Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) - Rat Genome Database

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Gene: Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) Mus musculus
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Symbol: Ace
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
RGD ID: 10468
MGI Page MGI
Description: Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; benazepril pharmacodynamics pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: angiotensin converting enzyme; angiotensin-converting enzyme; AW208573; CD143; dipeptidyl carboxypeptidase I; dipeptidyl peptidase; kininase II; MGC117827
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBImm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (IEP)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
Alcoholic Liver Diseases  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Angiotensin I-Converting Enzyme, Benign Serum Increase  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (ISO)
Arteriovenous Fistula  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
bipolar disorder  (IEA)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
CAKUT  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chemical colitis  (IEP)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholestasis  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Hepatic Fibrosis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Familial Cerebral Cavernous Malformation  (ISO)
familial Mediterranean fever  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
gallbladder adenocarcinoma  (ISO)
Gaucher's disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
glycogen storage disease V  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis A  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxia  (ISO)
hypertension  (IMP,ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
in situ carcinoma  (IMP)
Insulin Resistance  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (IEP)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (IAGP,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (IMP)
male infertility  (ISO)
Memory Disorders  (ISO)
Meningococcal Infections  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve disease  (ISO)
mitral valve prolapse  (ISO)
multiple myeloma  (ISO)
Mycobacterium Infections  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
ocular hypotension  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreatic cancer  (IMP)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (IMP,ISO)
Pleural Effusion  (ISO)
pneumonia  (ISO)
polycythemia  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Infant Diseases  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyelonephritis  (ISO)
Radiation Nephropathy  (ISO)
renal fibrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory system disease  (ISO)
Right Ventricular Hypertrophy  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Staphylococcal Infections  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
subacute sclerosing panencephalitis  (ISO)
substance-induced psychosis  (ISO)
Sudden Death  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
uveitis  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Remodeling  (ISO)
viral pneumonia  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
(S,S,S)-nicotianamine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP)
14,15-EET  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
aminoguanidine  (EXP)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
candesartan  (ISO)
captan  (EXP)
captopril  (EXP,ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
cilazapril monohydrate  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fenvalerate  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
fructose  (ISO)
furan  (ISO)
genistein  (ISO)
glucose  (ISO)
glycidol  (ISO)
GW 4064  (EXP)
herbimycin  (ISO)
hydralazine  (ISO)
hydrazines  (EXP)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipoic acid  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithium chloride  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
manganese(II) chloride  (ISO)
manidipine  (ISO)
methoxychlor  (ISO)
metoprolol  (ISO)
microcystin RR  (EXP)
mifepristone  (ISO)
monocrotaline  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
Nandrolone decanoate  (ISO)
naringin  (ISO)
nicotianamine  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
NS-398  (ISO)
omapatrilat  (ISO)
ouabain  (ISO)
paraquat  (EXP,ISO)
perindopril  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pregabalin  (ISO)
proanthocyanidin  (ISO)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
spironolactone  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trandolapril  (ISO)
tributylstannane  (EXP)
triclosan  (ISO)
triptonide  (EXP)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta metabolic process  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
animal organ regeneration  (ISO)
arachidonic acid secretion  (ISO)
bradykinin catabolic process  (ISO)
brain development  (ISO)
cell proliferation in bone marrow  (IMP)
cellular response to aldosterone  (ISO)
cellular response to glucose stimulus  (ISO)
eating behavior  (ISO)
embryo development ending in birth or egg hatching  (ISO)
female pregnancy  (ISO)
heart contraction  (IMP)
hormone catabolic process  (IDA,ISO)
kidney development  (IMP,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
male gonad development  (ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of gap junction assembly  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of glucose import  (ISO)
negative regulation of protein binding  (IMP)
negative regulation of renal sodium excretion  (ISO)
neutrophil mediated immunity  (IMP)
peptide catabolic process  (ISO)
peptide metabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of peptidyl-cysteine S-nitrosylation  (IMP)
positive regulation of peptidyl-tyrosine autophosphorylation  (IMP)
positive regulation of protein binding  (IMP)
positive regulation of protein tyrosine kinase activity  (IMP)
positive regulation of systemic arterial blood pressure  (IBA,IMP,ISO)
positive regulation of vasoconstriction  (ISO)
posttranscriptional regulation of gene expression  (IMP)
proteolysis  (IEA)
regulation of angiotensin metabolic process  (ISO)
regulation of blood pressure  (IDA,ISO)
regulation of hematopoietic stem cell proliferation  (IMP)
regulation of smooth muscle cell migration  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IBA,ISO)
response to dexamethasone  (ISO)
response to hypoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISO)
spermatogenesis  (IMP)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiotensin I-converting enzyme activity  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating angiotensinogen level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal interleukin level  (IAGP)
abnormal kidney arterial blood vessel morphology  (IAGP)
abnormal kidney blood vessel morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney corticomedullary boundary morphology  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney medullary ray morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney papilla morphology  (IAGP)
abnormal kidney pelvis morphology  (IAGP)
abnormal renal artery morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal sperm physiology  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal urine osmolality  (IAGP)
albuminuria  (IAGP)
atrial fibrillation  (IAGP)
decreased angiotensin I-converting enzyme activity  (IAGP)
decreased angiotensin II level  (IAGP)
decreased body weight  (IAGP)
decreased circulating angiotensin II level  (IAGP)
decreased circulating angiotensinogen level  (IAGP)
decreased fertilization frequency  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased hematocrit  (IAGP)
decreased insulin secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IAGP)
decreased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased tumor growth/size  (IAGP)
decreased urine aldosterone level  (IAGP)
decreased urine osmolality  (IAGP)
dilated heart  (IAGP)
dilated kidney calyx  (IAGP)
dilated renal glomerular capsule  (IAGP)
enlarged heart atrium  (IAGP)
hydronephrosis  (IAGP)
hypotension  (IAGP)
impaired binding of sperm to zona pellucida  (IAGP)
impaired fertilization  (IAGP)
increased angiotensin I-converting enzyme activity  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased body weight  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating renin level  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased glomerular capsule space  (IAGP)
increased heart rate  (IAGP)
increased heart weight  (IAGP)
increased insulin secretion  (IAGP)
increased renin activity  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased T cell number  (IAGP)
increased urine potassium level  (IAGP)
kidney atrophy  (IAGP)
kidney cortex atrophy  (IAGP)
kidney cysts  (IAGP)
kidney inflammation  (IAGP)
kidney medulla atrophy  (IAGP)
kidney medulla cysts  (IAGP)
kidney medulla hypoplasia  (IAGP)
kidney papillary atrophy  (IAGP)
polyuria  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
reduced male fertility  (IAGP)
renal tubule atrophy  (IAGP)
tubulointerstitial nephritis  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
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PMID:20614101   PMID:20667972   PMID:20937811   PMID:21115616   PMID:21116821   PMID:21148418   PMID:21267068   PMID:21386911   PMID:21622682   PMID:21677750   PMID:21873635   PMID:21964607  
PMID:22203735   PMID:22580272   PMID:22999937   PMID:23055941   PMID:23535237   PMID:23619363   PMID:23633567   PMID:23846498   PMID:24194600   PMID:24414175   PMID:24475296   PMID:24487585  
PMID:24501175   PMID:24614194   PMID:24800825   PMID:24952961   PMID:25012170   PMID:25017399   PMID:25249154   PMID:25273883   PMID:25924878   PMID:27055902   PMID:27601681   PMID:27879415  
PMID:27880904   PMID:27988209   PMID:28273875   PMID:28390948   PMID:28394320   PMID:28515091   PMID:28665931   PMID:28935757   PMID:29101168   PMID:29187372   PMID:29549541   PMID:29684311  
PMID:29750573   PMID:29884907   PMID:30088535   PMID:30185469   PMID:30670595   PMID:31345929   PMID:31455729   PMID:31615657   PMID:31794021   PMID:31871049   PMID:32238693   PMID:32325033  
PMID:32669323   PMID:33480126  


Genomics

Comparative Map Data
Ace
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBImm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
ACE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
Ace
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21090,910,316 - 90,930,437 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1090,910,316 - 90,931,131 (+)Ensembl
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ACE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0panPan3
ACE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,497,182 - 11,516,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,497,182 - 11,516,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,457,866 - 12,477,045 (+)NCBI
ROS_Cfam_1.0913,160,704 - 13,179,888 (+)NCBI
UMICH_Zoey_3.1912,105,344 - 12,124,523 (+)NCBI
UNSW_CanFamBas_1.0915,407,255 - 15,426,429 (-)NCBI
UU_Cfam_GSD_1.0915,410,134 - 15,429,354 (-)NCBI
LOC101968921
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBI
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,394,487 - 15,414,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ace
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624849998,262 - 1,019,305 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AW208573  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,989,000 - 105,989,092UniSTSGRCm38
MGSCv3711105,850,314 - 105,850,406UniSTSGRCm37
Celera11117,720,546 - 117,720,638UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS
Whitehead/MRC_RH111424.74UniSTS
D11Mit13  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,975,635 - 105,975,795UniSTSGRCm38
MGSCv3711105,836,949 - 105,837,109UniSTSGRCm37
Celera11117,707,159 - 117,707,319UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS
Whitehead Genetic1165.6UniSTS
Whitehead_YAC11 UniSTS
D10Mit1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,975,635 - 105,975,795UniSTSGRCm38
MGSCv3711105,836,949 - 105,837,109UniSTSGRCm37
Celera11117,707,159 - 117,707,319UniSTS
Cytogenetic Map11E1UniSTS
cM Map103.0UniSTS
cM Map106.0UniSTS
cM Map1165.0UniSTS
Whitehead Genetic103.3UniSTS
Whitehead/MRC_RH10159.89UniSTS
D10Wox18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,975,646 - 105,975,785UniSTSGRCm38
MGSCv3711105,836,960 - 105,837,099UniSTSGRCm37
Celera11117,707,170 - 117,707,309UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS
Ace  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811105,989,113 - 105,989,238UniSTSGRCm38
MGSCv3711105,850,427 - 105,850,552UniSTSGRCm37
Celera11117,720,659 - 117,720,784UniSTS
Cytogenetic Map11E1UniSTS
cM Map1165.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196285639108915558Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1197006867110713165Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101613994114581537Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101613994114581537Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101613994114581537Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101613994114581537Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102453297112493297Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103383166115130618Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1042
Count of miRNA genes:476
Interacting mature miRNAs:539
Transcripts:ENSMUST00000001963, ENSMUST00000001964, ENSMUST00000132280, ENSMUST00000151657
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001281819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_207624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK087056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY197083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY210311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001963   ⟹   ENSMUSP00000001963
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)Ensembl
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)Ensembl
RefSeq Acc Id: ENSMUST00000001964   ⟹   ENSMUSP00000001964
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,866,034 - 105,880,079 (+)Ensembl
GRCm38.p6 Ensembl11105,975,208 - 105,989,253 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132280   ⟹   ENSMUSP00000119826
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,862,149 - 105,880,086 (+)Ensembl
GRCm38.p6 Ensembl11105,971,323 - 105,989,260 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151657
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11105,867,431 - 105,875,939 (+)Ensembl
GRCm38.p6 Ensembl11105,976,605 - 105,985,113 (+)Ensembl
RefSeq Acc Id: NM_001281819   ⟹   NP_001268748
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,858,774 - 105,880,790 (+)NCBI
GRCm3811105,967,948 - 105,989,964 (+)NCBI
Celera11117,699,473 - 117,721,510 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009598   ⟹   NP_033728
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,866,015 - 105,880,790 (+)NCBI
GRCm3811105,975,189 - 105,989,964 (+)NCBI
MGSCv3711105,829,261 - 105,851,259 (+)RGD
Celera11117,699,473 - 117,721,510 (+)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_207624   ⟹   NP_997507
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911105,858,774 - 105,880,790 (+)NCBI
GRCm3811105,967,948 - 105,989,964 (+)NCBI
MGSCv3711105,829,261 - 105,851,259 (+)RGD
Celera11117,699,473 - 117,721,510 (+)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_997507   ⟸   NM_207624
- Peptide Label: isoform 1 precursor
- UniProtKB: P09470 (UniProtKB/Swiss-Prot),   Q3TU20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_033728   ⟸   NM_009598
- Peptide Label: isoform 2 precursor
- UniProtKB: P09470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001268748   ⟸   NM_001281819
- Peptide Label: isoform 3 precursor
- UniProtKB: Q3TU20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000119826   ⟸   ENSMUST00000132280
RefSeq Acc Id: ENSMUSP00000001963   ⟸   ENSMUST00000001963
RefSeq Acc Id: ENSMUSP00000001964   ⟸   ENSMUST00000001964

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
ACE N-Terminal pdb 2c6f P09470 35-635 view protein structure  
ACE C-Terminal pdb 108a P09470 636-1237 view protein structure view video

Promoters
RGD ID:6820264
Promoter ID:MM_KWN:10200
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000006415,   UC007LXV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611105,829,191 - 105,829,691 (+)MPROMDB
RGD ID:6820263
Promoter ID:MM_KWN:10202
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000001964
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611105,835,741 - 105,836,492 (+)MPROMDB
RGD ID:6820265
Promoter ID:MM_KWN:10203
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000006418
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611105,836,731 - 105,837,231 (+)MPROMDB
RGD ID:8677042
Promoter ID:EPDNEW_M16552
Type:multiple initiation site
Name:Ace_1
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811105,967,948 - 105,968,008EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87874 AgrOrtholog
Ensembl Genes ENSMUSG00000020681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000001963 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000001964 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000119826 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001963 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000001964 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000132280 ENTREZGENE, UniProtKB/TrEMBL
InterPro Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87874 ENTREZGENE
NCBI Gene 11421 ENTREZGENE
PANTHER PTHR10514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ACE RGD
PhenoGen Ace PhenoGen
PRINTS PEPDIPTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
UniProt ACE_MOUSE UniProtKB/Swiss-Prot
  F6QCP8_MOUSE UniProtKB/TrEMBL
  P09470 ENTREZGENE
  Q3TU20 ENTREZGENE, UniProtKB/TrEMBL
  Q3U3Q7_MOUSE UniProtKB/TrEMBL
  Q5XK22_MOUSE UniProtKB/TrEMBL
  Q7TSV8_MOUSE UniProtKB/TrEMBL
  Q8C339_MOUSE UniProtKB/TrEMBL
  Q8K233_MOUSE UniProtKB/TrEMBL
UniProt Secondary P22967 UniProtKB/Swiss-Prot
  Q6GTS2 UniProtKB/Swiss-Prot