Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus
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Symbol: Ace
Name: angiotensin I converting enzyme
Description: Exhibits drug binding activity, metallopeptidase activity, and peptidyl-dipeptidase activity; involved in several processes, including animal organ development, negative regulation of transport, and response to steroid hormone; localizes to several cellular components, including the basal plasma membrane, extracellular space, and plasma membrane bounded cell projection part; used to study several diseases, including artery disease (multiple), glomerulonephritis (multiple), kidney failure (multiple), lung disease (multiple), and proteinuria (multiple); biomarker of several diseases, including artery disease (multiple), autosomal recessive polycystic kidney disease, congenital diaphragmatic hernia, congestive heart failure, and lung disease (multiple); orthologous to human ACE (angiotensin I converting enzyme); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; angiotensin II signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-colchicine; 14,15-EET.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: angiotensin 1 converting enzyme; angiotensin 1 converting enzyme 1; angiotensin converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme; CD143; Dcp1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; kininase II; StsRR92
Orthologs:
Allele / Splice: Aceem1Mcwi   Aceem2Mcwi  
Genetic Models: SS-Aceem1Mcwi SS-Aceem2Mcwi
Is Marker For: Strains:   SD-Tg(Ren2)27   SS.MNS-(D10M11Mit119-D10Mit11)/Jr   LOU.BN-(D10Mgh1-D10Mgh14)/Ins  
QTLs:   Bp9   Bw57   Bp342   Bw102  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
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Genetic Models

Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

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Nomenclature History
RGD Curation Notes
 
More on Ace
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 2493
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.