RGD Reference Report - Genetic polymorphisms of the renin-angiotensin system in breast cancer patients. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Genetic polymorphisms of the renin-angiotensin system in breast cancer patients.

Authors: Fishchuk, LE  Gorovenko, NG 
Citation: Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
RGD ID: 8548866
Pubmed: PMID:23828384   (View Abstract at PubMed)

BACKGROUND: Breast cancer (BC) is one of the most common cancer pathologies in women. Genetic polymorphism of genes of renin-angiotensin system (RAS) is considered to be associated with cancer development, in particular, with BC. AIM: To study the influence of polymorphic variants of genes coding for RAS components, on the risk of BC development in Ukrainian women. MATERIALS AND METHODS: In the study 131 patients with histologically proven diagnosis of BC of I and II stages were enrolled. The control group was composed from 102 women without cancer. Polymorphic variants of AGT, ACE, AT2R1 genes were studied with the use of PCR and PCR-RFLP methods. RESULTS: It has been revealed that the presence of 1166capital A, Cyrilliccapital ES, Cyrillic genotype of AT2R1 gene elevates the risk of BC development nearly 2-fold. The results of analysis for common group and subgroups distributed by age are different. For women from 18 to 35 years old the significant differences were not found. For women from 36 to 54 years old an increased risk of BC development is determined by the presence of D allele of capital A, Cyrilliccapital ES, Cyrilliccapital IE, Cyrillic gene. Decreased risk of BC development was associated with the presence of combined genotypes ACE II/AGT 174TT and ACE II/AGT 235capital EM, Cyrilliccapital TE, Cyrillic. In women older than 54 years an increased risk of BC development was found to be related to the presence of genotypes 235capital TE, CyrillicT of AGT gene and 1166capital A, Cyrilliccapital ES, Cyrillic of AT2R1 gene. The presence of genotype combinations AGT 235capital TE, Cyrilliccapital TE, Cyrillic/AGT 174capital TE, Cyrilliccapital EM, Cyrillic and AGT 235capital TE, Cyrilliccapital TE, Cyrillic/AT2R1 1166AA in women of this age subgroup also significantly increases the risk of BC development. CONCLUSION: These polymorphic gene variants and their associations may be considered as possible prognostic markers of BC development. The results of analysis are different in total cohort and in subgroups distributed by age.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer susceptibilityIAGP 8548866DNA:insertion/deletion and haplotypeRGD 
breast cancer  IAGP 8548866DNA:polymorphisms more ...RGD 
breast cancer  IAGP 8548866DNA:polymorphism and haplotype: :1166A>C (human) RGD 
breast cancer susceptibilityISOACE (Homo sapiens)8548866; 8548866DNA:insertion/deletion and haplotypeRGD 
breast cancer  ISOAGT (Homo sapiens)8548866; 8548866DNA:polymorphisms more ...RGD 
breast cancer  ISOAGTR1 (Homo sapiens)8548866; 8548866DNA:polymorphism and haplotype: :1166A>C (human) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)
Agt  (angiotensinogen)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)
Agt  (angiotensinogen)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)
AGT  (angiotensinogen)
AGTR1  (angiotensin II receptor type 1)


Additional Information