2
Alliance
DIOPT (PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Ance-3
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
acn-1
Alliance
DIOPT (OMA, OrthoInspector, PhylomeDB)
Allele / Splice:
Aceem1Mcwi
Aceem2Mcwi
Genetic Models:
SS-Aceem1Mcwi
SS-Aceem2Mcwi
Is Marker For:
Strains:
SD-Tg(Ren2)27
SS.MNS-(D10M11Mit119-D10Mit11 )/Jr
LOU.BN-(D10Mgh1-D10Mgh14 )/Ins QTLs:
Bp9
Bw57
Bp342
Bw102
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 10 94,170,766 - 94,213,831 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 94,170,766 - 94,187,822 (+) Ensembl Rnor_5.0 10 93,922,062 - 93,965,127 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 95,361,338 - 95,381,455 (+) NCBI RGSC3.4 rn4 RGSC3.4 Celera 10 89,588,544 - 89,608,666 (+) NCBI Celera Cytogenetic Map 10 q32.1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
abdominal aortic aneurysm treatment IMP 11039028 RGD acute kidney failure treatment IMP 11039053 RGD Albuminuria ISO RGD:737323 7829770 associated with Diabetes Mellitus, Type 1, protein:increased activity:serum (human) RGD Albuminuria treatment IMP 12879427 associated with Diabetic Nephropathies RGD allergic hypersensitivity disease susceptibility ISO RGD:737323 8142344 DNA:deletion:intron:IVS16+1464-1751del (human) RGD allergic rhinitis no_association ISO RGD:737323 8142345 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Alzheimer's disease IMP 2325232 RGD anemia ISO RGD:737323 11038916 associated with Carcinoma, Non-Small-Cell Lung, DNA:deletion:intron:IVS16+1464-1751del (human) RGD anemia ISO RGD:737323 11038919 RGD ankylosing spondylitis susceptibility ISO RGD:737323 7829800 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Aortic Coarctation IEP 12859271 mRNA, protein:increased expression:myocardium (rat) RGD Arteriovenous Fistula IEP 12859285 protein:increased activity:heart left ventricle (rat) RGD Arteriovenous Fistula treatment IMP 12880017 RGD aspiration pneumonia ISO RGD:737323 4140926 associated with Cerebrovascular Accident RGD asthma susceptibility ISO RGD:737323 4140913 ; 4140919 DNA:polymorphism (human) RGD atrial fibrillation susceptibility ISO RGD:737323 7829797 ; 8142351 DNA:deletion:intron:IVS16+1464-1751del (human) RGD autosomal recessive polycystic kidney disease IEP 12879406 mRNA:increased expression:kidney (rat) RGD autosomal recessive polycystic kidney disease IMP 2325220 RGD Behcet's disease susceptibility ISO RGD:737323 7829810 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Behcet's disease no_association ISO RGD:737323 8142349 DNA:deletion:intron:IVS16+1464-1751del (human) RGD breast cancer susceptibility ISO RGD:737323 8548866 DNA:insertion/deletion, haplotype RGD bronchiolitis obliterans IMP 4140933 RGD Cardiac Arrhythmias ISO RGD:737323 8548864 associated with Kidney Failure, Chronic, DNA:insertion/deletion RGD Cardiomegaly treatment IMP 11039415 RGD cerebral infarction ISO RGD:737323 11038922 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Chemotherapy-Induced Febrile Neutropenia severity ISO RGD:737323 11038917 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Chronic Intermittent Hypoxia IEP 11039031 mRNA:increased expression:carotid body RGD chronic myeloid leukemia ISO RGD:737323 11039056 RGD chronic obstructive pulmonary disease susceptibility ISO RGD:737323 4140480 DNA:polymorphism (human) RGD chronic obstructive pulmonary disease disease_progression ISO RGD:737323 4140912 RGD chronic obstructive pulmonary disease ISO RGD:737323 4140487 RGD congenital diaphragmatic hernia IEP 12859277 protein:increased activity:lung (rat) RGD Congenital Hepatic Fibrosis IEP 2325215 associated with Polycystic Kidney, Autosomal Recessive, mRNA:increased expression:liver RGD congestive heart failure IMP 2325224 associated with Myocardial Infarction RGD congestive heart failure IMP 6893472 associated with Hypertension RGD congestive heart failure treatment IEP 12859272 RGD coronary artery disease susceptibility ISO RGD:737323 1566498 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Coronary Disease susceptibility ISO RGD:737323 8142364 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Coronavirus Infections ISO RGD:737323 4140930 Severe Acute Respiratory Syndrome RGD Cough ISO RGD:737323 4140914 RGD Diabetes Mellitus, Experimental IEP 2313799 protein:increased expression:kidney RGD Diabetic Cardiomyopathies treatment IEP 9685456 associated with Diabetes Mellitus, Experimental RGD Diabetic Nephropathies no_association ISO RGD:737323 7829780 associated with Diabetes Mellitus, Type 1, DNA:deletion:intron:IVS16+1464-1751del (human) RGD Diabetic Nephropathies no_association ISO RGD:737323 8548885 associated with Diabetes Mellitus, Type 2, DNA:insertion/deletion RGD Diabetic Nephropathies IMP 2311449 RGD Diabetic Nephropathies ISO RGD:737323 8548872 associated with Diabetes Mellitus, Type 1, DNA:insertion/deletion RGD Diabetic Nephropathies susceptibility ISO RGD:737323 7829777 associated with Diabetes Mellitus, Type 1, DNA:deletion:intron:IVS16+1464-1751del (human) RGD Diabetic Nephropathies treatment IDA 11039044 associated with Diabetes Mellitus, Experimental RGD diabetic retinopathy ISO RGD:737323 8142360 associated with Diabetes Mellitus, Type 2, protein:increased expression:serum (human) RGD diabetic retinopathy no_association ISO RGD:737323 7829780 associated with Diabetes Mellitus, Type 1, DNA:deletion:intron:IVS16+1464-1751del (human) RGD diabetic retinopathy susceptibility ISO RGD:737323 7829783 associated with Diabetes Mellitus, Type 2, DNA:deletion:intron:IVS16+1464-1751del (human) RGD diabetic retinopathy susceptibility ISO RGD:737323 7829794 associated with Diabetes Mellitus, Type 2, DNA:snp:exon:g.2350G>A (rs4343) (human) RGD dilated cardiomyopathy no_association ISO RGD:737323 1566491 DNA:insertion/deletion:intron RGD end stage renal failure ISO RGD:737323 6903283 associated with Vesico-Ureteral Reflux, DNA:deletion RGD end stage renal failure treatment IMP 12879398 RGD end stage renal failure susceptibility ISO RGD:737323 8142355 associated with Diabetes Mellitus, Type 2, DNA:deletion:intron:IVS16+1464-1751del (human) RGD endomyocardial fibrosis IEP 8157600 protein:increased activity:lung, heart left ventricle, plasma (rat) RGD Endotoxemia IEP 8142370 associated with Hemorrhage, protein:decreased activity:plasma (rat) RGD Experimental Arthritis IEP 2325221 RGD extrinsic allergic alveolitis ISO RGD:737323 4140920 protein:increased expression:plasma RGD Fabry disease treatment ISO RGD:737323 12879402 RGD Familial Cerebral Cavernous Malformation ISO RGD:737323 11039024 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Fetal Death ISO RGD:737323 11038921 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Fetal Growth Retardation IEP 12879387 mRNA:increased expression:kidney (rat) RGD focal segmental glomerulosclerosis 1 treatment IMP 12880006 RGD gallbladder adenocarcinoma ISO RGD:737323 2325207 DNA:polymorphism: :rs4646994 (human) RGD glomerulonephritis IMP 2325229 RGD glomerulosclerosis treatment IMP 12879389 RGD Henoch-Schoenlein purpura disease_progression ISO RGD:737323 11038920 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Hyperoxia IEP 12880008 mRNA, protein:increased expression:lung (rat) RGD hypertension treatment IMP 8157611 ; 11039415 RGD hypertension susceptibility ISO RGD:737323 1601114 DNA:polymorphism RGD hypertension IDA 1601113 RGD hypertension IEP 1581743 protein:increased activity:lung (rat) RGD Hypertension, Pregnancy-Induced IEP 8548898 RGD Hypertensive Nephrosclerosis treatment IMP 12879397 RGD hypertrophic cardiomyopathy no_association ISO RGD:737323 1566491 DNA:insertion/deletion:intron RGD IgA glomerulonephritis disease_progression ISO RGD:737323 7257515 DNA:polymorphism:intron: RGD in situ carcinoma ISO RGD:10468 2325208 associated with Pancreatic Neoplasms RGD intermediate coronary syndrome ISO RGD:737323 8142363 mRNA:increased expression:ventricular myocardium (human) RGD intermediate coronary syndrome ISO RGD:737323 8548894 mRNA:increased expression:myocardium RGD Intestinal Reperfusion Injury IEP 13515113 RGD Kidney Reperfusion Injury IMP 6893484 RGD Left Ventricular Hypertrophy IEP 8157600 protein:increased activity:lung, heart left ventricle, plasma (rat) RGD Left Ventricular Hypertrophy treatment IMP 12880015 ; 12879391 associated with Aortic Coarctation RGD Left Ventricular Hypertrophy susceptibility ISO RGD:737323 8142350 associated with Hypertension, Essential, DNA:deletion:intron:IVS16+1464-1751del (human) RGD Left Ventricular Hypertrophy treatment ISO RGD:737323 11038918 associated with Anemia RGD leukemia disease_progression ISO RGD:737323 11039000 DNA:deletion:intron:IVS16+1464-1751del (human) RGD leukostasis IMP 11039403 associated with Diabetes Mellitus, Experimental RGD lung cancer susceptibility ISO RGD:737323 4140486 DNA:polymorphism (human) RGD lung disease IMP 2325231 associated with Endotoxemia RGD lung disease ISO RGD:10468 5129168 Lung Injury RGD lung disease ISO RGD:10468 4140488 associated with Diabetes Mellitus, Experimental RGD lung disease IEP 4140485 associated with Poisoning, mRNA:decreased expression:lung RGD Memory Disorders IMP 6893483 RGD middle cerebral artery infarction treatment IMP 11039026 RGD mitral valve prolapse severity ISO RGD:737323 13432357 associated with Marfan Syndrome more ... RGD multiple myeloma ISO RGD:737323 11038914 protein:increased activity:serum RGD myocardial infarction treatment IEP 1558664 ; 9685449 RGD myocardial infarction IMP 6893480 associated with Myocardial Reperfusion Injury RGD myocardial infarction susceptibility ISO RGD:737323 7829785 associated with Diabetes Mellitus, Type 1, DNA:deletion:intron:IVS16+1464-1751del (human) RGD myocarditis treatment IMP 11039042 RGD nephritis susceptibility ISO RGD:737323 11533935 associated with Purpura, Schoenlein-Henoch more ... RGD nephrosis treatment IMP 12879388 Adriamycin Nephrosis RGD nephrosis IEP 8157608 protein:increased activity:multiple (rats) RGD Nephrosis, Puromycin Aminonucleoside treatment IMP 12879820 RGD nephrotic syndrome IDA 11038913 protein:increased activity:multiple RGD nephrotic syndrome treatment IMP 1598707 RGD non-arteritic anterior ischemic optic neuropathy onset ISO RGD:737323 8548899 DNA:insertion/deletion:intron RGD obesity no_association ISO RGD:737323 1601115 RGD obesity IEP 2325227 protein:increased expression:liver RGD obstructive sleep apnea IEP 11039043 mRNA:increased expression:cardiac atrium RGD obstructive sleep apnea severity ISO RGD:737323 4140917 associated with Hypertension, DNA:polymorphism (human) RGD obstructive sleep apnea susceptibility ISO RGD:737323 4140915 DNA:polymorphism (human) RGD ocular hypotension IMP 11039029 RGD osteoporosis IMP 2325225 associated with Hypertension RGD Pain IMP 2325233 RGD pancreatic cancer ISO RGD:10468 2325208 RGD pancreatic ductal carcinoma ISO RGD:737323 2325211 mRNA, protein:increased expression:pancreas RGD Peritoneal Fibrosis treatment ISO RGD:10468 12879821 RGD Peritoneal Fibrosis treatment IMP 12879430 RGD pneumonia ISO RGD:737323 4140922 RGD pneumonia disease_progression ISO RGD:737323 4140918 RGD pneumonia ISO RGD:737323 4140916 associated with Hypertension RGD polycythemia treatment ISO RGD:737323 11038827 RGD pre-malignant neoplasm treatment IMP 11039027 associated with Colonic Neoplasms RGD primary biliary cirrhosis IEP 2325226 mRNA:increased expression:liver RGD proteinuria severity ISO RGD:737323 11038828 associated with Henoch-Schoenlein purpura, DNA:deletion:intron:IVS16+1464- 1751del (human) RGD proteinuria treatment IMP 12879396 associated with Acute Kidney Injury RGD pulmonary fibrosis IMP 4140923 associated with Hypertension RGD pulmonary fibrosis IMP 4140925 associated with Radiation Pneumonitis RGD pulmonary fibrosis ISO RGD:10468 4140478 associated with Lung Injury RGD pulmonary fibrosis IEP 4140483 associated with Lung Injury, protein:decreased expression:lung RGD pyelonephritis ISO RGD:737323 8158033 protein:decreased expression:kidney, brush border epithelial cell (human) RGD Radiation Nephropathy treatment IMP 12880012 RGD renal fibrosis ISO RGD:737323 8158033 protein:decreased expression:renal medulla, renal cortex, brush border epithelial cell (human) RGD renal fibrosis treatment IMP 12879403 RGD renovascular hypertension treatment IDA 8157609 RGD renovascular hypertension IEP 6893471 RGD Reperfusion Injury IMP 2325213 RGD Right Ventricular Hypertrophy IEP 8142368 associated with Hypertension, protein:increased activity:heart right ventricle (rat) RGD sarcoidosis disease_progression ISO RGD:737323 11039025 RGD Stroke IMP 6893481 RGD systemic scleroderma ISO RGD:737323 8548889 protein:decreased expression:plasma RGD type 1 diabetes mellitus disease progression ISO RGD:737323 7829799 DNA:deletion:intron:IVS16+1464-1751del (human) RGD type 1 diabetes mellitus ISO RGD:737323 7829770 protein:increased activity:serum (human) RGD type 2 diabetes mellitus susceptibility ISO RGD:737323 8142353 DNA:deletion:intron:IVS16+1464-1751del (human) RGD ureteral obstruction treatment IMP 12880020 RGD uveitis ISO RGD:737323 8142348 Chronic Granulomatous Uveitis, protein:increased expression:serum (human) RGD Vascular System Injuries susceptibility IAGP 8157602 DNA:repeat:intron:IVS13+40(CA)?-26 (rat) RGD Venous Thromboembolism susceptibility ISO RGD:737323 11038826 DNA:deletion:intron:IVS16+1464-1751del (human) RGD Ventricular Fibrillation treatment IMP 11039030 associated with Myocardial Reperfusion Injury RGD Ventricular Remodeling treatment IDA 9685440 associated with Acute Kidney Injury RGD
Imported Annotations - ClinVar
Angiotensin I-Converting Enzyme, Benign Serum Increase ISO RGD:737323 8554872 ClinVar Annotator: match by term: Angiotensin i-converting enzyme, benign serum increase ClinVar PMID:11076943 more ... Cerebral Hemorrhage ISO RGD:737323 8554872 ClinVar Annotator: match by term: Stroke, hemorrhagic, susceptibility to ClinVar PMID:10099885 more ... cerebral infarction ISO RGD:737323 8554872 ClinVar Annotator: match by term: Stroke, ischemic, susceptibility to ClinVar PMID:10099885 more ... diabetic angiopathy ISO RGD:737323 8554872 ClinVar Annotator: match by term: END-STAGE RENAL DISEASE, DIABETIC, SUSCEPTIBILITY TO ClinVar PMID:10099885 more ... IgA glomerulonephritis ISO RGD:737323 8554872 ClinVar Annotator: match by term: Susceptibility to progression to renal failure in IgA nephropathy ClinVar PMID:10099885 more ... kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:22095942 , PMID:24163131 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:25741868 , PMID:28492532 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:28492532 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:22095942 , PMID:25741868 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:22095942 , PMID:24033266 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:22095942 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:16116425 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar PMID:25741868 kidney disease ISO RGD:737323 8554872 ClinVar Annotator: match by term: Renal dysplasia ClinVar myocardial infarction ISO RGD:737323 8554872 ClinVar Annotator: match by term: Heart attack ClinVar PMID:10099885 more ...
Imported Annotations - CTD
adenocarcinoma ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21552421 Albuminuria ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23733546 Allanson Pantzar McLeod Syndrome ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16116425 Alzheimer's disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9916793 more ... atrial fibrillation ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15331425 autistic disorder ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27082637 berylliosis ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10194187 brain ischemia ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15534175 Cardiac Arrhythmias ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15331425 cardiovascular system disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11498459 more ... celiac disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30097691 Cerebral Hemorrhage ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15277638 congestive heart failure ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18586661 coronary artery disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14989558 Coronary Disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8170965 coronary restenosis ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9236417 Cough ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12848919 , PMID:15498266 Diabetes Mellitus, Experimental ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22191573 Diabetic Nephropathies ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7909524 more ... drug allergy ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18727619 end stage renal failure ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7593601 , PMID:10099885 Gaucher's disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12359135 Genetic Predisposition to Disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18727619 glycogen storage disease V ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12666117 hepatocellular carcinoma ISO RGD:737323 11554173 CTD Direct Evidence: therapeutic CTD PMID:16328049 hypertension ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15773232 more ... Hypotension ISO RGD:737323 11554173 CTD Direct Evidence: therapeutic CTD PMID:3544871 IgA glomerulonephritis ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7593601 , PMID:9259580 kidney disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8642790 kidney failure ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9259580 Left Ventricular Hypertrophy ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8349331 lung disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18702808 Lung Neoplasms ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21552421 male infertility ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8642790 Meningococcal Infections ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11956052 myocardial infarction ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:1328889 , PMID:8131300 Neoplasm Metastasis ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18059164 non-alcoholic fatty liver disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21664615 pre-eclampsia ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17114810 Premature Infant Diseases ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14657821 Prostatic Neoplasms ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17465223 pulmonary hypertension ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12359135 Renal Tubular Dysgenesis ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20454656 respiratory system disease ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14657821 severe acute respiratory syndrome ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15381116 Staphylococcal Infections ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8186310 Stomach Neoplasms ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18059164 Stroke ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15534175 substance-induced psychosis ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17196621 Sudden Death ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15331425 Vascular System Injuries ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19258495 viral pneumonia ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15381116 Weight Gain ISO RGD:737323 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25322899 Imported Annotations - Genetic Association Database
adult respiratory distress syndrome ISO RGD:737323 1331525 GAD alcoholic cardiomyopathy ISO RGD:737323 1331525 GAD Alzheimer's disease ISO RGD:737323 1331525 GAD bipolar disorder IEA 1331525 GAD carotid artery disease ISO RGD:737323 1331525 GAD coronary artery disease ISO RGD:737323 1331525 GAD Diabetic Nephropathies ISO RGD:737323 1331525 GAD diabetic retinopathy ISO RGD:737323 1331525 GAD end stage renal failure ISO RGD:737323 1331525 GAD hypertension ISO RGD:737323 1331525 GAD IgA glomerulonephritis ISO RGD:737323 1331525 GAD Insulin Resistance ISO RGD:737323 1331525 GAD intracranial aneurysm ISO RGD:737323 1331525 GAD Left Ventricular Hypertrophy ISO RGD:737323 1331525 GAD Memory Disorders ISO RGD:737323 1331525 GAD mitral valve prolapse ISO RGD:737323 1331525 GAD myocardial infarction ISO RGD:737323 1331525 GAD Parkinson's disease ISO RGD:737323 1331525 GAD sarcoidosis ISO RGD:737323 1331525 GAD Stroke ISO RGD:737323 1331525 GAD systemic lupus erythematosus ISO RGD:737323 1331525 GAD systemic scleroderma ISO RGD:737323 1331525 GAD type 2 diabetes mellitus ISO RGD:737323 1331525 GAD Imported Annotations - OMIM
Cerebral Hemorrhage susceptibility ISO RGD:737323 7240710 OMIM diabetic angiopathy ISO RGD:737323 7240710 OMIM Renal Tubular Dysgenesis ISO RGD:737323 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ACE mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:737323 6480464 Ascorbic Acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein] more ... CTD PMID:28544013 (R)-lipoic acid multiple interactions ISO RGD:10468 6480464 Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein], Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA] CTD PMID:27260466 (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE] CTD PMID:26518973 (S)-colchicine multiple interactions EXP 6480464 carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein] more ... CTD PMID:17135773 more ... (S)-colchicine decreases activity EXP 6480464 Colchicine results in decreased activity of ACE protein CTD PMID:17135773 more ... (S)-colchicine decreases expression EXP 6480464 Colchicine results in decreased expression of ACE protein CTD PMID:17652827 (S)-nicotine increases expression ISO RGD:737323 6480464 Nicotine results in increased expression of ACE mRNA CTD PMID:11166759 1,10-phenanthroline decreases expression ISO RGD:737323 6480464 1, 10-phenanthroline results in decreased expression of ACE mRNA CTD PMID:19502547 14,15-EET decreases activity EXP 6480464 14 more ... CTD PMID:27428043 17alpha-ethynylestradiol multiple interactions ISO RGD:10468 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACE mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:10468 6480464 Ethinyl Estradiol results in increased expression of ACE mRNA CTD PMID:17942748 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Testosterone] results in increased expression of ACE mRNA CTD PMID:11375906 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10468 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACE mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ACE mRNA CTD PMID:19490992 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects activity EXP 6480464 Puromycin Aminonucleoside affects the activity of ACE protein CTD PMID:1318808 3,3',5-triiodo-L-thyronine multiple interactions EXP 6480464 Triiodothyronine results in increased expression of and results in increased activity of ACE protein CTD PMID:1659346 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:737323 6480464 bisindolylmaleimide I inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of ACE mRNA CTD PMID:28522335 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile decreases expression EXP 6480464 Fadrozole results in decreased expression of ACE protein CTD PMID:18586661 4-hydroxyphenyl retinamide decreases expression ISO RGD:10468 6480464 Fenretinide results in decreased expression of ACE mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of ACE mRNA CTD PMID:24780913 , PMID:25825206 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression ISO RGD:10468 6480464 Uric Acid results in increased expression of ACE mRNA CTD PMID:30710622 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:10468 6480464 APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA] CTD PMID:30710622 acetylsalicylic acid affects response to substance ISO RGD:737323 6480464 ACE polymorphism affects the susceptibility to Aspirin CTD PMID:18727619 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein], Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] CTD PMID:15932931 aldehydo-D-glucose increases expression ISO RGD:737323 6480464 Glucose results in increased expression of ACE protein CTD PMID:16452552 aldehydo-D-glucose multiple interactions ISO RGD:737323 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] CTD PMID:16452552 aldosterone increases activity EXP 6480464 Aldosterone results in increased activity of ACE protein CTD PMID:15932931 aldosterone increases expression EXP 6480464 Aldosterone results in increased expression of ACE mRNA CTD PMID:15932931 aldosterone multiple interactions EXP 6480464 AG 1879 inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] more ... CTD PMID:15932931 aluminium atom decreases activity ISO RGD:10468 6480464 Aluminum results in decreased activity of ACE protein CTD PMID:12008977 aluminium(0) decreases activity ISO RGD:10468 6480464 Aluminum results in decreased activity of ACE protein CTD PMID:12008977 aminoguanidine multiple interactions ISO RGD:10468 6480464 pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein] CTD PMID:12161173 amitrole multiple interactions EXP 6480464 Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein] CTD PMID:25891026 amlodipine decreases expression EXP 6480464 Amlodipine results in decreased expression of ACE mRNA CTD PMID:16392774 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ACE mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:737323 6480464 Antirheumatic Agents results in increased expression of ACE mRNA CTD PMID:24449571 atrazine multiple interactions ISO RGD:737323 6480464 [Atrazine co-treated with Arsenates] results in increased expression of ACE mRNA CTD PMID:18585445 benazepril decreases activity ISO RGD:737323 6480464 benazepril results in decreased activity of ACE protein CTD PMID:8359184 benazepril affects response to substance ISO RGD:737323 6480464 ACE gene polymorphism affects the susceptibility to benazepril CTD PMID:11007831 more ... benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of ACE mRNA CTD PMID:21839799 benzo[a]pyrene increases expression ISO RGD:10468 6480464 Benzo(a)pyrene results in increased expression of ACE mRNA CTD PMID:22610609 , PMID:27195522 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACE mRNA CTD PMID:18164116 bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA], Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein] CTD PMID:16979161 bis(2-chloroethyl) sulfide affects response to substance ISO RGD:737323 6480464 ACE gene affects the susceptibility to Mustard Gas CTD PMID:18702808 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of ACE mRNA CTD PMID:15651846 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ACE mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA CTD PMID:27622962 bisphenol A increases expression ISO RGD:737323 6480464 bisphenol A results in increased expression of ACE mRNA CTD PMID:27622962 bisphenol A decreases methylation ISO RGD:10468 6480464 bisphenol A results in decreased methylation of ACE promoter CTD PMID:27312807 boric acid multiple interactions ISO RGD:737323 6480464 boric acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein] CTD PMID:28544013 bortezomib multiple interactions ISO RGD:737323 6480464 [Butyrates co-treated with Bortezomib] results in increased activity of ACE protein mutant form CTD PMID:20454656 caffeine decreases methylation EXP 6480464 Caffeine results in decreased methylation of ACE promoter CTD PMID:30423288 caffeine increases expression EXP 6480464 Caffeine results in increased expression of ACE mRNA, Caffeine results in increased expression of ACE protein CTD PMID:30423288 candesartan affects expression EXP 6480464 candesartan affects the expression of ACE mRNA CTD PMID:18796534 carbon nanotube affects expression ISO RGD:10468 6480464 Nanotubes, Carbon affects the expression of ACE protein CTD PMID:21135415 carvedilol multiple interactions EXP 6480464 carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein] CTD PMID:18992766 carvedilol multiple interactions ISO RGD:737323 6480464 carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA] CTD PMID:15071347 chromium atom decreases activity EXP 6480464 Chromium results in decreased activity of ACE protein CTD PMID:18374418 chromium(6+) affects expression ISO RGD:10468 6480464 chromium hexavalent ion affects the expression of ACE mRNA CTD PMID:28472532 cilazapril monohydrate affects response to substance ISO RGD:737323 6480464 ACE gene polymorphism affects the susceptibility to Cilazapril CTD PMID:15498266 cobalt dichloride increases expression ISO RGD:10468 6480464 cobaltous chloride results in increased expression of ACE mRNA, cobaltous chloride results in increased expression of ACE protein CTD PMID:25511041 cocaine multiple interactions ISO RGD:737323 6480464 ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone], ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol] CTD PMID:14738173 corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of ACE mRNA CTD PMID:15755911 , PMID:30423288 corticosterone decreases methylation EXP 6480464 Corticosterone results in decreased methylation of ACE promoter CTD PMID:30423288 corticosterone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in increased expression of ACE mRNA] CTD PMID:30423288 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] CTD PMID:10666014 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of ACE mRNA CTD PMID:27281708 D-glucose multiple interactions ISO RGD:737323 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] CTD PMID:16452552 D-glucose increases expression ISO RGD:737323 6480464 Glucose results in increased expression of ACE protein CTD PMID:16452552 DDT decreases expression EXP 6480464 DDT results in decreased expression of ACE mRNA CTD PMID:30207508 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of ACE mRNA CTD PMID:15932931 dexamethasone multiple interactions ISO RGD:10468 6480464 diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein] more ... CTD PMID:30940551 dexamethasone decreases activity EXP 6480464 Dexamethasone results in decreased activity of ACE protein CTD PMID:1659346 , PMID:9498404 dexamethasone increases expression ISO RGD:10468 6480464 Dexamethasone results in increased expression of ACE mRNA, Dexamethasone results in increased expression of ACE protein CTD PMID:22733784 , PMID:30940551 dexamethasone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in increased expression of ACE mRNA] CTD PMID:15932931 dextran sulfate multiple interactions ISO RGD:10468 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ACE mRNA CTD PMID:29950665 diisononyl phthalate increases expression ISO RGD:10468 6480464 diisononyl phthalate results in increased expression of ACE protein CTD PMID:30940551 diisononyl phthalate multiple interactions ISO RGD:10468 6480464 diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein], Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]] CTD PMID:30940551 dioxygen increases expression ISO RGD:10468 6480464 Oxygen deficiency results in increased expression of ACE mRNA, Oxygen deficiency results in increased expression of ACE protein CTD PMID:25511041 dioxygen multiple interactions ISO RGD:10468 6480464 Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein] CTD PMID:25511041 doxorubicin affects activity EXP 6480464 Doxorubicin affects the activity of ACE protein CTD PMID:8303709 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor decreases activity EXP 6480464 Angiotensin-Converting Enzyme Inhibitors results in decreased activity of ACE protein CTD PMID:15667801 enalapril decreases activity ISO RGD:737323 6480464 Enalapril results in decreased activity of ACE protein CTD PMID:20679179 , PMID:28973481 enalapril multiple interactions ISO RGD:10468 6480464 Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein], Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]] CTD PMID:30940551 enalapril decreases activity EXP 6480464 Enalapril results in decreased activity of ACE protein CTD PMID:15728788 , PMID:15816410 enalapril multiple interactions ISO RGD:737323 6480464 ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride], ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form] CTD PMID:20829712 enalapril increases expression EXP 6480464 Enalapril results in increased expression of ACE mRNA CTD PMID:15728788 enalapril multiple interactions EXP 6480464 Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA] more ... CTD PMID:15728788 , PMID:23733546 enalaprilat dihydrate multiple interactions ISO RGD:737323 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] CTD PMID:16452552 ethanol increases expression EXP 6480464 Ethanol results in increased expression of ACE mRNA CTD PMID:29548890 ethylbenzene multiple interactions ISO RGD:737323 6480464 [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ACE gene, [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ACE mRNA CTD PMID:26018793 ethylenediaminetetraacetic acid multiple interactions ISO RGD:737323 6480464 Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein] CTD PMID:28544013 ethylenediaminetetraacetic acid decreases activity ISO RGD:737323 6480464 Edetic Acid results in decreased activity of ACE protein CTD PMID:28544013 fenvalerate affects methylation ISO RGD:10468 6480464 fenvalerate affects the methylation of ACE gene CTD PMID:23548413 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of ACE mRNA CTD PMID:18035473 folic acid multiple interactions EXP 6480464 Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA] CTD PMID:15728788 folic acid increases expression EXP 6480464 Folic Acid results in increased expression of ACE mRNA CTD PMID:15728788 fructose increases expression EXP 6480464 Fructose results in increased expression of ACE mRNA CTD PMID:17587757 , PMID:30710622 fructose multiple interactions EXP 6480464 [bisphenol A co-treated with Fructose] results in increased expression of ACE mRNA, APLN protein modified form inhibits the reaction [Fructose results in increased expression of ACE mRNA] CTD PMID:27622962 , PMID:30710622 furan increases expression EXP 6480464 furan results in increased expression of ACE mRNA CTD PMID:27387713 genistein multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of ACE mRNA, Genistein inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] CTD PMID:15932931 , PMID:21782745 genistein increases expression EXP 6480464 Genistein results in increased expression of ACE mRNA CTD PMID:21782745 glucose multiple interactions ISO RGD:737323 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] CTD PMID:16452552 glucose increases expression ISO RGD:737323 6480464 Glucose results in increased expression of ACE protein CTD PMID:16452552 glycidol increases expression EXP 6480464 glycidol results in increased expression of ACE mRNA CTD PMID:24395379 GW 4064 increases expression ISO RGD:10468 6480464 GW 4064 results in increased expression of ACE mRNA CTD PMID:26655953 herbimycin multiple interactions ISO RGD:737323 6480464 herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 hydralazine multiple interactions EXP 6480464 Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA] CTD PMID:16326922 hydrazines decreases expression ISO RGD:10468 6480464 Hydrazines results in decreased expression of ACE mRNA CTD PMID:21647536 hydrochlorothiazide increases expression EXP 6480464 Hydrochlorothiazide results in increased expression of ACE mRNA CTD PMID:18796534 hydrochlorothiazide multiple interactions EXP 6480464 Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA] CTD PMID:16326922 hydrogen peroxide multiple interactions ISO RGD:737323 6480464 [GPX1 gene polymorphism co-treated with ACE gene polymorphism] affects the susceptibility to Hydrogen Peroxide CTD PMID:20444272 hydrogen peroxide increases expression ISO RGD:10468 6480464 Hydrogen Peroxide results in increased expression of ACE mRNA CTD PMID:30710622 indometacin multiple interactions ISO RGD:737323 6480464 Indomethacin promotes the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 indoxyl sulfate increases expression EXP 6480464 Indican results in increased expression of ACE mRNA CTD PMID:25056788 ketamine increases expression EXP 6480464 Ketamine results in increased expression of ACE mRNA CTD PMID:20080153 L-ascorbic acid multiple interactions ISO RGD:737323 6480464 Ascorbic Acid inhibits the reaction [epigallocatechin gallate results in decreased activity of ACE protein] CTD PMID:28544013 Lasiocarpine decreases expression ISO RGD:737323 6480464 lasiocarpine metabolite results in decreased expression of ACE mRNA CTD PMID:30465738 lead diacetate affects expression EXP 6480464 lead acetate affects the expression of ACE mRNA CTD PMID:21864555 , PMID:22641619 lead(0) increases activity EXP 6480464 Lead results in increased activity of ACE protein CTD PMID:21364929 lead(2+) increases activity EXP 6480464 Lead results in increased activity of ACE protein CTD PMID:21364929 lipoic acid multiple interactions ISO RGD:10468 6480464 Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein], Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA] CTD PMID:27260466 lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE] CTD PMID:26518973 lisinopril dihydrate decreases activity ISO RGD:737323 6480464 Lisinopril analog results in decreased activity of ACE protein CTD PMID:22200082 losartan multiple interactions ISO RGD:10468 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein], Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein] CTD PMID:25511041 , PMID:28578904 losartan multiple interactions ISO RGD:737323 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein] CTD PMID:28578904 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of ACE mRNA CTD PMID:28801915 manidipine decreases expression EXP 6480464 manidipine results in decreased expression of ACE mRNA CTD PMID:16392774 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of ACE mRNA CTD PMID:21782745 methoxychlor multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of ACE mRNA CTD PMID:21782745 metoprolol affects response to substance ISO RGD:737323 6480464 ACE gene polymorphism affects the susceptibility to Metoprolol CTD PMID:20819590 microcystin RR increases expression ISO RGD:10468 6480464 microcystin RR results in increased expression of ACE mRNA, microcystin RR results in increased expression of ACE protein CTD PMID:28330766 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in increased expression of ACE mRNA], Mifepristone inhibits the reaction [Dexamethasone results in increased expression of ACE mRNA] CTD PMID:15932931 , PMID:30423288 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:737323 6480464 [Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the localization of ACE protein mutant form, [Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased activity of ACE protein mutant form CTD PMID:20454656 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACE mRNA CTD PMID:18164116 Nandrolone decanoate increases expression EXP 6480464 nandrolone decanoate results in increased expression of ACE mRNA CTD PMID:17906098 nicotine increases expression ISO RGD:737323 6480464 Nicotine results in increased expression of ACE mRNA CTD PMID:11166759 nicotinic acid decreases activity EXP 6480464 Niacin results in decreased activity of ACE protein CTD PMID:18374418 nitric oxide multiple interactions EXP 6480464 Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA], Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA] CTD PMID:16326922 nitric oxide increases expression EXP 6480464 Nitric Oxide deficiency results in increased expression of ACE mRNA CTD PMID:10948087 , PMID:16326922 nitrofen decreases activity EXP 6480464 nitrofen results in decreased activity of ACE protein CTD PMID:9498404 NS-398 multiple interactions ISO RGD:737323 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 omapatrilat decreases activity ISO RGD:737323 6480464 omapatrilat results in decreased activity of ACE protein CTD PMID:11762555 ouabain affects expression EXP 6480464 Ouabain affects the expression of ACE mRNA, Ouabain affects the expression of ACE protein CTD PMID:16565308 paraquat multiple interactions ISO RGD:10468 6480464 pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein] CTD PMID:12161173 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of ACE mRNA CTD PMID:20465954 paraquat decreases activity EXP 6480464 Paraquat results in decreased activity of ACE protein CTD PMID:16182431 paraquat affects expression EXP 6480464 Paraquat affects the expression of ACE protein CTD PMID:10666014 paraquat multiple interactions EXP 6480464 Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein], Unithiol inhibits the reaction [Paraquat results in decreased expression of ACE mRNA] CTD PMID:10666014 , PMID:20465954 paraquat decreases activity ISO RGD:10468 6480464 Paraquat results in decreased activity of ACE protein CTD PMID:12161173 perindopril affects response to substance ISO RGD:737323 6480464 ACE gene polymorphism affects the susceptibility to Perindopril CTD PMID:11007831 phenylephrine affects response to substance ISO RGD:737323 6480464 ACE protein affects the susceptibility to Phenylephrine CTD PMID:18431347 phorbol 13-acetate 12-myristate increases expression ISO RGD:737323 6480464 Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA CTD PMID:15071347 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:737323 6480464 carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 , PMID:15071347 pioglitazone multiple interactions EXP 6480464 pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE mRNA], pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE protein] CTD PMID:16979161 pirinixic acid decreases expression ISO RGD:10468 6480464 pirinixic acid results in decreased expression of ACE mRNA CTD PMID:17426115 potassium dichromate decreases expression ISO RGD:10468 6480464 Potassium Dichromate results in decreased expression of ACE mRNA CTD PMID:23608068 proanthocyanidin decreases activity EXP 6480464 Proanthocyanidins results in decreased activity of ACE protein CTD PMID:16390204 prostaglandin E2 multiple interactions ISO RGD:737323 6480464 ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone] CTD PMID:14738173 prostaglandin I2 multiple interactions ISO RGD:737323 6480464 ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol] CTD PMID:14738173 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein] CTD PMID:18980205 quercetin multiple interactions ISO RGD:10468 6480464 Quercetin affects the reaction [Dietary Fats affects the activity of ACE protein], Quercetin affects the reaction [Dietary Fats affects the expression of ACE mRNA] CTD PMID:27260466 quercetin increases expression EXP 6480464 Quercetin results in increased expression of ACE mRNA CTD PMID:18095365 quinapril hydrochloride decreases activity EXP 6480464 Quinapril results in decreased activity of ACE protein CTD PMID:15728788 quinapril hydrochloride decreases activity ISO RGD:737323 6480464 Quinapril results in decreased activity of ACE protein CTD PMID:8227822 raloxifene decreases expression ISO RGD:737323 6480464 Raloxifene Hydrochloride results in decreased expression of ACE mRNA CTD PMID:15849065 ramipril decreases activity ISO RGD:737323 6480464 Ramipril results in decreased activity of ACE protein CTD PMID:10543928 , PMID:3034026 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of ACE protein CTD PMID:21962734 resveratrol multiple interactions ISO RGD:10468 6480464 resveratrol affects the reaction [Dietary Fats affects the activity of ACE protein], resveratrol affects the reaction [Dietary Fats affects the expression of ACE mRNA] CTD PMID:27260466 resveratrol multiple interactions EXP 6480464 Resveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein], Resveratrol inhibits the reaction [Streptozocin results in increased expression of ACE mRNA] CTD PMID:17135773 , PMID:22191573 rivastigmine multiple interactions EXP 6480464 Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein] CTD PMID:17652827 silver atom increases expression EXP 6480464 Silver results in increased expression of ACE mRNA CTD PMID:26277626 silver(0) increases expression EXP 6480464 Silver results in increased expression of ACE mRNA CTD PMID:26277626 sodium arsenite increases expression ISO RGD:737323 6480464 sodium arsenite results in increased expression of ACE mRNA, sodium arsenite results in increased expression of ACE protein CTD PMID:28973481 sodium arsenite decreases expression ISO RGD:737323 6480464 sodium arsenite results in decreased expression of ACE mRNA CTD PMID:29301061 sodium arsenite multiple interactions ISO RGD:737323 6480464 ERN1 affects the reaction [sodium arsenite results in increased expression of ACE mRNA] more ... CTD PMID:28973481 sodium chloride multiple interactions ISO RGD:737323 6480464 ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride], ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form] CTD PMID:20829712 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of ACE mRNA CTD PMID:22561333 sodium fluoride decreases expression ISO RGD:10468 6480464 Sodium Fluoride results in decreased expression of ACE protein CTD PMID:28918527 spironolactone multiple interactions EXP 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein], Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] CTD PMID:15932931 spironolactone decreases expression EXP 6480464 Spironolactone results in decreased expression of ACE protein CTD PMID:18586661 streptozocin multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA] more ... CTD PMID:16979161 more ... streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of ACE mRNA, Streptozocin results in increased expression of ACE protein CTD PMID:15793251 more ... sunitinib decreases expression ISO RGD:737323 6480464 Sunitinib results in decreased expression of ACE mRNA CTD PMID:31533062 telmisartan decreases expression EXP 6480464 telmisartan results in decreased expression of ACE mRNA CTD PMID:19171132 testosterone multiple interactions EXP 6480464 [Estradiol co-treated with Testosterone] results in increased expression of ACE mRNA CTD PMID:11375906 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of ACE mRNA, Carbon Tetrachloride results in increased expression of ACE protein CTD PMID:12629582 , PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ACE mRNA] CTD PMID:31150632 titanium dioxide decreases expression ISO RGD:10468 6480464 titanium dioxide results in decreased expression of ACE mRNA CTD PMID:23557971 titanium dioxide multiple interactions ISO RGD:10468 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ACE mRNA CTD PMID:29950665 titanium dioxide increases expression ISO RGD:10468 6480464 titanium dioxide results in increased expression of ACE mRNA CTD PMID:29264374 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of ACE mRNA CTD PMID:26277626 toluene multiple interactions ISO RGD:737323 6480464 [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased methylation of ACE gene, [Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased expression of ACE mRNA CTD PMID:26018793 trandolapril decreases activity EXP 6480464 trandolapril results in decreased activity of ACE protein CTD PMID:27428043 triclosan decreases expression ISO RGD:737323 6480464 Triclosan results in decreased expression of ACE mRNA CTD PMID:30510588 tyrphostin AG 1478 multiple interactions EXP 6480464 RTKI cpd inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] CTD PMID:15932931 valproic acid increases methylation ISO RGD:737323 6480464 Valproic Acid results in increased methylation of ACE gene CTD PMID:29154799 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA], Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein] CTD PMID:23733546 venlafaxine hydrochloride increases expression EXP 6480464 Venlafaxine Hydrochloride results in increased expression of ACE mRNA CTD PMID:25423262 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of ACE mRNA CTD PMID:19015723 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of ACE mRNA CTD PMID:30207508 zinc atom decreases activity ISO RGD:737323 6480464 Zinc results in decreased activity of ACE protein CTD PMID:17114810 zinc sulfate multiple interactions ISO RGD:737323 6480464 Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein] CTD PMID:28544013 zinc(0) decreases activity ISO RGD:737323 6480464 Zinc results in decreased activity of ACE protein CTD PMID:17114810
Biological Process aging IEP 6893473 RGD amyloid-beta metabolic process ISO RGD:737323 1624291 (PMID:18495113), (PMID:19773553) RGD PMID:18495113 , PMID:19773553 amyloid-beta metabolic process IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 angiogenesis involved in coronary vascular morphogenesis IMP 6893472 RGD animal organ regeneration IMP 6893485 RGD arachidonic acid secretion ISO RGD:737323 1624291 (PMID:17077303) RGD PMID:17077303 arachidonic acid secretion IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 bradykinin catabolic process IDA 8142366 RGD bradykinin catabolic process IMP 7401264 RGD brain development IEP 8142371 RGD cell proliferation in bone marrow ISO RGD:10468 1624291 (MGI:MGI:5613472, PMID:20116413) RGD MGI:MGI:5613472 , PMID:20116413 cell proliferation in bone marrow IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to aldosterone IEP 12859284 RGD cellular response to glucose stimulus IEP 8142381 RGD eating behavior IMP 2325227 RGD embryo development ending in birth or egg hatching IMP 12879818 RGD female pregnancy IEP 8548898 RGD heart contraction ISO RGD:10468 1624291 (MGI:MGI:3710915, PMID:16585392) RGD MGI:MGI:3710915 , PMID:16585392 heart contraction IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 hormone catabolic process ISO RGD:10468 1624291 (MGI:MGI:3793932, PMID:11303049) RGD MGI:MGI:3793932 , PMID:11303049 hormone catabolic process IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 hormone catabolic process IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 hormone catabolic process ISO RGD:737323 1624291 (PMID:7876104) RGD PMID:7876104 kidney development IEP 8158036 RGD kidney development IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 kidney development IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 kidney development ISO RGD:737323 1624291 (PMID:16116425) RGD PMID:16116425 kidney development ISO RGD:10468 1624291 MGI:MGI:1857115 (MGI:MGI:3770099 , PMID:17135368) RGD MGI:MGI:3770099 , PMID:17135368 lung alveolus development IMP 6893470 RGD lung development IEP 8158036 RGD male gonad development IEP 8158036 RGD negative regulation of blood vessel diameter IMP 12879819 RGD negative regulation of calcium ion import IMP 8142367 RGD negative regulation of gap junction assembly ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 negative regulation of gap junction assembly IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of gene expression ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 negative regulation of gene expression IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of glucose import IMP 11039409 RGD negative regulation of protein binding ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 negative regulation of protein binding IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of renal sodium excretion IMP 12880016 RGD neutrophil mediated immunity ISO RGD:10468 1624291 (MGI:MGI:3814166, PMID:17082641) RGD MGI:MGI:3814166 , PMID:17082641 neutrophil mediated immunity IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptide catabolic process IDA 8157607 RGD peptide catabolic process IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptide catabolic process ISO RGD:737323 1624291 (PMID:15283675), (PMID:4322742) RGD PMID:15283675 , PMID:4322742 peptide metabolic process IMP 1581953 RGD positive regulation of apoptotic process IMP 2311449 RGD positive regulation of blood pressure IMP 12879819 RGD positive regulation of blood pressure IBA MGI:MGI:87874 more ... 13792537 PMID:21873635 GO_Central positive regulation of inflammatory response IMP 2325219 RGD positive regulation of neurogenesis IMP 2325223 RGD positive regulation of peptidyl-cysteine S-nitrosylation ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 positive regulation of peptidyl-cysteine S-nitrosylation IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of peptidyl-tyrosine autophosphorylation ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 positive regulation of peptidyl-tyrosine autophosphorylation IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein binding ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 positive regulation of protein binding IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein tyrosine kinase activity ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 positive regulation of protein tyrosine kinase activity IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of systemic arterial blood pressure IMP 8142367 RGD positive regulation of systemic arterial blood pressure IBA MGI:MGI:87874 more ... 13792537 PMID:21873635 GO_Central positive regulation of systemic arterial blood pressure IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of systemic arterial blood pressure ISO RGD:10468 1624291 MGI:MGI:1857115 (MGI:MGI:1096074 more ... RGD MGI:MGI:1096074 more ... posttranscriptional regulation of gene expression ISO RGD:10468 1624291 (MGI:MGI:5607357, PMID:25017399) RGD MGI:MGI:5607357 , PMID:25017399 posttranscriptional regulation of gene expression IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 proteolysis IEA UniRule:UR000127453 1600115 GO_REF:0000104 UniProt GO_REF:0000104 proteolysis IEA UniProtKB-KW:KW-0645 1600115 GO_REF:0000037 UniProt GO_REF:0000037 regulation of angiotensin metabolic process ISO RGD:737323 1624291 (PMID:1851160) RGD PMID:1851160 regulation of angiotensin metabolic process IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of blood pressure TAS 61036 RGD regulation of blood pressure IDA 8553744 PMID:1750504 BHF-UCL regulation of blood pressure ISO RGD:10468 1624291 (MGI:MGI:3793932, PMID:11303049) RGD MGI:MGI:3793932 , PMID:11303049 regulation of hematopoietic stem cell proliferation ISO RGD:10468 1624291 (MGI:MGI:5613472, PMID:20116413) RGD MGI:MGI:5613472 , PMID:20116413 regulation of hematopoietic stem cell proliferation IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of smooth muscle cell migration IDA 8553744 PMID:1750504 BHF-UCL regulation of systemic arterial blood pressure by renin-angiotensin ISO RGD:737323 1624291 (PMID:174834) RGD PMID:174834 regulation of systemic arterial blood pressure by renin-angiotensin IBA PANTHER:PTN000053931 , UniProtKB:P12821 13792537 PMID:21873635 GO_Central regulation of systemic arterial blood pressure by renin-angiotensin IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to dexamethasone IEP 8157606 RGD response to drug IEP 8142365 enalapril RGD response to hypoxia IEP 1358270 RGD response to laminar fluid shear stress IEP 8142369 RGD response to lipopolysaccharide IMP 2325231 RGD response to nutrient levels IEP 2325234 RGD response to thyroid hormone IEP 8157606 triiodothyronine RGD sensory perception of pain IMP 2325233 RGD spermatogenesis ISO RGD:10468 1624291 MGI:MGI:1857115 (MGI:MGI:3770099 , PMID:17135368) RGD MGI:MGI:3770099 , PMID:17135368 spermatogenesis IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 vasoconstriction IMP 2325222 RGD Cellular Component basal plasma membrane IDA 8157610 RGD brush border membrane IDA 8142378 RGD cytoplasm ISO RGD:10468 1624291 (MGI:MGI:5582870, PMID:23535237) RGD MGI:MGI:5582870 , PMID:23535237 endosome ISO RGD:737323 1624291 (PMID:17077303) RGD PMID:17077303 endosome IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 external side of plasma membrane ISO RGD:737323 1624291 (PMID:9449382) RGD PMID:9449382 external side of plasma membrane IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular exosome ISO RGD:737323 1624291 (PMID:15326289), (PMID:21082674) RGD PMID:15326289 , PMID:21082674 extracellular exosome IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular space IDA 2313695 RGD extracellular space IBA FB:FBgn0012037 more ... 13792537 PMID:21873635 GO_Central extracellular space ISO RGD:737323 1624291 (PMID:15283675), (PMID:1668266), (PMID:4322742) RGD PMID:15283675 more ... integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProt GO_REF:0000037 lysosome ISO RGD:737323 1624291 (PMID:11076943) RGD PMID:11076943 lysosome IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane IDA 2325212 RGD plasma membrane IBA MGI:MGI:1917258 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISO RGD:737323 1624291 (PMID:16186248), (PMID:17077303) RGD PMID:16186248 , PMID:17077303 plasma membrane ISO RGD:10468 1624291 (MGI:MGI:5582870, PMID:23535237) RGD MGI:MGI:5582870 , PMID:23535237 sperm midpiece IDA 1298874 RGD vesicle IDA 8157610 RGD Molecular Function actin binding ISO RGD:737323 1624291 (PMID:16186248) RGD PMID:16186248 bradykinin receptor binding ISO RGD:737323 1624291 UniProtKB:P30411 (PMID:17077303) RGD PMID:17077303 bradykinin receptor binding IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 carboxypeptidase activity IEA UniProtKB-KW:KW-0121 1600115 GO_REF:0000037 UniProt GO_REF:0000037 carboxypeptidase activity IEA UniProtKB-KW:KW-0121 1600115 GO_REF:0000038 UniProt GO_REF:0000038 chloride ion binding ISO RGD:737323 1624291 (PMID:12540854) RGD PMID:12540854 chloride ion binding IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 dipeptidyl-peptidase activity IBA PANTHER:PTN000053976 more ... 13792537 PMID:21873635 GO_Central drug binding ISO RGD:737323 1624291 (PMID:1320019) RGD PMID:1320019 drug binding IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 drug binding IPI CHEBI:43755 8142376 RGD endopeptidase activity ISO RGD:737323 1624291 (PMID:15283675), (PMID:18495113) RGD PMID:15283675 , PMID:18495113 endopeptidase activity IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 exopeptidase activity ISO RGD:737323 1624291 (PMID:2983326) RGD PMID:2983326 exopeptidase activity IBA FB:FBgn0012037 more ... 13792537 PMID:21873635 GO_Central metallodipeptidase activity ISO RGD:737323 1624291 (PMID:1848554), (PMID:1851160), (PMID:20011602), (PMID:2846041) RGD PMID:1848554 more ... metallopeptidase activity IMP 7401264 RGD metallopeptidase activity IBA MGI:MGI:87874 more ... 13792537 PMID:21873635 GO_Central metallopeptidase activity IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 metallopeptidase activity IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 metallopeptidase activity ISO RGD:737323 1624291 (PMID:1320019), (PMID:1668266), (PMID:17077303), (PMID:2849100) RGD PMID:1320019 more ... metallopeptidase activity ISO RGD:10468 1624291 (MGI:MGI:3793932, PMID:11303049) RGD MGI:MGI:3793932 , PMID:11303049 mitogen-activated protein kinase binding ISO RGD:737323 1624291 UniProtKB:P45983 (PMID:14615289) RGD PMID:14615289 mitogen-activated protein kinase binding IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitogen-activated protein kinase kinase binding ISO RGD:737323 1624291 UniProtKB:O14733 (PMID:14615289) RGD PMID:14615289 mitogen-activated protein kinase kinase binding IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidase activity ISO RGD:10468 1624291 MGI:MGI:1857115 (MGI:MGI:1096074 , PMID:9231832) RGD MGI:MGI:1096074 , PMID:9231832 peptidyl-dipeptidase activity IDA 1298871 RGD peptidyl-dipeptidase activity IBA FB:FBgn0012037 more ... 13792537 PMID:21873635 GO_Central peptidyl-dipeptidase activity IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-dipeptidase activity IEA UniProtKB:P09470 , ensembl:ENSMUSP000000019631600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-dipeptidase activity ISO RGD:737323 1624291 (PMID:1320019), (PMID:15283675), (PMID:1668266), (PMID:17077303), (PMID:1851160), (PMID:19773553), (PMID:2849100), (PMID:6208535), (PMID:7683654), (PMID:7876104) RGD PMID:1320019 more ... peptidyl-dipeptidase activity ISO RGD:10468 1624291 (MGI:MGI:3793932, PMID:11303049) RGD MGI:MGI:3793932 , PMID:11303049 protein binding ISO RGD:10468 1624291 UniProtKB:E9Q9D5 (MGI:MGI:5468889 , PMID:23055941) RGD MGI:MGI:5468889 , PMID:23055941 protein binding ISO RGD:737323 1624291 UniProtKB:P35579 (PMID:16186248) RGD PMID:16186248 tripeptidyl-peptidase activity ISO RGD:737323 1624291 (PMID:2983326) RGD PMID:2983326 tripeptidyl-peptidase activity IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107 zinc ion binding ISO RGD:737323 1624291 (PMID:12540854) RGD PMID:12540854 zinc ion binding IEA UniProtKB:P12821 , ensembl:ENSP000002908661600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
