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| Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus |  Analyze |
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| Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Angiotensin I-Converting Enzyme, Benign Serum Increase | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Angiotensin i-converting enzyme, benign serum increase | ClinVar | PMID:11076943 more ... | Cerebral Hemorrhage | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Stroke, hemorrhagic, susceptibility to | ClinVar | PMID:10099885 more ... | cerebral infarction | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Stroke, ischemic, susceptibility to | ClinVar | PMID:10099885 more ... | IgA glomerulonephritis | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Susceptibility to progression to renal failure in IgA nephropathy | ClinVar | PMID:10099885 more ... | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 PMID:24163131 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 PMID:25741868 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 PMID:24033266 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:22095942 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:16116425 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | PMID:25741868 | kidney disease | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Renal dysplasia | ClinVar | | Microvascular Complications of Diabetes, Susceptibility to, 2 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: END-STAGE RENAL DISEASE, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 3 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 4 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 6 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | Microvascular Complications of Diabetes, Susceptibility to, 7 | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: NEPHROPATHY, DIABETIC, SUSCEPTIBILITY TO | ClinVar | PMID:10099885 more ... | myocardial infarction | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Heart attack | ClinVar | PMID:10099885 more ... | Smith-Magenis syndrome | | ISO | RGD:737323 | 8554872 | ClinVar Annotator: match by term: Smith-Magenis syndrome | ClinVar | PMID:25087610 | |
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References - curated| 1. | Abdel-Wahab BA, etal., Chem Biol Interact. 2014 Jun 5;216:43-52. doi: 10.1016/j.cbi.2014.03.012. Epub 2014 Apr 5. |
| 2. | Agarwal R, etal., Eur J Pharmacol. 2014 May 5;730:8-13. doi: 10.1016/j.ejphar.2014.02.021. Epub 2014 Feb 26. |
| 3. | al-Shabanah OA, etal., Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):221-30. |
| 4. | Albayrak M, etal., J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):259-64. doi: 10.1177/1470320312437070. Epub 2012 Feb 16. |
| 5. | Altas M, etal., J Clin Neurosci. 2010 Aug;17(8):1034-7. doi: 10.1016/j.jocn.2009.12.002. Epub 2010 May 21. |
| 6. | Antus B, etal., J Heart Lung Transplant. 2006 Nov;25(11):1324-9. |
| 7. | Arafat HA, etal., J Am Coll Surg. 2007 May;204(5):996-1005; discussion 1005-6. |
| 8. | Arevalo AE, etal., Clin Chim Acta. 1990 Nov 5;191(3):175-84. |
| 9. | Bardi E, etal., Pediatr Blood Cancer. 2005 Aug;45(2):217-21. |
| 10. | Batista EC, etal., J Mol Med (Berl). 2011 Jan;89(1):65-74. doi: 10.1007/s00109-010-0686-2. Epub 2010 Oct 13. |
| 11. | Baybutt RC, etal., Curr Pharm Des. 2007;13(13):1327-33. |
| 12. | Becker KG, etal., Nat Genet. 2004 May;36(5):431-2. |
| 13. | Bell CG, etal., Eur J Hum Genet. 2007 Mar;15(3):320-7. Epub 2006 Dec 13. |
| 14. | Benigni A, etal., Am J Pathol. 2011 Aug;179(2):628-38. doi: 10.1016/j.ajpath.2011.04.003. Epub 2011 Jun 2. |
| 15. | Benigni A, etal., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10. |
| 16. | Boonyapisit W and Tresukosol D, J Med Assoc Thai. 2010 Jan;93 Suppl 1:S48-53. |
| 17. | Bos H, etal., J Renin Angiotensin Aldosterone Syst 2003 Jun;4(2):106-12. |
| 18. | Burchill L, etal., Exp Physiol. 2008 May;93(5):622-30. doi: 10.1113/expphysiol.2007.040386. Epub 2008 Jan 25. |
| 19. | Burrell LM, etal., Eur Heart J 2005 Feb;26(4):369-75; discussion 322-4. Epub 2005 Jan 25. |
| 20. | Capelari DN, etal., Regul Pept. 2012 Aug 20;177(1-3):97-106. Epub 2012 May 12. |
| 21. | Ceravolo GS, etal., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10. |
| 22. | Ceron CS, etal., Matrix Biol. 2012 May;31(4):261-70. Epub 2012 Feb 10. |
| 23. | Challah M, etal., Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):235-43. |
| 24. | Challah M, etal., Cardiovasc Res. 1995 Aug;30(2):231-9. |
| 25. | Chao J, etal., Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2264-70. Epub 2011 Sep 30. |
| 26. | Chappell MC, etal., Hypertension. 2000 Jan;35(1 Pt 2):348-52. |
| 27. | Chen P, etal., Exp Eye Res. 2006 Nov;83(5):1041-51. Epub 2006 Jul 5. |
| 28. | Chen Q, etal., Asia Pac J Clin Nutr. 2007;16 Suppl:281-5. |
| 29. | Cooke CL, etal., J Dev Orig Health Dis. 2014 Feb;5(1):36-44. doi: 10.1017/S2040174413000524. |
| 30. | Costerousse O, etal., Am J Physiol. 1994 Nov;267(5 Pt 1):E745-53. |
| 31. | Costerousse O, etal., J Pharmacol Exp Ther. 1998 Mar;284(3):1180-7. |
| 32. | Cruz CI, etal., Am J Physiol Renal Physiol. 2000 Jan;278(1):F122-9. |
| 33. | Deitz DM, etal., Circ Shock. 1987;21(1):23-9. |
| 34. | Dendorfer A, etal., Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2182-8. |
| 35. | Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7 |
| 36. | Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72 |
| 37. | Di B, etal., Mol Med Rep. 2012 Nov;6(5):1171-7. doi: 10.3892/mmr.2012.1032. Epub 2012 Aug 10. |
| 38. | Di Marco F, etal., Pulm Pharmacol Ther. 2010 Jun;23(3):159-64. Epub 2010 Jan 22. |
| 39. | Duman S, etal., Int J Artif Organs. 2005 Feb;28(2):156-63. |
| 40. | Echeverria-Rodriguez O, etal., Peptides. 2014 Jan;51:26-30. doi: 10.1016/j.peptides.2013.10.022. Epub 2013 Oct 31. |
| 41. | Efrati S, etal., Nephrol Dial Transplant. 2012 Jan;27(1):136-45. Epub 2011 Jun 16. |
| 42. | Eryuksel E, etal., J Asthma. 2009 May;46(4):335-8. |
| 43. | Fatini C, etal., Blood Coagul Fibrinolysis. 2000 Oct;11(7):657-62. |
| 44. | Fatini C, etal., Int J Cardiol. 2008 Jan 24;123(3):293-7. Epub 2007 Mar 26. |
| 45. | Fendrich V, etal., Gut. 2010 May;59(5):630-7. Epub 2009 Nov 1. |
| 46. | Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4. |
| 47. | Fogo A, etal., J Clin Invest. 1988 Jul;82(1):322-30. |
| 48. | Fradin S, etal., Diabetes Metab. 2002 Feb;28(1):27-32. |
| 49. | Fujisawa T, etal., Diabetes Care. 1995 Jul;18(7):983-5. |
| 50. | Geng ZH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jul;29(7):1461-4. |
| 51. | GOA data from the GO Consortium |
| 52. | Gonzalez Ordonez AJ, etal., Blood Coagul Fibrinolysis. 2000 Jul;11(5):485-90. |
| 53. | Goto M, etal., J Pediatr Gastroenterol Nutr. 2010 Apr 14. |
| 54. | Goto M, etal., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27. |
| 55. | Guo S, etal., J Int Med Res. 2009 Mar-Apr;37(2):351-8. |
| 56. | Hagiwara S, etal., Crit Care Med. 2009 Feb;37(2):626-33. |
| 57. | Hajek D, etal., Med Hypotheses. 2003 Jul;61(1):80-5. |
| 58. | Hallab M, etal., Arch Mal Coeur Vaiss. 1992 Aug;85(8):1185-8. |
| 59. | Harada E, etal., Circulation. 2001 Jul 10;104(2):137-9. |
| 60. | Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404. |
| 61. | Hegde LG, etal., Pharmacol Res. 1997 Aug;36(2):109-14. |
| 62. | Herath CB, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G98-G106. Epub 2009 Apr 23. |
| 63. | Hibberd ML, etal., J Diabetes Complications. 1997 Jan-Feb;11(1):2-8. |
| 64. | Holla L, etal., J Allergy Clin Immunol. 1999 Apr;103(4):702-8. |
| 65. | Hou DR, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2320-3. |
| 66. | Imai E, etal., Clin Exp Nephrol. 2003 Jun;7(2):113-9. |
| 67. | Inanir A, etal., Mol Vis. 2012;18:2107-13. Epub 2012 Jul 26. |
| 68. | Ismael MA, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):66-72. Epub 2008 May 16. |
| 69. | Jacob HJ, etal., Cell 1991 Oct 4;67(1):213-24 |
| 70. | Jenrow KA, etal., Radiat Oncol. 2010 Feb 1;5:6. |
| 71. | Jia G, etal., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. |
| 72. | Jiang JS, etal., Neonatology. 2012;101(1):47-54. doi: 10.1159/000329451. Epub 2011 Jul 26. |
| 73. | Kang YM, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):436-44. doi: 10.1016/j.taap.2013.12.001. Epub 2013 Dec 14. |
| 74. | Karabuga I, etal., Urol Res. 2012 Feb;40(1):27-34. doi: 10.1007/s00240-011-0393-7. Epub 2011 Jun 11. |
| 75. | Karram T, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1351-8. Epub 2005 May 13. |
| 76. | Kedzierska K, etal., Clin Transplant. 2008 Mar-Apr;22(2):156-61. doi: 10.1111/j.1399-0012.2007.00760.x. |
| 77. | Kim JJ, etal., Ann Otol Rhinol Laryngol. 2004 Apr;113(4):297-302. |
| 78. | Kochi T, etal., Oncol Lett. 2014 Jul;8(1):223-229. Epub 2014 May 12. |
| 79. | Kohara K, etal., Hypertension. 1993 Jun;21(6 Pt 2):975-9. |
| 80. | Koike G, etal., Biochem Biophys Res Commun 1994 Jan 14;198(1):380-6. |
| 81. | Koyama RG, etal., Sleep Med. 2009 Dec;10(10):1107-11. Epub 2009 May 23. |
| 82. | Koyama T and Taka A, Adv Exp Med Biol. 2010;662:83-8. |
| 83. | Kreutz R, etal., Circulation 1995 Nov 1;92(9):2381-4. |
| 84. | Krskova K, etal., J Physiol Pharmacol. 2011 Aug;62(4):403-10. |
| 85. | Kulah E, etal., Blood Press Monit. 2007 Aug;12(4):207-13. |
| 86. | Laksmi NK, etal., J Pediatr Urol. 2010 Dec;6(6):560-6. Epub 2010 Feb 10. |
| 87. | Laliberte F, etal., Lab Invest. 1987 Apr;56(4):364-71. |
| 88. | Laliberte MF, etal., Lab Invest. 1988 Aug;59(2):263-70. |
| 89. | Lam SY, etal., Exp Physiol. 2014 Jan;99(1):220-31. doi: 10.1113/expphysiol.2013.074591. Epub 2013 Sep 13. |
| 90. | Lam SY, etal., J Appl Physiol 2004 Feb;96(2):809-13. Epub 2003 Oct 3. |
| 91. | Lavrentyev EN, etal., Circ Res. 2007 Aug 31;101(5):455-64. Epub 2007 Jul 12. |
| 92. | Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32. |
| 93. | Leclerc P, etal., Sem Hop. 1982 May 27;58(21):1291-4. |
| 94. | Leshem-Rubinow E, etal., Mayo Clin Proc. 2012 Dec;87(12):1189-95. doi: 10.1016/j.mayocp.2012.07.020. Epub 2012 Nov 7. |
| 95. | Li P, etal., Am J Pathol. 2010 Jul 22. |
| 96. | Liang S, etal., Mol Biol Rep. 2013 Jan;40(1):463-8. doi: 10.1007/s11033-012-2081-2. Epub 2012 Oct 13. |
| 97. | Ling Q, etal., Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):63-6. |
| 98. | Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23. |
| 99. | Macconi D, etal., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22. |
| 100. | Markoula S, etal., Mol Vis. 2011;17:1254-60. Epub 2011 May 6. |
| 101. | Marre M, etal., Diabetes. 1994 Mar;43(3):384-8. |
| 102. | Matsumoto A, etal., Diabetes Res Clin Pract. 2000 Dec;50(3):195-202. |
| 103. | Matus M, etal., Mol Cell Biochem. 2015 May;403(1-2):199-208. doi: 10.1007/s11010-015-2350-1. Epub 2015 Feb 8. |
| 104. | Meng Y, etal., Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC. |
| 105. | Metayer S, etal., Biol Reprod 2002 Dec;67(6):1763-7. |
| 106. | Metzger R, etal., Kidney Int. 1999 Oct;56(4):1442-54. |
| 107. | MGD data from the GO Consortium |
| 108. | Michel B, etal., Arch Mal Coeur Vaiss. 1991 Aug;84(8):1201-4. |
| 109. | Migdalis IN, etal., South Med J. 1990 Apr;83(4):425-7. |
| 110. | Molteni A, etal., Curr Pharm Des. 2007;13(13):1307-16. |
| 111. | Moon JY, etal., Nephron Exp Nephrol. 2008;110(1):e8-e16. Epub 2008 Aug 4. |
| 112. | Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38. |
| 113. | Mortensen EM, etal., Respir Res. 2009 Jun 3;10:45. |
| 114. | Mroz RM, etal., J Physiol Pharmacol. 2008 Dec;59 Suppl 6:499-505. |
| 115. | Mukamal KJ, etal., J Hypertens. 2010 Feb;28(2):401-5. |
| 116. | Murca TM, etal., Regul Pept. 2012 Aug 20;177(1-3):107-15. doi: 10.1016/j.regpep.2012.05.093. Epub 2012 May 14. |
| 117. | Myles PR, etal., Pharmacoepidemiol Drug Saf. 2009 Aug;18(8):697-703. |
| 118. | Nacak M, etal., Cancer Genet Cytogenet. 2010 Apr 1;198(1):22-6. |
| 119. | Nakagiri A, etal., J Physiol Pharmacol. 2010 Apr;61(2):171-9. |
| 120. | Nakaya H, etal., Hypertens Res. 1999 Nov;22(4):303-12. |
| 121. | Nakhoul F, etal., Am J Physiol Renal Physiol. 2005 Oct;289(4):F880-90. Epub 2005 Jun 7. |
| 122. | Nambu K, etal., Arzneimittelforschung. 1986;36(1):47-51. |
| 123. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 124. | Neri Serneri GG, etal., Circ Res. 2004 Jun 25;94(12):1630-7. Epub 2004 May 6. |
| 125. | Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55. |
| 126. | Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31. |
| 127. | Ocaranza MP, etal., Hypertension. 2006 Oct;48(4):572-8. Epub 2006 Aug 14. |
| 128. | Ocaranza MP, etal., J Cardiovasc Pharmacol. 2002 Aug;40(2):246-54. |
| 129. | Ocaranza MP, etal., J Hypertens 2002 Mar;20(3):413-20. |
| 130. | Ocaranza MP, etal., Life Sci. 2006 Feb 28;78(14):1535-42. Epub 2005 Oct 17. |
| 131. | Ogus C, etal., Biochem Genet. 2010 Jun;48(5-6):516-23. Epub 2010 Feb 25. |
| 132. | Ohkubo T, etal., Am J Respir Crit Care Med. 2004 May 1;169(9):1041-5. Epub 2004 Feb 27. |
| 133. | Oikawa T, etal., Kidney Int. 1997 Jan;51(1):164-72. |
| 134. | Oka T, etal., Eur J Pharmacol. 1993 Mar 30;234(1):55-60. |
| 135. | Okoye BO, etal., J Pediatr Surg. 1998 Feb;33(2):286-91. |
| 136. | OMIM Disease Annotation Pipeline |
| 137. | Ozturk MA, etal., Clin Rheumatol. 2004 Apr;23(2):142-6. Epub 2004 Feb 24. |
| 138. | Pabst S, etal., Eur J Med Res. 2009 Dec 7;14 Suppl 4:177-81. |
| 139. | Panahpour H, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):220-6. doi: 10.1111/1440-1681.12210. |
| 140. | Park HC, etal., Yonsei Med J. 2005 Dec 31;46(6):779-87. |
| 141. | Parlakpinar H, etal., Cytokine. 2011 Dec;56(3):688-94. Epub 2011 Oct 4. |
| 142. | Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14. |
| 143. | Pipeline to import KEGG annotations from KEGG into RGD |
| 144. | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 145. | Prescott MF, etal., Am J Pathol. 1991 Dec;139(6):1291-6. |
| 146. | Qi Y, etal., Hypertension. 2013 Oct;62(4):746-52. doi: 10.1161/HYPERTENSIONAHA.113.01337. Epub 2013 Aug 19. |
| 147. | Qiu QM, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Apr;28(4):275-9. |
| 148. | Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9. |
| 149. | Ramos P, etal., Respir Res. 2014 Apr 28;15:54. doi: 10.1186/1465-9921-15-54. |
| 150. | Rasic S, etal., Acta Med Croatica. 2004;58(3):193-6. |
| 151. | RGD automated data pipeline |
| 152. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 153. | RGD automated import pipeline for gene-chemical interactions |
| 154. | Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4. |
| 155. | Rice GI, etal., Biochem J. 2004 Oct 1;383(Pt 1):45-51. |
| 156. | Rieder MJ, etal., Circ Res. 1997 Mar;80(3):312-9. |
| 157. | Riviere G, etal., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3. |
| 158. | Ronchi FA, etal., J Hypertens. 2005 Oct;23(10):1869-78. |
| 159. | Rousseau-Ralliard D, etal., J Dairy Sci. 2010 Jul;93(7):2906-21. doi: 10.3168/jds.2010-3060. |
| 160. | Sakuta T, etal., Arthritis Rheum. 2010 May;62(5):1319-28. |
| 161. | Sawada T, etal., Perit Dial Int. 2009 Feb;29 Suppl 2:S49-50. |
| 162. | Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28. |
| 163. | Sedov VA, Veterinariia. 1978 Dec;(12):10-2. |
| 164. | Settin A, etal., J Renin Angiotensin Aldosterone Syst. 2014 Jan 22. |
| 165. | Sharifi AM, etal., Acta Physiol Hung. 2008 Mar;95(1):55-63. |
| 166. | Shenoy V, etal., Am J Respir Crit Care Med. 2010 Jun 25. |
| 167. | Shimizu H, etal., Hypertens Res. 2009 Sep;32(9):786-90. Epub 2009 Jul 10. |
| 168. | Srivastava K, etal., DNA Cell Biol. 2010 May 3. |
| 169. | Staessen JA, etal., J Hypertens. 1997 Dec;15(12 Pt 2):1579-92. |
| 170. | Strittmatter SM, etal., Brain Res. 1986 Oct;394(2):207-15. |
| 171. | Sun HL, etal., Exp Clin Endocrinol Diabetes. 2009 Jul;117(7):336-44. Epub 2009 Mar 19. |
| 172. | Szolnoki Z, etal., J Neurol. 2001 Sep;248(9):756-61. |
| 173. | Tarnow L, etal., Diabetes. 1995 May;44(5):489-94. |
| 174. | Taskin E, etal., Ren Fail. 2014 May;36(4):606-12. doi: 10.3109/0886022X.2014.882737. Epub 2014 Feb 6. |
| 175. | Telford SE, etal., Br J Pharmacol. 1995 Mar;114(6):1185-92. |
| 176. | Thoene-Reineke C, etal., PLoS One. 2011;6(8):e23646. Epub 2011 Aug 25. |
| 177. | Tota S, etal., Behav Brain Res. 2012 Jan 1;226(1):317-30. Epub 2011 Aug 16. |
| 178. | Tseng CT, etal., J Virol. 2007 Feb;81(3):1162-73. Epub 2006 Nov 15. |
| 179. | Turgut S, etal., Med Princ Pract. 2005 Jul-Aug;14(4):213-6. |
| 180. | Uyy E, etal., Microvasc Res. 2010 Mar;79(2):154-9. Epub 2010 Jan 6. |
| 181. | van de Garde EM, etal., Clin Chem Lab Med. 2007;45(10):1326-31. |
| 182. | van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7. |
| 183. | Velkoska E, etal., Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):49-55. Epub 2009 Apr 9. |
| 184. | Venkatesan N, etal., Toxicology. 1993 Dec 31;85(2-3):137-48. |
| 185. | Wang F, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):113-6. |
| 186. | Wang H, etal., Circ Res. 1999 Oct 1;85(7):614-22. |
| 187. | Wang JL, etal., Kidney Int. 2000 Jun;57(6):2334-42. |
| 188. | Wang LJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Apr;20(4):218-22. |
| 189. | Wang W, etal., Pediatr Surg Int. 2012 May;28(5):533-41. Epub 2012 Mar 24. |
| 190. | Wapstra FH, etal., Clin Sci (Lond). 1996 May;90(5):393-401. |
| 191. | Watanabe H, etal., Heart Rhythm. 2009 Sep;6(9):1327-32. doi: 10.1016/j.hrthm.2009.05.014. Epub 2009 May 15. |
| 192. | Wei CC, etal., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29. |
| 193. | Weinreb RN, etal., Invest Ophthalmol Vis Sci. 1979 Dec;18(12):1285-7. |
| 194. | Winaver J, etal., Am J Physiol. 1988 May;254(5 Pt 2):R776-84. |
| 195. | Wosten-van Asperen RM, etal., Am J Pathol. 2010 May;176(5):2219-27. Epub 2010 Mar 19. |
| 196. | Xiong F, etal., J Surg Res. 2014 Jun 1;189(1):166-73. doi: 10.1016/j.jss.2014.01.057. Epub 2014 Feb 5. |
| 197. | Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8. |
| 198. | Yang HY, etal., Br J Nutr. 2014 Jan 14;111(1):78-85. doi: 10.1017/S0007114513001876. Epub 2013 Jun 27. |
| 199. | Yaren A, etal., Exp Biol Med (Maywood). 2008 Jan;233(1):32-7. |
| 200. | Yazawa H, etal., J Card Fail. 2011 Dec;17(12):1041-50. Epub 2011 Oct 17. |
| 201. | Ye S, etal., Heart. 2003 Oct;89(10):1195-9. |
| 202. | Yoon HJ, etal., Clin Genet. 2002 Aug;62(2):128-34. |
| 203. | Yoshida T and Nosaka S, J Neurochem. 1990 Dec;55(6):1861-9. |
| 204. | Yoshioka M, etal., Am J Physiol. 1987 Dec;253(6 Pt 1):G781-6. |
| 205. | Yoshioka T, etal., Arch Dis Child. 1998 Nov;79(5):394-9. |
| 206. | Zderkiewicz E Pol Tyg Lek 1978 Jul 17;33(29):1157-9. |
| 207. | Zhang L, etal., Hypertens Res. 2006 Oct;29(10):751-8. |
| 208. | Zhang XL, etal., Exp Ther Med. 2012 Oct;4(4):741-747. Epub 2012 Jul 31. |
| 209. | Zhou J, etal., J Huazhong Univ Sci Technolog Med Sci. 2004;24(2):158-61. |
References - uncurated| PubMed | 174834 1298871 1320019 1668266 1848554 1851160 2846041 2849100 2983326 4322742 6208535 7683654 7876104 9231832 9449382 10406820 11076943 11303049 11702851 12193663 12477932 12540854 12963491 14527934 14615289 14693687 14872008 15047629 15194348 15326289 15475532 15489334 15531746 15869764 15932931 15961527 15992826 16009784 16027241 16116425 16186248 16230508 16325859 16434838 16502470 16585392 17077303 17082641 17135368 17487824 17785632 17898118 17903697 18174884 18495113 18957386 19012043 19056867 19255705 19419949 19472100 19733634 19773553 20011602 20022959 20051229 20116413 20570682 20888351 21053061 21082674 21167844 21495912 21602471 21720771 21788250 21873635 21959517 22191573 22311897 22378820 22498331 23132538 23365412 23376485 23533145 23535237 23603844 23661144 23706365 23733546 23749777 23975725 24035938 24126381 24781988 25017399 25031298 25194129 25205218 25217176 25401104 25766467 25768373 26010093 26371174 26400542 26697495 27465904 27710705 27923787 28003214 28536140 |
RGD Disease Portals| Ace has been annotated in the following RGD Disease Portals. |
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Genomics
Candidate Gene Status |
Ace is a candidate Gene for QTL Bp1 |
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Ace is a candidate Gene for QTL Bp9 |
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Ace is a candidate Gene for QTL Bp72 |
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Ace is a candidate Gene for QTL Bp128 |
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Ace is a candidate Gene for QTL Bp342 |
Comparative Map Data| Ace (Rattus norvegicus - Norway rat) |
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| ACE (Homo sapiens - human) |
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| Ace (Mus musculus - house mouse) |
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| ACE (Canis lupus familiaris - dog) |
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| LOC101968921 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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Position Markers| D10Mit1 |
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| D10Wox18 |
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| RH94768 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat StrainsThe following Strains have been annotated to Ace
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Genetic ModelsSequence
Nucleotide Sequences| RefSeq Transcripts | NM_012544 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR07030583 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07030584 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01066252 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF201331 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF201332 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF532783 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF532784 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF539425 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF539701 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AY344961 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC085760 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| L36664 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U03708 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U03734 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_012544 | ||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
CGCCGCACCGCGCGCACCGCGCCATGGGGGCCGCGTCCGGCCAGCGGGGGCGGTGGCCGTTGTChide sequence |
Protein Sequences| Protein RefSeqs | NP_036676 | (Get FASTA) | NCBI Sequence Viewer |
| GenBank Protein | AAA50505 | (Get FASTA) | NCBI Sequence Viewer |
| AAA82110 | (Get FASTA) | NCBI Sequence Viewer | |
| AAA82111 | (Get FASTA) | NCBI Sequence Viewer | |
| AAG35596 | (Get FASTA) | NCBI Sequence Viewer | |
| AAG35597 | (Get FASTA) | NCBI Sequence Viewer | |
| AAH85760 | (Get FASTA) | NCBI Sequence Viewer | |
| AAN17280 | (Get FASTA) | NCBI Sequence Viewer | |
| AAN17281 | (Get FASTA) | NCBI Sequence Viewer | |
| AAP80808 | (Get FASTA) | NCBI Sequence Viewer | |
| AAP80809 | (Get FASTA) | NCBI Sequence Viewer | |
| AAQ23132 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM06348 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM06349 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM06350 | (Get FASTA) | NCBI Sequence Viewer | |
| P47820 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| Protein Acc Id: | NP_036676 |
| Peptide Label: | precursor |
| Sequence: |
MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGNFSADEAGAQLFADSYNSSAEhide sequence |
Protein Structures| Name | Modeller | Protein Id | AA Range | Protein Structure | Video |
| ACE N-Terminal | pdb 2c6f | P47820 | 36-636 | view protein structure | |
| ACE C-Terminal | pdb 108a | P47820 | 637-1238 | view protein structure | view video |
TranscriptomePromoters| RGD ID: | 13697829 | |||||||||
| Promoter ID: | EPDNEW_R8353 | |||||||||
| Type: | multiple initiation site | |||||||||
| Name: | Ace_1 | |||||||||
| Description: | angiotensin I converting enzyme | |||||||||
| SO ACC ID: | SO:0000170 | |||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
| Experiment Methods: | Single-end sequencing. | |||||||||
| Position: |
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| RGD ID: | 13697846 | |||||||||
| Promoter ID: | EPDNEW_R8354 | |||||||||
| Type: | multiple initiation site | |||||||||
| Name: | Ace_2 | |||||||||
| Description: | angiotensin I converting enzyme | |||||||||
| SO ACC ID: | SO:0000170 | |||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
| Experiment Methods: | Single-end sequencing. | |||||||||
| Position: |
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Strain Variation
Strain Sequence Variants (Rnor 5.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000062101 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000010627 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000010627 | ENTREZGENE, UniProtKB/TrEMBL |
| IMAGE_CLONE | IMAGE:7097136 | IMAGE-MGC_LOAD |
| InterPro | Peptidase_M2 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24310 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93629 | IMAGE-MGC_LOAD |
| NCBI Gene | 24310 | ENTREZGENE |
| PANTHER | Peptidase_M2 | UniProtKB/Swiss-Prot |
| Pfam | Peptidase_M2 | UniProtKB/Swiss-Prot |
| PharmGKB | ACE | RGD |
| PhenoGen | Ace | PhenoGen |
| PRINTS | PEPDIPTASEA | UniProtKB/Swiss-Prot |
| PROSITE | ZINC_PROTEASE | UniProtKB/Swiss-Prot |
| UniGene | Rn.10149 | ENTREZGENE |
| UniProt | A0A0A0MXV4_RAT | UniProtKB/TrEMBL |
| ACE_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
| UniProt Secondary | Q7TMC6 | UniProtKB/Swiss-Prot |
| Q8CFN1 | UniProtKB/Swiss-Prot | |
| Q9EQM9 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | angiotensin 1 converting enzyme | Name updated | 1299863 | APPROVED | |
| 2004-12-14 | Ace | angiotensin 1 converting enzyme | angiotensin 1 converting enzyme 1 | Name updated | 1299863 | APPROVED | |
| 2002-06-10 | Ace | angiotensin 1 converting enzyme 1 | Symbol and Name updated | 70585 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | affects heart mass independent of blood pressure | 1357231 |
| gene_process | functions in the renin-angiotensin system | 61036 |
| gene_process | plays an important role in the regulation of blood volume and pressure | 61036 |
| gene_process | level of plasma enzyme activity does not directly link to blood pressure | 619632 |
| More on Ace | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 2493 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2018-05-29 |
| Status: | ACTIVE |
