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| Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus |  Analyze |
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| Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Angiotensin I-Converting Enzyme, Benign Serum Increase | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Angiotensin i-converting enzyme, benign serum increase | ClinVar | PMID:11076943 more ... | Cerebral Hemorrhage | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Stroke, hemorrhagic, susceptibility to | ClinVar | PMID:10099885 more ... | cerebral infarction | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Stroke, ischemic, susceptibility to | ClinVar | PMID:10099885 more ... | IgA glomerulonephritis | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Susceptibility to progression to renal failure in IgA nephropathy | ClinVar | PMID:10099885 more ... | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 PMID:24163131 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 PMID:25741868 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 PMID:24033266 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:16116425 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:25741868 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | | Microvascular Complications of Diabetes, Susceptibility to, 2 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: END-STAGE RENAL DISEASE, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 3 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 4 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 6 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 7 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | myocardial infarction | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Heart attack | ClinVar | PMID:10099885 more ... | Smith-Magenis syndrome | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Smith-Magenis syndrome | ClinVar | PMID:25087610 | |
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References - uncurated| PubMed | 174834 1298871 1320019 1668266 1848554 1851160 2846041 2849100 2983326 4322742 6208535 7683654 7876104 9231832 9449382 10406820 11076943 11303049 11702851 12193663 12477932 12540854 12963491 14527934 14615289 14693687 14872008 15047629 15194348 15326289 15475532 15489334 15531746 15869764 15932931 15961527 15992826 16009784 16027241 16116425 16186248 16230508 16325859 16434838 16502470 16585392 17077303 17082641 17135368 17487824 17785632 17898118 17903697 18174884 18495113 18957386 19012043 19056867 19255705 19419949 19472100 19733634 19773553 20011602 20022959 20051229 20116413 20570682 20888351 21053061 21082674 21167844 21495912 21602471 21720771 21788250 21873635 21959517 22191573 22311897 22378820 22498331 23132538 23365412 23376485 23533145 23535237 23603844 23661144 23706365 23733546 23749777 23975725 24035938 24126381 24781988 25017399 25031298 25194129 25205218 25217176 25401104 25766467 25768373 26010093 26371174 26400542 26697495 27465904 27710705 27923787 28003214 28536140 |
RGD Disease Portals| Ace has been annotated in the following RGD Disease Portals. |
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Genomics
Candidate Gene Status |
Ace is a candidate Gene for QTL Bp1 |
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Ace is a candidate Gene for QTL Bp9 |
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Ace is a candidate Gene for QTL Bp72 |
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Ace is a candidate Gene for QTL Bp128 |
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Ace is a candidate Gene for QTL Bp342 |
Comparative Map Data| Ace (Rattus norvegicus - Norway rat) |
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| ACE (Homo sapiens - human) |
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| Ace (Mus musculus - house mouse) |
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| ACE (Canis lupus familiaris - dog) |
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| LOC101968921 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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Position Markers| D10Mit1 |
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| D10Wox18 |
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| RH94768 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat StrainsThe following Strains have been annotated to Ace
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Genetic ModelsSequence
Nucleotide Sequences| RefSeq Transcripts | NM_012544 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR07030583 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07030584 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01066252 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF201331 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF201332 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF532783 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF532784 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF539425 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF539701 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AY344961 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC085760 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| L36664 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U03708 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U03734 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_012544 | ||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
CGCCGCACCGCGCGCACCGCGCCATGGGGGCCGCGTCCGGCCAGCGGGGGCGGTGGCCGTTGTChide sequence |
Protein Sequences| Protein RefSeqs | NP_036676 | (Get FASTA) | NCBI Sequence Viewer |
| GenBank Protein | AAA50505 | (Get FASTA) | NCBI Sequence Viewer |
| AAA82110 | (Get FASTA) | NCBI Sequence Viewer | |
| AAA82111 | (Get FASTA) | NCBI Sequence Viewer | |
| AAG35596 | (Get FASTA) | NCBI Sequence Viewer | |
| AAG35597 | (Get FASTA) | NCBI Sequence Viewer | |
| AAH85760 | (Get FASTA) | NCBI Sequence Viewer | |
| AAN17280 | (Get FASTA) | NCBI Sequence Viewer | |
| AAN17281 | (Get FASTA) | NCBI Sequence Viewer | |
| AAP80808 | (Get FASTA) | NCBI Sequence Viewer | |
| AAP80809 | (Get FASTA) | NCBI Sequence Viewer | |
| AAQ23132 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM06348 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM06349 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM06350 | (Get FASTA) | NCBI Sequence Viewer | |
| P47820 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| Protein Acc Id: | NP_036676 |
| Peptide Label: | precursor |
| Sequence: |
MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGNFSADEAGAQLFADSYNSSAEhide sequence |
Protein Structures| Name | Modeller | Protein Id | AA Range | Protein Structure | Video |
| ACE N-Terminal | pdb 2c6f | P47820 | 36-636 | view protein structure | |
| ACE C-Terminal | pdb 108a | P47820 | 637-1238 | view protein structure | view video |
TranscriptomeStrain Variation
Strain Sequence Variants (Rnor 5.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000062101 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000010627 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000010627 | ENTREZGENE, UniProtKB/TrEMBL |
| IMAGE_CLONE | IMAGE:7097136 | IMAGE-MGC_LOAD |
| InterPro | Peptidase_M2 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24310 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93629 | IMAGE-MGC_LOAD |
| NCBI Gene | 24310 | ENTREZGENE |
| PANTHER | Peptidase_M2 | UniProtKB/Swiss-Prot |
| Pfam | Peptidase_M2 | UniProtKB/Swiss-Prot |
| PharmGKB | ACE | RGD |
| PhenoGen | Ace | PhenoGen |
| PRINTS | PEPDIPTASEA | UniProtKB/Swiss-Prot |
| PROSITE | ZINC_PROTEASE | UniProtKB/Swiss-Prot |
| UniGene | Rn.10149 | ENTREZGENE |
| UniProt | A0A0A0MXV4_RAT | UniProtKB/TrEMBL |
| ACE_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
| UniProt Secondary | Q7TMC6 | UniProtKB/Swiss-Prot |
| Q8CFN1 | UniProtKB/Swiss-Prot | |
| Q9EQM9 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | angiotensin 1 converting enzyme | Name updated | 1299863 | APPROVED | |
| 2004-12-14 | Ace | angiotensin 1 converting enzyme | angiotensin 1 converting enzyme 1 | Name updated | 1299863 | APPROVED | |
| 2002-06-10 | Ace | angiotensin 1 converting enzyme 1 | Symbol and Name updated | 70585 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | affects heart mass independent of blood pressure | 1357231 |
| gene_process | functions in the renin-angiotensin system | 61036 |
| gene_process | plays an important role in the regulation of blood volume and pressure | 61036 |
| gene_process | level of plasma enzyme activity does not directly link to blood pressure | 619632 |
| More on Ace | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 2493 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2018-05-29 |
| Status: | ACTIVE |
