Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) Mus musculus
Symbol: Ace
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
RGD ID: 10468
Description: Exhibits metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Localizes to cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including Coronavirus infectious disease (multiple); artery disease (multiple); autoimmune disease (multiple); lung disease (multiple); and nephritis (multiple). Orthologous to human ACE (angiotensin I converting enzyme); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; benazepril pharmacodynamics pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: angiotensin converting enzyme; angiotensin-converting enzyme; AW208573; CD143; dipeptidyl carboxypeptidase I; dipeptidyl peptidase; kininase II; MGC117827
Homo sapiens (human) : ACE (angiotensin I converting enzyme)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ace (angiotensin I converting enzyme)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ACE (angiotensin I converting enzyme)
Canis lupus familiaris (dog) : ACE (angiotensin I converting enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101968921 (angiotensin-converting enzyme)
Sus scrofa (pig) : ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)
Heterocephalus glaber (naked mole-rat) : Ace (angiotensin I converting enzyme)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911105,858,774 - 105,880,790 (+)NCBI
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBImm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Protein Structures

Additional Information

External Database Links
More on Ace
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10468
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.