Ace (angiotensin I converting enzyme) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus
Analyze
Symbol: Ace
Name: angiotensin I converting enzyme
RGD ID: 2493
Description: Exhibits metallopeptidase activity; peptide binding activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Localizes to several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Coronavirus infectious disease (multiple); artery disease (multiple); autoimmune disease (multiple); lung disease (multiple); and nephritis (multiple). Orthologous to human ACE (angiotensin I converting enzyme); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; angiotensin II signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: angiotensin 1 converting enzyme; angiotensin 1 converting enzyme 1; angiotensin converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme; CD143; Dcp1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; kininase II; StsRR92
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Aceem1Mcwi   Aceem2Mcwi  
Genetic Models: SS-Aceem1Mcwi SS-Aceem2Mcwi
Is Marker For: Strains:   SD-Tg(Ren2)27   SS.MNS-(D10M11Mit119-D10Mit11)/Jr   LOU.BN-(D10Mgh1-D10Mgh14)/Ins  
QTLs:   Bp9   Bw57   Bp342   Bw102  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21090,910,316 - 90,930,437 (+)NCBI
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP)
Acute Hepatitis  (IEP)
acute kidney failure  (IMP)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (IMP,ISO)
alcoholic cardiomyopathy  (ISO)
Alcoholic Liver Diseases  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IMP,ISO)
anemia  (ISO)
Angiotensin I-Converting Enzyme, Benign Serum Increase  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (IEP)
Arteriovenous Fistula  (IEP,IMP)
aspiration pneumonia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (IEP,IMP)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
bipolar disorder  (IEA)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (IMP)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IMP)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chemical colitis  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholestasis  (IEP)
Chronic Hepatitis C  (IEP,ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (IEP)
Congenital Hepatic Fibrosis  (IEP)
congestive heart failure  (IEP,IMP,ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IDA,IMP,ISO)
diabetic retinopathy  (ISO)
diastolic heart failure  (IMP,ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
end stage renal disease  (IMP,ISO)
endomyocardial fibrosis  (IEP)
Endotoxemia  (IEP)
Experimental Arthritis  (IEP)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Familial Cerebral Cavernous Malformation  (ISO)
familial Mediterranean fever  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (IEP)
focal segmental glomerulosclerosis 1  (IMP)
gallbladder adenocarcinoma  (ISO)
Gaucher's disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (IMP)
glomerulosclerosis  (IMP)
glycogen storage disease V  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis A  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxia  (IEP)
hypertension  (IDA,IEP,IMP,ISO)
Hypertensive Nephrosclerosis  (IMP,ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (IEP)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (IMP)
Left Ventricular Hypertrophy  (IEP,IMP,ISO)
leukemia  (ISO)
leukostasis  (IMP)
liver cirrhosis  (IEP,ISO)
Liver Metastasis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (IEP,IMP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
male infertility  (ISO)
Memory Disorders  (IMP,ISO)
Meningococcal Infections  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (IMP)
mitral valve disease  (ISO)
mitral valve prolapse  (ISO)
multiple myeloma  (ISO)
Mycobacterium Infections  (ISO)
myocardial infarction  (IEP,IMP,ISO)
myocarditis  (IMP)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephrosis  (IEP,IMP)
nephrotic syndrome  (IDA,IMP)
non-alcoholic fatty liver disease  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (IEP,ISO)
ocular hypotension  (IMP)
osteoporosis  (IMP)
Pain  (IMP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (IMP,ISO)
Pleural Effusion  (ISO)
pneumonia  (ISO)
polycythemia  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (IMP)
Pregnancy-Induced Hypertension  (IEP)
Premature Infant Diseases  (ISO)
primary biliary cholangitis  (IEP)
Prostatic Neoplasms  (ISO)
proteinuria  (IMP,ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (IMP)
pyelonephritis  (ISO)
Radiation Nephropathy  (IMP)
renal fibrosis  (IMP,ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (IDA,IEP)
Reperfusion Injury  (IMP)
respiratory system disease  (ISO)
Right Ventricular Hypertrophy  (IEP)
sarcoidosis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Staphylococcal Infections  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (IMP,ISO)
subacute sclerosing panencephalitis  (ISO)
substance-induced psychosis  (ISO)
Sudden Death  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (IMP)
uveitis  (ISO)
Vascular System Injuries  (IAGP,ISO)
Venous Thromboembolism  (ISO)
Ventricular Fibrillation  (IMP)
Ventricular Remodeling  (IDA)
viral pneumonia  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
(S,S,S)-nicotianamine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
14,15-EET  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
aminoguanidine  (ISO)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
boric acid  (ISO)
bortezomib  (ISO)
caffeine  (EXP)
candesartan  (EXP)
captan  (ISO)
captopril  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
cilazapril monohydrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
corticosterone  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
D-glucose  (ISO)
DDT  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
ethanol  (EXP)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fenvalerate  (ISO)
flavonoids  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
herbimycin  (ISO)
hydralazine  (EXP)
hydrazines  (ISO)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
indoxyl sulfate  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lipoic acid  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithium chloride  (EXP)
losartan  (EXP,ISO)
Magnolol  (EXP)
manganese(II) chloride  (EXP)
manidipine  (EXP)
methoxychlor  (EXP)
metoprolol  (ISO)
microcystin RR  (ISO)
mifepristone  (EXP)
monocrotaline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
Nandrolone decanoate  (EXP)
nicotianamine  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
NS-398  (ISO)
omapatrilat  (ISO)
ouabain  (EXP)
paraquat  (EXP,ISO)
perindopril  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP)
pirfenidone  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregabalin  (EXP)
proanthocyanidin  (EXP)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP,ISO)
raloxifene  (ISO)
ramipril  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
spironolactone  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
telmisartan  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trandolapril  (EXP)
tributylstannane  (ISO)
triclosan  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
amyloid-beta metabolic process  (IEA,ISO)
angiogenesis involved in coronary vascular morphogenesis  (IMP)
animal organ regeneration  (IMP)
arachidonic acid secretion  (IEA,ISO)
bradykinin catabolic process  (IDA,IMP)
brain development  (IEP)
cell proliferation in bone marrow  (IEA,ISO)
cellular response to aldosterone  (IEP)
cellular response to glucose stimulus  (IEP)
eating behavior  (IMP)
embryo development ending in birth or egg hatching  (IMP)
female pregnancy  (IEP)
heart contraction  (IEA,ISO)
hormone catabolic process  (IEA,ISO)
kidney development  (IEA,IEP,ISO)
lung alveolus development  (IMP)
lung development  (IEP)
male gonad development  (IEP)
negative regulation of calcium ion import  (IMP)
negative regulation of gap junction assembly  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glucose import  (IMP)
negative regulation of protein binding  (IEA,ISO)
negative regulation of renal sodium excretion  (IMP)
neutrophil mediated immunity  (IEA,ISO)
obsolete negative regulation of blood vessel diameter  (IMP)
peptide catabolic process  (IDA,IEA,ISO)
peptide metabolic process  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of inflammatory response  (IMP)
positive regulation of neurogenesis  (IMP)
positive regulation of peptidyl-cysteine S-nitrosylation  (IEA,ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (IEA,ISO)
positive regulation of protein binding  (IEA,ISO)
positive regulation of protein tyrosine kinase activity  (IEA,ISO)
positive regulation of systemic arterial blood pressure  (IBA,IEA,IMP,ISO)
posttranscriptional regulation of gene expression  (IEA,ISO)
proteolysis  (IEA)
regulation of angiotensin metabolic process  (IEA,ISO)
regulation of blood pressure  (IDA,ISO,TAS)
regulation of hematopoietic stem cell proliferation  (IEA,ISO)
regulation of smooth muscle cell migration  (IDA)
regulation of systemic arterial blood pressure by renin-angiotensin  (IBA,IEA,ISO)
response to dexamethasone  (IEP)
response to drug  (IEP)
response to hypoxia  (IEP)
response to laminar fluid shear stress  (IEP)
response to lipopolysaccharide  (IMP)
response to nutrient levels  (IEP)
response to thyroid hormone  (IEP)
sensory perception of pain  (IMP)
spermatogenesis  (IEA,ISO)
vasoconstriction  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Abdel-Wahab BA, etal., Chem Biol Interact. 2014 Jun 5;216:43-52. doi: 10.1016/j.cbi.2014.03.012. Epub 2014 Apr 5.
2. Agarwal R, etal., Eur J Pharmacol. 2014 May 5;730:8-13. doi: 10.1016/j.ejphar.2014.02.021. Epub 2014 Feb 26.
3. Akar T, Rev Assoc Med Bras (1992). 2018 Mar;64(3):224-229. doi: 10.1590/1806-9282.64.03.224.
4. al-Shabanah OA, etal., Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):221-30.
5. Albayrak M, etal., J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):259-64. doi: 10.1177/1470320312437070. Epub 2012 Feb 16.
6. Altas M, etal., J Clin Neurosci. 2010 Aug;17(8):1034-7. doi: 10.1016/j.jocn.2009.12.002. Epub 2010 May 21.
7. Antus B, etal., J Heart Lung Transplant. 2006 Nov;25(11):1324-9.
8. Arafat HA, etal., J Am Coll Surg. 2007 May;204(5):996-1005; discussion 1005-6.
9. Arevalo AE, etal., Clin Chim Acta. 1990 Nov 5;191(3):175-84.
10. Atalar E, etal., J Heart Valve Dis. 2003 Jan;12(1):7-10.
11. Bardi E, etal., Pediatr Blood Cancer. 2005 Aug;45(2):217-21.
12. Batista EC, etal., J Mol Med (Berl). 2011 Jan;89(1):65-74. doi: 10.1007/s00109-010-0686-2. Epub 2010 Oct 13.
13. Baybutt RC, etal., Curr Pharm Des. 2007;13(13):1327-33.
14. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
15. Bell CG, etal., Eur J Hum Genet. 2007 Mar;15(3):320-7. Epub 2006 Dec 13.
16. Benigni A, etal., Am J Pathol. 2011 Aug;179(2):628-38. doi: 10.1016/j.ajpath.2011.04.003. Epub 2011 Jun 2.
17. Benigni A, etal., Nephron Exp Nephrol. 2006;104(4):e158-68. Epub 2006 Aug 10.
18. Beyazit Y, etal., Dig Dis Sci. 2011 Jul;56(7):2160-5. doi: 10.1007/s10620-011-1580-7. Epub 2011 Feb 3.
19. Boonyapisit W and Tresukosol D, J Med Assoc Thai. 2010 Jan;93 Suppl 1:S48-53.
20. Bos H, etal., J Renin Angiotensin Aldosterone Syst 2003 Jun;4(2):106-12.
21. Burchill L, etal., Exp Physiol. 2008 May;93(5):622-30. doi: 10.1113/expphysiol.2007.040386. Epub 2008 Jan 25.
22. Burrell LM, etal., Eur Heart J 2005 Feb;26(4):369-75; discussion 322-4. Epub 2005 Jan 25.
23. Capelari DN, etal., Regul Pept. 2012 Aug 20;177(1-3):97-106. Epub 2012 May 12.
24. Ceravolo GS, etal., Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10.
25. Ceron CS, etal., Matrix Biol. 2012 May;31(4):261-70. Epub 2012 Feb 10.
26. Challah M, etal., Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):235-43.
27. Challah M, etal., Cardiovasc Res. 1995 Aug;30(2):231-9.
28. Chao J, etal., Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2264-70. Epub 2011 Sep 30.
29. Chappell MC, etal., Hypertension. 2000 Jan;35(1 Pt 2):348-52.
30. Chen P, etal., Exp Eye Res. 2006 Nov;83(5):1041-51. Epub 2006 Jul 5.
31. Chen Q, etal., Asia Pac J Clin Nutr. 2007;16 Suppl:281-5.
32. Cogulu O, etal., Pediatr Int. 2008 Aug;50(4):477-80. doi: 10.1111/j.1442-200X.2008.02583.x.
33. Cooke CL, etal., J Dev Orig Health Dis. 2014 Feb;5(1):36-44. doi: 10.1017/S2040174413000524.
34. Costerousse O, etal., Am J Physiol. 1994 Nov;267(5 Pt 1):E745-53.
35. Costerousse O, etal., J Pharmacol Exp Ther. 1998 Mar;284(3):1180-7.
36. Cruz CI, etal., Am J Physiol Renal Physiol. 2000 Jan;278(1):F122-9.
37. Deitz DM, etal., Circ Shock. 1987;21(1):23-9.
38. Delanghe JR, etal., Clin Chem Lab Med. 2020 Jun 25;58(7):1125-1126. doi: 10.1515/cclm-2020-0425.
39. Dendorfer A, etal., Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2182-8.
40. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
41. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
42. Di B, etal., Mol Med Rep. 2012 Nov;6(5):1171-7. doi: 10.3892/mmr.2012.1032. Epub 2012 Aug 10.
43. Di Marco F, etal., Pulm Pharmacol Ther. 2010 Jun;23(3):159-64. Epub 2010 Jan 22.
44. Dou XM, etal., Biosci Rep. 2017 Apr 28;37(2). pii: BSR20170145. doi: 10.1042/BSR20170145. Print 2017 Apr 30.
45. Duman S, etal., Int J Artif Organs. 2005 Feb;28(2):156-63.
46. Echeverria-Rodriguez O, etal., Peptides. 2014 Jan;51:26-30. doi: 10.1016/j.peptides.2013.10.022. Epub 2013 Oct 31.
47. Efrati S, etal., Nephrol Dial Transplant. 2012 Jan;27(1):136-45. Epub 2011 Jun 16.
48. Eryuksel E, etal., J Asthma. 2009 May;46(4):335-8.
49. Fabris C, etal., Hepatol Res. 2009 Aug;39(8):795-804. doi: 10.1111/j.1872-034X.2009.00518.x. Epub 2009 Apr 23.
50. Fahmy SR, etal., Toxicol Lett. 2019 Feb;301:73-78. doi: 10.1016/j.toxlet.2018.11.006. Epub 2018 Nov 17.
51. Fatini C, etal., Blood Coagul Fibrinolysis. 2000 Oct;11(7):657-62.
52. Fatini C, etal., Int J Cardiol. 2008 Jan 24;123(3):293-7. Epub 2007 Mar 26.
53. Fazal Y, etal., J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):1046-51. doi: 10.1177/1470320314545777. Epub 2014 Aug 20.
54. Fendrich V, etal., Gut. 2010 May;59(5):630-7. Epub 2009 Nov 1.
55. Feng Q, etal., Biosci Rep. 2018 Jun 27;38(3). pii: BSR20171522. doi: 10.1042/BSR20171522. Print 2018 Jun 29.
56. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
57. Fogo A, etal., J Clin Invest. 1988 Jul;82(1):322-30.
58. Fradin S, etal., Diabetes Metab. 2002 Feb;28(1):27-32.
59. Fujisawa T, etal., Diabetes Care. 1995 Jul;18(7):983-5.
60. Gadelha A, etal., Psychiatry Res. 2015 Oct 30;229(3):702-7. doi: 10.1016/j.psychres.2015.08.018. Epub 2015 Aug 12.
61. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
62. Geng ZH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jul;29(7):1461-4.
63. GOA data from the GO Consortium
64. Gonzalez Ordonez AJ, etal., Blood Coagul Fibrinolysis. 2000 Jul;11(5):485-90.
65. Goto M, etal., J Pediatr Gastroenterol Nutr. 2010 Apr 14.
66. Goto M, etal., Pediatr Nephrol. 2010 Dec;25(12):2449-57. doi: 10.1007/s00467-010-1621-z. Epub 2010 Aug 27.
67. Gross V, etal., J Hepatol. 1993 Jan;17(1):40-7. doi: 10.1016/s0168-8278(05)80519-7.
68. Grosser M, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Mar;22(1):66-74.
69. Guo S, etal., J Int Med Res. 2009 Mar-Apr;37(2):351-8.
70. Hagiwara S, etal., Crit Care Med. 2009 Feb;37(2):626-33.
71. Hajek D, etal., Med Hypotheses. 2003 Jul;61(1):80-5.
72. Hallab M, etal., Arch Mal Coeur Vaiss. 1992 Aug;85(8):1185-8.
73. Harada E, etal., Circulation. 2001 Jul 10;104(2):137-9.
74. Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
75. Hatazawa J, etal., Stroke. 2004 Sep;35(9):2117-22. doi: 10.1161/01.STR.0000136034.86144.e9. Epub 2004 Jul 15.
76. Hegde LG, etal., Pharmacol Res. 1997 Aug;36(2):109-14.
77. Herath CB, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G98-G106. Epub 2009 Apr 23.
78. Hibberd ML, etal., J Diabetes Complications. 1997 Jan-Feb;11(1):2-8.
79. Holla L, etal., J Allergy Clin Immunol. 1999 Apr;103(4):702-8.
80. Hou DR, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2320-3.
81. Hsieh WY, etal., Int J Biol Sci. 2012;8(8):1197-205. doi: 10.7150/ijbs.5087. Epub 2012 Oct 17.
82. Hu Q, etal., Prostaglandins Other Lipid Mediat. 2017 Jul;131:75-82. doi: 10.1016/j.prostaglandins.2017.08.008. Epub 2017 Aug 16.
83. Huang Q, etal., Int J Mol Med. 2009 Jun;23(6):717-23. doi: 10.3892/ijmm_00000185.
84. Huang Q, etal., Zhonghua Gan Zang Bing Za Zhi. 2013 Jan;21(1):47-52. doi: 10.3760/cma.j.issn.1007-3418.2013.01.013.
85. Husic-Selimovic A, etal., Med Arch. 2016 Apr;70(2):92-6. doi: 10.5455/medarh.2016.70.92-96. Epub 2016 Apr 1.
86. Imai E, etal., Clin Exp Nephrol. 2003 Jun;7(2):113-9.
87. Inanir A, etal., Mol Vis. 2012;18:2107-13. Epub 2012 Jul 26.
88. Ismael MA, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):66-72. Epub 2008 May 16.
89. Jacob HJ, etal., Cell 1991 Oct 4;67(1):213-24
90. Jenrow KA, etal., Radiat Oncol. 2010 Feb 1;5:6.
91. Jia G, etal., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13.
92. Jiang JS, etal., Neonatology. 2012;101(1):47-54. doi: 10.1159/000329451. Epub 2011 Jul 26.
93. Kang YM, etal., Toxicol Appl Pharmacol. 2014 Feb 1;274(3):436-44. doi: 10.1016/j.taap.2013.12.001. Epub 2013 Dec 14.
94. Karabuga I, etal., Urol Res. 2012 Feb;40(1):27-34. doi: 10.1007/s00240-011-0393-7. Epub 2011 Jun 11.
95. Karram T, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1351-8. Epub 2005 May 13.
96. Kedzierska K, etal., Clin Transplant. 2008 Mar-Apr;22(2):156-61. doi: 10.1111/j.1399-0012.2007.00760.x.
97. Kim JJ, etal., Ann Otol Rhinol Laryngol. 2004 Apr;113(4):297-302.
98. Kochi T, etal., Oncol Lett. 2014 Jul;8(1):223-229. Epub 2014 May 12.
99. Kohara K, etal., Hypertension. 1993 Jun;21(6 Pt 2):975-9.
100. Koike G, etal., Biochem Biophys Res Commun 1994 Jan 14;198(1):380-6.
101. Koyama RG, etal., Sleep Med. 2009 Dec;10(10):1107-11. Epub 2009 May 23.
102. Koyama T and Taka A, Adv Exp Med Biol. 2010;662:83-8.
103. Kreutz R, etal., Circulation 1995 Nov 1;92(9):2381-4.
104. Krskova K, etal., J Physiol Pharmacol. 2011 Aug;62(4):403-10.
105. Kulah E, etal., Blood Press Monit. 2007 Aug;12(4):207-13.
106. La Merrill MA, etal., Environ Health Perspect. 2016 Nov;124(11):1722-1727. doi: 10.1289/EHP164. Epub 2016 Jun 21.
107. Lahtela E, etal., Respir Med. 2017 Nov;132:92-94. doi: 10.1016/j.rmed.2017.09.014. Epub 2017 Oct 3.
108. Laksmi NK, etal., J Pediatr Urol. 2010 Dec;6(6):560-6. Epub 2010 Feb 10.
109. Laliberte F, etal., Lab Invest. 1987 Apr;56(4):364-71.
110. Laliberte MF, etal., Lab Invest. 1988 Aug;59(2):263-70.
111. Lam SY, etal., Exp Physiol. 2014 Jan;99(1):220-31. doi: 10.1113/expphysiol.2013.074591. Epub 2013 Sep 13.
112. Lam SY, etal., J Appl Physiol 2004 Feb;96(2):809-13. Epub 2003 Oct 3.
113. Lavrentyev EN, etal., Circ Res. 2007 Aug 31;101(5):455-64. Epub 2007 Jul 12.
114. Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
115. Leclerc P, etal., Sem Hop. 1982 May 27;58(21):1291-4.
116. Lee C, etal., Life Sci. 2014 Jan 24;95(1):29-39. doi: 10.1016/j.lfs.2013.11.005. Epub 2013 Nov 15.
117. Leshem-Rubinow E, etal., Mayo Clin Proc. 2012 Dec;87(12):1189-95. doi: 10.1016/j.mayocp.2012.07.020. Epub 2012 Nov 7.
118. Li P, etal., Am J Pathol. 2010 Jul 22.
119. Li XY, etal., Chin J Integr Med. 2018 Nov;24(11):853-859. doi: 10.1007/s11655-017-2909-7. Epub 2018 Jan 15.
120. Liang S, etal., Mol Biol Rep. 2013 Jan;40(1):463-8. doi: 10.1007/s11033-012-2081-2. Epub 2012 Oct 13.
121. Ling Q, etal., Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):63-6.
122. Liu J, etal., Life Sci. 2018 Sep 1;208:139-148. doi: 10.1016/j.lfs.2018.07.013. Epub 2018 Jul 7.
123. Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23.
124. Macconi D, etal., Am J Pathol. 2009 Mar;174(3):797-807. Epub 2009 Jan 22.
125. Markoula S, etal., Mol Vis. 2011;17:1254-60. Epub 2011 May 6.
126. Marre M, etal., Diabetes. 1994 Mar;43(3):384-8.
127. Matsumoto A, etal., Diabetes Res Clin Pract. 2000 Dec;50(3):195-202.
128. Matus M, etal., Mol Cell Biochem. 2015 May;403(1-2):199-208. doi: 10.1007/s11010-015-2350-1. Epub 2015 Feb 8.
129. Meng Y, etal., Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.
130. Metayer S, etal., Biol Reprod 2002 Dec;67(6):1763-7.
131. Metzger R, etal., Kidney Int. 1999 Oct;56(4):1442-54.
132. MGD data from the GO Consortium
133. Michel B, etal., Arch Mal Coeur Vaiss. 1991 Aug;84(8):1201-4.
134. Migdalis IN, etal., South Med J. 1990 Apr;83(4):425-7.
135. Molteni A, etal., Curr Pharm Des. 2007;13(13):1307-16.
136. Moon JY, etal., Nephron Exp Nephrol. 2008;110(1):e8-e16. Epub 2008 Aug 4.
137. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
138. Mortensen EM, etal., Respir Res. 2009 Jun 3;10:45.
139. Moskowitz DW, Diabetes Technol Ther. 2002;4(5):683-711. doi: 10.1089/152091502320798321.
140. Mroz RM, etal., J Physiol Pharmacol. 2008 Dec;59 Suppl 6:499-505.
141. Mukamal KJ, etal., J Hypertens. 2010 Feb;28(2):401-5.
142. Murca TM, etal., Regul Pept. 2012 Aug 20;177(1-3):107-15. doi: 10.1016/j.regpep.2012.05.093. Epub 2012 May 14.
143. Myles PR, etal., Pharmacoepidemiol Drug Saf. 2009 Aug;18(8):697-703.
144. Mărginean MO, etal., Medicine (Baltimore). 2017 Jul;96(30):e7612. doi: 10.1097/MD.0000000000007612.
145. Nacak M, etal., Cancer Genet Cytogenet. 2010 Apr 1;198(1):22-6.
146. Nakagiri A, etal., J Physiol Pharmacol. 2010 Apr;61(2):171-9.
147. Nakaya H, etal., Hypertens Res. 1999 Nov;22(4):303-12.
148. Nakhoul F, etal., Am J Physiol Renal Physiol. 2005 Oct;289(4):F880-90. Epub 2005 Jun 7.
149. Nambu K, etal., Arzneimittelforschung. 1986;36(1):47-51.
150. NCBI rat LocusLink and RefSeq merged data July 26, 2002
151. Neo JH, etal., BMC Cancer. 2010 Apr 10;10:134. doi: 10.1186/1471-2407-10-134.
152. Neri Serneri GG, etal., Circ Res. 2004 Jun 25;94(12):1630-7. Epub 2004 May 6.
153. Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55.
154. Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31.
155. Noguchi R, etal., World J Gastroenterol. 2017 Sep 28;23(36):6705-6714. doi: 10.3748/wjg.v23.i36.6705.
156. Ocaranza MP, etal., Hypertension. 2006 Oct;48(4):572-8. Epub 2006 Aug 14.
157. Ocaranza MP, etal., J Cardiovasc Pharmacol. 2002 Aug;40(2):246-54.
158. Ocaranza MP, etal., J Hypertens 2002 Mar;20(3):413-20.
159. Ocaranza MP, etal., Life Sci. 2006 Feb 28;78(14):1535-42. Epub 2005 Oct 17.
160. Ogus C, etal., Biochem Genet. 2010 Jun;48(5-6):516-23. Epub 2010 Feb 25.
161. Ohkubo T, etal., Am J Respir Crit Care Med. 2004 May 1;169(9):1041-5. Epub 2004 Feb 27.
162. Oikawa T, etal., Kidney Int. 1997 Jan;51(1):164-72.
163. Oka T, etal., Eur J Pharmacol. 1993 Mar 30;234(1):55-60.
164. Okoye BO, etal., J Pediatr Surg. 1998 Feb;33(2):286-91.
165. Okuno F, etal., Alcohol. 1986 Nov-Dec;3(6):357-9. doi: 10.1016/0741-8329(86)90053-4.
166. OMIM Disease Annotation Pipeline
167. Ozisik K, etal., J Heart Valve Dis. 2004 Jan;13(1):33-7.
168. Ozturk MA, etal., Clin Rheumatol. 2004 Apr;23(2):142-6. Epub 2004 Feb 24.
169. Pabst S, etal., Eur J Med Res. 2009 Dec 7;14 Suppl 4:177-81.
170. Panahpour H, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):220-6. doi: 10.1111/1440-1681.12210.
171. Park HC, etal., Yonsei Med J. 2005 Dec 31;46(6):779-87.
172. Parlakpinar H, etal., Cytokine. 2011 Dec;56(3):688-94. Epub 2011 Oct 4.
173. Pehlivan M, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):474-81. doi: 10.1089/gtmb.2014.0004. Epub 2014 May 12.
174. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
175. Pipeline to import KEGG annotations from KEGG into RGD
176. Pipeline to import SMPDB annotations from SMPDB into RGD
177. Prescott MF, etal., Am J Pathol. 1991 Dec;139(6):1291-6.
178. Qi Y, etal., Hypertension. 2013 Oct;62(4):746-52. doi: 10.1161/HYPERTENSIONAHA.113.01337. Epub 2013 Aug 19.
179. Qiu QM, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Apr;28(4):275-9.
180. Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9.
181. Ramos P, etal., Respir Res. 2014 Apr 28;15:54. doi: 10.1186/1465-9921-15-54.
182. Rasic S, etal., Acta Med Croatica. 2004;58(3):193-6.
183. RGD automated data pipeline
184. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
185. RGD automated import pipeline for gene-chemical interactions
186. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
187. Rice GI, etal., Biochem J. 2004 Oct 1;383(Pt 1):45-51.
188. Rieder MJ, etal., Circ Res. 1997 Mar;80(3):312-9.
189. Riviere G, etal., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3.
190. Ronchi FA, etal., J Hypertens. 2005 Oct;23(10):1869-78.
191. Rousseau-Ralliard D, etal., J Dairy Sci. 2010 Jul;93(7):2906-21. doi: 10.3168/jds.2010-3060.
192. Saadat M, Clin Chem Lab Med. 2020 Jun 25;58(7):1127-1128. doi: 10.1515/cclm-2020-0577.
193. Sakuta T, etal., Arthritis Rheum. 2010 May;62(5):1319-28.
194. Salmenkari H, etal., World J Gastroenterol. 2015 Sep 21;21(35):10072-9. doi: 10.3748/wjg.v21.i35.10072.
195. Sawada T, etal., Perit Dial Int. 2009 Feb;29 Suppl 2:S49-50.
196. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
197. Schürmann M, etal., J Intern Med. 2001 Jan;249(1):77-83. doi: 10.1046/j.1365-2796.2001.00776.x.
198. Sedov VA, Veterinariia. 1978 Dec;(12):10-2.
199. Settin A, etal., J Renin Angiotensin Aldosterone Syst. 2014 Jan 22.
200. Shahid SM, etal., Pak J Pharm Sci. 2013 Sep;26(5):853-7.
201. Sharifi AM, etal., Acta Physiol Hung. 2008 Mar;95(1):55-63.
202. Shenoy V, etal., Am J Respir Crit Care Med. 2010 Jun 25.
203. Shimizu H, etal., Hypertens Res. 2009 Sep;32(9):786-90. Epub 2009 Jul 10.
204. Shu Y, etal., J Sci Food Agric. 2019 Dec;99(15):6822-6832. doi: 10.1002/jsfa.9967. Epub 2019 Sep 18.
205. Silverstein E, etal., Ann N Y Acad Sci. 1976;278:498-513. doi: 10.1111/j.1749-6632.1976.tb47062.x.
206. Spencer AU, etal., Dig Dis Sci. 2007 Apr;52(4):1060-70. doi: 10.1007/s10620-006-9124-2. Epub 2007 Mar 7.
207. Srivastava K, etal., DNA Cell Biol. 2010 May 3.
208. Staessen JA, etal., J Hypertens. 1997 Dec;15(12 Pt 2):1579-92.
209. Stokkeland K, etal., Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):104-110. doi: 10.1111/bcpt.12844. Epub 2017 Jul 30.
210. Strittmatter SM, etal., Brain Res. 1986 Oct;394(2):207-15.
211. Sugimoto M, etal., Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1929-34. doi: 10.1158/1055-9965.EPI-06-0339.
212. Sun HL, etal., Exp Clin Endocrinol Diabetes. 2009 Jul;117(7):336-44. Epub 2009 Mar 19.
213. Szolnoki Z, etal., J Neurol. 2001 Sep;248(9):756-61.
214. Tahir M, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2007 Sep;24(2):106-12.
215. Tarnow L, etal., Diabetes. 1995 May;44(5):489-94.
216. Taskin E, etal., Ren Fail. 2014 May;36(4):606-12. doi: 10.3109/0886022X.2014.882737. Epub 2014 Feb 6.
217. Taşdemir N, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):445-8. doi: 10.1002/ajmg.b.30343.
218. Telford SE, etal., Br J Pharmacol. 1995 Mar;114(6):1185-92.
219. Thoene-Reineke C, etal., PLoS One. 2011;6(8):e23646. Epub 2011 Aug 25.
220. Tota S, etal., Behav Brain Res. 2012 Jan 1;226(1):317-30. Epub 2011 Aug 16.
221. Tseng CT, etal., J Virol. 2007 Feb;81(3):1162-73. Epub 2006 Nov 15.
222. Turgut S, etal., Med Princ Pract. 2005 Jul-Aug;14(4):213-6.
223. Turhan NK, etal., Genet Mol Res. 2015 Dec 16;14(4):17079-90. doi: 10.4238/2015.December.16.8.
224. Uma R, etal., J Matern Fetal Neonatal Med. 2010 Aug;23(8):874-9. doi: 10.3109/14767050903456667.
225. Uyy E, etal., Microvasc Res. 2010 Mar;79(2):154-9. Epub 2010 Jan 6.
226. van de Garde EM, etal., Clin Chem Lab Med. 2007;45(10):1326-31.
227. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
228. Velkoska E, etal., Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):49-55. Epub 2009 Apr 9.
229. Venkatesan N, etal., Toxicology. 1993 Dec 31;85(2-3):137-48.
230. Ventura PDS, etal., Malar J. 2019 Jun 24;18(1):213. doi: 10.1186/s12936-019-2846-3.
231. Wang F, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):113-6.
232. Wang G, etal., Kidney Blood Press Res. 2011;34(3):141-9. doi: 10.1159/000324521. Epub 2011 Feb 24.
233. Wang H, etal., Circ Res. 1999 Oct 1;85(7):614-22.
234. Wang JL, etal., Kidney Int. 2000 Jun;57(6):2334-42.
235. Wang LJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Apr;20(4):218-22.
236. Wang W, etal., Pediatr Surg Int. 2012 May;28(5):533-41. Epub 2012 Mar 24.
237. Wapstra FH, etal., Clin Sci (Lond). 1996 May;90(5):393-401.
238. Watanabe H, etal., Heart Rhythm. 2009 Sep;6(9):1327-32. doi: 10.1016/j.hrthm.2009.05.014. Epub 2009 May 15.
239. Wei CC, etal., PLoS One. 2012;7(6):e40110. doi: 10.1371/journal.pone.0040110. Epub 2012 Jun 29.
240. Weinreb RN, etal., Invest Ophthalmol Vis Sci. 1979 Dec;18(12):1285-7.
241. Winaver J, etal., Am J Physiol. 1988 May;254(5 Pt 2):R776-84.
242. Wosten-van Asperen RM, etal., Am J Pathol. 2010 May;176(5):2219-27. Epub 2010 Mar 19.
243. Wu CK, etal., Eur J Clin Invest. 2008 Nov;38(11):789-97. doi: 10.1111/j.1365-2362.2008.02017.x.
244. Wu CK, etal., Pharmacogenomics J. 2010 Feb;10(1):46-53. doi: 10.1038/tpj.2009.39. Epub 2009 Sep 15.
245. Xiong F, etal., J Surg Res. 2014 Jun 1;189(1):166-73. doi: 10.1016/j.jss.2014.01.057. Epub 2014 Feb 5.
246. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
247. Yang HY, etal., Br J Nutr. 2014 Jan 14;111(1):78-85. doi: 10.1017/S0007114513001876. Epub 2013 Jun 27.
248. Yaren A, etal., Exp Biol Med (Maywood). 2008 Jan;233(1):32-7.
249. Yazawa H, etal., J Card Fail. 2011 Dec;17(12):1041-50. Epub 2011 Oct 17.
250. Ye S, etal., Heart. 2003 Oct;89(10):1195-9.
251. Yigit S, etal., Cytokine. 2014 May;67(1):1-6. doi: 10.1016/j.cyto.2014.01.007. Epub 2014 Feb 22.
252. Yoon HJ, etal., Clin Genet. 2002 Aug;62(2):128-34.
253. Yoshida J, etal., Hypertension. 2004 Mar;43(3):686-91. doi: 10.1161/01.HYP.0000118017.02160.fa. Epub 2004 Feb 2.
254. Yoshida T and Nosaka S, J Neurochem. 1990 Dec;55(6):1861-9.
255. Yoshiji H, etal., World J Gastroenterol. 2006 Nov 14;12(42):6786-91. doi: 10.3748/wjg.v12.i42.6786.
256. Yoshioka M, etal., Am J Physiol. 1987 Dec;253(6 Pt 1):G781-6.
257. Yoshioka T, etal., Arch Dis Child. 1998 Nov;79(5):394-9.
258. Zderkiewicz E Pol Tyg Lek 1978 Jul 17;33(29):1157-9.
259. Zha Y, etal., J Renin Angiotensin Aldosterone Syst. 2015 Sep;16(3):695-9. doi: 10.1177/1470320314539829. Epub 2014 Sep 10.
260. Zhang L, etal., Hypertens Res. 2006 Oct;29(10):751-8.
261. Zhang XL, etal., Exp Ther Med. 2012 Oct;4(4):741-747. Epub 2012 Jul 31.
262. Zhou J, etal., J Huazhong Univ Sci Technolog Med Sci. 2004;24(2):158-61.
Additional References at PubMed
PMID:174834   PMID:1298871   PMID:1320019   PMID:1668266   PMID:1848554   PMID:1851160   PMID:2846041   PMID:2849100   PMID:2983326   PMID:4322742   PMID:6208535   PMID:7683654  
PMID:7876104   PMID:9231832   PMID:9449382   PMID:10406820   PMID:11076943   PMID:11303049   PMID:11702851   PMID:12193663   PMID:12477932   PMID:12540854   PMID:12963491   PMID:14527934  
PMID:14615289   PMID:14693687   PMID:14872008   PMID:15047629   PMID:15194348   PMID:15326289   PMID:15475532   PMID:15489334   PMID:15531746   PMID:15869764   PMID:15932931   PMID:15961527  
PMID:15992826   PMID:16009784   PMID:16027241   PMID:16116425   PMID:16186248   PMID:16230508   PMID:16325859   PMID:16434838   PMID:16502470   PMID:16585392   PMID:17077303   PMID:17082641  
PMID:17135368   PMID:17487824   PMID:17785632   PMID:17898118   PMID:17903697   PMID:18174884   PMID:18495113   PMID:18957386   PMID:19012043   PMID:19056867   PMID:19255705   PMID:19419949  
PMID:19472100   PMID:19733634   PMID:19773553   PMID:20011602   PMID:20022959   PMID:20051229   PMID:20116413   PMID:20570682   PMID:20888351   PMID:21053061   PMID:21082674   PMID:21167844  
PMID:21495912   PMID:21602471   PMID:21720771   PMID:21788250   PMID:21959517   PMID:22191573   PMID:22311897   PMID:22378820   PMID:22498331   PMID:23132538   PMID:23365412   PMID:23376485  
PMID:23533145   PMID:23535237   PMID:23603844   PMID:23661144   PMID:23706365   PMID:23733546   PMID:23749777   PMID:23975725   PMID:24126381   PMID:24781988   PMID:25017399   PMID:25031298  
PMID:25194129   PMID:25205218   PMID:25217176   PMID:25401104   PMID:25766467   PMID:25768373   PMID:26010093   PMID:26371174   PMID:26400542   PMID:26697495   PMID:27465904   PMID:27710705  
PMID:27923787   PMID:27995995   PMID:28003214   PMID:28536140   PMID:29360395   PMID:30806143   PMID:31346990  


Genomics

Candidate Gene Status
Ace is a candidate Gene for QTL Bp1
Ace is a candidate Gene for QTL Bp9
Ace is a candidate Gene for QTL Bp72
Ace is a candidate Gene for QTL Bp128
Ace is a candidate Gene for QTL Bp342
Comparative Map Data
Ace
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21090,910,316 - 90,930,437 (+)NCBI
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ACE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,734 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371761,554,422 - 61,575,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
Ace
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39mm39
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBImm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
ACE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0panPan3
ACE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl911,497,182 - 11,516,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1911,497,182 - 11,516,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101968921
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,394,487 - 15,414,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ace
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624849998,262 - 1,019,305 (+)NCBI

Position Markers
D10Mit1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01093,929,621 - 93,929,812NCBIRnor5.0
RGSC_v3.41095,368,898 - 95,369,088RGDRGSC3.4
RGSC_v3.11095,383,268 - 95,383,458RGD
SHRSP x BN Map1068.71RGD
SHRSP x BN Map1068.71UniSTS
FHH x ACI Map1075.81RGD
Cytogenetic Map10q32.1UniSTS
D10Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01094,178,338 - 94,178,506NCBIRnor6.0
Rnor_5.01093,929,634 - 93,929,802UniSTSRnor5.0
RGSC_v3.41095,368,909 - 95,369,078RGDRGSC3.4
RGSC_v3.41095,368,910 - 95,369,078UniSTSRGSC3.4
RGSC_v3.11095,383,279 - 95,383,448RGD
Celera1089,596,121 - 89,596,289UniSTS
RH 3.4 Map10978.1UniSTS
RH 3.4 Map10978.1RGD
RH 2.0 Map101075.9RGD
Cytogenetic Map10q32.1UniSTS
RH94768  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01094,084,710 - 94,084,825NCBIRnor6.0
Rnor_5.01093,840,108 - 93,840,223UniSTSRnor5.0
RGSC_v3.41095,381,340 - 95,381,455UniSTSRGSC3.4
Celera1089,608,551 - 89,608,666UniSTS
Cytogenetic Map10q32.1UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)1020170031102897474Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1023861015112626471Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)1027237530101482600Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1027237530102427718Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103618592995845311Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1041260363106105607Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1043289657108540162Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104659302198939209Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105063833795638337Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105310471898104718Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1053621375112626471Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1053621375112626471Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105362581598939209Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105363748594807701Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)1055224855100224855Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1055678976112626471Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)1055679084102427604Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1056698730101698730Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1060450007105450007Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1060875260105875260Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1060875260105875260Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1060875260105875260Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1062096293107096293Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)1064648175101691360Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1064648175102149713Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1064648175102149713Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1065590122110590122Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1065992275110992275Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1065992275110992275Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1067880046112626471Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1067988218110992091Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1069123603101482600Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1069385595112626471Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1069385595112626471Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1070166960112626471Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1070800069112626471Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1071692298112626471Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1073008136112626471Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1073008136112626471Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1073008136112626471Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1073467158112626471Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107504539197308358Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1075544754112626471Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1075544754112626471Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107598380599492217Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107598380599492217Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107705574198282519Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107897027998282519Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1078970279112626471Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1079927661112626471Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1080239190112626471Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1081515116101758478Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108338982894488181Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1083389828104994768Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1085079943112626471Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108551382295638337Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1086566908112626471Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108696256399303173Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108696256399303173Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108697786197308569Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1088544136107545372Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1090041957112626471Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)109029689799492409Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1090296897112626471Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109154814599492409Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1091689348112626471Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1093662786112626471Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1093662786112626471Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1093662786112626471Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1093662786112626471Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)93662786112626471Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)93662786112626471Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1093886117110992275Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1093886117112626471Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1094170766112626471Rat


Related Rat Strains
The following Strains have been annotated to Ace


Genetic Models
This gene Ace is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 23 10 15
Low 30 2 2 2 40 14 15
Below cutoff 2 20 20 20

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010627   ⟹   ENSRNOP00000010627
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1094,177,889 - 94,187,822 (+)Ensembl
RefSeq Acc Id: NM_012544   ⟹   NP_036676
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21090,910,316 - 90,930,437 (+)NCBI
Rnor_6.01094,170,766 - 94,213,831 (+)NCBI
Rnor_5.01093,922,062 - 93,965,127 (+)NCBI
RGSC_v3.41095,361,338 - 95,381,455 (+)RGD
Celera1089,588,544 - 89,608,666 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036676   ⟸   NM_012544
- Peptide Label: precursor
- UniProtKB: P47820 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010627   ⟸   ENSRNOT00000010627

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
ACE N-Terminal pdb 2c6f P47820 36-636 view protein structure  
ACE C-Terminal pdb 108a P47820 637-1238 view protein structure view video

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697829
Promoter ID:EPDNEW_R8353
Type:multiple initiation site
Name:Ace_1
Description:angiotensin I converting enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8354  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,170,755 - 94,170,815EPDNEW
RGD ID:13697846
Promoter ID:EPDNEW_R8354
Type:multiple initiation site
Name:Ace_2
Description:angiotensin I converting enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8353  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,177,884 - 94,177,944EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
10 93954844 93954845 T G snv SR/JrHsd (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2493 AgrOrtholog
Ensembl Genes ENSRNOG00000062101 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010627 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010627 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097136 IMAGE-MGC_LOAD
InterPro Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24310 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93629 IMAGE-MGC_LOAD
NCBI Gene 24310 ENTREZGENE
PANTHER PTHR10514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ACE RGD
PhenoGen Ace PhenoGen
PRINTS PEPDIPTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
UniProt A0A0A0MXV4_RAT UniProtKB/TrEMBL
  ACE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CJ04_RAT UniProtKB/TrEMBL
UniProt Secondary Q7TMC6 UniProtKB/Swiss-Prot
  Q8CFN1 UniProtKB/Swiss-Prot
  Q9EQM9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ace  angiotensin I converting enzyme (peptidyl-dipeptidase A) 1    angiotensin 1 converting enzyme  Name updated 1299863 APPROVED
2004-12-14 Ace  angiotensin 1 converting enzyme    angiotensin 1 converting enzyme 1  Name updated 1299863 APPROVED
2002-06-10 Ace  angiotensin 1 converting enzyme 1      Symbol and Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease affects heart mass independent of blood pressure 1357231
gene_process functions in the renin-angiotensin system 61036
gene_process plays an important role in the regulation of blood volume and pressure 61036
gene_process level of plasma enzyme activity does not directly link to blood pressure 619632